Nicholas J Dyson

Nicholas J Dyson

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Nicholas J Dyson

Nicholas J Dyson

Publications by authors named "Nicholas J Dyson"

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A Code of Mono-phosphorylation Modulates the Function of RB.

Mol Cell 2019 03 30;73(5):985-1000.e6. Epub 2019 Jan 30.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424368PMC
March 2019

Non-canonical functions of the RB protein in cancer.

Nat Rev Cancer 2018 07;18(7):442-451

Massachusetts General Hospital Cancer Center, Laboratory of Molecular Oncology, Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.1038/s41568-018-0008-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693677PMC
July 2018

E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression.

Dev Cell 2017 12 7;43(6):689-703.e5. Epub 2017 Dec 7.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149 13(th) Street, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901703PMC
December 2017

pRB Takes an EZ Path to a Repetitive Task.

Mol Cell 2016 12;64(6):1015-1017

Massachusetts General Hospital Cancer Center, Laboratory of Molecular Oncology, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.11.035DOI Listing
December 2016

RB1: a prototype tumor suppressor and an enigma.

Authors:
Nicholas J Dyson

Genes Dev 2016 07;30(13):1492-502

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.282145.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949322PMC
July 2016

Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation.

Mol Cell Oncol 2014 Oct-Dec;1(4):e968074. Epub 2014 Dec 31.

Massachusetts General Hospital Cancer Center and Harvard Medical School ; Charlestown, MA USA.

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http://dx.doi.org/10.4161/23723548.2014.968074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905203PMC
June 2016

RB-loss puts focus on Myc.

Nat Cell Biol 2015 Aug;17(8):968-9

Harvard Medical School Laboratory of Molecular Oncology The MGH Cancer Center, Bldg 149, 13th Street Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/ncb3213DOI Listing
August 2015

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells.

EMBO J 2014 Oct 6;33(19):2201-15. Epub 2014 Aug 6.

Massachusetts General Hospital Cancer Center and Harvard Medical School Laboratory of Molecular Oncology, Charlestown, MA, USA

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http://dx.doi.org/10.15252/embj.201488057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282507PMC
October 2014

dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes.

Nucleic Acids Res 2014 Aug 22;42(14):8939-53. Epub 2014 Jul 22.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA

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http://dx.doi.org/10.1093/nar/gku609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132727PMC
August 2014

CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers.

Cancer Res 2014 Jul 1;74(14):3947-58. Epub 2014 Jul 1.

Authors' Affiliation: Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122288PMC
July 2014

Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion.

Mol Cell 2014 Mar 6;53(6):993-1004. Epub 2014 Mar 6.

Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765140012
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http://dx.doi.org/10.1016/j.molcel.2014.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047977PMC
March 2014

The multiple connections between pRB and cell metabolism.

Curr Opin Cell Biol 2013 Dec 3;25(6):735-40. Epub 2013 Aug 3.

Laboratory of Molecular Oncology, Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2013.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836918PMC
December 2013

H4K20 methylation regulates quiescence and chromatin compaction.

Mol Biol Cell 2013 Oct 7;24(19):3025-37. Epub 2013 Aug 7.

Department of Molecular Biology, Princeton University, Princeton, NJ 08544 Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129 Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104 Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, and Department of Biological Chemistry, David Geffen School of Medicine, Los Angeles, CA 90095.

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http://dx.doi.org/10.1091/mbc.E12-07-0529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784377PMC
October 2013

Loss of RBF1 changes glutamine catabolism.

Genes Dev 2013 Jan 15;27(2):182-96. Epub 2013 Jan 15.

Laboratory of Molecular Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.206227.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566311PMC
January 2013

It's all in the timing: too much E2F is a bad thing.

PLoS Genet 2012 16;8(8):e1002909. Epub 2012 Aug 16.

Massachusetts General Hospital Cancer Research Center, Charlestown, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420940PMC
December 2012

In vivo regulation of E2F1 by Polycomb group genes in Drosophila.

G3 (Bethesda) 2012 Dec 1;2(12):1651-60. Epub 2012 Dec 1.

Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M Health Science Center, College Station, Texas 77843-1114, USA.

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http://dx.doi.org/10.1534/g3.112.004333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516486PMC
December 2012

RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.

Mol Cell Biol 2012 Nov 27;32(21):4375-87. Epub 2012 Aug 27.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.00536-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486151PMC
November 2012

Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation.

Dev Dyn 2012 Nov 17;241(11):1695-707. Epub 2012 Sep 17.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Laboratory of Molecular Oncology, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1002/dvdy.23857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760379PMC
November 2012

A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity.

PLoS Genet 2012 5;8(4):e1002618. Epub 2012 Apr 5.

Department of Molecular Genetics, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1371/journal.pgen.1002618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320600PMC
September 2012

Phosphorylation puts the pRb tumor suppressor into shape.

Genes Dev 2012 Jun;26(11):1128-30

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.195552.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371403PMC
June 2012

RB: mitotic implications of a tumour suppressor.

Nat Rev Cancer 2012 Feb 9;12(3):220-6. Epub 2012 Feb 9.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nrc3216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800194PMC
February 2012

Pumilio facilitates miRNA regulation of the E2F3 oncogene.

Genes Dev 2012 Feb;26(4):356-68

Massachusetts General Hospital Cancer Center, Laboratory of Molecular Oncology, Harvard Medical School, Charlestown, 02129, USA.

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http://dx.doi.org/10.1101/gad.182568.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289884PMC
February 2012

Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells.

J Cell Sci 2011 Dec 22;124(Pt 24):4203-12. Epub 2011 Dec 22.

Department of Biology, Developmental Biology Research Initiative, McGill University, Montreal, Quebec H3A 1B1, Canada.

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http://jcs.biologists.org/lookup/doi/10.1242/jcs.088773
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http://dx.doi.org/10.1242/jcs.088773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258105PMC
December 2011

Modeling tumor invasion and metastasis in Drosophila.

Dis Model Mech 2011 Nov 6;4(6):753-61. Epub 2011 Oct 6.

Massachusetts General Hospital Center for Cancer Research and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1242/dmm.006908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209645PMC
November 2011

pRB, a tumor suppressor with a stabilizing presence.

Trends Cell Biol 2011 Aug 12;21(8):433-41. Epub 2011 Jun 12.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, USA.

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http://dx.doi.org/10.1016/j.tcb.2011.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149724PMC
August 2011

Functional antagonism between histone H3K4 demethylases in vivo.

Genes Dev 2011 Jan;25(1):17-28

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.1983711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012933PMC
January 2011

Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression.

Mol Cell 2010 Dec;40(5):736-48

Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.11.008DOI Listing
December 2010

Loss of pRB causes centromere dysfunction and chromosomal instability.

Genes Dev 2010 Jul 15;24(13):1364-76. Epub 2010 Jun 15.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.1917310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895196PMC
July 2010

pRb, a local chromatin organizer with global possibilities.

Chromosoma 2010 Feb 28;119(1):1-11. Epub 2009 Aug 28.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1007/s00412-009-0238-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760338PMC
February 2010

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway.

Nat Cell Biol 2009 Dec 22;11(12):1444-50. Epub 2009 Nov 22.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1038/ncb1993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819909PMC
December 2009

Conserved functions of the pRB and E2F families.

Nat Rev Mol Cell Biol 2008 Sep;9(9):713-24

Developmental Biology, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nrm2469DOI Listing
September 2008

E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.

Nature 2008 Sep 14;455(7212):552-6. Epub 2008 Sep 14.

Laboratory of Molecular Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, 13th Street, Building 149, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nature07310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148807PMC
September 2008

E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage.

PLoS Genet 2008 Aug 8;4(8):e1000153. Epub 2008 Aug 8.

Massachusetts General Hospital Cancer Research Center, Charlestown, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491587PMC
August 2008

RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3.

Genes Dev 2008 Apr 26;22(8):1011-24. Epub 2008 Mar 26.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.1631508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2335323PMC
April 2008

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.

Nat Cell Biol 2007 Feb 24;9(2):225-32. Epub 2006 Dec 24.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, MA 02129, USA.

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http://www.nature.com/articles/ncb1532
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http://dx.doi.org/10.1038/ncb1532DOI Listing
February 2007

Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo.

PLoS Genet 2006 Nov;2(11):e196

Massachusetts General Hospital Cancer Center, Laboratory of Molecular Oncology, Charlestown, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.0020196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636698PMC
November 2006

Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development.

Dev Cell 2005 Oct;9(4):463-75

Massachusetts General Hospital Cancer Research Center, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1016/j.devcel.2005.08.015DOI Listing
October 2005

Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes.

Cell Cycle 2005 Sep 29;4(9):1272-80. Epub 2005 Sep 29.

Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.4161/cc.4.9.1982DOI Listing
September 2005

dDP is needed for normal cell proliferation.

Mol Cell Biol 2005 Apr;25(8):3027-39

Massachusetts General Hospital Cancer Center, Bldg. 149, 13th St., Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1128/MCB.25.8.3027-3039.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069608PMC
April 2005

The E2F transcriptional network: old acquaintances with new faces.

Oncogene 2005 Apr;24(17):2810-26

Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1038/sj.onc.1208612DOI Listing
April 2005

Molecular mechanisms of E2F-dependent activation and pRB-mediated repression.

J Cell Sci 2004 May;117(Pt 11):2173-81

Massachusetts General Hospital Cancer Center, Bldg 149, 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1242/jcs.01227DOI Listing
May 2004

Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway.

Genes Dev 2003 Sep;17(18):2308-20

Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, 02129 USA.

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http://dx.doi.org/10.1101/gad.1116703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC196467PMC
September 2003

Dp1 is required for extra-embryonic development.

Development 2003 Apr;130(7):1295-305

Department of Biological Sciences, Columbia University, New York, NY 10027 USA.

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http://dx.doi.org/10.1242/dev.00355DOI Listing
April 2003

A revised picture of the E2F transcriptional network and RB function.

Curr Opin Cell Biol 2002 Dec;14(6):684-91

Massachusetts General Hospital Cancer Center, Laboratory of Molecular Oncology, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/s0955-0674(02)00388-5DOI Listing
December 2002

Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.

J Virol 2002 Jun;76(12):6224-34

Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136242PMC
http://dx.doi.org/10.1128/jvi.76.12.6224-6234.2002DOI Listing
June 2002

Quantitatively determined survivin expression levels are of prognostic value in human gliomas.

J Clin Oncol 2002 Feb;20(4):1063-8

Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA.

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http://dx.doi.org/10.1200/JCO.2002.20.4.1063DOI Listing
February 2002

Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.

Cancer Res 2002 Jan;62(1):200-7

Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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January 2002