Publications by authors named "Nick Barker"

84Publications

The Function of Cells in the Gastric Antrum Does Not Require or In Vivo.

Biomedicines 2019 Jul 8;7(3). Epub 2019 Jul 8.

University of Melbourne & Victorian Infectious Diseases Reference Laboratory, Doherty Institute of Infection and Immunity, Melbourne VIC 3000, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biomedicines7030050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783992PMC
July 2019

Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach.

Int J Mol Sci 2019 Jun 17;20(12). Epub 2019 Jun 17.

Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20122955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628191PMC
June 2019

A contemporary snapshot of intestinal stem cells and their regulation.

Differentiation 2019 Jul - Aug;108:3-7. Epub 2019 Jan 25.

A⁎STAR Institute of Medical Biology, 138648 Singapore, Singapore; Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan; Centre for Regenerative Medicine, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK; School of Biological Sciences, Nanyang Technological University, Singapore 308232, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diff.2019.01.004DOI Listing
January 2020

Is Required for Wnt Signaling in Gastric Tumors with and Without Mutations.

Cancer Res 2019 03 8;79(5):970-981. Epub 2019 Jan 8.

University of Melbourne & Victorian Infectious Diseases Reference Laboratory, Doherty Institute of Infection and Immunity, Melbourne, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-18-2095DOI Listing
March 2019

Recent Advances in Lgr5 Stem Cell Research.

Trends Cell Biol 2018 05 21;28(5):380-391. Epub 2018 Feb 21.

A*STAR Institute of Medical Biology, 138648, Singapore; Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan; Centre for Regenerative Medicine, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcb.2018.01.010DOI Listing
May 2018

The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy.

Prog Mol Biol Transl Sci 2018 01 21;153:299-319. Epub 2017 Dec 21.

Doherty Institute of Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia; European Cancer Stem Cell Research Institute, Cardiff University, Cardiff, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.pmbts.2017.11.009DOI Listing
January 2018

Wnt Signaling in Adult Epithelial Stem Cells and Cancer.

Prog Mol Biol Transl Sci 2018 01 8;153:21-79. Epub 2018 Jan 8.

A*STAR Institute of Medical Biology, Singapore; Kanazawa University, Kanazawa, Japan; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.pmbts.2017.11.017DOI Listing
January 2018

Stem cells in 2017: Digesting recent stem cell advances in the gut.

Authors:
Nick Barker

Nat Rev Gastroenterol Hepatol 2018 02 4;15(2):78-80. Epub 2018 Jan 4.

A*STAR Institute of Medical Biology, 8a Biomedical Grove, 138648 Singapore; the Cancer Research Institute, Kanazawa University, Kakuma-machi Kanazawa, 920-1192, Japan; and the Centre for Regenerative Medicine, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrgastro.2017.176DOI Listing
February 2018

Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer.

Cancer Cell 2018 01 28;33(1):137-150.e5. Epub 2017 Dec 28.

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore 169856, Singapore; Cellular and Molecular Research, National Cancer Centre, Singapore 169610, Singapore; Singapore Gastric Cancer Consortium, Singapore 119074, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2017.11.018DOI Listing
January 2018

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation .

Dis Model Mech 2017 08 9;10(8):971-980. Epub 2017 Jun 9.

University of Melbourne and Victorian Infectious Diseases Reference Laboratory, Doherty Institute of Infection and Immunity, Melbourne, Victoria 3000, Australia

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.029876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560064PMC
August 2017

Quantifying Lgr5-positive stem cell behaviour in the pyloric epithelium.

Sci Rep 2016 Feb 26;6:21923. Epub 2016 Feb 26.

Gut Health and Food Safety Programme. Institute of Food Research, Norwich, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep21923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768140PMC
February 2016

Organoids as an in vitro model of human development and disease.

Nat Cell Biol 2016 Mar;18(3):246-54

A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb3312DOI Listing
March 2016

Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate.

Cancer Cell 2015 Dec;28(6):683-685

Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648 Singapore, Singapore; MRC Centre for Regenerative Medicine, The University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596 Singapore, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2015.11.004DOI Listing
December 2015

Ovary and fimbrial stem cells: biology, niche and cancer origins.

Nat Rev Mol Cell Biol 2015 Oct 9;16(10):625-38. Epub 2015 Sep 9.

A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648 Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrm4056DOI Listing
October 2015

Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.

Stem Cell Reports 2015 May 16;4(5):759-67. Epub 2015 Apr 16.

Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, VIC 3010, Australia; Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC 3000, Australia; Curtin University, Perth, WA 6845, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2015.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437483PMC
May 2015

Lgr5 marks stem/progenitor cells in ovary and tubal epithelia.

Nat Cell Biol 2014 Aug 6;16(8):745-57. Epub 2014 Jul 6.

1] A-STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore [2] Centre for Regenerative Medicine, 47 Little France Crescent, University of Edinburgh, EH16 4TJ, UK [3] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb3000DOI Listing
August 2014

Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development.

J Biol Chem 2014 Aug 25;289(34):23809-16. Epub 2014 Jun 25.

the Stowers Institute for Medical Research, Kansas City, Missouri 64110, Pathology, University of Kansas Medical Center, Kansas City, Kansas 66160

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.568170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156055PMC
August 2014

Ex vivo culture of the intestinal epithelium: strategies and applications.

Gut 2014 Aug 19;63(8):1345-54. Epub 2014 May 19.

A*STAR Institute of Medical Biology, Singapore Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2014-307204DOI Listing
August 2014

Epithelial stem cells and intestinal cancer.

Semin Cancer Biol 2015 Jun 19;32:40-53. Epub 2014 Feb 19.

A-STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648 Singapore, Singapore; Centre for Regenerative Medicine, 47 Little France Crescent, University of Edinburgh, EH164TJ, UK; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596 Singapore, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcancer.2014.02.005DOI Listing
June 2015

Ovarian LGR5 is critical for successful pregnancy.

FASEB J 2014 May 27;28(5):2380-9. Epub 2014 Jan 27.

1Cincinnati Children's Hospital Medical Center, Division of Reproductive Sciences, MLC 7045, 3333 Burnet Ave., Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.13-248344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986831PMC
May 2014

Intestinal stem cells and their defining niche.

Curr Top Dev Biol 2014 ;107:77-107

Institute of Medical Biology, Singapore; MRC Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-416022-4.00003-2DOI Listing
September 2014

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration.

Authors:
Nick Barker

Nat Rev Mol Cell Biol 2014 Jan 11;15(1):19-33. Epub 2013 Dec 11.

A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648 Singapore. MRC Centre for Regenerative Medicine, The University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596 Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrm3721DOI Listing
January 2014

LGR5 positivity defines stem-like cells in colorectal cancer.

Carcinogenesis 2014 Apr 26;35(4):849-58. Epub 2013 Nov 26.

Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgt377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977143PMC
April 2014

Lgr proteins in epithelial stem cell biology.

Development 2013 Jun;140(12):2484-94

Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648 Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.083113DOI Listing
June 2013

Stem cell reprogramming as a driver of basal cell carcinoma.

Nat Cell Biol 2012 Dec;14(12):1246-7

Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648 Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb2631DOI Listing
December 2012

Identifying the stem cell of the intestinal crypt: strategies and pitfalls.

Cell Stem Cell 2012 Oct;11(4):452-60

Institute of Medical Biology, 8A Biomedical Grove, Immunos 138648, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2012.09.009DOI Listing
October 2012

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.

Nat Cell Biol 2012 10 23;14(10):1099-1104. Epub 2012 Sep 23.

Hubrecht Institute for Developmental Biology and Stem Cell Research & University Medical Centre Utrecht, Uppsalalaan 8, 3584CT Utrecht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb2581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789123PMC
October 2012

Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.

Cell Rep 2012 Sep 20;2(3):540-52. Epub 2012 Sep 20.

Hubrecht Institute for Developmental Biology and Stem Cell Research/University Medical Centre Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2012.08.018DOI Listing
September 2012

Epithelial stem cells in the esophagus: who needs them?

Authors:
Nick Barker

Cell Stem Cell 2012 Sep;11(3):284-6

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2012.08.005DOI Listing
September 2012

Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".

Mol Cell Biol 2012 Sep 9;32(18):3639-47. Epub 2012 Jul 9.

Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, and University Medical Centre Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00434-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430189PMC
September 2012

Alteration of colonic stem cell gene signatures during the regenerative response to injury.

Biochim Biophys Acta 2012 Oct 30;1822(10):1600-7. Epub 2012 Jun 30.

Center for Environmental & Rural Health, Texas A&M University, College Station, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2012.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418394PMC
October 2012

Gut stem cells in tissue renewal and disease: methods, markers, and myths.

Wiley Interdiscip Rev Syst Biol Med 2012 Sep-Oct;4(5):475-96. Epub 2012 May 29.

Institute of Medical Biology, A-STAR, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/wsbm.1176DOI Listing
January 2013

Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells.

Gut 2012 Dec 23;61(12):1678-85. Epub 2011 Dec 23.

Nashville VA Medical Center and the Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2733, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2011-301193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767919PMC
December 2012

Cdx2 determines the fate of postnatal intestinal endoderm.

Development 2012 Feb 21;139(3):465-74. Epub 2011 Dec 21.

Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.070722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252350PMC
February 2012

Gastrointestinal stem cells in self-renewal and cancer.

J Gastroenterol 2011 Sep 5;46(9):1039-55. Epub 2011 Jul 5.

Institute of Medical Biology, 8A Biomedical Grove, #06-06 Immunos, Singapore 138648, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00535-011-0424-8DOI Listing
September 2011

Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.

Proc Natl Acad Sci U S A 2011 Mar 14;108(10):4099-104. Epub 2011 Feb 14.

Center for Biosciences and Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 141 83 Huddinge, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1014489108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054016PMC
March 2011

A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt.

PLoS Comput Biol 2011 Jan 6;7(1):e1001045. Epub 2011 Jan 6.

Interdisciplinary Centre for Bioinformatics, University Leipzig, Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1001045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017108PMC
January 2011

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

Nature 2011 Jan 28;469(7330):415-8. Epub 2010 Nov 28.

Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature09637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547360PMC
January 2011

Tissue-resident adult stem cell populations of rapidly self-renewing organs.

Cell Stem Cell 2010 Dec;7(6):656-70

Hubrecht Institute, Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19345909100063
Publisher Site
http://dx.doi.org/10.1016/j.stem.2010.11.016DOI Listing
December 2010

Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis.

Proc Natl Acad Sci U S A 2010 Nov 1;107(46):20027-32. Epub 2010 Nov 1.

University of Pittsburgh Cancer Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1010430107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993406PMC
November 2010

Lineage tracing in the intestinal epithelium.

Curr Protoc Stem Cell Biol 2010 May;Chapter 5:Unit5A.4

Hubrecht Institute for Developmental Biology and Stem Cell Research, and University Medical Center Utrecht (UMCU), Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/9780470151808.sc05a04s13DOI Listing
May 2010

Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells.

Gastroenterology 2010 May;138(5):1681-96

Hubrecht Institute, Uppsalalaan, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S001650851000336
Publisher Site
http://dx.doi.org/10.1053/j.gastro.2010.03.002DOI Listing
May 2010

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.

Science 2010 Mar;327(5971):1385-9

Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1184733DOI Listing
March 2010

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

Cell Stem Cell 2010 Feb;6(2):175-81

Cell and Developmental Biology, University of Dundee, Dundee, DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2009.12.007DOI Listing
February 2010

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.

Nat Genet 2009 Oct 30;41(10):1138-43. Epub 2009 Aug 30.

Institute of Molecular Medicine and Max-Planck-Research Department on Stem Cell Aging, University of Ulm, Ulm, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.426DOI Listing
October 2009

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

Nature 2009 May 29;459(7244):262-5. Epub 2009 Mar 29.

Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nature07935
Publisher Site
http://dx.doi.org/10.1038/nature07935DOI Listing
May 2009

Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.

Gastroenterology 2009 Jun 24;136(7):2187-2194.e1. Epub 2009 Mar 24.

Hubrecht Institute, KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2009.03.002DOI Listing
June 2009

Detection of beta-catenin localization by immunohistochemistry.

Methods Mol Biol 2008 ;468:91-8

Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-249-6_7DOI Listing
January 2009

The canonical Wnt/beta-catenin signalling pathway.

Authors:
Nick Barker

Methods Mol Biol 2008 ;468:5-15

Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-249-6_1DOI Listing
January 2009

Crypt stem cells as the cells-of-origin of intestinal cancer.

Nature 2009 Jan 17;457(7229):608-11. Epub 2008 Dec 17.

Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature07602DOI Listing
January 2009

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

Nat Genet 2008 Nov 12;40(11):1291-9. Epub 2008 Oct 12.

Karolinska Institutet, Department of Biosciences and Nutrition, Novum, SE-141 57 Huddinge, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.239DOI Listing
November 2008

The intestinal stem cell.

Genes Dev 2008 Jul;22(14):1856-64

Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.1674008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735277PMC
July 2008

The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression.

Clin Exp Metastasis 2008 19;25(6):657-63. Epub 2008 Mar 19.

Cancer Biology Laboratory, Department of Anatomy and Cell Biology, University of Melbourne, Level 7, Medical Building, Parkville, VIC 3010, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10585-008-9156-4DOI Listing
September 2008

Tracking down the stem cells of the intestine: strategies to identify adult stem cells.

Gastroenterology 2007 Dec;133(6):1755-60

Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2007.10.029DOI Listing
December 2007

Identification of stem cells in small intestine and colon by marker gene Lgr5.

Nature 2007 Oct 14;449(7165):1003-7. Epub 2007 Oct 14.

Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature06196DOI Listing
October 2007

Mining the Wnt pathway for cancer therapeutics.

Nat Rev Drug Discov 2006 Dec;5(12):997-1014

Hubrecht laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8 3584CT, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd2154DOI Listing
December 2006

WNT signaling in the normal intestine and colorectal cancer.

Front Biosci 2007 Jan 1;12:471-91. Epub 2007 Jan 1.

Hubrecht Laboratory, Netherlands Institute for Developmental Biology, 3584 CT Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2741/2076DOI Listing
January 2007

Functional interaction between beta-catenin and FOXO in oxidative stress signaling.

Science 2005 May;308(5725):1181-4

Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1109083DOI Listing
May 2005

You Wnt some, you lose some: oncogenes in the Wnt signaling pathway.

Curr Opin Genet Dev 2003 Feb;13(1):28-33

Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0959-437x(02)00012-6DOI Listing
February 2003

Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein.

Biochem J 2002 May;364(Pt 1):255-64

University Medical Centre Utrecht, Department of Immunology, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222568PMC
http://dx.doi.org/10.1042/bj3640255DOI Listing
May 2002

TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling.

Biol Chem 2002 Feb;383(2):255-61

Department of Immunology, University Hospital Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
https://www.degruyter.com/view/j/bchm.2002.383.issue-2/bc.20
Publisher Site
http://dx.doi.org/10.1515/BC.2002.027DOI Listing
February 2002