Nicholas J Timpson

Nicholas J Timpson

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Nicholas J Timpson

Nicholas J Timpson

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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

Authors:
Nicole M Warrington Robin N Beaumont Momoko Horikoshi Felix R Day Øyvind Helgeland Charles Laurin Jonas Bacelis Shouneng Peng Ke Hao Bjarke Feenstra Andrew R Wood Anubha Mahajan Jessica Tyrrell Neil R Robertson N William Rayner Zhen Qiao Gunn-Helen Moen Marc Vaudel Carmen J Marsit Jia Chen Michael Nodzenski Theresia M Schnurr Mohammad H Zafarmand Jonathan P Bradfield Niels Grarup Marjolein N Kooijman Ruifang Li-Gao Frank Geller Tarunveer S Ahluwalia Lavinia Paternoster Rico Rueedi Ville Huikari Jouke-Jan Hottenga Leo-Pekka Lyytikäinen Alana Cavadino Sarah Metrustry Diana L Cousminer Ying Wu Elisabeth Thiering Carol A Wang Christian T Have Natalia Vilor-Tejedor Peter K Joshi Jodie N Painter Ioanna Ntalla Ronny Myhre Niina Pitkänen Elisabeth M van Leeuwen Raimo Joro Vasiliki Lagou Rebecca C Richmond Ana Espinosa Sheila J Barton Hazel M Inskip John W Holloway Loreto Santa-Marina Xavier Estivill Wei Ang Julie A Marsh Christoph Reichetzeder Letizia Marullo Berthold Hocher Kathryn L Lunetta Joanne M Murabito Caroline L Relton Manolis Kogevinas Leda Chatzi Catherine Allard Luigi Bouchard Marie-France Hivert Ge Zhang Louis J Muglia Jani Heikkinen Camilla S Morgen Antoine H C van Kampen Barbera D C van Schaik Frank D Mentch Claudia Langenberg Jian'an Luan Robert A Scott Jing Hua Zhao Gibran Hemani Susan M Ring Amanda J Bennett Kyle J Gaulton Juan Fernandez-Tajes Natalie R van Zuydam Carolina Medina-Gomez Hugoline G de Haan Frits R Rosendaal Zoltán Kutalik Pedro Marques-Vidal Shikta Das Gonneke Willemsen Hamdi Mbarek Martina Müller-Nurasyid Marie Standl Emil V R Appel Cilius E Fonvig Caecilie Trier Catharina E M van Beijsterveldt Mario Murcia Mariona Bustamante Sílvia Bonas-Guarch David M Hougaard Josep M Mercader Allan Linneberg Katharina E Schraut Penelope A Lind Sarah E Medland Beverley M Shields Bridget A Knight Jin-Fang Chai Kalliope Panoutsopoulou Meike Bartels Friman Sánchez Jakob Stokholm David Torrents Rebecca K Vinding Sara M Willems Mustafa Atalay Bo L Chawes Peter Kovacs Inga Prokopenko Marcus A Tuke Hanieh Yaghootkar Katherine S Ruth Samuel E Jones Po-Ru Loh Anna Murray Michael N Weedon Anke Tönjes Michael Stumvoll Kim F Michaelsen Aino-Maija Eloranta Timo A Lakka Cornelia M van Duijn Wieland Kiess Antje Körner Harri Niinikoski Katja Pahkala Olli T Raitakari Bo Jacobsson Eleftheria Zeggini George V Dedoussis Yik-Ying Teo Seang-Mei Saw Grant W Montgomery Harry Campbell James F Wilson Tanja G M Vrijkotte Martine Vrijheid Eco J C N de Geus M Geoffrey Hayes Haja N Kadarmideen Jens-Christian Holm Lawrence J Beilin Craig E Pennell Joachim Heinrich Linda S Adair Judith B Borja Karen L Mohlke Johan G Eriksson Elisabeth E Widén Andrew T Hattersley Tim D Spector Mika Kähönen Jorma S Viikari Terho Lehtimäki Dorret I Boomsma Sylvain Sebert Peter Vollenweider Thorkild I A Sørensen Hans Bisgaard Klaus Bønnelykke Jeffrey C Murray Mads Melbye Ellen A Nohr Dennis O Mook-Kanamori Fernando Rivadeneira Albert Hofman Janine F Felix Vincent W V Jaddoe Torben Hansen Charlotta Pisinger Allan A Vaag Oluf Pedersen André G Uitterlinden Marjo-Riitta Järvelin Christine Power Elina Hyppönen Denise M Scholtens William L Lowe George Davey Smith Nicholas J Timpson Andrew P Morris Nicholas J Wareham Hakon Hakonarson Struan F A Grant Timothy M Frayling Debbie A Lawlor Pål R Njølstad Stefan Johansson Ken K Ong Mark I McCarthy John R B Perry David M Evans Rachel M Freathy

Nat Genet 2019 May 1;51(5):804-814. Epub 2019 May 1.

Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.

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http://dx.doi.org/10.1038/s41588-019-0403-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522365PMC
May 2019

Prenatal alcohol exposure and offspring mental health: A systematic review.

Drug Alcohol Depend 2019 04 28;197:344-353. Epub 2019 Feb 28.

UK Centre for Tobacco and Alcohol Studies, School of Psychological Science, University of Bristol, UK; MRC Integrative Epidemiology Unit, University of Bristol, UK.

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http://dx.doi.org/10.1016/j.drugalcdep.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446223PMC
April 2019

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.

Cell 2019 Apr;177(3):587-596.e9

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193029
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http://dx.doi.org/10.1016/j.cell.2019.03.028DOI Listing
April 2019

Letter regarding article, "Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis".

Int J Epidemiol 2019 Mar 11. Epub 2019 Mar 11.

Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health Sciences.

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http://dx.doi.org/10.1093/ije/dyz013DOI Listing
March 2019

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Authors:
Ayush Giri Jacklyn N Hellwege Jacob M Keaton Jihwan Park Chengxiang Qiu Helen R Warren Eric S Torstenson Csaba P Kovesdy Yan V Sun Otis D Wilson Cassianne Robinson-Cohen Christianne L Roumie Cecilia P Chung Kelly A Birdwell Scott M Damrauer Scott L DuVall Derek Klarin Kelly Cho Yu Wang Evangelos Evangelou Claudia P Cabrera Louise V Wain Rojesh Shrestha Brian S Mautz Elvis A Akwo Muralidharan Sargurupremraj Stéphanie Debette Michael Boehnke Laura J Scott Jian'an Luan Jing-Hua Zhao Sara M Willems Sébastien Thériault Nabi Shah Christopher Oldmeadow Peter Almgren Ruifang Li-Gao Niek Verweij Thibaud S Boutin Massimo Mangino Ioanna Ntalla Elena Feofanova Praveen Surendran James P Cook Savita Karthikeyan Najim Lahrouchi Chunyu Liu Nuno Sepúlveda Tom G Richardson Aldi Kraja Philippe Amouyel Martin Farrall Neil R Poulter Markku Laakso Eleftheria Zeggini Peter Sever Robert A Scott Claudia Langenberg Nicholas J Wareham David Conen Colin Neil Alexander Palmer John Attia Daniel I Chasman Paul M Ridker Olle Melander Dennis Owen Mook-Kanamori Pim van der Harst Francesco Cucca David Schlessinger Caroline Hayward Tim D Spector Marjo-Riitta Jarvelin Branwen J Hennig Nicholas J Timpson Wei-Qi Wei Joshua C Smith Yaomin Xu Michael E Matheny Edward E Siew Cecilia Lindgren Karl-Heinz Herzig George Dedoussis Joshua C Denny Bruce M Psaty Joanna M M Howson Patricia B Munroe Christopher Newton-Cheh Mark J Caulfield Paul Elliott J Michael Gaziano John Concato Peter W F Wilson Philip S Tsao Digna R Velez Edwards Katalin Susztak Christopher J O'Donnell Adriana M Hung Todd L Edwards

Nat Genet 2019 01 21;51(1):51-62. Epub 2018 Dec 21.

Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.

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http://www.nature.com/articles/s41588-018-0303-9
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http://dx.doi.org/10.1038/s41588-018-0303-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365102PMC
January 2019

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.

Authors:
Aldi T Kraja Chunyu Liu Jessica L Fetterman Mariaelisa Graff Christian Theil Have Charles Gu Lisa R Yanek Mary F Feitosa Dan E Arking Daniel I Chasman Kristin Young Symen Ligthart W David Hill Stefan Weiss Jian'an Luan Franco Giulianini Ruifang Li-Gao Fernando P Hartwig Shiow J Lin Lihua Wang Tom G Richardson Jie Yao Eliana P Fernandez Mohsen Ghanbari Mary K Wojczynski Wen-Jane Lee Maria Argos Sebastian M Armasu Ruteja A Barve Kathleen A Ryan Ping An Thomas J Baranski Suzette J Bielinski Donald W Bowden Ulrich Broeckel Kaare Christensen Audrey Y Chu Janie Corley Simon R Cox Andre G Uitterlinden Fernando Rivadeneira Cheryl D Cropp E Warwick Daw Diana van Heemst Lisa de Las Fuentes He Gao Ioanna Tzoulaki Tarunveer S Ahluwalia Renée de Mutsert Leslie S Emery A Mesut Erzurumluoglu James A Perry Mao Fu Nita G Forouhi Zhenglong Gu Yang Hai Sarah E Harris Gibran Hemani Steven C Hunt Marguerite R Irvin Anna E Jonsson Anne E Justice Nicola D Kerrison Nicholas B Larson Keng-Hung Lin Latisha D Love-Gregory Rasika A Mathias Joseph H Lee Matthias Nauck Raymond Noordam Ken K Ong James Pankow Amit Patki Alison Pattie Astrid Petersmann Qibin Qi Rasmus Ribel-Madsen Rebecca Rohde Kevin Sandow Theresia M Schnurr Tamar Sofer John M Starr Adele M Taylor Alexander Teumer Nicholas J Timpson Hugoline G de Haan Yujie Wang Peter E Weeke Christine Williams Hongsheng Wu Wei Yang Donglin Zeng Daniel R Witte Bruce S Weir Nicholas J Wareham Henrik Vestergaard Stephen T Turner Christian Torp-Pedersen Evie Stergiakouli Wayne Huey-Herng Sheu Frits R Rosendaal M Arfan Ikram Oscar H Franco Paul M Ridker Thomas T Perls Oluf Pedersen Ellen A Nohr Anne B Newman Allan Linneberg Claudia Langenberg Tuomas O Kilpeläinen Sharon L R Kardia Marit E Jørgensen Torben Jørgensen Thorkild I A Sørensen Georg Homuth Torben Hansen Mark O Goodarzi Ian J Deary Cramer Christensen Yii-Der Ida Chen Aravinda Chakravarti Ivan Brandslund Klaus Bonnelykke Kent D Taylor James G Wilson Santiago Rodriguez Gail Davies Bernardo L Horta Bharat Thyagarajan D C Rao Niels Grarup Victor G Davila-Roman Gavin Hudson Xiuqing Guo Donna K Arnett Caroline Hayward Dhananjay Vaidya Dennis O Mook-Kanamori Hemant K Tiwari Daniel Levy Ruth J F Loos Abbas Dehghan Paul Elliott Afshan N Malik Robert A Scott Diane M Becker Mariza de Andrade Michael A Province James B Meigs Jerome I Rotter Kari E North

Am J Hum Genet 2019 Jan 27;104(1):112-138. Epub 2018 Dec 27.

Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27516, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323610PMC
January 2019

Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis.

Nat Commun 2019 01 18;10(1):333. Epub 2019 Jan 18.

Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1038/s41467-018-08219-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338768PMC
January 2019

Reassessing the Association between Circulating Vitamin D and IGFBP-3: Observational and Mendelian Randomization Estimates from Independent Sources.

Cancer Epidemiol Biomarkers Prev 2018 Dec 2;27(12):1462-1471. Epub 2018 Aug 2.

IGFs & Metabolic Endocrinology Group, School of Translational Health Sciences, Learning & Research Building, Southmead Hospital, Bristol, United Kingdom.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0113DOI Listing
December 2018

Associations of Body Mass and Fat Indexes With Cardiometabolic Traits.

J Am Coll Cardiol 2018 Dec;72(24):3142-3154

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1016/j.jacc.2018.09.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290112PMC
December 2018

BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization.

Obesity (Silver Spring) 2018 Nov;26(11):1796-1806

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/oby.22313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334168PMC
November 2018

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease.

Hum Mol Genet 2018 09;27(18):3293-3304

MRC Integrative Epidemiology Unit (IEU), Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.

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http://dx.doi.org/10.1093/hmg/ddy210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121186PMC
September 2018

Associations of device-measured physical activity across adolescence with metabolic traits: Prospective cohort study.

PLoS Med 2018 09 11;15(9):e1002649. Epub 2018 Sep 11.

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1002649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133272PMC
September 2018

secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort.

Wellcome Open Res 2018 25;3:65. Epub 2018 Sep 25.

Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.

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https://wellcomeopenresearch.org/articles/3-65/v1
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http://dx.doi.org/10.12688/wellcomeopenres.14636.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171556.2PMC
September 2018

Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study.

PLoS Med 2018 08 28;15(8):e1002641. Epub 2018 Aug 28.

Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1002641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112630PMC
August 2018

Genotype-Based Recall Studies in Complex Cardiometabolic Traits.

Circ Genom Precis Med 2018 Aug;11(8):e001947

MRC Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, United Kingdom (N.J.T.).

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.001947
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http://dx.doi.org/10.1161/CIRCGEN.118.001947DOI Listing
August 2018

Longitudinal serological measures of common infection in the Avon Longitudinal Study of Parents and Children cohort.

Wellcome Open Res 2018 23;3:49. Epub 2018 Jul 23.

Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.12688/wellcomeopenres.14565.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124408.2PMC
July 2018

Age 23 years + oral health questionnaire in Avon Longitudinal Study of Parents and Children.

Wellcome Open Res 2018 26;3:34. Epub 2018 Mar 26.

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.12688/wellcomeopenres.14159.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941244PMC
March 2018

Genetic architecture: the shape of the genetic contribution to human traits and disease.

Nat Rev Genet 2018 Feb 11;19(2):110-124. Epub 2017 Dec 11.

Departments of Human Genetics and Epidemiology, Biostatistics and Occupational Health, McGill University, 3755 Cote Ste Catherine, Montréal, Québec H3T 1E2, Canada.

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http://dx.doi.org/10.1038/nrg.2017.101DOI Listing
February 2018

Heritable contributions versus genetic architecture.

Nat Rev Genet 2018 Feb;19(3):185

Departments of Human Genetics and Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/nrg.2018.7DOI Listing
February 2018

Using Y-Chromosomal Haplogroups in Genetic Association Studies and Suggested Implications.

Genes (Basel) 2018 Jan 22;9(1). Epub 2018 Jan 22.

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.3390/genes9010045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793196PMC
January 2018

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk.

Am J Hum Genet 2017 Oct;101(4):590-602

MRC Integrative Epidemiology Unit, Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.1016/j.ajhg.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630190PMC
October 2017

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.

Am J Hum Genet 2017 Aug 27;101(2):227-238. Epub 2017 Jul 27.

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada; Department of Twin Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK; Department of Medicine, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544392PMC
August 2017

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.

Authors:
Felix R Day Deborah J Thompson Hannes Helgason Daniel I Chasman Hilary Finucane Patrick Sulem Katherine S Ruth Sean Whalen Abhishek K Sarkar Eva Albrecht Elisabeth Altmaier Marzyeh Amini Caterina M Barbieri Thibaud Boutin Archie Campbell Ellen Demerath Ayush Giri Chunyan He Jouke J Hottenga Robert Karlsson Ivana Kolcic Po-Ru Loh Kathryn L Lunetta Massimo Mangino Brumat Marco George McMahon Sarah E Medland Ilja M Nolte Raymond Noordam Teresa Nutile Lavinia Paternoster Natalia Perjakova Eleonora Porcu Lynda M Rose Katharina E Schraut Ayellet V Segrè Albert V Smith Lisette Stolk Alexander Teumer Irene L Andrulis Stefania Bandinelli Matthias W Beckmann Javier Benitez Sven Bergmann Murielle Bochud Eric Boerwinkle Stig E Bojesen Manjeet K Bolla Judith S Brand Hiltrud Brauch Hermann Brenner Linda Broer Thomas Brüning Julie E Buring Harry Campbell Eulalia Catamo Stephen Chanock Georgia Chenevix-Trench Tanguy Corre Fergus J Couch Diana L Cousminer Angela Cox Laura Crisponi Kamila Czene George Davey Smith Eco J C N de Geus Renée de Mutsert Immaculata De Vivo Joe Dennis Peter Devilee Isabel Dos-Santos-Silva Alison M Dunning Johan G Eriksson Peter A Fasching Lindsay Fernández-Rhodes Luigi Ferrucci Dieter Flesch-Janys Lude Franke Marike Gabrielson Ilaria Gandin Graham G Giles Harald Grallert Daniel F Gudbjartsson Pascal Guénel Per Hall Emily Hallberg Ute Hamann Tamara B Harris Catharina A Hartman Gerardo Heiss Maartje J Hooning John L Hopper Frank Hu David J Hunter M Arfan Ikram Hae Kyung Im Marjo-Riitta Järvelin Peter K Joshi David Karasik Manolis Kellis Zoltan Kutalik Genevieve LaChance Diether Lambrechts Claudia Langenberg Lenore J Launer Joop S E Laven Stefania Lenarduzzi Jingmei Li Penelope A Lind Sara Lindstrom YongMei Liu Jian'an Luan Reedik Mägi Arto Mannermaa Hamdi Mbarek Mark I McCarthy Christa Meisinger Thomas Meitinger Cristina Menni Andres Metspalu Kyriaki Michailidou Lili Milani Roger L Milne Grant W Montgomery Anna M Mulligan Mike A Nalls Pau Navarro Heli Nevanlinna Dale R Nyholt Albertine J Oldehinkel Tracy A O'Mara Sandosh Padmanabhan Aarno Palotie Nancy Pedersen Annette Peters Julian Peto Paul D P Pharoah Anneli Pouta Paolo Radice Iffat Rahman Susan M Ring Antonietta Robino Frits R Rosendaal Igor Rudan Rico Rueedi Daniela Ruggiero Cinzia F Sala Marjanka K Schmidt Robert A Scott Mitul Shah Rossella Sorice Melissa C Southey Ulla Sovio Meir Stampfer Maristella Steri Konstantin Strauch Toshiko Tanaka Emmi Tikkanen Nicholas J Timpson Michela Traglia Thérèse Truong Jonathan P Tyrer André G Uitterlinden Digna R Velez Edwards Veronique Vitart Uwe Völker Peter Vollenweider Qin Wang Elisabeth Widen Ko Willems van Dijk Gonneke Willemsen Robert Winqvist Bruce H R Wolffenbuttel Jing Hua Zhao Magdalena Zoledziewska Marek Zygmunt Behrooz Z Alizadeh Dorret I Boomsma Marina Ciullo Francesco Cucca Tõnu Esko Nora Franceschini Christian Gieger Vilmundur Gudnason Caroline Hayward Peter Kraft Debbie A Lawlor Patrik K E Magnusson Nicholas G Martin Dennis O Mook-Kanamori Ellen A Nohr Ozren Polasek David Porteous Alkes L Price Paul M Ridker Harold Snieder Tim D Spector Doris Stöckl Daniela Toniolo Sheila Ulivi Jenny A Visser Henry Völzke Nicholas J Wareham James F Wilson Amanda B Spurdle Unnur Thorsteindottir Katherine S Pollard Douglas F Easton Joyce Y Tung Jenny Chang-Claude David Hinds Anna Murray Joanne M Murabito Kari Stefansson Ken K Ong John R B Perry

Nat Genet 2017 Jun 24;49(6):834-841. Epub 2017 Apr 24.

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841952PMC
June 2017

Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

Authors:
Ioanna Tachmazidou Dániel Süveges Josine L Min Graham R S Ritchie Julia Steinberg Klaudia Walter Valentina Iotchkova Jeremy Schwartzentruber Jie Huang Yasin Memari Shane McCarthy Andrew A Crawford Cristina Bombieri Massimiliano Cocca Aliki-Eleni Farmaki Tom R Gaunt Pekka Jousilahti Marjolein N Kooijman Benjamin Lehne Giovanni Malerba Satu Männistö Angela Matchan Carolina Medina-Gomez Sarah J Metrustry Abhishek Nag Ioanna Ntalla Lavinia Paternoster Nigel W Rayner Cinzia Sala William R Scott Hashem A Shihab Lorraine Southam Beate St Pourcain Michela Traglia Katerina Trajanoska Gialuigi Zaza Weihua Zhang María S Artigas Narinder Bansal Marianne Benn Zhongsheng Chen Petr Danecek Wei-Yu Lin Adam Locke Jian'an Luan Alisa K Manning Antonella Mulas Carlo Sidore Anne Tybjaerg-Hansen Anette Varbo Magdalena Zoledziewska Chris Finan Konstantinos Hatzikotoulas Audrey E Hendricks John P Kemp Alireza Moayyeri Kalliope Panoutsopoulou Michal Szpak Scott G Wilson Michael Boehnke Francesco Cucca Emanuele Di Angelantonio Claudia Langenberg Cecilia Lindgren Mark I McCarthy Andrew P Morris Børge G Nordestgaard Robert A Scott Martin D Tobin Nicholas J Wareham Paul Burton John C Chambers George Davey Smith George Dedoussis Janine F Felix Oscar H Franco Giovanni Gambaro Paolo Gasparini Christopher J Hammond Albert Hofman Vincent W V Jaddoe Marcus Kleber Jaspal S Kooner Markus Perola Caroline Relton Susan M Ring Fernando Rivadeneira Veikko Salomaa Timothy D Spector Oliver Stegle Daniela Toniolo André G Uitterlinden Inês Barroso Celia M T Greenwood John R B Perry Brian R Walker Adam S Butterworth Yali Xue Richard Durbin Kerrin S Small Nicole Soranzo Nicholas J Timpson Eleftheria Zeggini

Am J Hum Genet 2017 Jun 25;100(6):865-884. Epub 2017 May 25.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473732PMC
June 2017

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Authors:
Philip C Haycock Stephen Burgess Aayah Nounu Jie Zheng George N Okoli Jack Bowden Kaitlin Hazel Wade Nicholas J Timpson David M Evans Peter Willeit Abraham Aviv Tom R Gaunt Gibran Hemani Massimo Mangino Hayley Patricia Ellis Kathreena M Kurian Karen A Pooley Rosalind A Eeles Jeffrey E Lee Shenying Fang Wei V Chen Matthew H Law Lisa M Bowdler Mark M Iles Qiong Yang Bradford B Worrall Hugh Stephen Markus Rayjean J Hung Chris I Amos Amanda B Spurdle Deborah J Thompson Tracy A O'Mara Brian Wolpin Laufey Amundadottir Rachael Stolzenberg-Solomon Antonia Trichopoulou N Charlotte Onland-Moret Eiliv Lund Eric J Duell Federico Canzian Gianluca Severi Kim Overvad Marc J Gunter Rosario Tumino Ulrika Svenson Andre van Rij Annette F Baas Matthew J Bown Nilesh J Samani Femke N G van t'Hof Gerard Tromp Gregory T Jones Helena Kuivaniemi James R Elmore Mattias Johansson James Mckay Ghislaine Scelo Robert Carreras-Torres Valerie Gaborieau Paul Brennan Paige M Bracci Rachel E Neale Sara H Olson Steven Gallinger Donghui Li Gloria M Petersen Harvey A Risch Alison P Klein Jiali Han Christian C Abnet Neal D Freedman Philip R Taylor John M Maris Katja K Aben Lambertus A Kiemeney Sita H Vermeulen John K Wiencke Kyle M Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew-Kee Low Krina T Zondervan Grant W Montgomery Dale R Nyholt David A van Heel Karen Hunt Dan E Arking Foram N Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand Mary E Comeau W Mark Brown Edwin K Silverman John E Hokanson Michael H Cho Jennie Hui Manuel A Ferreira Philip J Thompson Alanna C Morrison Janine F Felix Nicholas L Smith Angela M Christiano Lynn Petukhova Regina C Betz Xing Fan Xuejun Zhang Caihong Zhu Carl D Langefeld Susan D Thompson Feijie Wang Xu Lin David A Schwartz Tasha Fingerlin Jerome I Rotter Mary Frances Cotch Richard A Jensen Matthias Munz Henrik Dommisch Arne S Schaefer Fang Han Hanna M Ollila Ryan P Hillary Omar Albagha Stuart H Ralston Chenjie Zeng Wei Zheng Xiao-Ou Shu Andre Reis Steffen Uebe Ulrike Hüffmeier Yoshiya Kawamura Takeshi Otowa Tsukasa Sasaki Martin Lloyd Hibberd Sonia Davila Gang Xie Katherine Siminovitch Jin-Xin Bei Yi-Xin Zeng Asta Försti Bowang Chen Stefano Landi Andre Franke Annegret Fischer David Ellinghaus Carlos Flores Imre Noth Shwu-Fan Ma Jia Nee Foo Jianjun Liu Jong-Won Kim David G Cox Olivier Delattre Olivier Mirabeau Christine F Skibola Clara S Tang Merce Garcia-Barcelo Kai-Ping Chang Wen-Hui Su Yu-Sun Chang Nicholas G Martin Scott Gordon Tracey D Wade Chaeyoung Lee Michiaki Kubo Pei-Chieng Cha Yusuke Nakamura Daniel Levy Masayuki Kimura Shih-Jen Hwang Steven Hunt Tim Spector Nicole Soranzo Ani W Manichaikul R Graham Barr Bratati Kahali Elizabeth Speliotes Laura M Yerges-Armstrong Ching-Yu Cheng Jost B Jonas Tien Yin Wong Isabella Fogh Kuang Lin John F Powell Kenneth Rice Caroline L Relton Richard M Martin George Davey Smith

JAMA Oncol 2017 May;3(5):636-651

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.

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http://dx.doi.org/10.1001/jamaoncol.2016.5945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638008PMC
May 2017

Screening for familial hypercholesterolaemia in childhood: Avon Longitudinal Study of Parents and Children (ALSPAC).

Atherosclerosis 2017 05 8;260:47-55. Epub 2017 Mar 8.

Genetic Epidemiology Group, Institute of Cardiovascular Science, Farr Institute for Health Informatics, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414415PMC
May 2017

Incorporating Non-Coding Annotations into Rare Variant Analysis.

PLoS One 2016 29;11(4):e0154181. Epub 2016 Apr 29.

MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154181PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851421PMC
March 2017

A Protein Domain and Family Based Approach to Rare Variant Association Analysis.

PLoS One 2016 29;11(4):e0153803. Epub 2016 Apr 29.

MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153803PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851355PMC
February 2017

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Authors:
Nicola Barban Rick Jansen Ronald de Vlaming Ahmad Vaez Jornt J Mandemakers Felix C Tropf Xia Shen James F Wilson Daniel I Chasman Ilja M Nolte Vinicius Tragante Sander W van der Laan John R B Perry Augustine Kong Tarunveer S Ahluwalia Eva Albrecht Laura Yerges-Armstrong Gil Atzmon Kirsi Auro Kristin Ayers Andrew Bakshi Danny Ben-Avraham Klaus Berger Aviv Bergman Lars Bertram Lawrence F Bielak Gyda Bjornsdottir Marc Jan Bonder Linda Broer Minh Bui Caterina Barbieri Alana Cavadino Jorge E Chavarro Constance Turman Maria Pina Concas Heather J Cordell Gail Davies Peter Eibich Nicholas Eriksson Tõnu Esko Joel Eriksson Fahimeh Falahi Janine F Felix Mark Alan Fontana Lude Franke Ilaria Gandin Audrey J Gaskins Christian Gieger Erica P Gunderson Xiuqing Guo Caroline Hayward Chunyan He Edith Hofer Hongyan Huang Peter K Joshi Stavroula Kanoni Robert Karlsson Stefan Kiechl Annette Kifley Alexander Kluttig Peter Kraft Vasiliki Lagou Cecile Lecoeur Jari Lahti Ruifang Li-Gao Penelope A Lind Tian Liu Enes Makalic Crysovalanto Mamasoula Lindsay Matteson Hamdi Mbarek Patrick F McArdle George McMahon S Fleur W Meddens Evelin Mihailov Mike Miller Stacey A Missmer Claire Monnereau Peter J van der Most Ronny Myhre Mike A Nalls Teresa Nutile Ioanna Panagiota Kalafati Eleonora Porcu Inga Prokopenko Kumar B Rajan Janet Rich-Edwards Cornelius A Rietveld Antonietta Robino Lynda M Rose Rico Rueedi Kathleen A Ryan Yasaman Saba Daniel Schmidt Jennifer A Smith Lisette Stolk Elizabeth Streeten Anke Tönjes Gudmar Thorleifsson Sheila Ulivi Juho Wedenoja Juergen Wellmann Peter Willeit Jie Yao Loic Yengo Jing Hua Zhao Wei Zhao Daria V Zhernakova Najaf Amin Howard Andrews Beverley Balkau Nir Barzilai Sven Bergmann Ginevra Biino Hans Bisgaard Klaus Bønnelykke Dorret I Boomsma Julie E Buring Harry Campbell Stefania Cappellani Marina Ciullo Simon R Cox Francesco Cucca Daniela Toniolo George Davey-Smith Ian J Deary George Dedoussis Panos Deloukas Cornelia M van Duijn Eco J C de Geus Johan G Eriksson Denis A Evans Jessica D Faul Cinzia Felicita Sala Philippe Froguel Paolo Gasparini Giorgia Girotto Hans-Jörgen Grabe Karin Halina Greiser Patrick J F Groenen Hugoline G de Haan Johannes Haerting Tamara B Harris Andrew C Heath Kauko Heikkilä Albert Hofman Georg Homuth Elizabeth G Holliday John Hopper Elina Hyppönen Bo Jacobsson Vincent W V Jaddoe Magnus Johannesson Astanand Jugessur Mika Kähönen Eero Kajantie Sharon L R Kardia Bernard Keavney Ivana Kolcic Päivikki Koponen Peter Kovacs Florian Kronenberg Zoltan Kutalik Martina La Bianca Genevieve Lachance William G Iacono Sandra Lai Terho Lehtimäki David C Liewald Cecilia M Lindgren Yongmei Liu Robert Luben Michael Lucht Riitta Luoto Per Magnus Patrik K E Magnusson Nicholas G Martin Matt McGue Ruth McQuillan Sarah E Medland Christa Meisinger Dan Mellström Andres Metspalu Michela Traglia Lili Milani Paul Mitchell Grant W Montgomery Dennis Mook-Kanamori Renée de Mutsert Ellen A Nohr Claes Ohlsson Jørn Olsen Ken K Ong Lavinia Paternoster Alison Pattie Brenda W J H Penninx Markus Perola Patricia A Peyser Mario Pirastu Ozren Polasek Chris Power Jaakko Kaprio Leslie J Raffel Katri Räikkönen Olli Raitakari Paul M Ridker Susan M Ring Kathryn Roll Igor Rudan Daniela Ruggiero Dan Rujescu Veikko Salomaa David Schlessinger Helena Schmidt Reinhold Schmidt Nicole Schupf Johannes Smit Rossella Sorice Tim D Spector John M Starr Doris Stöckl Konstantin Strauch Michael Stumvoll Morris A Swertz Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Joyce Y Tung André G Uitterlinden Simona Vaccargiu Jorma Viikari Veronique Vitart Henry Völzke Peter Vollenweider Dragana Vuckovic Johannes Waage Gert G Wagner Jie Jin Wang Nicholas J Wareham David R Weir Gonneke Willemsen Johann Willeit Alan F Wright Krina T Zondervan Kari Stefansson Robert F Krueger James J Lee Daniel J Benjamin David Cesarini Philipp D Koellinger Marcel den Hoed Harold Snieder Melinda C Mills

Nat Genet 2016 12 31;48(12):1462-1472. Epub 2016 Oct 31.

Department of Sociology and Nuffield College, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695684PMC
December 2016

The CHRNA5-A3-B4 Gene Cluster and Smoking: From Discovery to Therapeutics.

Trends Neurosci 2016 12 18;39(12):851-861. Epub 2016 Nov 18.

UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, UK; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1016/j.tins.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152594PMC
December 2016

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Authors:
Aysu Okbay Bart M L Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G Nivard Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A Rietveld Jaime Derringer Jacob Gratten James J Lee Jimmy Z Liu Ronald de Vlaming Tarunveer S Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C Frazier-Wood Nicholas A Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W van der Laan Karl-Heinz Ladwig Jari Lahti Sven J van der Lee Penelope A Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael B Miller Camelia C Minica Ilja M Nolte Dennis Mook-Kanamori Peter J van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V Smith Evie Stergiakouli Toshiko Tanaka Kent Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyda Bjornsdottir Patricia A Boyle Samantha Cherney Simon R Cox Gail Davies Oliver S P Davis Jun Ding Nese Direk Peter Eibich Rebecca T Emeny Ghazaleh Fatemifar Jessica D Faul Luigi Ferrucci Andreas J Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette M Harris Elizabeth G Holliday Jouke-Jan Hottenga Philip L De Jager Marika A Kaakinen Eero Kajantie Ville Karhunen Ivana Kolcic Meena Kumari Lenore J Launer Lude Franke Ruifang Li-Gao David C Liewald Marisa Koini Anu Loukola Pedro Marques-Vidal Grant W Montgomery Miriam A Mosing Lavinia Paternoster Alison Pattie Katja E Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J Scott Jennifer A Smith Angelina R Sutin Maciej Trzaskowski Anna E Vinkhuyzen Lei Yu Delilah Zabaneh John R Attia David A Bennett Klaus Berger Lars Bertram Dorret I Boomsma Harold Snieder Shun-Chiao Chang Francesco Cucca Ian J Deary Cornelia M van Duijn Johan G Eriksson Ute Bültmann Eco J C de Geus Patrick J F Groenen Vilmundur Gudnason Torben Hansen Catharine A Hartman Claire M A Haworth Caroline Hayward Andrew C Heath David A Hinds Elina Hyppönen William G William Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Liisa Keltikangas-Järvinen Peter Kraft Laura D Kubzansky Terho Lehtimäki Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Melinda Mills Renée de Mutsert Albertine J Oldehinkel Gerard Pasterkamp Nancy L Pedersen Robert Plomin Ozren Polasek Christine Power Stephen S Rich Frits R Rosendaal Hester M den Ruijter David Schlessinger Helena Schmidt Rauli Svento Reinhold Schmidt Behrooz Z Alizadeh Thorkild I A Sørensen Tim D Spector John M Starr Kari Stefansson Andrew Steptoe Antonio Terracciano Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier André G Uitterlinden Peter Vollenweider Gert G Wagner David R Weir Jian Yang Dalton C Conley George Davey Smith Albert Hofman Magnus Johannesson David I Laibson Sarah E Medland Michelle N Meyer Joseph K Pickrell Tõnu Esko Robert F Krueger Jonathan P Beauchamp Philipp D Koellinger Daniel J Benjamin Meike Bartels David Cesarini

Nat Genet 2016 11;48(12):1591

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http://dx.doi.org/10.1038/ng1216-1587bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509058PMC
November 2016

Collapsed methylation quantitative trait loci analysis for low frequency and rare variants.

Hum Mol Genet 2016 10 24;25(19):4339-4349. Epub 2016 Aug 24.

MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK

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http://dx.doi.org/10.1093/hmg/ddw283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291201PMC
October 2016

Commentary: One size fits all: are there standard rules for the use of genetic instruments in Mendelian randomization?

Int J Epidemiol 2016 10 4;45(5):1617-1618. Epub 2016 Sep 4.

MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.1093/ije/dyw197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100619PMC
October 2016

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts.

J Am Acad Child Adolesc Psychiatry 2016 10 5;55(10):896-905.e6. Epub 2016 Aug 5.

Dr. Middeldorp is with Biological Psychology, Neuroscience Campus Amsterdam, VU University Amsterdam, and GGZinGeest/ VU University Medical Center, Amsterdam. Ms. Hammerschlag is with the Generation R Study Group, Erasmus MC Rotterdam, the Netherlands, and Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam. Mr. Ouwens and Dr. Groen-Blokhuis are with Biological Psychology, VU University Amsterdam, and the EMGO+ Institute for Health and Care Research, VU University Medical Center. Dr. St. Pourcain is with MRC Integrative Epidemiology Unit (MRC IEU), University of Bristol, UK, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands, and School of Experimental Psychology, University of Bristol. Dr. Greven is with Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Karakter, Child and Adolescent Psychiatry University Center, Radboud University Nijmegen, and MRC Social Genetic and Developmental Psychiatry Centre, King's College London. Dr. Pappa is with Generation R Study Group, and Pedagogical and Education Science, Erasmus University Rotterdam, The Netherlands. Drs. Tiesler and Thiering are with Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany and the Division of Metabolic and Nutritional Medicine, Munich, and Dr. von Hauner Children's Hospital, University of Munich Medical Center, Germany. Mr. Ang, Ms. Wang, and Dr. Pennell are with School of Women's and Infants' Health, University of Western Australia, Perth. Dr. Nolte is with University of Groningen, University Medical Center Groningen, The Netherlands. Ms. Vilor-Tejedor is with Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Universitat Pompeu Fabra (UPF), Barcelona, and CIBER Epidemiology and Public Health (CIBERESP), Madrid. Mr. Bacelis is with Gothenburg University, Sweden. Drs. Ebejer, Martin, and Medland are with QIMR Berghofer Medical Research Institute, Brisbane, Australia. Drs. Zhao and Nyholt are with Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia. Drs. Davies and Ehli are with Avera Institute for Human Genetics, SD. Drs. Evans, Kemp, and Ring are with MRC IEU, School of Social and Community Medicine, and School of Social and Community Medicine, University of Bristol, and Diamantina Institute, Translational Research Institute, University of Queensland, Brisbane. Ms. Fedko is with Biological Psychology, VU University Amsterdam. Dr. Guxens is with CREAL, UPF, CIBERESP, and Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center-Sophia Children´s Hospital, The Netherlands. Dr. Hottenga is with Biological Psychology, VU University, and EMGO+ Institute for Health and Care Research, VU University Medical Center. Dr. Hudziak is with Vermont Center for Children, Youth and Families and College of Medicine, University of Vermont, Burlington, and Child and Adolescent Psychiatry, Erasmus Medical Center. Drs. Jugessur, Myhre, and Stoltenberg are with the Norwegian Institute of Public Health, Oslo. Ms. Krapohl and Drs. Trzaskowski and Plomin are with MRC Social, Genetic and Developmental Psychiatry Centre, King's College London. Mr. Murcia is with CIBERESP, and FISABIO-Universitat Jaume I-Universitat de València Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain. Drs. Ormel and Hartman are with the Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University Medical Center Groningen. Drs. Standl and Heinrich are with Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany. Drs. Stergiakouli and Timpson are with MRC IEU; Dr. Timpson is also with School of Social and Community Medicine, University of Bristol. Dr. van der Most is with University of Groningen and University Medical Center Groningen. Dr. Neale is with Program in Medical and Population Genetics and Stanley Center for Psychiatric Genetics, Broad Institute of Massachusetts Institute of Technology, Boston, Analytic and Translation Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, and Harvard University, Cambridge, MA. Dr. Jacobsson is with Obstetrics and Gynecology, Gothenburg University, and the Norwegian Institute of Public Health. Dr. Sunyer is with CREAL, IMIM (Hospital del Mar Medical Research Institute), Barcelona, UPF, and CIBERESP. Dr. Whitehouse is with Telethon Kids Institute, University of Western Australia, Perth. Dr. Davey Smith is with MRC IEU, and School of Social and Community Medicine. Dr. Tiemeier is with Epidemiology, Child and Adolescent Psychiatry, and Psychiatry, Erasmus Medical Center. Dr. Posthuma is with the Generation R Study Group, Erasmus MC Rotterdam, the Netherlands, Child and Adolescent Psychiatry, Erasmus Medical Center, Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, and Clinical Genetics, VU University Medical Center. Dr. Boomsma is with Biological Psychology, VU University, Neuroscience Campus Amsterdam, VU University, and EMGO+ Institute for Health and Care Research, VU University Medical Center.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068552PMC
http://dx.doi.org/10.1016/j.jaac.2016.05.025DOI Listing
October 2016

Genome-wide associations for birth weight and correlations with adult disease.

Authors:
Momoko Horikoshi Robin N Beaumont Felix R Day Nicole M Warrington Marjolein N Kooijman Juan Fernandez-Tajes Bjarke Feenstra Natalie R van Zuydam Kyle J Gaulton Niels Grarup Jonathan P Bradfield David P Strachan Ruifang Li-Gao Tarunveer S Ahluwalia Eskil Kreiner Rico Rueedi Leo-Pekka Lyytikäinen Diana L Cousminer Ying Wu Elisabeth Thiering Carol A Wang Christian T Have Jouke-Jan Hottenga Natalia Vilor-Tejedor Peter K Joshi Eileen Tai Hui Boh Ioanna Ntalla Niina Pitkänen Anubha Mahajan Elisabeth M van Leeuwen Raimo Joro Vasiliki Lagou Michael Nodzenski Louise A Diver Krina T Zondervan Mariona Bustamante Pedro Marques-Vidal Josep M Mercader Amanda J Bennett Nilufer Rahmioglu Dale R Nyholt Ronald Ching Wan Ma Claudia Ha Ting Tam Wing Hung Tam Santhi K Ganesh Frank Ja van Rooij Samuel E Jones Po-Ru Loh Katherine S Ruth Marcus A Tuke Jessica Tyrrell Andrew R Wood Hanieh Yaghootkar Denise M Scholtens Lavinia Paternoster Inga Prokopenko Peter Kovacs Mustafa Atalay Sara M Willems Kalliope Panoutsopoulou Xu Wang Lisbeth Carstensen Frank Geller Katharina E Schraut Mario Murcia Catharina Em van Beijsterveldt Gonneke Willemsen Emil V R Appel Cilius E Fonvig Caecilie Trier Carla Mt Tiesler Marie Standl Zoltán Kutalik Sílvia Bonas-Guarch David M Hougaard Friman Sánchez David Torrents Johannes Waage Mads V Hollegaard Hugoline G de Haan Frits R Rosendaal Carolina Medina-Gomez Susan M Ring Gibran Hemani George McMahon Neil R Robertson Christopher J Groves Claudia Langenberg Jian'an Luan Robert A Scott Jing Hua Zhao Frank D Mentch Scott M MacKenzie Rebecca M Reynolds William L Lowe Anke Tönjes Michael Stumvoll Virpi Lindi Timo A Lakka Cornelia M van Duijn Wieland Kiess Antje Körner Thorkild Ia Sørensen Harri Niinikoski Katja Pahkala Olli T Raitakari Eleftheria Zeggini George V Dedoussis Yik-Ying Teo Seang-Mei Saw Mads Melbye Harry Campbell James F Wilson Martine Vrijheid Eco Jcn de Geus Dorret I Boomsma Haja N Kadarmideen Jens-Christian Holm Torben Hansen Sylvain Sebert Andrew T Hattersley Lawrence J Beilin John P Newnham Craig E Pennell Joachim Heinrich Linda S Adair Judith B Borja Karen L Mohlke Johan G Eriksson Elisabeth E Widén Mika Kähönen Jorma S Viikari Terho Lehtimäki Peter Vollenweider Klaus Bønnelykke Hans Bisgaard Dennis O Mook-Kanamori Albert Hofman Fernando Rivadeneira André G Uitterlinden Charlotta Pisinger Oluf Pedersen Christine Power Elina Hyppönen Nicholas J Wareham Hakon Hakonarson Eleanor Davies Brian R Walker Vincent Wv Jaddoe Marjo-Riitta Jarvelin Struan Fa Grant Allan A Vaag Debbie A Lawlor Timothy M Frayling George Davey Smith Andrew P Morris Ken K Ong Janine F Felix Nicholas J Timpson John Rb Perry David M Evans Mark I McCarthy Rachel M Freathy

Nature 2016 10 28;538(7624):248-252. Epub 2016 Sep 28.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK.

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http://dx.doi.org/10.1038/nature19806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164934PMC
October 2016

Body mass index: Has epidemiology started to break down causal contributions to health and disease?

Obesity (Silver Spring) 2016 08;24(8):1630-8

MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/oby.21554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972005PMC
August 2016

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Authors:
Aysu Okbay Bart M L Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G Nivard Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A Rietveld Jaime Derringer Jacob Gratten James J Lee Jimmy Z Liu Ronald de Vlaming Tarunveer S Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C Frazier-Wood Nicholas A Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W van der Laan Karl-Heinz Ladwig Jari Lahti Sven J van der Lee Penelope A Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael B Miller Camelia C Minica Ilja M Nolte Dennis Mook-Kanamori Peter J van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V Smith Evie Stergiakouli Toshiko Tanaka Kent Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyda Bjornsdottir Patricia A Boyle Samantha Cherney Simon R Cox Gail Davies Oliver S P Davis Jun Ding Nese Direk Peter Eibich Rebecca T Emeny Ghazaleh Fatemifar Jessica D Faul Luigi Ferrucci Andreas J Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette M Harris Elizabeth G Holliday Jouke-Jan Hottenga Philip L De Jager Marika A Kaakinen Eero Kajantie Ville Karhunen Ivana Kolcic Meena Kumari Lenore J Launer Lude Franke Ruifang Li-Gao David C Liewald Marisa Koini Anu Loukola Pedro Marques-Vidal Grant W Montgomery Miriam A Mosing Lavinia Paternoster Alison Pattie Katja E Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J Scott Jennifer A Smith Angelina R Sutin Maciej Trzaskowski Anna E Vinkhuyzen Lei Yu Delilah Zabaneh John R Attia David A Bennett Klaus Berger Lars Bertram Dorret I Boomsma Harold Snieder Shun-Chiao Chang Francesco Cucca Ian J Deary Cornelia M van Duijn Johan G Eriksson Ute Bültmann Eco J C de Geus Patrick J F Groenen Vilmundur Gudnason Torben Hansen Catharine A Hartman Claire M A Haworth Caroline Hayward Andrew C Heath David A Hinds Elina Hyppönen William G Iacono Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Liisa Keltikangas-Järvinen Peter Kraft Laura D Kubzansky Terho Lehtimäki Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Melinda Mills Renée de Mutsert Albertine J Oldehinkel Gerard Pasterkamp Nancy L Pedersen Robert Plomin Ozren Polasek Christine Power Stephen S Rich Frits R Rosendaal Hester M den Ruijter David Schlessinger Helena Schmidt Rauli Svento Reinhold Schmidt Behrooz Z Alizadeh Thorkild I A Sørensen Tim D Spector John M Starr Kari Stefansson Andrew Steptoe Antonio Terracciano Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier André G Uitterlinden Peter Vollenweider Gert G Wagner David R Weir Jian Yang Dalton C Conley George Davey Smith Albert Hofman Magnus Johannesson David I Laibson Sarah E Medland Michelle N Meyer Joseph K Pickrell Tõnu Esko Robert F Krueger Jonathan P Beauchamp Philipp D Koellinger Daniel J Benjamin Meike Bartels David Cesarini

Nat Genet 2016 07;48(8):970

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http://dx.doi.org/10.1038/ng0816-970cDOI Listing
July 2016

Re-Examining the Association between Vitamin D and Childhood Caries.

PLoS One 2015 21;10(12):e0143769. Epub 2015 Dec 21.

MRC Integrative Epidemiology Unit, School of Community and Social Medicine, University of Bristol, Bristol, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143769PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686942PMC
June 2016

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Authors:
Aysu Okbay Bart M L Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G Nivard Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A Rietveld Jaime Derringer Jacob Gratten James J Lee Jimmy Z Liu Ronald de Vlaming Tarunveer S Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C Frazier-Wood Nicholas A Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W van der Laan Karl-Heinz Ladwig Jari Lahti Sven J van der Lee Penelope A Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael B Miller Camelia C Minica Ilja M Nolte Dennis Mook-Kanamori Peter J van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V Smith Evie Stergiakouli Toshiko Tanaka Kent Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyda Bjornsdottir Patricia A Boyle Samantha Cherney Simon R Cox Gail Davies Oliver S P Davis Jun Ding Nese Direk Peter Eibich Rebecca T Emeny Ghazaleh Fatemifar Jessica D Faul Luigi Ferrucci Andreas J Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette M Harris Elizabeth G Holliday Jouke-Jan Hottenga Philip L De Jager Marika A Kaakinen Eero Kajantie Ville Karhunen Ivana Kolcic Meena Kumari Lenore J Launer Lude Franke Ruifang Li-Gao David C Liewald Marisa Koini Anu Loukola Pedro Marques-Vidal Grant W Montgomery Miriam A Mosing Lavinia Paternoster Alison Pattie Katja E Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J Scott Jennifer A Smith Angelina R Sutin Maciej Trzaskowski Anna E Vinkhuyzen Lei Yu Delilah Zabaneh John R Attia David A Bennett Klaus Berger Lars Bertram Dorret I Boomsma Harold Snieder Shun-Chiao Chang Francesco Cucca Ian J Deary Cornelia M van Duijn Johan G Eriksson Ute Bültmann Eco J C de Geus Patrick J F Groenen Vilmundur Gudnason Torben Hansen Catharine A Hartman Claire M A Haworth Caroline Hayward Andrew C Heath David A Hinds Elina Hyppönen William G Iacono Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Liisa Keltikangas-Järvinen Peter Kraft Laura D Kubzansky Terho Lehtimäki Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Melinda Mills Renée de Mutsert Albertine J Oldehinkel Gerard Pasterkamp Nancy L Pedersen Robert Plomin Ozren Polasek Christine Power Stephen S Rich Frits R Rosendaal Hester M den Ruijter David Schlessinger Helena Schmidt Rauli Svento Reinhold Schmidt Behrooz Z Alizadeh Thorkild I A Sørensen Tim D Spector John M Starr Kari Stefansson Andrew Steptoe Antonio Terracciano Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier André G Uitterlinden Peter Vollenweider Gert G Wagner David R Weir Jian Yang Dalton C Conley George Davey Smith Albert Hofman Magnus Johannesson David I Laibson Sarah E Medland Michelle N Meyer Joseph K Pickrell Tõnu Esko Robert F Krueger Jonathan P Beauchamp Philipp D Koellinger Daniel J Benjamin Meike Bartels David Cesarini

Nat Genet 2016 06 18;48(6):624-33. Epub 2016 Apr 18.

Department of Economics, New York University, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884152PMC
June 2016

Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects.

Circ Cardiovasc Genet 2016 Jun 25;9(3):231-9. Epub 2016 Apr 25.

From the MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol (F.D., G.D.S., M.A.-K., D.A.L., T.R.G., N.J.T.); Institute of Cardiovascular Science, University College London, London, United Kingdom (F.D., C.D., J.-P.C.); Computational Medicine, Faculty of Medicine, University of Oulu & Biocenter Oulu, Oulu (M.A.-K., J.K., P.W., P.S., A.J.K.); NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio (M.A.-K., J.K., P.S.); Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (J.K.); and Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom (C.D., J.-P.C.).

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920206PMC
June 2016

Obesity and Multiple Sclerosis: A Mendelian Randomization Study.

PLoS Med 2016 06 28;13(6):e1002053. Epub 2016 Jun 28.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1371/journal.pmed.1002053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924848PMC
June 2016

Genome-wide association study identifies 74 loci associated with educational attainment.

Authors:
Aysu Okbay Jonathan P Beauchamp Mark Alan Fontana James J Lee Tune H Pers Cornelius A Rietveld Patrick Turley Guo-Bo Chen Valur Emilsson S Fleur W Meddens Sven Oskarsson Joseph K Pickrell Kevin Thom Pascal Timshel Ronald de Vlaming Abdel Abdellaoui Tarunveer S Ahluwalia Jonas Bacelis Clemens Baumbach Gyda Bjornsdottir Johannes H Brandsma Maria Pina Concas Jaime Derringer Nicholas A Furlotte Tessel E Galesloot Giorgia Girotto Richa Gupta Leanne M Hall Sarah E Harris Edith Hofer Momoko Horikoshi Jennifer E Huffman Kadri Kaasik Ioanna P Kalafati Robert Karlsson Augustine Kong Jari Lahti Sven J van der Lee Christiaan deLeeuw Penelope A Lind Karl-Oskar Lindgren Tian Liu Massimo Mangino Jonathan Marten Evelin Mihailov Michael B Miller Peter J van der Most Christopher Oldmeadow Antony Payton Natalia Pervjakova Wouter J Peyrot Yong Qian Olli Raitakari Rico Rueedi Erika Salvi Börge Schmidt Katharina E Schraut Jianxin Shi Albert V Smith Raymond A Poot Beate St Pourcain Alexander Teumer Gudmar Thorleifsson Niek Verweij Dragana Vuckovic Juergen Wellmann Harm-Jan Westra Jingyun Yang Wei Zhao Zhihong Zhu Behrooz Z Alizadeh Najaf Amin Andrew Bakshi Sebastian E Baumeister Ginevra Biino Klaus Bønnelykke Patricia A Boyle Harry Campbell Francesco P Cappuccio Gail Davies Jan-Emmanuel De Neve Panos Deloukas Ilja Demuth Jun Ding Peter Eibich Lewin Eisele Niina Eklund David M Evans Jessica D Faul Mary F Feitosa Andreas J Forstner Ilaria Gandin Bjarni Gunnarsson Bjarni V Halldórsson Tamara B Harris Andrew C Heath Lynne J Hocking Elizabeth G Holliday Georg Homuth Michael A Horan Jouke-Jan Hottenga Philip L de Jager Peter K Joshi Astanand Jugessur Marika A Kaakinen Mika Kähönen Stavroula Kanoni Liisa Keltigangas-Järvinen Lambertus A L M Kiemeney Ivana Kolcic Seppo Koskinen Aldi T Kraja Martin Kroh Zoltan Kutalik Antti Latvala Lenore J Launer Maël P Lebreton Douglas F Levinson Paul Lichtenstein Peter Lichtner David C M Liewald Anu Loukola Pamela A Madden Reedik Mägi Tomi Mäki-Opas Riccardo E Marioni Pedro Marques-Vidal Gerardus A Meddens George McMahon Christa Meisinger Thomas Meitinger Yusplitri Milaneschi Lili Milani Grant W Montgomery Ronny Myhre Christopher P Nelson Dale R Nyholt William E R Ollier Aarno Palotie Lavinia Paternoster Nancy L Pedersen Katja E Petrovic David J Porteous Katri Räikkönen Susan M Ring Antonietta Robino Olga Rostapshova Igor Rudan Aldo Rustichini Veikko Salomaa Alan R Sanders Antti-Pekka Sarin Helena Schmidt Rodney J Scott Blair H Smith Jennifer A Smith Jan A Staessen Elisabeth Steinhagen-Thiessen Konstantin Strauch Antonio Terracciano Martin D Tobin Sheila Ulivi Simona Vaccargiu Lydia Quaye Frank J A van Rooij Cristina Venturini Anna A E Vinkhuyzen Uwe Völker Henry Völzke Judith M Vonk Diego Vozzi Johannes Waage Erin B Ware Gonneke Willemsen John R Attia David A Bennett Klaus Berger Lars Bertram Hans Bisgaard Dorret I Boomsma Ingrid B Borecki Ute Bültmann Christopher F Chabris Francesco Cucca Daniele Cusi Ian J Deary George V Dedoussis Cornelia M van Duijn Johan G Eriksson Barbara Franke Lude Franke Paolo Gasparini Pablo V Gejman Christian Gieger Hans-Jörgen Grabe Jacob Gratten Patrick J F Groenen Vilmundur Gudnason Pim van der Harst Caroline Hayward David A Hinds Wolfgang Hoffmann Elina Hyppönen William G Iacono Bo Jacobsson Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Terho Lehtimäki Steven F Lehrer Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Neil Pendleton Brenda W J H Penninx Markus Perola Nicola Pirastu Mario Pirastu Ozren Polasek Danielle Posthuma Christine Power Michael A Province Nilesh J Samani David Schlessinger Reinhold Schmidt Thorkild I A Sørensen Tim D Spector Kari Stefansson Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier Joyce Y Tung André G Uitterlinden Veronique Vitart Peter Vollenweider David R Weir James F Wilson Alan F Wright Dalton C Conley Robert F Krueger George Davey Smith Albert Hofman David I Laibson Sarah E Medland Michelle N Meyer Jian Yang Magnus Johannesson Peter M Visscher Tõnu Esko Philipp D Koellinger David Cesarini Daniel J Benjamin

Nature 2016 05 11;533(7604):539-42. Epub 2016 May 11.

Center for Economic and Social Research, University of Southern California, Los Angeles, California 90089-3332, USA.

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http://dx.doi.org/10.1038/nature17671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883595PMC
May 2016

Assumption-free estimation of the genetic contribution to refractive error across childhood.

Mol Vis 2015 26;21:621-32. Epub 2015 May 26.

School of Social and Community Medicine, University of Bristol, Bristol, UK.

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April 2016

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.

Authors:
Stéphanie M van den Berg Marleen H M de Moor Karin J H Verweij Robert F Krueger Michelle Luciano Alejandro Arias Vasquez Lindsay K Matteson Jaime Derringer Tõnu Esko Najaf Amin Scott D Gordon Narelle K Hansell Amy B Hart Ilkka Seppälä Jennifer E Huffman Bettina Konte Jari Lahti Minyoung Lee Mike Miller Teresa Nutile Toshiko Tanaka Alexander Teumer Alexander Viktorin Juho Wedenoja Abdel Abdellaoui Goncalo R Abecasis Daniel E Adkins Arpana Agrawal Jüri Allik Katja Appel Timothy B Bigdeli Fabio Busonero Harry Campbell Paul T Costa George Davey Smith Gail Davies Harriet de Wit Jun Ding Barbara E Engelhardt Johan G Eriksson Iryna O Fedko Luigi Ferrucci Barbara Franke Ina Giegling Richard Grucza Annette M Hartmann Andrew C Heath Kati Heinonen Anjali K Henders Georg Homuth Jouke-Jan Hottenga William G Iacono Joost Janzing Markus Jokela Robert Karlsson John P Kemp Matthew G Kirkpatrick Antti Latvala Terho Lehtimäki David C Liewald Pamela A F Madden Chiara Magri Patrik K E Magnusson Jonathan Marten Andrea Maschio Hamdi Mbarek Sarah E Medland Evelin Mihailov Yuri Milaneschi Grant W Montgomery Matthias Nauck Michel G Nivard Klaasjan G Ouwens Aarno Palotie Erik Pettersson Ozren Polasek Yong Qian Laura Pulkki-Råback Olli T Raitakari Anu Realo Richard J Rose Daniela Ruggiero Carsten O Schmidt Wendy S Slutske Rossella Sorice John M Starr Beate St Pourcain Angelina R Sutin Nicholas J Timpson Holly Trochet Sita Vermeulen Eero Vuoksimaa Elisabeth Widen Jasper Wouda Margaret J Wright Lina Zgaga David Porteous Alessandra Minelli Abraham A Palmer Dan Rujescu Marina Ciullo Caroline Hayward Igor Rudan Andres Metspalu Jaakko Kaprio Ian J Deary Katri Räikkönen James F Wilson Liisa Keltikangas-Järvinen Laura J Bierut John M Hettema Hans J Grabe Brenda W J H Penninx Cornelia M van Duijn David M Evans David Schlessinger Nancy L Pedersen Antonio Terracciano Matt McGue Nicholas G Martin Dorret I Boomsma

Behav Genet 2016 Mar 11;46(2):170-82. Epub 2015 Sep 11.

Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751159PMC
March 2016

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.

Authors:
Qiao Fan Virginie J M Verhoeven Robert Wojciechowski Veluchamy A Barathi Pirro G Hysi Jeremy A Guggenheim René Höhn Veronique Vitart Anthony P Khawaja Kenji Yamashiro S Mohsen Hosseini Terho Lehtimäki Yi Lu Toomas Haller Jing Xie Cécile Delcourt Mario Pirastu Juho Wedenoja Puya Gharahkhani Cristina Venturini Masahiro Miyake Alex W Hewitt Xiaobo Guo Johanna Mazur Jenifer E Huffman Katie M Williams Ozren Polasek Harry Campbell Igor Rudan Zoran Vatavuk James F Wilson Peter K Joshi George McMahon Beate St Pourcain David M Evans Claire L Simpson Tae-Hwi Schwantes-An Robert P Igo Alireza Mirshahi Audrey Cougnard-Gregoire Céline Bellenguez Maria Blettner Olli Raitakari Mika Kähönen Ilkka Seppala Tanja Zeller Thomas Meitinger Janina S Ried Christian Gieger Laura Portas Elisabeth M van Leeuwen Najaf Amin André G Uitterlinden Fernando Rivadeneira Albert Hofman Johannes R Vingerling Ya Xing Wang Xu Wang Eileen Tai-Hui Boh M Kamran Ikram Charumathi Sabanayagam Preeti Gupta Vincent Tan Lei Zhou Candice E H Ho Wan'e Lim Roger W Beuerman Rosalynn Siantar E-Shyong Tai Eranga Vithana Evelin Mihailov Chiea-Chuen Khor Caroline Hayward Robert N Luben Paul J Foster Barbara E K Klein Ronald Klein Hoi-Suen Wong Paul Mitchell Andres Metspalu Tin Aung Terri L Young Mingguang He Olavi Pärssinen Cornelia M van Duijn Jie Jin Wang Cathy Williams Jost B Jonas Yik-Ying Teo David A Mackey Konrad Oexle Nagahisa Yoshimura Andrew D Paterson Norbert Pfeiffer Tien-Yin Wong Paul N Baird Dwight Stambolian Joan E Bailey Wilson Ching-Yu Cheng Christopher J Hammond Caroline C W Klaver Seang-Mei Saw Jugnoo S Rahi Jean-François Korobelnik John P Kemp Nicholas J Timpson George Davey Smith Jamie E Craig Kathryn P Burdon Rhys D Fogarty Sudha K Iyengar Emily Chew Sarayut Janmahasatian Nicholas G Martin Stuart MacGregor Liang Xu Maria Schache Vinay Nangia Songhomitra Panda-Jonas Alan F Wright Jeremy R Fondran Jonathan H Lass Sheng Feng Jing Hua Zhao Kay-Tee Khaw Nick J Wareham Taina Rantanen Jaakko Kaprio Chi Pui Pang Li Jia Chen Pancy O Tam Vishal Jhanji Alvin L Young Angela Döring Leslie J Raffel Mary-Frances Cotch Xiaohui Li Shea Ping Yip Maurice K H Yap Ginevra Biino Simona Vaccargiu Maurizio Fossarello Brian Fleck Seyhan Yazar Jan Willem L Tideman Milly Tedja Margaret M Deangelis Margaux Morrison Lindsay Farrer Xiangtian Zhou Wei Chen Nobuhisa Mizuki Akira Meguro Kari Matti Mäkelä

Nat Commun 2016 Mar 29;7:11008. Epub 2016 Mar 29.

Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820539PMC
March 2016

Paradoxical Relationship Between Body Mass Index and Thyroid Hormone Levels: A Study Using Mendelian Randomization.

J Clin Endocrinol Metab 2016 Feb 23;101(2):730-8. Epub 2015 Nov 23.

Thyroid Research Group (P.N.T., O.O., J.W.G., C.M.D.) and Institute of Molecular and Experimental Medicine (A.R.), Cardiff University School of Medicine, Cardiff, CF14 4XN United Kingdom; Medical Research Council Integrative Epidemiology Unit (R.R., N.D., G.D.S., N.J.T.), University of Bristol, Bristol, BS8 2BN United Kingdom; Department of Social and Community Medicine (A.S., A.G., K.N., S.R.), University of Bristol, Bristol, BS8 2BN United Kingdom; Department of Biochemistry (K.S.), Bristol Royal Infirmary University Hospitals Bristol National Health Service Foundation Trust, Bristol, BS2 8HW United Kingdom; Geschäftsleiter Medizinisches Versorgungszentrum Labor Dr. Reising-Ackermann und Kollegen (W.W.), D-04289 Leipzig, Germany; Department of Biochemistry (A.T.), Royal United Hospital, Bath, BA1 3NG United Kingdom; Department of Non-Communicable Disease Epidemiology (D.N.), Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, CF14 4XN United Kingdom; Molecular Endocrinology Group (G.R.W.), Department of Medicine, Imperial College London, London, WC1E 7HT United Kingdom; and Musculoskeletal Research Unit (J.H.T.), University of Bristol, Learning and Research Southmead Hospital, Westbury on Trym, Bristol, BS10 5NB United Kingdom.

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http://dx.doi.org/10.1210/jc.2015-3505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880123PMC
February 2016

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Authors:
Tuomas O Kilpeläinen Jayne F Martin Carli Alicja A Skowronski Qi Sun Jennifer Kriebel Mary F Feitosa Åsa K Hedman Alexander W Drong James E Hayes Jinghua Zhao Tune H Pers Ursula Schick Niels Grarup Zoltán Kutalik Stella Trompet Massimo Mangino Kati Kristiansson Marian Beekman Leo-Pekka Lyytikäinen Joel Eriksson Peter Henneman Jari Lahti Toshiko Tanaka Jian'an Luan Fabiola Del Greco M Dorota Pasko Frida Renström Sara M Willems Anubha Mahajan Lynda M Rose Xiuqing Guo Yongmei Liu Marcus E Kleber Louis Pérusse Tom Gaunt Tarunveer S Ahluwalia Yun Ju Sung Yolande F Ramos Najaf Amin Antoinette Amuzu Inês Barroso Claire Bellis John Blangero Brendan M Buckley Stefan Böhringer Yii-Der I Chen Anton J N de Craen David R Crosslin Caroline E Dale Zari Dastani Felix R Day Joris Deelen Graciela E Delgado Ayse Demirkan Francis M Finucane Ian Ford Melissa E Garcia Christian Gieger Stefan Gustafsson Göran Hallmans Susan E Hankinson Aki S Havulinna Christian Herder Dena Hernandez Andrew A Hicks David J Hunter Thomas Illig Erik Ingelsson Andreea Ioan-Facsinay John-Olov Jansson Nancy S Jenny Marit E Jørgensen Torben Jørgensen Magnus Karlsson Wolfgang Koenig Peter Kraft Joanneke Kwekkeboom Tiina Laatikainen Karl-Heinz Ladwig Charles A LeDuc Gordon Lowe Yingchang Lu Pedro Marques-Vidal Christa Meisinger Cristina Menni Andrew P Morris Richard H Myers Satu Männistö Mike A Nalls Lavinia Paternoster Annette Peters Aruna D Pradhan Tuomo Rankinen Laura J Rasmussen-Torvik Wolfgang Rathmann Treva K Rice J Brent Richards Paul M Ridker Naveed Sattar David B Savage Stefan Söderberg Nicholas J Timpson Liesbeth Vandenput Diana van Heemst Hae-Won Uh Marie-Claude Vohl Mark Walker Heinz-Erich Wichmann Elisabeth Widén Andrew R Wood Jie Yao Tanja Zeller Yiying Zhang Ingrid Meulenbelt Margreet Kloppenburg Arne Astrup Thorkild I A Sørensen Mark A Sarzynski D C Rao Pekka Jousilahti Erkki Vartiainen Albert Hofman Fernando Rivadeneira André G Uitterlinden Eero Kajantie Clive Osmond Aarno Palotie Johan G Eriksson Markku Heliövaara Paul B Knekt Seppo Koskinen Antti Jula Markus Perola Risto K Huupponen Jorma S Viikari Mika Kähönen Terho Lehtimäki Olli T Raitakari Dan Mellström Mattias Lorentzon Juan P Casas Stefanie Bandinelli Winfried März Aaron Isaacs Ko W van Dijk Cornelia M van Duijn Tamara B Harris Claude Bouchard Matthew A Allison Daniel I Chasman Claes Ohlsson Lars Lind Robert A Scott Claudia Langenberg Nicholas J Wareham Luigi Ferrucci Timothy M Frayling Peter P Pramstaller Ingrid B Borecki Dawn M Waterworth Sven Bergmann Gérard Waeber Peter Vollenweider Henrik Vestergaard Torben Hansen Oluf Pedersen Frank B Hu P Eline Slagboom Harald Grallert Tim D Spector J W Jukema Robert J Klein Erik E Schadt Paul W Franks Cecilia M Lindgren Rudolph L Leibel Ruth J F Loos

Nat Commun 2016 Feb 1;7:10494. Epub 2016 Feb 1.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/ncomms10494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740377PMC
February 2016

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

Authors:
Janine F Felix Jonathan P Bradfield Claire Monnereau Ralf J P van der Valk Evie Stergiakouli Alessandra Chesi Romy Gaillard Bjarke Feenstra Elisabeth Thiering Eskil Kreiner-Møller Anubha Mahajan Niina Pitkänen Raimo Joro Alana Cavadino Ville Huikari Steve Franks Maria M Groen-Blokhuis Diana L Cousminer Julie A Marsh Terho Lehtimäki John A Curtin Jesus Vioque Tarunveer S Ahluwalia Ronny Myhre Thomas S Price Natalia Vilor-Tejedor Loïc Yengo Niels Grarup Ioanna Ntalla Wei Ang Mustafa Atalay Hans Bisgaard Alexandra I Blakemore Amelie Bonnefond Lisbeth Carstensen Johan Eriksson Claudia Flexeder Lude Franke Frank Geller Mandy Geserick Anna-Liisa Hartikainen Claire M A Haworth Joel N Hirschhorn Albert Hofman Jens-Christian Holm Momoko Horikoshi Jouke Jan Hottenga Jinyan Huang Haja N Kadarmideen Mika Kähönen Wieland Kiess Hanna-Maaria Lakka Timo A Lakka Alexandra M Lewin Liming Liang Leo-Pekka Lyytikäinen Baoshan Ma Per Magnus Shana E McCormack George McMahon Frank D Mentch Christel M Middeldorp Clare S Murray Katja Pahkala Tune H Pers Roland Pfäffle Dirkje S Postma Christine Power Angela Simpson Verena Sengpiel Carla M T Tiesler Maties Torrent André G Uitterlinden Joyce B van Meurs Rebecca Vinding Johannes Waage Jane Wardle Eleftheria Zeggini Babette S Zemel George V Dedoussis Oluf Pedersen Philippe Froguel Jordi Sunyer Robert Plomin Bo Jacobsson Torben Hansen Juan R Gonzalez Adnan Custovic Olli T Raitakari Craig E Pennell Elisabeth Widén Dorret I Boomsma Gerard H Koppelman Sylvain Sebert Marjo-Riitta Järvelin Elina Hyppönen Mark I McCarthy Virpi Lindi Niinikoski Harri Antje Körner Klaus Bønnelykke Joachim Heinrich Mads Melbye Fernando Rivadeneira Hakon Hakonarson Susan M Ring George Davey Smith Thorkild I A Sørensen Nicholas J Timpson Struan F A Grant Vincent W V Jaddoe

Hum Mol Genet 2016 Jan 24;25(2):389-403. Epub 2015 Nov 24.

The Generation R Study Group, Department of Pediatrics, Department of Epidemiology.

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January 2016

A pathway-centric approach to rare variant association analysis.

Eur J Hum Genet 2016 01 31;25(1):123-129. Epub 2016 Aug 31.

MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/ejhg.2016.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136291PMC
January 2016

An interactive genome browser of association results from the UK10K cohorts project.

Bioinformatics 2015 Dec 26;31(24):4029-31. Epub 2015 Aug 26.

Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, UK, Department of Haematology, University of Cambridge, Cambridge CB2 1TN, UK.

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http://dx.doi.org/10.1093/bioinformatics/btv491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673976PMC
December 2015

Genome-wide association study identifies SNPs in the MHC class II loci that are associated with self-reported history of whooping cough.

Hum Mol Genet 2015 Oct 30;24(20):5930-9. Epub 2015 Jul 30.

School of Social and Community Medicine and MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK

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http://dx.doi.org/10.1093/hmg/ddv293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581602PMC
October 2015

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Authors:
Hou-Feng Zheng Vincenzo Forgetta Yi-Hsiang Hsu Karol Estrada Alberto Rosello-Diez Paul J Leo Chitra L Dahia Kyung Hyun Park-Min Jonathan H Tobias Charles Kooperberg Aaron Kleinman Unnur Styrkarsdottir Ching-Ti Liu Charlotta Uggla Daniel S Evans Carrie M Nielson Klaudia Walter Ulrika Pettersson-Kymmer Shane McCarthy Joel Eriksson Tony Kwan Mila Jhamai Katerina Trajanoska Yasin Memari Josine Min Jie Huang Petr Danecek Beth Wilmot Rui Li Wen-Chi Chou Lauren E Mokry Alireza Moayyeri Melina Claussnitzer Chia-Ho Cheng Warren Cheung Carolina Medina-Gómez Bing Ge Shu-Huang Chen Kwangbom Choi Ling Oei James Fraser Robert Kraaij Matthew A Hibbs Celia L Gregson Denis Paquette Albert Hofman Carl Wibom Gregory J Tranah Mhairi Marshall Brooke B Gardiner Katie Cremin Paul Auer Li Hsu Sue Ring Joyce Y Tung Gudmar Thorleifsson Anke W Enneman Natasja M van Schoor Lisette C P G M de Groot Nathalie van der Velde Beatrice Melin John P Kemp Claus Christiansen Adrian Sayers Yanhua Zhou Sophie Calderari Jeroen van Rooij Chris Carlson Ulrike Peters Soizik Berlivet Josée Dostie Andre G Uitterlinden Stephen R Williams Charles Farber Daniel Grinberg Andrea Z LaCroix Jeff Haessler Daniel I Chasman Franco Giulianini Lynda M Rose Paul M Ridker John A Eisman Tuan V Nguyen Jacqueline R Center Xavier Nogues Natalia Garcia-Giralt Lenore L Launer Vilmunder Gudnason Dan Mellström Liesbeth Vandenput Najaf Amin Cornelia M van Duijn Magnus K Karlsson Östen Ljunggren Olle Svensson Göran Hallmans François Rousseau Sylvie Giroux Johanne Bussière Pascal P Arp Fjorda Koromani Richard L Prince Joshua R Lewis Bente L Langdahl A Pernille Hermann Jens-Erik B Jensen Stephen Kaptoge Kay-Tee Khaw Jonathan Reeve Melissa M Formosa Angela Xuereb-Anastasi Kristina Åkesson Fiona E McGuigan Gaurav Garg Jose M Olmos Maria T Zarrabeitia Jose A Riancho Stuart H Ralston Nerea Alonso Xi Jiang David Goltzman Tomi Pastinen Elin Grundberg Dominique Gauguier Eric S Orwoll David Karasik George Davey-Smith Albert V Smith Kristin Siggeirsdottir Tamara B Harris M Carola Zillikens Joyce B J van Meurs Unnur Thorsteinsdottir Matthew T Maurano Nicholas J Timpson Nicole Soranzo Richard Durbin Scott G Wilson Evangelia E Ntzani Matthew A Brown Kari Stefansson David A Hinds Tim Spector L Adrienne Cupples Claes Ohlsson Celia M T Greenwood Rebecca D Jackson David W Rowe Cynthia A Loomis David M Evans Cheryl L Ackert-Bicknell Alexandra L Joyner Emma L Duncan Douglas P Kiel Fernando Rivadeneira J Brent Richards

Nature 2015 Oct 14;526(7571):112-7. Epub 2015 Sep 14.

Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.

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http://dx.doi.org/10.1038/nature14878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755714PMC
October 2015

Exploring possible epigenetic mediation of early-life environmental exposures on adiposity and obesity development.

Int J Epidemiol 2015 Aug 7;44(4):1191-8. Epub 2015 May 7.

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark and Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, Copenhagen, Denmark

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http://dx.doi.org/10.1093/ije/dyv066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588870PMC
August 2015

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors.

Eur J Epidemiol 2015 Jul 15;30(7):543-52. Epub 2015 Mar 15.

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK,

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http://dx.doi.org/10.1007/s10654-015-0011-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516908PMC
July 2015

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.

Authors:
Marleen H M de Moor Stéphanie M van den Berg Karin J H Verweij Robert F Krueger Michelle Luciano Alejandro Arias Vasquez Lindsay K Matteson Jaime Derringer Tõnu Esko Najaf Amin Scott D Gordon Narelle K Hansell Amy B Hart Ilkka Seppälä Jennifer E Huffman Bettina Konte Jari Lahti Minyoung Lee Mike Miller Teresa Nutile Toshiko Tanaka Alexander Teumer Alexander Viktorin Juho Wedenoja Goncalo R Abecasis Daniel E Adkins Arpana Agrawal Jüri Allik Katja Appel Timothy B Bigdeli Fabio Busonero Harry Campbell Paul T Costa George Davey Smith Gail Davies Harriet de Wit Jun Ding Barbara E Engelhardt Johan G Eriksson Iryna O Fedko Luigi Ferrucci Barbara Franke Ina Giegling Richard Grucza Annette M Hartmann Andrew C Heath Kati Heinonen Anjali K Henders Georg Homuth Jouke-Jan Hottenga William G Iacono Joost Janzing Markus Jokela Robert Karlsson John P Kemp Matthew G Kirkpatrick Antti Latvala Terho Lehtimäki David C Liewald Pamela A F Madden Chiara Magri Patrik K E Magnusson Jonathan Marten Andrea Maschio Sarah E Medland Evelin Mihailov Yuri Milaneschi Grant W Montgomery Matthias Nauck Klaasjan G Ouwens Aarno Palotie Erik Pettersson Ozren Polasek Yong Qian Laura Pulkki-Råback Olli T Raitakari Anu Realo Richard J Rose Daniela Ruggiero Carsten O Schmidt Wendy S Slutske Rossella Sorice John M Starr Beate St Pourcain Angelina R Sutin Nicholas J Timpson Holly Trochet Sita Vermeulen Eero Vuoksimaa Elisabeth Widen Jasper Wouda Margaret J Wright Lina Zgaga David Porteous Alessandra Minelli Abraham A Palmer Dan Rujescu Marina Ciullo Caroline Hayward Igor Rudan Andres Metspalu Jaakko Kaprio Ian J Deary Katri Räikkönen James F Wilson Liisa Keltikangas-Järvinen Laura J Bierut John M Hettema Hans J Grabe Cornelia M van Duijn David M Evans David Schlessinger Nancy L Pedersen Antonio Terracciano Matt McGue Brenda W J H Penninx Nicholas G Martin Dorret I Boomsma

JAMA Psychiatry 2015 Jul;72(7):642-50

Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667957PMC
July 2015

Directional dominance on stature and cognition in diverse human populations.

Authors:
Peter K Joshi Tonu Esko Hannele Mattsson Niina Eklund Ilaria Gandin Teresa Nutile Anne U Jackson Claudia Schurmann Albert V Smith Weihua Zhang Yukinori Okada Alena Stančáková Jessica D Faul Wei Zhao Traci M Bartz Maria Pina Concas Nora Franceschini Stefan Enroth Veronique Vitart Stella Trompet Xiuqing Guo Daniel I Chasman Jeffery R O'Connel Tanguy Corre Suraj S Nongmaithem Yuning Chen Massimo Mangino Daniela Ruggiero Michela Traglia Aliki-Eleni Farmaki Tim Kacprowski Andrew Bjonnes Ashley van der Spek Ying Wu Anil K Giri Lisa R Yanek Lihua Wang Edith Hofer Cornelius A Rietveld Olga McLeod Marilyn C Cornelis Cristian Pattaro Niek Verweij Clemens Baumbach Abdel Abdellaoui Helen R Warren Dragana Vuckovic Hao Mei Claude Bouchard John R B Perry Stefania Cappellani Saira S Mirza Miles C Benton Ulrich Broeckel Sarah E Medland Penelope A Lind Giovanni Malerba Alexander Drong Loic Yengo Lawrence F Bielak Degui Zhi Peter J van der Most Daniel Shriner Reedik Mägi Gibran Hemani Tugce Karaderi Zhaoming Wang Tian Liu Ilja Demuth Jing Hua Zhao Weihua Meng Lazaros Lataniotis Sander W van der Laan Jonathan P Bradfield Andrew R Wood Amelie Bonnefond Tarunveer S Ahluwalia Leanne M Hall Erika Salvi Seyhan Yazar Lisbeth Carstensen Hugoline G de Haan Mark Abney Uzma Afzal Matthew A Allison Najaf Amin Folkert W Asselbergs Stephan J L Bakker R Graham Barr Sebastian E Baumeister Daniel J Benjamin Sven Bergmann Eric Boerwinkle Erwin P Bottinger Archie Campbell Aravinda Chakravarti Yingleong Chan Stephen J Chanock Constance Chen Y-D Ida Chen Francis S Collins John Connell Adolfo Correa L Adrienne Cupples George Davey Smith Gail Davies Marcus Dörr Georg Ehret Stephen B Ellis Bjarke Feenstra Mary F Feitosa Ian Ford Caroline S Fox Timothy M Frayling Nele Friedrich Frank Geller Generation Scotland Irina Gillham-Nasenya Omri Gottesman Misa Graff Francine Grodstein Charles Gu Chris Haley Christopher J Hammond Sarah E Harris Tamara B Harris Nicholas D Hastie Nancy L Heard-Costa Kauko Heikkilä Lynne J Hocking Georg Homuth Jouke-Jan Hottenga Jinyan Huang Jennifer E Huffman Pirro G Hysi M Arfan Ikram Erik Ingelsson Anni Joensuu Åsa Johansson Pekka Jousilahti J Wouter Jukema Mika Kähönen Yoichiro Kamatani Stavroula Kanoni Shona M Kerr Nazir M Khan Philipp Koellinger Heikki A Koistinen Manraj K Kooner Michiaki Kubo Johanna Kuusisto Jari Lahti Lenore J Launer Rodney A Lea Benjamin Lehne Terho Lehtimäki David C M Liewald Lars Lind Marie Loh Marja-Liisa Lokki Stephanie J London Stephanie J Loomis Anu Loukola Yingchang Lu Thomas Lumley Annamari Lundqvist Satu Männistö Pedro Marques-Vidal Corrado Masciullo Angela Matchan Rasika A Mathias Koichi Matsuda James B Meigs Christa Meisinger Thomas Meitinger Cristina Menni Frank D Mentch Evelin Mihailov Lili Milani May E Montasser Grant W Montgomery Alanna Morrison Richard H Myers Rajiv Nadukuru Pau Navarro Mari Nelis Markku S Nieminen Ilja M Nolte George T O'Connor Adesola Ogunniyi Sandosh Padmanabhan Walter R Palmas James S Pankow Inga Patarcic Francesca Pavani Patricia A Peyser Kirsi Pietilainen Neil Poulter Inga Prokopenko Sarju Ralhan Paul Redmond Stephen S Rich Harri Rissanen Antonietta Robino Lynda M Rose Richard Rose Cinzia Sala Babatunde Salako Veikko Salomaa Antti-Pekka Sarin Richa Saxena Helena Schmidt Laura J Scott William R Scott Bengt Sennblad Sudha Seshadri Peter Sever Smeeta Shrestha Blair H Smith Jennifer A Smith Nicole Soranzo Nona Sotoodehnia Lorraine Southam Alice V Stanton Maria G Stathopoulou Konstantin Strauch Rona J Strawbridge Matthew J Suderman Nikhil Tandon Sian-Tsun Tang Kent D Taylor Bamidele O Tayo Anna Maria Töglhofer Maciej Tomaszewski Natalia Tšernikova Jaakko Tuomilehto Andre G Uitterlinden Dhananjay Vaidya Astrid van Hylckama Vlieg Jessica van Setten Tuula Vasankari Sailaja Vedantam Efthymia Vlachopoulou Diego Vozzi Eero Vuoksimaa Melanie Waldenberger Erin B Ware William Wentworth-Shields John B Whitfield Sarah Wild Gonneke Willemsen Chittaranjan S Yajnik Jie Yao Gianluigi Zaza Xiaofeng Zhu The BioBank Japan Project Rany M Salem Mads Melbye Hans Bisgaard Nilesh J Samani Daniele Cusi David A Mackey Richard S Cooper Philippe Froguel Gerard Pasterkamp Struan F A Grant Hakon Hakonarson Luigi Ferrucci Robert A Scott Andrew D Morris Colin N A Palmer George Dedoussis Panos Deloukas Lars Bertram Ulman Lindenberger Sonja I Berndt Cecilia M Lindgren Nicholas J Timpson Anke Tönjes Patricia B Munroe Thorkild I A Sørensen Charles N Rotimi Donna K Arnett Albertine J Oldehinkel Sharon L R Kardia Beverley Balkau Giovanni Gambaro Andrew P Morris Johan G Eriksson Margie J Wright Nicholas G Martin Steven C Hunt John M Starr Ian J Deary Lyn R Griffiths Henning Tiemeier Nicola Pirastu Jaakko Kaprio Nicholas J Wareham Louis Pérusse James G Wilson Giorgia Girotto Mark J Caulfield Olli Raitakari Dorret I Boomsma Christian Gieger Pim van der Harst Andrew A Hicks Peter Kraft Juha Sinisalo Paul Knekt Magnus Johannesson Patrik K E Magnusson Anders Hamsten Reinhold Schmidt Ingrid B Borecki Erkki Vartiainen Diane M Becker Dwaipayan Bharadwaj Karen L Mohlke Michael Boehnke Cornelia M van Duijn Dharambir K Sanghera Alexander Teumer Eleftheria Zeggini Andres Metspalu Paolo Gasparini Sheila Ulivi Carole Ober Daniela Toniolo Igor Rudan David J Porteous Marina Ciullo Tim D Spector Caroline Hayward Josée Dupuis Ruth J F Loos Alan F Wright Giriraj R Chandak Peter Vollenweider Alan Shuldiner Paul M Ridker Jerome I Rotter Naveed Sattar Ulf Gyllensten Kari E North Mario Pirastu Bruce M Psaty David R Weir Markku Laakso Vilmundur Gudnason Atsushi Takahashi John C Chambers Jaspal S Kooner David P Strachan Harry Campbell Joel N Hirschhorn Markus Perola Ozren Polašek James F Wilson

Nature 2015 Jul 1;523(7561):459-462. Epub 2015 Jul 1.

Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.

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http://dx.doi.org/10.1038/nature14618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516141PMC
July 2015

Blood pressure and mortality: using offspring blood pressure as an instrument for own blood pressure in the HUNT study.

Sci Rep 2015 Jul 22;5:12399. Epub 2015 Jul 22.

Department of Public Health and General Practice, Norwegian University of Science and Technology, N-7491 Trondheim, Norway.

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http://dx.doi.org/10.1038/srep12399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510525PMC
July 2015

Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD.

J Am Acad Child Adolesc Psychiatry 2015 Apr 29;54(4):322-7. Epub 2015 Jan 29.

Medical Research Centre (MRC) Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1016/j.jaac.2015.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382052PMC
April 2015

A genome-wide association study of body mass index across early life and childhood.

Int J Epidemiol 2015 Apr 7;44(2):700-12. Epub 2015 May 7.

School of Women's and Infants' Health, University of Western Australia, Perth, WA, Australia, University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD, Australia, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK, School of Social and Community Medicine, University of Bristol, Bristol, UK, Biocenter Oulu, and Institute of Health Sciences, University of Oulu, Oulu, Finland, Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, Department of Epidemiology and Biostatistics, MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London, London, UK, Unit of Primary Care, Oulu University Hospital, Oulu, Finland and The Joanna Briggs Institute, The Robinson Research Institute, and School of Translational Health Science, University of Adelaide, Adelaide, SA, Australia.

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http://dx.doi.org/10.1093/ije/dyv077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469798PMC
April 2015

Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium.

Int J Epidemiol 2015 Apr 6;44(2):638-50. Epub 2015 Jun 6.

Department of Public Health and Clinical Medicine, Section for Medicine, Umeå University, Umeå, Sweden, Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden, Department of Odontology, Umeå University, Umeå, Sweden, Department of Nutrition, Harvard School of Public Health, Boston, MA, USA, Department of Pediatric Dentistry, School of Dentistry, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA, Department of Periodontology, and Department of Dental Ecology, School of Dentistry, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA, Department of Prosthodontics, Gerodontology and Biomaterials, University Medicine, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany, Human Genetics Center, and Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, TX, USA, Emeritus, Department of Periodontics, West Virginia University School of Dentistry, Morgantown, WV, USA, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Department of Biobank Research, Umeå University, Umeå, Sweden, Department of Clinical Sciences, Diabetes and Cardiovascular Disease Genetic Epidemiology, Lund University Diabetes Center, Skåne University Hosptial, Malmö, Sweden, Dental Practice and Rural Health, Morgantown, WV, USA, Department of Clinical Sciences, Hypertension and Cardiovascular Disease, Lund University Diabetes Center, Skåne University Hospital, Malmö, Sweden, Department of

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http://dx.doi.org/10.1093/ije/dyv075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817600PMC
April 2015

Mendelian randomization: where are we now and where are we going?

Int J Epidemiol 2015 Apr;44(2):379-88

MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol

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http://dx.doi.org/10.1093/ije/dyv108DOI Listing
April 2015

Using inactivating mutations to provide insight into drug action.

Genome Med 2015 28;7(1). Epub 2015 Jan 28.

MRC Integrative Epidemiology Unit (IEU), University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN UK.

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http://dx.doi.org/10.1186/s13073-015-0130-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307143PMC
January 2015