Nicholas T Seyfried

Nicholas T Seyfried

UNVERIFIED PROFILE

Are you Nicholas T Seyfried?   Register this Author

Register author
Nicholas T Seyfried

Nicholas T Seyfried

Publications by authors named "Nicholas T Seyfried"

Are you Nicholas T Seyfried?   Register this Author

85Publications

2281Reads

36Profile Views

Transcriptional regulation of homeostatic and disease-associated-microglial genes by IRF1, LXRβ, and CEBPα.

Glia 2019 10 13;67(10):1958-1975. Epub 2019 Jul 13.

Department of Neurology, Emory University, Atlanta, GA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/glia.23678DOI Listing
October 2019

Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease.

Cell Rep 2019 Oct;29(2):301-316.e10

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.08.104DOI Listing
October 2019

Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer's Disease.

Proteomes 2019 Aug 27;7(3). Epub 2019 Aug 27.

Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/proteomes7030030DOI Listing
August 2019

Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue.

Sci Rep 2019 Aug 29;9(1):12546. Epub 2019 Aug 29.

Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-48972-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715797PMC
August 2019

Mass Spectrometry-Based Quantification of Tau in Human Cerebrospinal Fluid Using a Complementary Tryptic Peptide Standard.

J Proteome Res 2019 Jun 29;18(6):2422-2432. Epub 2019 Apr 29.

Department of Neurology, Second Xiangya Hospital , Central South University , Changsha , Hunan 410078 , China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.8b00920DOI Listing
June 2019

Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2.

J Proteome Res 2019 Jun 14;18(6):2571-2584. Epub 2019 May 14.

Department of Pharmacology and Chemical Biology, Rollins Research Center , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.9b00103DOI Listing
June 2019

Effects of Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease.

Front Mol Neurosci 2018 18;11:454. Epub 2018 Dec 18.

Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2018.00454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305300PMC
December 2018

Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease.

Proteomics 2018 10;18(20):e1800108

Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201800108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283072PMC
October 2018

Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease.

Mol Neurodegener 2018 10 4;13(1):52. Epub 2018 Oct 4.

Department of Neurology, Emory University School of Medicine, Whitehead Building-Suite 505C, 615 Michael Street, Atlanta, GA, 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13024-018-0282-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172707PMC
October 2018

Evidence for brain glucose dysregulation in Alzheimer's disease.

Alzheimers Dement 2018 03 19;14(3):318-329. Epub 2017 Oct 19.

Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2017.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866736PMC
March 2018

Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's Disease.

Sci Data 2018 03 13;5:180036. Epub 2018 Mar 13.

Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sdata.2018.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848788PMC
March 2018

Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.

J Neuropathol Exp Neurol 2018 Jan;77(1):40-49

Boston University Alzheimer's Disease and CTE Center; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts; Center for Neurodegenerative Disease, Emory University School of Medicine; Department of Biochemistry, Emory University School of Medicine; Department of Neurology, Emory University School of Medicine, Atlanta, Georgia; Department of Anatomy and Neurobiology; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts; VA Boston Healthcare System, Boston, Massachusetts; and Department of Veterans Affairs Medical Center, Bedford, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnen/nlx100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939631PMC
January 2018

Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.

Sci Adv 2018 01 3;4(1):e1701393. Epub 2018 Jan 3.

Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.1701393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756662PMC
January 2018

Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain.

Bioconjug Chem 2017 10 22;28(10):2627-2637. Epub 2017 Sep 22.

Department of Biochemistry, ‡Yerkes National Primate Research Center, §Department of Pathology and Laboratory Medicine, and ∥Department of Neurology, Emory University , Atlanta, Georgia 30322, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.bioconjchem.7b00500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845826PMC
October 2017

Enrichment of Detergent-insoluble Protein Aggregates from Human Postmortem Brain.

J Vis Exp 2017 10 24(128). Epub 2017 Oct 24.

Department of Biochemistry, Emory School of Medicine;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/55835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755167PMC
October 2017

Integrating Next-Generation Genomic Sequencing and Mass Spectrometry To Estimate Allele-Specific Protein Abundance in Human Brain.

J Proteome Res 2017 09 9;16(9):3336-3347. Epub 2017 Aug 9.

Division of Neurology, Department of Veterans Affairs Medical Center , Decatur, Georgia 30033, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.7b00324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698003PMC
September 2017

Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase.

J Biol Chem 2016 Feb 16;291(7):3280-90. Epub 2015 Dec 16.

From the Department of Pediatrics, Division of Pulmonology, Allergy/Immunology, Cystic Fibrosis and Sleep and the Emory-Children's Center for Cystic Fibrosis Research, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, the Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.706853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751374PMC
February 2016

CSF complement 3 and factor H are staging biomarkers in Alzheimer's disease.

Acta Neuropathol Commun 2016 Feb 17;4:14. Epub 2016 Feb 17.

School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40478-016-0277-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758165PMC
February 2016

Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells.

Nat Methods 2016 Jan 30;13(1):81-6. Epub 2015 Nov 30.

Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.3675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697867PMC
January 2016

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease.

Nat Commun 2015 Nov 9;6:8762. Epub 2015 Nov 9.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms9762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659940PMC
November 2015

Proteomics of protein post-translational modifications implicated in neurodegeneration.

Transl Neurodegener 2014 30;3(1):23. Epub 2014 Oct 30.

Department of Neurology,Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, GA 30322 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2047-9158-3-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323146PMC
February 2015

Stress induces p38 MAPK-mediated phosphorylation and inhibition of Drosha-dependent cell survival.

Mol Cell 2015 Feb;57(4):721-734

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2015.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502444PMC
February 2015

Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins.

Proteomics 2015 Jan 17;15(2-3):508-519. Epub 2014 Dec 17.

Department of Biochemistry, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201400189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404162PMC
January 2015

Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease.

J Biol Chem 2014 Dec 29;289(51):35296-313. Epub 2014 Oct 29.

From the Departments of Biochemistry and the Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 Neurology,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.562959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271217PMC
December 2014

Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease.

Alzheimers Res Ther 2013 13;5(3):32. Epub 2013 Jun 13.

Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, 615 Michael Street NE, Atlanta, Georgia 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/alzrt186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054949PMC
August 2014

Aggregates of small nuclear ribonucleic acids (snRNAs) in Alzheimer's disease.

Brain Pathol 2014 Jul 14;24(4):344-51. Epub 2014 Apr 14.

Center for Neurodegenerative Disease, Emory University, Atlanta, GA; Department of Neurology, Emory University School of Medicine, Atlanta, GA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bpa.12133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096308PMC
July 2014

FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.

J Neurosci 2014 Jun;34(23):7802-13

Department of Pharmacology, Center for Neurodegenerative Disease, Department of Neurology, Emory University, School of Medicine, Atlanta, Georgia 30322,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0172-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044245PMC
June 2014

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.

J Neurosci 2013 Dec;33(49):19086-98

Center for Neurodegenerative Disease, and Departments of Neurology, Cell Biology, and Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, Medicinal Chemistry, Translational Research Institute, The Scripps Research Institute, Jupiter, Florida 33458, Department of Pathology, University of Washington, Seattle, Washington 98104, Departments of Pathology and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and Unit of Clinical and Translational Neuroscience and Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2508-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850036PMC
December 2013

Tissue-type plasminogen activator mediates neuronal detection and adaptation to metabolic stress.

J Cereb Blood Flow Metab 2013 Nov 24;33(11):1761-9. Epub 2013 Jul 24.

Department of Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/jcbfm.2013.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824174PMC
November 2013

Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems.

Mol Cell Proteomics 2013 Nov 14;12(11):3285-96. Epub 2013 Aug 14.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.M113.030437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820939PMC
November 2013

Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes.

J Neuropathol Exp Neurol 2013 Nov;72(11):1009-15

From the Department of Neurology (CMH, HR, AIL, JJL, TSW), Center for Neurodegenerative Disease (CMH, HR, NTS, EBD, DMD, MG, AIL, JJL, TSW), Departments of Biochemistry (NTS) and Human Genetics (EBD, TSW), and Pathology and Laboratory Medicine (MG), Emory University School of Medicine, Atlanta, Georgia; Department of Pathology, University of Washington, Seattle, Washington (TJM); Departments of Pathology and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland (JCT); National Institute of Aging, National Institutes of Health, Bethesda, Maryland (MT); and Atlanta Veterans Administration Medical Center, Atlanta, Georgia (TSW).

View Article

Download full-text PDF

Source
https://academic.oup.com/jnen/article-lookup/doi/10.1097/01.
Publisher Site
http://dx.doi.org/10.1097/01.jnen.0000435847.59828.dbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037931PMC
November 2013

Neuron enriched nuclear proteome isolated from human brain.

J Proteome Res 2013 Jul 17;12(7):3193-206. Epub 2013 Jun 17.

Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr400246tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734798PMC
July 2013

Expression, purification and proteomic analysis of recombinant histone H4 acetylated at lysine 16.

Proteomics 2013 May 26;13(10-11):1687-91. Epub 2013 Apr 26.

Department of Biology, Emory University, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201300025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771349PMC
May 2013

Asparaginyl endopeptidase cleaves TDP-43 in brain.

Proteomics 2012 Aug;12(15-16):2455-63

Department of Neurology, Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201200006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787696PMC
August 2012

Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production.

J Biol Chem 2011 Feb 8;286(8):6117-27. Epub 2010 Dec 8.

Department of Neurology, the Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.167239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057792PMC
February 2011

Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration.

J Proteome Res 2010 Dec 22;9(12):6368-79. Epub 2010 Oct 22.

Department of Neurology, the Center for Neurodegenerative Diseases, Laboratory Medicine, and Proteomics Service Center, Emory University School of Medicine, Atlanta, Georgia 30322, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr100666cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997170PMC
December 2010

Systematic approach for validating the ubiquitinated proteome.

Anal Chem 2008 Jun 24;80(11):4161-9. Epub 2008 Apr 24.

Department of Human Genetics, Center for Neurodegenerative Diseases, Emory University, Atlanta, Georgia 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac702516aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673951PMC
June 2008

Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse astrocytoma: a membrane proteomics approach.

Cancer Lett 2008 May 20;263(2):243-52. Epub 2008 Feb 20.

Complex Carbohydrate Research Center, University of Georgia, 330 Riverbend Road, Athens, GA 30602, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2008.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726046PMC
May 2008

Determination of protein-RNA interaction sites in the Cbf5-H/ACA guide RNA complex by mass spectrometric protein footprinting.

Biochemistry 2008 Feb 19;47(6):1500-10. Epub 2008 Jan 19.

Department of Biochemistry and Molecular Biology, and Genetics, University of Georgia, Athens, Georgia 30602, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/bi701606m
Publisher Site
http://dx.doi.org/10.1021/bi701606mDOI Listing
February 2008

Fourier transform mass spectrometry to monitor hyaluronan-protein interactions: use of hydrogen/deuterium amide exchange.

Rapid Commun Mass Spectrom 2007 ;21(2):121-31

Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcm.2817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189122PMC
February 2007

Versican-thrombospondin-1 binding in vitro and colocalization in microfibrils induced by inflammation on vascular smooth muscle cells.

J Cell Sci 2006 Nov 17;119(Pt 21):4499-509. Epub 2006 Oct 17.

Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.03171DOI Listing
November 2006

Preparation and application of biologically active fluorescent hyaluronan oligosaccharides.

Glycobiology 2005 Mar 20;15(3):303-12. Epub 2004 Oct 20.

MRC Immunochemistry Unit, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/glycob/cwi008DOI Listing
March 2005

Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides.

J Biol Chem 2005 Feb 8;280(7):5435-48. Epub 2004 Dec 8.

Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M411297200DOI Listing
February 2005