Publications by authors named "Nicholas C Harvey"

100Publications

The treatment gap: The missed opportunities for osteoporosis therapy.

Bone 2020 Dec 23;144:115833. Epub 2020 Dec 23.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK; Rheumatology Department, University Hospitals Southampton NHS Foundation Trust, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospitals Southampton NHS Foundation Trust, Southampton, UK; NIHR Oxford Biomedical Research Unit, University of Oxford, Oxford, UK. Electronic address:

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December 2020

Ethnic Differences in Bone Microarchitecture.

Curr Osteoporos Rep 2020 Dec 17;18(6):803-810. Epub 2020 Nov 17.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.

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December 2020

Rheumatoid arthritis and bone health.

Clin Med (Lond) 2020 Nov;20(6):565-567

MRC Lifecourse Epidemiology Unit, Southampton, UK

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November 2020

Cardiovascular magnetic resonance imaging in the UK Biobank: a major international health research resource.

Eur Heart J Cardiovasc Imaging 2020 Nov 9. Epub 2020 Nov 9.

William Harvey Research Institute, Centre for Advanced Cardiovascular Imaging, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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November 2020

Fracture risk assessment in nursing homes.

Eur Geriatr Med 2020 Sep 2. Epub 2020 Sep 2.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.

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September 2020

Age, sex and disease-specific associations between resting heart rate and cardiovascular mortality in the UK BIOBANK.

PLoS One 2020 29;15(5):e0233898. Epub 2020 May 29.

William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, United Kingdom.

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August 2020

Variation in left ventricular cardiac magnetic resonance normal reference ranges: systematic review and meta-analysis.

Eur Heart J Cardiovasc Imaging 2020 May 27. Epub 2020 May 27.

William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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May 2020

The epidemiology of osteoporosis.

Br Med Bull 2020 05;133(1):105-117

The MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.

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May 2020

Cardiac magnetic resonance radiomics: basic principles and clinical perspectives.

Eur Heart J Cardiovasc Imaging 2020 04;21(4):349-356

Department of advanced cardiovascular imaging, William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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April 2020

General and Specific Considerations as to why Osteoporosis-Related Care Is Often Suboptimal.

Curr Osteoporos Rep 2020 02;18(1):38-46

MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, UK.

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February 2020

A decade of FRAX: how has it changed the management of osteoporosis?

Aging Clin Exp Res 2020 Feb 11;32(2):187-196. Epub 2020 Feb 11.

Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.

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February 2020

Reassessment Intervals for Transition From Low to High Fracture Risk Among Adults Older Than 50 Years.

JAMA Netw Open 2020 01 3;3(1):e1918954. Epub 2020 Jan 3.

Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, United Kingdom.

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January 2020

Investigating a suitable model for the study of vitamin D mediated regulation of human placental gene expression.

J Steroid Biochem Mol Biol 2020 05 2;199:105576. Epub 2020 Jan 2.

Institute of Developmental Sciences, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK. Electronic address:

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May 2020

Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank.

Front Endocrinol (Lausanne) 2019 26;10:817. Epub 2019 Nov 26.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.

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November 2019

Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review.

Nutrients 2019 Aug 12;11(8). Epub 2019 Aug 12.

Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.

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August 2019

Fracture Risk in Women with Breast Cancer Initiating Aromatase Inhibitor Therapy: A Registry-Based Cohort Study.

Oncologist 2019 11 10;24(11):1432-1438. Epub 2019 Jul 10.

Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, United Kingdom.

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November 2019

Temporal changes in access to FRAX® in Thailand between 2010 and 2018.

Arch Osteoporos 2019 06 21;14(1):66. Epub 2019 Jun 21.

Academic Unit of Bone Metabolism, Department of Oncology and Metabolism, The Mellanby Centre For Bone Research, University of Sheffield, Sheffield, UK.

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June 2019

Fracture prediction, imaging and screening in osteoporosis.

Nat Rev Endocrinol 2019 09;15(9):535-547

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

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September 2019

Vitamin D, and Maternal and Child Health.

Calcif Tissue Int 2020 01 14;106(1):30-46. Epub 2019 May 14.

MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK.

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January 2020

Performance of FRAX in Women with Breast Cancer Initiating Aromatase Inhibitor Therapy: A Registry-Based Cohort Study.

J Bone Miner Res 2019 08 9;34(8):1428-1435. Epub 2019 May 9.

Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK.

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August 2019

Vitamin D supplementation: are multivitamins sufficient?

Arch Dis Child 2020 08 25;105(8):791-793. Epub 2019 Feb 25.

MRC Lifecourse Epidemiology Unit, University Hospital Southampton, Southampton, UK.

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August 2020

Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study.

Clin Epidemiol 2018 12;10:1851-1864. Epub 2018 Dec 12.

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK,

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December 2018

Vitamin D supplementation for musculoskeletal health outcomes in adults - The end of the beginning?

Maturitas 2019 04 25;122:87-88. Epub 2018 Oct 25.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.

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April 2019

A brief history of FRAX.

Arch Osteoporos 2018 10 31;13(1):118. Epub 2018 Oct 31.

Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.

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October 2018

Comparison of Methods for Improving Fracture Risk Assessment in Diabetes: The Manitoba BMD Registry.

J Bone Miner Res 2018 11 16;33(11):1923-1930. Epub 2018 Jul 16.

Bone and Joint Department, Lausanne University Hospital, Lausanne, Switzerland.

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November 2018

Maternal vitamin D supplementation during pregnancy.

Br Med Bull 2018 06;126(1):57-77

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

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June 2018

Advanced body composition assessment: from body mass index to body composition profiling.

J Investig Med 2018 06 25;66(5):1-9. Epub 2018 Mar 25.

Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.

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June 2018

Improving recruitment to clinical trials during pregnancy: A mixed methods investigation.

Soc Sci Med 2018 03 17;200:73-82. Epub 2018 Jan 17.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, UK.

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March 2018

Switching to biosimilar infliximab: real world data in patients with severe inflammatory arthritis.

Clin Exp Rheumatol 2018 Jan-Feb;36(1):171-172. Epub 2018 Jan 15.

Musculoskeletal Research Unit, University Hospital Southampton NHS Foundation Trust, and NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, UK.

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April 2018

Bisphosphonates in osteoporosis: NICE and easy?

Lancet 2017 Nov;390(10109):2243-2244

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, SO16 6YD, UK; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, UK; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. Electronic address:

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November 2017

Response to Letter: Genetics and Vitamin D Supplementation in Pregnancy.

J Clin Endocrinol Metab 2017 09;102(9):3565-3566

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, United Kingdom.

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September 2017

FRAX Update.

J Clin Densitom 2017 Jul - Sep;20(3):360-367. Epub 2017 Jul 18.

Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK.

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June 2018

Overview of Fracture Prediction Tools.

J Clin Densitom 2017 Jul - Sep;20(3):444-450. Epub 2017 Jul 14.

Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.

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June 2018

Reprint of: The impact of fragility fracture and approaches to osteoporosis risk assessment worldwide.

Int J Orthop Trauma Nurs 2017 Aug 26;26:7-17. Epub 2017 Apr 26.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, SO16 6YD, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD, UK; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, OX3 7LD, UK. Electronic address:

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August 2017

Gestational vitamin D and childhood bone health.

Lancet Diabetes Endocrinol 2017 06;5(6):417

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK; National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK. Electronic address:

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June 2017

Analysis of the MAVIDOS trial - Author's reply.

Lancet Diabetes Endocrinol 2017 05;5(5):328-329

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK. Electronic address:

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May 2017

Seasonal variation in Internet searches for vitamin D.

Arch Osteoporos 2017 Dec 10;12(1):28. Epub 2017 Mar 10.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

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December 2017

Developmental Origins of Health and Disease: A Lifecourse Approach to the Prevention of Non-Communicable Diseases.

Healthcare (Basel) 2017 Mar 8;5(1). Epub 2017 Mar 8.

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK.

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March 2017

The impact of fragility fracture and approaches to osteoporosis risk assessment worldwide.

Bone 2017 Nov 22;104:29-38. Epub 2017 Jan 22.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK; NIHR Southampton Biomedical Research Centre, University of Southampton, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford OX3 7LD, UK. Electronic address:

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November 2017

Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation During Pregnancy.

J Clin Endocrinol Metab 2016 12 27;101(12):5012-5020. Epub 2016 Oct 27.

Medical Research Council (MRC) Lifecourse Epidemiology Unit (University of Southampton) (R.J.M., N.C.H., C.C., S.D., S.R.C., H.M.I., E.M.D., K.M.G., S.M.R.), Southampton General Hospital; Paediatric Endocrinology (R.J.M.), University Hospital Southampton NHS Foundation Trust; and National Institute for Health Research (NIHR) Southampton Nutrition Biomedical Research Centre (N.C.H., C.C., K.M.G.), University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, United Kingdom; NIHR Musculoskeletal Biomedical Research Unit (C.C., N.K.A., A.C., M.K.J.), University of Oxford, Oxford OX3 7LD, United Kingdom; MRC Human Nutrition Research (I.S., A.P.), Elsie Widdowson Laboratory, Cambridge, United Kingdom CB1 9NL; Academic Unit of Child Health (N.J.B.), Sheffield Children's Hospital, University of Sheffield, Sheffield, United Kingdom S10 2TH; Academic Unit of Bone Metabolism (R.E.), University of Sheffield, Sheffield, United Kingdom S5 7AU; Sheffield Hospitals NHS Trust (University of Sheffield) (R.F., S.V.G.), Sheffield, United Kingdom S10 2SF; Nuffield Department of Obstetrics and Gynaecology (S.K., A.T.P.), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom OX3 9DU; Department of Paediatric Endocrinology (M.Z.M.), Royal Manchester Children's Hospitals, Manchester, United Kingdom M13 9WL; and School of Medicine and Dentistry (D.M.R.), Medical School, University of Aberdeen, Aberdeen, United Kingdom AB25 2ZD; Department of Medicine (I.S.), Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom NR4 7TJ.

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December 2016

The use of incretins and fractures - a meta-analysis on population-based real life data.

Br J Clin Pharmacol 2017 04 7;83(4):923-926. Epub 2016 Dec 7.

Department of Medicine, Maastricht University Medical Centre+, Maastricht, the Netherlands.

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April 2017

On epidemiology of fractures and variation with age and ethnicity.

Bone 2016 12 17;93:230-231. Epub 2016 Jul 17.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Nuffield Orthopedic Centre, Headington, Oxford OX3 7HE, UK. Electronic address:

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December 2016

Placental Size Is Associated Differentially With Postnatal Bone Size and Density.

J Bone Miner Res 2016 10 22;31(10):1855-1864. Epub 2016 Apr 22.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

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October 2016

Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization: results from the Southampton Women's Survey cohort.

Am J Clin Nutr 2016 10 14;104(4):1183-1188. Epub 2016 Sep 14.

Medical Research Council Lifecourse Epidemiology Unit, National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust, and.

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October 2016

DNA methylation at birth within the promoter of ANRIL predicts markers of cardiovascular risk at 9 years.

Clin Epigenetics 2016 2;8:90. Epub 2016 Sep 2.

Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK ; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust (UHSFT) and University of Southampton, Southampton, UK ; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

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April 2017

Recent advances in the pathogenesis and treatment of osteoporosis.

Clin Med (Lond) 2016 Aug;16(4):360-4

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK, NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK, and NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK

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August 2016

Use of FRAX(®) in men.

Joint Bone Spine 2016 Oct 3;83(5):477-8. Epub 2016 Jun 3.

Centre for Metabolic Bone Diseases, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom; Institute for Health and Ageing, Catholic University of Australia, Melbourne, Australia. Electronic address:

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October 2016

Inaccurate dissemination of the MAVIDOS trial results - Authors' reply.

Lancet Diabetes Endocrinol 2016 06;4(6):481-2

Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK; National Institute of Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.

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June 2016

FRAX updates 2016.

Curr Opin Rheumatol 2016 Jul;28(4):433-41

aCentre for Metabolic Bone Diseases bCentre for Integrated Research Musculoskeletal Ageing, Mellanby Centre for Bone Research, University of Sheffield, Sheffield cMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

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July 2016

Epidemiology of fractures in the United Kingdom 1988-2012: Variation with age, sex, geography, ethnicity and socioeconomic status.

Bone 2016 06 9;87:19-26. Epub 2016 Mar 9.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK.

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June 2016

Ethnic and geographic variations in the epidemiology of childhood fractures in the United Kingdom.

Bone 2016 Apr 21;85:9-14. Epub 2016 Jan 21.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK; NIHR Southampton Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK, SO16 6YD, UK; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, OX3 7LD, UK. Electronic address:

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April 2016

Local Variation in Femoral Neck Cortical Bone: In Vitro Measured Bone Mineral Density, Geometry and Mechanical Properties.

J Clin Densitom 2017 Apr - Jun;20(2):205-215. Epub 2015 Dec 23.

Faculty of Engineering and Environment and Faculty of Medicine, University of Southampton, Southampton, UK; Institute of Lightweight Design and Structural Biomechanics, TU Wien, Vienna, Austria.

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June 2018

High-dose vitamin D supplementation does not alter bone mass or muscle function over 1 year in postmenopausal women.

Evid Based Med 2016 Feb 16;21(1):30. Epub 2015 Dec 16.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK.

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February 2016

Maternal Factors Are Associated with the Expression of Placental Genes Involved in Amino Acid Metabolism and Transport.

PLoS One 2015 14;10(12):e0143653. Epub 2015 Dec 14.

Institute of Developmental Sciences, University of Southampton, Tremona Road, Southampton, SO16 6YD, United Kingdom.

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August 2016