Niccola Funel

Niccola Funel

UNVERIFIED PROFILE

Are you Niccola Funel?   Register this Author

Register author
Niccola Funel

Niccola Funel

Publications by authors named "Niccola Funel"

Are you Niccola Funel?   Register this Author

72Publications

1680Reads

12Profile Views

Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line.

Biochem Pharmacol 2019 Aug 10;166:128-138. Epub 2019 May 10.

Amsterdam UMC, VU University Medical Center, Laboratory Medical Oncology, Cancer Center Amsterdam, Amsterdam, Netherlands; Cancer Pharmacology Lab, AIRC Start-Up Unit, Fondazione Pisana per la Scienza, Pisa, Italy. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00062952193017
Publisher Site
http://dx.doi.org/10.1016/j.bcp.2019.05.014DOI Listing
August 2019

Author Correction: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression.

Nat Commun 2019 Aug 14;10(1):3738. Epub 2019 Aug 14.

Department of Surgery and Cancer, Division of Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM), London, W12 0NN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-11752-2DOI Listing
August 2019

Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer.

Anticancer Res 2019 Jul;39(7):3609-3614

Department of Medical Oncology, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.13508DOI Listing
July 2019

The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer.

Pharmacogenomics 2019 Jan 6;20(1):49-68. Epub 2018 Dec 6.

Unit of Clinical Pharmacology & Pharmacogenetics, Department of Clinical & Experimental Medicine, University of Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2018-0149DOI Listing
January 2019

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma.

EBioMedicine 2019 Jan 20;39:215-225. Epub 2018 Dec 20.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Center, location VUMC, Amsterdam, the Netherlands; Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa, Italy; CNR-Nano, Institute of Nanoscience and Nanotechnology, Pisa, Italy. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S23523964183060
Publisher Site
http://dx.doi.org/10.1016/j.ebiom.2018.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355829PMC
January 2019

Liquid biopsies to optimize therapeutic efficacy in unresponsive lung cancer patients.

Expert Opin Drug Metab Toxicol 2018 Aug 4;14(8):761-763. Epub 2018 Jul 4.

b Institute of Nanoscience and Nanotechnology , CNR-Nano , Pisa , Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17425255.2018.1491965DOI Listing
August 2018

Myoclonus epilepsy, retinitis pigmentosa, leukoencephalopathy and cerebral calcifications associated with a novel m.5513G>A mutation in the MT-TW gene.

Biochem Biophys Res Commun 2018 06 13;500(2):158-162. Epub 2018 Apr 13.

Department of Medicine, Surgery and Neuroscience, University of Siena, Viale Bracci 2, 53100, Siena, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2018.04.009DOI Listing
June 2018

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

Authors:
Alison P Klein Brian M Wolpin Harvey A Risch Rachael Z Stolzenberg-Solomon Evelina Mocci Mingfeng Zhang Federico Canzian Erica J Childs Jason W Hoskins Ashley Jermusyk Jun Zhong Fei Chen Demetrius Albanes Gabriella Andreotti Alan A Arslan Ana Babic William R Bamlet Laura Beane-Freeman Sonja I Berndt Amanda Blackford Michael Borges Ayelet Borgida Paige M Bracci Lauren Brais Paul Brennan Hermann Brenner Bas Bueno-de-Mesquita Julie Buring Daniele Campa Gabriele Capurso Giulia Martina Cavestro Kari G Chaffee Charles C Chung Sean Cleary Michelle Cotterchio Frederike Dijk Eric J Duell Lenka Foretova Charles Fuchs Niccola Funel Steven Gallinger J Michael M Gaziano Maria Gazouli Graham G Giles Edward Giovannucci Michael Goggins Gary E Goodman Phyllis J Goodman Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Peter Hegyi Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Eric J Jacobs Krzysztof Jamroziak Vladimir Janout Rudolf Kaaks Kay-Tee Khaw Eric A Klein Manolis Kogevinas Charles Kooperberg Matthew H Kulke Juozas Kupcinskas Robert J Kurtz Daniel Laheru Stefano Landi Rita T Lawlor I-Min Lee Loic LeMarchand Lingeng Lu Núria Malats Andrea Mambrini Satu Mannisto Roger L Milne Beatrice Mohelníková-Duchoňová Rachel E Neale John P Neoptolemos Ann L Oberg Sara H Olson Irene Orlow Claudio Pasquali Alpa V Patel Ulrike Peters Raffaele Pezzilli Miquel Porta Francisco X Real Nathaniel Rothman Ghislaine Scelo Howard D Sesso Gianluca Severi Xiao-Ou Shu Debra Silverman Jill P Smith Pavel Soucek Malin Sund Renata Talar-Wojnarowska Francesca Tavano Mark D Thornquist Geoffrey S Tobias Stephen K Van Den Eeden Yogesh Vashist Kala Visvanathan Pavel Vodicka Jean Wactawski-Wende Zhaoming Wang Nicolas Wentzensen Emily White Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Wei Zheng Peter Kraft Donghui Li Stephen Chanock Ofure Obazee Gloria M Petersen Laufey T Amundadottir

Nat Commun 2018 02 8;9(1):556. Epub 2018 Feb 8.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-02942-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805680PMC
February 2018

Robotic pancreatoduodenectomy with vascular resection.

Langenbecks Arch Surg 2016 Dec 24;401(8):1111-1122. Epub 2016 Aug 24.

Division of General and Transplant Surgery, University of Pisa and Azienda Ospedaliero Universitaria Pisana, Via Paradisa 2, 56124, Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00423-016-1499-8DOI Listing
December 2016

FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer.

World J Gastroenterol 2016 Aug;22(31):6987-7005

Chiara Caparello, Alfredo Falcone, Niccola Funel, Enrico Vasile, Elisa Giovannetti, University Hospital of Pisa, 56124 Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3748/wjg.v22.i31.6987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988311PMC
August 2016

The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy-Letter.

Clin Cancer Res 2016 05;22(10):2594

Cancer Pharmacology Lab, AIRC Start-UP Unit, University of Pisa, Pisa, Italy. Department of Medical Oncology, VU University Medical Center Amsterdam, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-16-0259DOI Listing
May 2016

TERT gene harbors multiple variants associated with pancreatic cancer susceptibility.

Int J Cancer 2015 Nov 19;137(9):2175-83. Epub 2015 Jun 19.

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.29590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548797PMC
November 2015

Synergistic activity of the c-Met and tubulin inhibitor tivantinib (ARQ197) with pemetrexed in mesothelioma cells.

Curr Drug Targets 2014 ;15(14):1331-40

Center for Biomedical Research of the Canary Islands, Instituto de Tecnologias Biomedicas, University of La Laguna, Campus de la Salud s/n, 38071 La Laguna, Tenerife, Spain.

View Article

Download full-text PDF

Source
August 2015

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.

Nat Genet 2015 Aug 22;47(8):911-6. Epub 2015 Jun 22.

1] Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. [2] Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520746PMC
August 2015

microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis.

Eur J Cancer 2015 Jul 19;51(11):1389-404. Epub 2015 May 19.

Division of Oncology, Dept. of Surgery & Cancer, Imperial Centre for Translational and Experimental Medicine (ICTEM), Imperial College, Hammersmith Hospital campus, Du Cane Road, London W12 0NN, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2015.04.006DOI Listing
July 2015

Pancreatic cancer.

Gastroenterol Res Pract 2015 24;2015:809036. Epub 2015 Mar 24.

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Teiskontie 35, P.O. Box 2000, 33521 Tampere, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2015/809036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387904PMC
April 2015

Contrast enhancement pattern on multidetector CT predicts malignancy in pancreatic endocrine tumours.

Eur Radiol 2015 Mar 2;25(3):751-9. Epub 2014 Dec 2.

Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy,

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007%2Fs00330-014-34
Web Search
http://link.springer.com/10.1007/s00330-014-3485-2
Publisher Site
http://dx.doi.org/10.1007/s00330-014-3485-2DOI Listing
March 2015

miR-211 modulates gemcitabine activity through downregulation of ribonucleotide reductase and inhibits the invasive behavior of pancreatic cancer cells.

Nucleosides Nucleotides Nucleic Acids 2014 ;33(4-6):384-93

a Department of Medical Oncology , VU University Medical Center , Amsterdam , Amsterdam , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15257770.2014.891741DOI Listing
February 2015

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.

Authors:
Brian M Wolpin Cosmeri Rizzato Peter Kraft Charles Kooperberg Gloria M Petersen Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Julie Buring Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Gary E Goodman Phyllis J Goodman Eric J Jacobs Aruna Kamineni Alison P Klein Laurence N Kolonel Matthew H Kulke Donghui Li Núria Malats Sara H Olson Harvey A Risch Howard D Sesso Kala Visvanathan Emily White Wei Zheng Christian C Abnet Demetrius Albanes Gabriella Andreotti Melissa A Austin Richard Barfield Daniela Basso Sonja I Berndt Marie-Christine Boutron-Ruault Michelle Brotzman Markus W Büchler H Bas Bueno-de-Mesquita Peter Bugert Laurie Burdette Daniele Campa Neil E Caporaso Gabriele Capurso Charles Chung Michelle Cotterchio Eithne Costello Joanne Elena Niccola Funel J Michael Gaziano Nathalia A Giese Edward L Giovannucci Michael Goggins Megan J Gorman Myron Gross Christopher A Haiman Manal Hassan Kathy J Helzlsouer Brian E Henderson Elizabeth A Holly Nan Hu David J Hunter Federico Innocenti Mazda Jenab Rudolf Kaaks Timothy J Key Kay-Tee Khaw Eric A Klein Manolis Kogevinas Vittorio Krogh Juozas Kupcinskas Robert C Kurtz Andrea LaCroix Maria T Landi Stefano Landi Loic Le Marchand Andrea Mambrini Satu Mannisto Roger L Milne Yusuke Nakamura Ann L Oberg Kouros Owzar Alpa V Patel Petra H M Peeters Ulrike Peters Raffaele Pezzilli Ada Piepoli Miquel Porta Francisco X Real Elio Riboli Nathaniel Rothman Aldo Scarpa Xiao-Ou Shu Debra T Silverman Pavel Soucek Malin Sund Renata Talar-Wojnarowska Philip R Taylor George E Theodoropoulos Mark Thornquist Anne Tjønneland Geoffrey S Tobias Dimitrios Trichopoulos Pavel Vodicka Jean Wactawski-Wende Nicolas Wentzensen Chen Wu Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Robert Hoover Patricia Hartge Charles Fuchs Stephen J Chanock Rachael S Stolzenberg-Solomon Laufey T Amundadottir

Nat Genet 2014 Sep 3;46(9):994-1000. Epub 2014 Aug 3.

1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191666PMC
September 2014

Expression of SP7, RUNX1, DLX5, and CTNNB1 in human mesenchymal stem cells cultured on xenogeneic bone substitute as compared with machined titanium.

Implant Dent 2014 Aug;23(4):407-15

*Adjunct Professor, Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy; Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy. †Postdoctoral Fellow, Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy; Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy. ‡Postdoctoral Fellow, Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy; Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy. §Associate Professor, Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy; Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy. ‖Professor, Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy; Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ID.0000000000000116DOI Listing
August 2014

Anti-diabetic properties of a non-conventional radical scavenger, as compared to pioglitazone and exendin-4, in streptozotocin-nicotinamide diabetic mice.

Eur J Pharmacol 2014 Apr 12;729:37-44. Epub 2014 Feb 12.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126 Pisa, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2014.01.071DOI Listing
April 2014

A polymorphism in the promoter is associated with EZH2 expression but not with outcome in advanced pancreatic cancer patients.

Pharmacogenomics 2014 Apr;15(5):609-18

Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, CCA room 1.52, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs.13.225DOI Listing
April 2014

Role of CYB5A in pancreatic cancer prognosis and autophagy modulation.

J Natl Cancer Inst 2014 Jan 3;106(1):djt346. Epub 2013 Dec 3.

Affiliations of authors: Department of Medical Oncology (EG, AA, GJP) and Department of Neurosurgery (TL, VC, TW), VU University Medical Center, and Centre for Integrative Bioinformatics (AvdV), VU University, Amsterdam, the Netherlands; Department of Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, University of Pisa, Pisa, Italy (NF, UB, EV); Department of Neurology, Stanford University, Stanford, CA (VC); Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA (TW); Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD (QW, J-HL, YW, GG).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djt346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906994PMC
January 2014

Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma.

Cancer Res 2013 Nov 1;73(22):6745-56. Epub 2013 Oct 1.

Authors' Affiliations: Departments of Medical Oncology, Hematology, Neurosurgery and Pediatric Oncology/Hematology, Neuro-oncology Research Group, VU University Medical Center; Diagnostic Oncology Division, Netherlands Cancer Institute; VisualSonics, Amsterdam, the Netherlands; Departments of Neurology and Pediatrics, Stanford University School of Medicine, Stanford, California; Division of Surgical Pathology, Division of General and Transplant Surgery, University of Pisa, Pisa, Italy; and Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-0837DOI Listing
November 2013

Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer.

Curr Pharm Des 2013 ;19(5):940-50

Dept. Medical Oncology, VUmc Cancer Center Amsterdam, VU University Medical Center, CCA room 1.52, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
July 2013

Dextran-catechin conjugate: a potential treatment against the pancreatic ductal adenocarcinoma.

Pharm Res 2012 Sep 24;29(9):2601-14. Epub 2012 May 24.

NEST Scuola Normale Superiore & Istituto Nanoscienze-CNR Piazza San Silvestro, 56126 Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-012-0790-9DOI Listing
September 2012

Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.

Clin Cancer Res 2012 Jan 29;18(2):524-33. Epub 2011 Nov 29.

Medical Oncology Branch, Genetic Branch, and Biostatistics and Data Management Section, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-11-1903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261299PMC
January 2012

Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy.

Pharmacogenomics 2011 Dec 25;12(12):1641-52. Epub 2011 Oct 25.

Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs.11.109DOI Listing
December 2011

Critical role of laser microdissection for genetic, epigenetic and proteomic analyses in pancreatic cancer.

Expert Rev Mol Diagn 2011 Sep;11(7):695-701

Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/erm.11.62DOI Listing
September 2011

Antiproliferative effects of novel aliphatic acetogenin analogs against aggressive solid tumor cell lines.

In Vivo 2011 Mar-Apr;25(2):203-7

BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

View Article

Download full-text PDF

Source
July 2011

Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma.

Lab Invest 2008 Jul 19;88(7):773-84. Epub 2008 May 19.

Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Surgical Pathology, Molecular and Ultrastructural Pathology, University of Pisa, Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/labinvest.2008.40DOI Listing
July 2008