Nicholas C Denko

Nicholas C Denko

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Nicholas C Denko

Nicholas C Denko

Publications by authors named "Nicholas C Denko"

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37Publications

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HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors.

Mol Cancer Res 2019 10 15;17(10):2089-2101. Epub 2019 Jul 15.

Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774878PMC
October 2019

Urinary miRNAs as Biomarkers for Noninvasive Evaluation of Radiation-Induced Renal Tubular Injury.

Radiat Res 2017 12 4;188(6):626-635. Epub 2017 Oct 4.

Department of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.

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http://dx.doi.org/10.1667/RR14828.1DOI Listing
December 2017

Concurrent Longitudinal EPR Monitoring of Tissue Oxygenation, Acidosis, and Reducing Capacity in Mouse Xenograft Tumor Models.

Cell Biochem Biophys 2017 Jun 18;75(2):247-253. Epub 2016 May 18.

In Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, WV, 26506, USA.

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http://dx.doi.org/10.1007/s12013-016-0733-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116002PMC
June 2017

Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells.

Adv Exp Med Biol 2016;899:113-20

Department of Radiation Oncology, Ohio State University Wexner School of Medicine and Comprehensive Cancer Center, Ohio Sate University, Columbus, OH, 43210, USA.

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http://link.springer.com/10.1007/978-3-319-26666-4_7
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http://dx.doi.org/10.1007/978-3-319-26666-4_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017243PMC
June 2017

Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours.

Sci Rep 2016 08 8;6:31146. Epub 2016 Aug 8.

Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center and Wexner Medical Center, Columbus OH 43210, USA.

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http://dx.doi.org/10.1038/srep31146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976358PMC
August 2016

Plant stilbenes induce endoplasmic reticulum stress and their anti-cancer activity can be enhanced by inhibitors of autophagy.

Exp Cell Res 2015 Nov 17;339(1):147-53. Epub 2015 Oct 17.

Department of Radiation Oncology, Wexner Medical Center and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144827153011
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http://dx.doi.org/10.1016/j.yexcr.2015.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822495PMC
November 2015

WNT16-expressing Acute Lymphoblastic Leukemia Cells are Sensitive to Autophagy Inhibitors after ER Stress Induction.

Anticancer Res 2015 Sep;35(9):4625-31

Department of Radiation Oncology, Wexner Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus OH, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810683PMC
September 2015

Hypoxic regulation of metabolism offers new opportunities for anticancer therapy.

Authors:
Nicholas C Denko

Expert Rev Anticancer Ther 2014 Sep 14;14(9):979-81. Epub 2014 Jun 14.

Department of Radiation Oncology, Ohio State University Wexner Medical Center and OSU Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1586/14737140.2014.930345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289602PMC
September 2014

Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth.

Cell Metab 2014 Feb;19(2):285-92

Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, Ohio State University Wexner School of Medicine, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920584PMC
February 2014

β-Catenin regulates hepatic mitochondrial function and energy balance in mice.

Gastroenterology 2012 Sep 7;143(3):754-764. Epub 2012 Jun 7.

Department of Surgery, Divison of Pediatric Surgery, Stanford University School of Medicine, Stanford, California; The Lucile Packard Children's Hospital, Stanford, California. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2012.05.048DOI Listing
September 2012

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

Int J Cancer 2011 Mar 7;128(5):1001-8. Epub 2010 Dec 7.

Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA.

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http://doi.wiley.com/10.1002/ijc.25728
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http://dx.doi.org/10.1002/ijc.25728DOI Listing
March 2011

Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.

PLoS One 2009 Sep 15;4(9):e7033. Epub 2009 Sep 15.

Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007033PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737639PMC
September 2009

Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress.

Mol Cell Biol 2008 Dec 29;28(23):7212-24. Epub 2008 Sep 29.

Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1128/MCB.00947-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593368PMC
December 2008

Hypoxia, HIF1 and glucose metabolism in the solid tumour.

Authors:
Nicholas C Denko

Nat Rev Cancer 2008 09;8(9):705-13

Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://www.nature.com/articles/nrc2468
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http://dx.doi.org/10.1038/nrc2468DOI Listing
September 2008

HIF-1alpha in endurance training: suppression of oxidative metabolism.

Am J Physiol Regul Integr Comp Physiol 2007 Nov 12;293(5):R2059-69. Epub 2007 Sep 12.

Div. of Biologicay, University of California, San Diego, La Jolla, CA 92093-0377, USA.

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http://dx.doi.org/10.1152/ajpregu.00335.2007DOI Listing
November 2007

Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy.

Proc Natl Acad Sci U S A 2007 May 15;104(22):9445-50. Epub 2007 May 15.

Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0611662104
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http://dx.doi.org/10.1073/pnas.0611662104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890514PMC
May 2007

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

Cell Metab 2006 Mar;3(3):187-97

Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1016/j.cmet.2006.01.012DOI Listing
March 2006

Histology-based expression profiling yields novel prognostic markers in human glioblastoma.

J Neuropathol Exp Neurol 2005 Nov;64(11):948-55

Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557632PMC
http://dx.doi.org/10.1097/01.jnen.0000186940.14779.90DOI Listing
November 2005

Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment.

Cancer Res 2005 Apr;65(8):3171-8

Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3395DOI Listing
April 2005

Hypoxic gene expression and metastasis.

Cancer Metastasis Rev 2004 Aug-Dec;23(3-4):293-310

Division of Cancer and Radiation Biology, Stanford University School of Medicine, Department of Radiation Oncology, CCSR - South, Room 1255, 269 Campus Drive, Stanford, CA 94305-5152.

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http://link.springer.com/10.1023/B:CANC.0000031768.89246.d7
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http://dx.doi.org/10.1023/B:CANC.0000031768.89246.d7DOI Listing
February 2005

The hypoxic tumor microenvironment and gene expression.

Semin Radiat Oncol 2004 Jul;14(3):207-14

Department of Gynecology, University of Leipzig, Germany.

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http://dx.doi.org/10.1016/j.semradonc.2004.04.007DOI Listing
July 2004

Investigating hypoxic tumor physiology through gene expression patterns.

Oncogene 2003 Sep;22(37):5907-14

Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1038/sj.onc.1206703DOI Listing
September 2003

Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.

J Biol Chem 2002 Oct 16;277(42):40112-7. Epub 2002 Aug 16.

Program in Cancer Biology, Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1074/jbc.M206922200DOI Listing
October 2002

Hypoxia links ATR and p53 through replication arrest.

Mol Cell Biol 2002 Mar;22(6):1834-43

Center for Clinical Sciences Research, Department of Radiation Oncology, Stanford University, Stanford, CA 94303-5152, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135616PMC
http://dx.doi.org/10.1128/mcb.22.6.1834-1843.2002DOI Listing
March 2002