Publications by authors named "Nicholas Vandegraaff"

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Bioactive glycosides from the African medicinal plant Boerhavia erecta L.

Nat Prod Res 2015 20;29(20):1954-8. Epub 2015 Feb 20.

a School of Chemistry, University of Wollongong , Northfields Avenue, Wollongong , New South Wales 2522 , Australia.

Phytochemical studies of the previously unexplored stem of Boerhavia erecta from Burkina Faso, resulted in the isolation of an unreported glycoside 4, 2,3-dihydroxypropylbenzoate-3-O-β-[4″-methoxy] glucuronide as well as seven known glycosides (1-3, 5-8). The major isolate 5 and 8 indicated a significant inhibition against HIV integrase (IC50 10 and 22 μg/mL, respectively). The extracts and isolates were also tested for anti-malarial activity, but insignificant activity was observed.
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December 2015