Publications by authors named "Niccola Funel"

84Publications

The occurrence of prion protein in surgically resected pancreatic adenocarcinoma.

Pancreatology 2020 Sep 11;20(6):1218-1225. Epub 2020 Aug 11.

General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56124, Pisa, Italy; EndoCAS (Center for Computer Assisted Surgery), University of Pisa, 56124, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.pan.2020.08.004DOI Listing
September 2020

Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targets.

JCI Insight 2020 Aug 6;5(15). Epub 2020 Aug 6.

Laboratory for Experimental Oncology and Radiobiology, Amsterdam University Medical Centers, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.1172/jci.insight.138290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455080PMC
August 2020

A Model of a Zebrafish Avatar for Co-Clinical Trials.

Cancers (Basel) 2020 Mar 13;12(3). Epub 2020 Mar 13.

Department of Biology, University di Pisa, S.S. 12 Abetone e Brennero 4, 56127 Pisa, Italy.

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http://dx.doi.org/10.3390/cancers12030677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140063PMC
March 2020

Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells.

Eur J Med Chem 2020 Mar 25;189:112088. Epub 2020 Jan 25.

Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2020.112088DOI Listing
March 2020

New avenues in pancreatic cancer: exploiting microRNAs as predictive biomarkers and new approaches to target aberrant metabolism.

Expert Rev Clin Pharmacol 2019 Dec 24;12(12):1081-1090. Epub 2019 Nov 24.

Cancer Pharmacology Lab, AIRC Start-Up Unit, Fondazione Pisa per la Scienza Pisa, Pisa, Italy.

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http://dx.doi.org/10.1080/17512433.2019.1693256DOI Listing
December 2019

Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer.

Anticancer Res 2019 Jul;39(7):3609-3614

Department of Medical Oncology, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands

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http://dx.doi.org/10.21873/anticanres.13508DOI Listing
July 2019

Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line.

Biochem Pharmacol 2019 08 10;166:128-138. Epub 2019 May 10.

Amsterdam UMC, VU University Medical Center, Laboratory Medical Oncology, Cancer Center Amsterdam, Amsterdam, Netherlands; Cancer Pharmacology Lab, AIRC Start-Up Unit, Fondazione Pisana per la Scienza, Pisa, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952193017
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http://dx.doi.org/10.1016/j.bcp.2019.05.014DOI Listing
August 2019

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma.

EBioMedicine 2019 Jan 20;39:215-225. Epub 2018 Dec 20.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Center, location VUMC, Amsterdam, the Netherlands; Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa, Italy; CNR-Nano, Institute of Nanoscience and Nanotechnology, Pisa, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183060
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http://dx.doi.org/10.1016/j.ebiom.2018.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355829PMC
January 2019

The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer.

Pharmacogenomics 2019 01 6;20(1):49-68. Epub 2018 Dec 6.

Unit of Clinical Pharmacology & Pharmacogenetics, Department of Clinical & Experimental Medicine, University of Pisa, Italy.

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http://dx.doi.org/10.2217/pgs-2018-0149DOI Listing
January 2019

Liquid biopsies to optimize therapeutic efficacy in unresponsive lung cancer patients.

Expert Opin Drug Metab Toxicol 2018 Aug 4;14(8):761-763. Epub 2018 Jul 4.

b Institute of Nanoscience and Nanotechnology , CNR-Nano , Pisa , Italy.

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http://dx.doi.org/10.1080/17425255.2018.1491965DOI Listing
August 2018

Myoclonus epilepsy, retinitis pigmentosa, leukoencephalopathy and cerebral calcifications associated with a novel m.5513G>A mutation in the MT-TW gene.

Biochem Biophys Res Commun 2018 06 13;500(2):158-162. Epub 2018 Apr 13.

Department of Medicine, Surgery and Neuroscience, University of Siena, Viale Bracci 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2018.04.009DOI Listing
June 2018

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

Authors:
Alison P Klein Brian M Wolpin Harvey A Risch Rachael Z Stolzenberg-Solomon Evelina Mocci Mingfeng Zhang Federico Canzian Erica J Childs Jason W Hoskins Ashley Jermusyk Jun Zhong Fei Chen Demetrius Albanes Gabriella Andreotti Alan A Arslan Ana Babic William R Bamlet Laura Beane-Freeman Sonja I Berndt Amanda Blackford Michael Borges Ayelet Borgida Paige M Bracci Lauren Brais Paul Brennan Hermann Brenner Bas Bueno-de-Mesquita Julie Buring Daniele Campa Gabriele Capurso Giulia Martina Cavestro Kari G Chaffee Charles C Chung Sean Cleary Michelle Cotterchio Frederike Dijk Eric J Duell Lenka Foretova Charles Fuchs Niccola Funel Steven Gallinger J Michael M Gaziano Maria Gazouli Graham G Giles Edward Giovannucci Michael Goggins Gary E Goodman Phyllis J Goodman Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Peter Hegyi Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Eric J Jacobs Krzysztof Jamroziak Vladimir Janout Rudolf Kaaks Kay-Tee Khaw Eric A Klein Manolis Kogevinas Charles Kooperberg Matthew H Kulke Juozas Kupcinskas Robert J Kurtz Daniel Laheru Stefano Landi Rita T Lawlor I-Min Lee Loic LeMarchand Lingeng Lu Núria Malats Andrea Mambrini Satu Mannisto Roger L Milne Beatrice Mohelníková-Duchoňová Rachel E Neale John P Neoptolemos Ann L Oberg Sara H Olson Irene Orlow Claudio Pasquali Alpa V Patel Ulrike Peters Raffaele Pezzilli Miquel Porta Francisco X Real Nathaniel Rothman Ghislaine Scelo Howard D Sesso Gianluca Severi Xiao-Ou Shu Debra Silverman Jill P Smith Pavel Soucek Malin Sund Renata Talar-Wojnarowska Francesca Tavano Mark D Thornquist Geoffrey S Tobias Stephen K Van Den Eeden Yogesh Vashist Kala Visvanathan Pavel Vodicka Jean Wactawski-Wende Zhaoming Wang Nicolas Wentzensen Emily White Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Wei Zheng Peter Kraft Donghui Li Stephen Chanock Ofure Obazee Gloria M Petersen Laufey T Amundadottir

Nat Commun 2018 02 8;9(1):556. Epub 2018 Feb 8.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-02942-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805680PMC
February 2018

FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer.

World J Gastroenterol 2016 Aug;22(31):6987-7005

Chiara Caparello, Alfredo Falcone, Niccola Funel, Enrico Vasile, Elisa Giovannetti, University Hospital of Pisa, 56124 Pisa, Italy.

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http://dx.doi.org/10.3748/wjg.v22.i31.6987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988311PMC
August 2016

Robotic pancreatoduodenectomy with vascular resection.

Langenbecks Arch Surg 2016 Dec 24;401(8):1111-1122. Epub 2016 Aug 24.

Division of General and Transplant Surgery, University of Pisa and Azienda Ospedaliero Universitaria Pisana, Via Paradisa 2, 56124, Pisa, Italy.

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http://dx.doi.org/10.1007/s00423-016-1499-8DOI Listing
December 2016

The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy-Letter.

Clin Cancer Res 2016 05;22(10):2594

Cancer Pharmacology Lab, AIRC Start-UP Unit, University of Pisa, Pisa, Italy. Department of Medical Oncology, VU University Medical Center Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0259DOI Listing
May 2016

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.

Nat Genet 2015 Aug 22;47(8):911-6. Epub 2015 Jun 22.

1] Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. [2] Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/ng.3341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520746PMC
August 2015

microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis.

Eur J Cancer 2015 Jul 19;51(11):1389-404. Epub 2015 May 19.

Division of Oncology, Dept. of Surgery & Cancer, Imperial Centre for Translational and Experimental Medicine (ICTEM), Imperial College, Hammersmith Hospital campus, Du Cane Road, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2015.04.006DOI Listing
July 2015

TERT gene harbors multiple variants associated with pancreatic cancer susceptibility.

Int J Cancer 2015 Nov 19;137(9):2175-83. Epub 2015 Jun 19.

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.29590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548797PMC
November 2015

Pancreatic cancer.

Gastroenterol Res Pract 2015 24;2015:809036. Epub 2015 Mar 24.

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Teiskontie 35, P.O. Box 2000, 33521 Tampere, Finland.

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http://dx.doi.org/10.1155/2015/809036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387904PMC
April 2015

Synergistic activity of the c-Met and tubulin inhibitor tivantinib (ARQ197) with pemetrexed in mesothelioma cells.

Curr Drug Targets 2014 ;15(14):1331-40

Center for Biomedical Research of the Canary Islands, Instituto de Tecnologias Biomedicas, University of La Laguna, Campus de la Salud s/n, 38071 La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.2174/1389450116666141205160924DOI Listing
August 2015

Contrast enhancement pattern on multidetector CT predicts malignancy in pancreatic endocrine tumours.

Eur Radiol 2015 Mar 2;25(3):751-9. Epub 2014 Dec 2.

Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy,

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http://link.springer.com/content/pdf/10.1007%2Fs00330-014-34
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http://link.springer.com/10.1007/s00330-014-3485-2
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http://dx.doi.org/10.1007/s00330-014-3485-2DOI Listing
March 2015

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.

Authors:
Brian M Wolpin Cosmeri Rizzato Peter Kraft Charles Kooperberg Gloria M Petersen Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Julie Buring Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Gary E Goodman Phyllis J Goodman Eric J Jacobs Aruna Kamineni Alison P Klein Laurence N Kolonel Matthew H Kulke Donghui Li Núria Malats Sara H Olson Harvey A Risch Howard D Sesso Kala Visvanathan Emily White Wei Zheng Christian C Abnet Demetrius Albanes Gabriella Andreotti Melissa A Austin Richard Barfield Daniela Basso Sonja I Berndt Marie-Christine Boutron-Ruault Michelle Brotzman Markus W Büchler H Bas Bueno-de-Mesquita Peter Bugert Laurie Burdette Daniele Campa Neil E Caporaso Gabriele Capurso Charles Chung Michelle Cotterchio Eithne Costello Joanne Elena Niccola Funel J Michael Gaziano Nathalia A Giese Edward L Giovannucci Michael Goggins Megan J Gorman Myron Gross Christopher A Haiman Manal Hassan Kathy J Helzlsouer Brian E Henderson Elizabeth A Holly Nan Hu David J Hunter Federico Innocenti Mazda Jenab Rudolf Kaaks Timothy J Key Kay-Tee Khaw Eric A Klein Manolis Kogevinas Vittorio Krogh Juozas Kupcinskas Robert C Kurtz Andrea LaCroix Maria T Landi Stefano Landi Loic Le Marchand Andrea Mambrini Satu Mannisto Roger L Milne Yusuke Nakamura Ann L Oberg Kouros Owzar Alpa V Patel Petra H M Peeters Ulrike Peters Raffaele Pezzilli Ada Piepoli Miquel Porta Francisco X Real Elio Riboli Nathaniel Rothman Aldo Scarpa Xiao-Ou Shu Debra T Silverman Pavel Soucek Malin Sund Renata Talar-Wojnarowska Philip R Taylor George E Theodoropoulos Mark Thornquist Anne Tjønneland Geoffrey S Tobias Dimitrios Trichopoulos Pavel Vodicka Jean Wactawski-Wende Nicolas Wentzensen Chen Wu Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Robert Hoover Patricia Hartge Charles Fuchs Stephen J Chanock Rachael S Stolzenberg-Solomon Laufey T Amundadottir

Nat Genet 2014 Sep 3;46(9):994-1000. Epub 2014 Aug 3.

1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].

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http://dx.doi.org/10.1038/ng.3052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191666PMC
September 2014

Expression of SP7, RUNX1, DLX5, and CTNNB1 in human mesenchymal stem cells cultured on xenogeneic bone substitute as compared with machined titanium.

Implant Dent 2014 Aug;23(4):407-15

*Adjunct Professor, Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy; Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy. †Postdoctoral Fellow, Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy; Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy. ‡Postdoctoral Fellow, Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy; Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy. §Associate Professor, Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy; Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy. ‖Professor, Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy; Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy.

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http://dx.doi.org/10.1097/ID.0000000000000116DOI Listing
August 2014

miR-211 modulates gemcitabine activity through downregulation of ribonucleotide reductase and inhibits the invasive behavior of pancreatic cancer cells.

Nucleosides Nucleotides Nucleic Acids 2014 ;33(4-6):384-93

a Department of Medical Oncology , VU University Medical Center , Amsterdam , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1080/15257770.2014.891741DOI Listing
February 2015

A polymorphism in the promoter is associated with EZH2 expression but not with outcome in advanced pancreatic cancer patients.

Pharmacogenomics 2014 Apr;15(5):609-18

Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, CCA room 1.52, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.2217/pgs.13.225DOI Listing
April 2014

Anti-diabetic properties of a non-conventional radical scavenger, as compared to pioglitazone and exendin-4, in streptozotocin-nicotinamide diabetic mice.

Eur J Pharmacol 2014 Apr 12;729:37-44. Epub 2014 Feb 12.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2014.01.071DOI Listing
April 2014

Role of CYB5A in pancreatic cancer prognosis and autophagy modulation.

J Natl Cancer Inst 2014 Jan 3;106(1):djt346. Epub 2013 Dec 3.

Affiliations of authors: Department of Medical Oncology (EG, AA, GJP) and Department of Neurosurgery (TL, VC, TW), VU University Medical Center, and Centre for Integrative Bioinformatics (AvdV), VU University, Amsterdam, the Netherlands; Department of Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, University of Pisa, Pisa, Italy (NF, UB, EV); Department of Neurology, Stanford University, Stanford, CA (VC); Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA (TW); Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD (QW, J-HL, YW, GG).

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http://dx.doi.org/10.1093/jnci/djt346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906994PMC
January 2014

Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma.

Cancer Res 2013 Nov 1;73(22):6745-56. Epub 2013 Oct 1.

Authors' Affiliations: Departments of Medical Oncology, Hematology, Neurosurgery and Pediatric Oncology/Hematology, Neuro-oncology Research Group, VU University Medical Center; Diagnostic Oncology Division, Netherlands Cancer Institute; VisualSonics, Amsterdam, the Netherlands; Departments of Neurology and Pediatrics, Stanford University School of Medicine, Stanford, California; Division of Surgical Pathology, Division of General and Transplant Surgery, University of Pisa, Pisa, Italy; and Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0837DOI Listing
November 2013

Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer.

Curr Pharm Des 2013 ;19(5):940-50

Dept. Medical Oncology, VUmc Cancer Center Amsterdam, VU University Medical Center, CCA room 1.52, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.

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July 2013

Dextran-catechin conjugate: a potential treatment against the pancreatic ductal adenocarcinoma.

Pharm Res 2012 Sep 24;29(9):2601-14. Epub 2012 May 24.

NEST Scuola Normale Superiore & Istituto Nanoscienze-CNR Piazza San Silvestro, 56126 Pisa, Italy.

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http://dx.doi.org/10.1007/s11095-012-0790-9DOI Listing
September 2012

Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.

Clin Cancer Res 2012 Jan 29;18(2):524-33. Epub 2011 Nov 29.

Medical Oncology Branch, Genetic Branch, and Biostatistics and Data Management Section, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261299PMC
January 2012

Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy.

Pharmacogenomics 2011 Dec 25;12(12):1641-52. Epub 2011 Oct 25.

Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.2217/pgs.11.109DOI Listing
December 2011

Critical role of laser microdissection for genetic, epigenetic and proteomic analyses in pancreatic cancer.

Expert Rev Mol Diagn 2011 Sep;11(7):695-701

Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy.

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http://dx.doi.org/10.1586/erm.11.62DOI Listing
September 2011

Antiproliferative effects of novel aliphatic acetogenin analogs against aggressive solid tumor cell lines.

In Vivo 2011 Mar-Apr;25(2):203-7

BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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July 2011

Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma.

Lab Invest 2008 Jul 19;88(7):773-84. Epub 2008 May 19.

Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Surgical Pathology, Molecular and Ultrastructural Pathology, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1038/labinvest.2008.40DOI Listing
July 2008