Publications by authors named "Nicholas Harman"

5 Publications

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Exercise training-induced adaptations in lung cancer patients who have undergone a lobectomy.

Exp Gerontol 2021 Oct 9;155:111587. Epub 2021 Oct 9.

School of Sport and Exercise Science, University of Northern Colorado, Greeley, CO, USA; University of Northern Colorado Cancer Rehabilitation Institute, University of Northern Colorado, Greeley, CO, USA. Electronic address:

Purpose: To determine the safety and effectiveness of a prescribed, individualized, 12-week exercise intervention on cardiorespiratory function, muscular strength, and quality of life in lung cancer patients who have undergone a lobectomy. In addition, we sought to compare the exercise training response of lung cancer patients who have undergone a lobectomy to a population of cancer patients with all other cancers in order to examine the specific effects of a lobectomy when compared to cancer patients at large.

Methods: Participants were referred by a physician, and upon entry, completed an exercise-based assessment and surveys to assess various quality of life measures. Participants were divided into two groups: lung cancer patients having undergone a lobectomy (LOB, n = 9) or those diagnosed with all other cancers (AOC, n = 201). Participants underwent 12 weeks of supervised exercise based on an individualized exercise prescription. Measures of cardiorespiratory function, muscular strength, and quality of life were collected prior to the intervention and after 12 weeks of exercise training.

Results: Significant improvements to VO (p < 0.05) were seen in both groups. Significant improvements to muscular strength (p < 0.05) were seen in both groups for all measures aside from shoulder press in the LOB group. Both groups showed significant improvements to aspects of fatigue and quality of life (p < 0.05), but only the AOC group significantly improved in measures of depression (p < 0.05).

Conclusion: Exercise-based rehabilitation is a safe and effective intervention for lung cancer survivors who have undergone a lobectomy. These individuals saw significant improvements in cardiorespiratory fitness, muscular strength, and quality of life. Although there were similarities in the pattern of these training-induced improvements for these groups, lung cancer patients undergoing a lobectomy consistently demonstrated lower absolute values when compared to patients with all other cancer diagnoses.
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http://dx.doi.org/10.1016/j.exger.2021.111587DOI Listing
October 2021

Kefir Is a Viable Exercise Recovery Beverage for Cancer Survivors Enrolled in a Structured Exercise Program.

Med Sci Sports Exerc 2021 Oct;53(10):2045-2053

School of Sport and Exercise Science, University of Northern Colorado, Greeley, CO.

Purpose: This study investigated the effects of 12 wk of postexercise kefir consumption in cancer survivors who have undergone chemotherapy and/or radiation therapy.

Methods: All participants were enrolled in a structured exercise training program and separated into kefir (KEF) or control (CON) treatment groups. KEF consumed 8 oz. of kefir after exercise sessions (3 d·wk-1) for 12 wk. Outcome measures included assessments for body size and composition, aerobic fitness and muscular strength, medical history, and psychological state at pre- and postintervention time points. Blood was collected and analyzed for C-reactive protein (CRP), interleukin 6 (IL-6), and lipopolysaccharide (LPS) concentrations, and LPS-stimulated whole blood IL-6 and tumor necrosis factor α production were obtained using enzyme-linked immunosorbent assays at both time points. Monocyte numbers and phenotype were obtained using flow cytometry.

Results: Participants (N = 24; 9 males and 15 females) were an average of 61 ± 9.9 yr old. Kefir consumption was associated with 6.3% (P = 0.034) improvements in lean body mass, as well as 51.4% (P = 0.046), 39.3% (P = 0.017), and 64.7% (P = 0.021) improvements in measures of depression, fatigue, and gastric distress, respectively. KEF also experienced a significant 35.4% (P = 0.01) reduction in circulating LPS along with an 18.0% increase (P < 0.001) in classical monocytes % and a 22.3% decrease (P = 0.04) in nonclassical monocytes %. There were no significant changes in any other variables.

Conclusion: Twelve weeks of kefir consumption improved lean body mass, depression, fatigue, gastric distress, and a biomarker of gut dysbiosis. Kefir improved overall and classical monocyte numbers. Kefir should be considered as a component of a postexercise dietary regimen for cancer survivors.
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http://dx.doi.org/10.1249/MSS.0000000000002690DOI Listing
October 2021

Structured Exercise in Cancer Survivors: Is it Enough for Neural, Mental Health and Well-being?

Int J Exerc Sci 2021 1;14(3):162-176. Epub 2021 Apr 1.

School of Sport and Exercise Science, University of Northern Colorado, Greeley, CO, USA.

The purpose of this cross-sectional study was to explore physical activity, depression, fatigue, and quality of life (QOL), and their relationship to brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in cancer survivors enrolled in a structured exercise program. Participants were recruited into two groups: in-treatment (IT), currently receiving chemotherapy and/or radiotherapy, and out of treatment (OT), not undergoing therapy. Participants wore accelerometers for 7 days and completed cardiorespiratory fitness, muscular strength, and depression, fatigue, and QOL assessments. Circulating BDNF and NGF concentrations were obtained using enzyme-linked immunosorbent assays. Thirty-two participants (IT: = 13, OT: = 19) with an average age of 63 years and BMI of 27.5, spent 78% of their waking hours engaged in sedentary behavior outside of exercise training. Significant correlations were observed between light physical activity (LPA) outside of exercise training and QOL in IT ( = 0.626, 0.030), and fatigue in OT ( = 0.553, 0.021). Moderate to vigorous physical activity (MVPA) outside of exercise training significantly correlated with leg press strength ( = 0.700, 0.008) in IT, and cardiorespiratory fitness ( = 0.440, 0.013) when groups were combined. Concentrations of NGF did not differ between groups, and in IT, BDNF was positively related to LPA outside of training and was significantly lower (87 ± 28.5 pg/mL) than in OT (137 ± 54 pg/mL; 0.010). While structured exercise programs should focus on improving cardiorespiratory fitness and muscular strength during exercise training, these programs should consider physical activity outside of training, if well-tolerated, to potentially further lower fatigue and improve QOL in cancer survivors.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136549PMC
April 2021

Genome sequence of a salmonella phage used to control salmonella transmission in Swine.

Genome Announc 2014 Sep 11;2(5). Epub 2014 Sep 11.

Department of Animal Sciences, Purdue University, West Lafayette, Indiana, USA

Salmonella shedding in swine often increases in response to transportation and lairage. We previously demonstrated that such increases can be limited by directly feeding microencapsulated Salmonella bacteriophages. Here we present the genome sequence of vB_SalM_SJ_3, a broader spectrum Viuna-like Salmonella phage used in those studies.
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http://dx.doi.org/10.1128/genomeA.00521-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161739PMC
September 2014

Complete Genome Sequences of Two Escherichia coli O157:H7 Phages Effective in Limiting Contamination of Food Products.

Genome Announc 2014 Sep 11;2(5). Epub 2014 Sep 11.

Department of Animal Sciences, Purdue University, West Lafayette, Indiana, USA

We previously demonstrated that application of bacteriophages significantly reduced Escherichia coli O157:H7 contamination in spinach and ground beef. Here, we present the genomic sequences of two bacteriophages, vB_EcoS_FFH_1, a T5-like phage, and vB_EcoM_FFH_2, an rV5-like phage, used in those treatments.
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http://dx.doi.org/10.1128/genomeA.00519-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161738PMC
September 2014
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