Nhu-An Pham

Nhu-An Pham

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Nhu-An Pham

Nhu-An Pham

Publications by authors named "Nhu-An Pham"

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30Publications

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Targeting the CDK4/6-Rb Pathway Enhances Response to PI3K Inhibition in -Mutant Lung Squamous Cell Carcinoma.

Clin Cancer Res 2018 12 9;24(23):5990-6000. Epub 2018 Aug 9.

University Health Network, Ontario Cancer Institute/Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0717DOI Listing
December 2018

An Anaplastic Lymphoma Kinase Immunohistochemistry-Negative but Fluorescence In Situ Hybridization-Positive Lung Adenocarcinoma Is Resistant to Crizotinib.

J Thorac Oncol 2016 12 6;11(12):2248-2252. Epub 2016 Sep 6.

University Health Network, Ontario Cancer Institute/Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.08.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573599PMC
December 2016

Cetuximab Inhibits T790M-Mediated Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in a Lung Adenocarcinoma Patient-Derived Xenograft Mouse Model.

Clin Lung Cancer 2016 09 22;17(5):375-383.e2. Epub 2016 Jan 22.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2016.01.002DOI Listing
September 2016

Patient-derived tumor xenograft models established from samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration.

Lung Cancer 2015 Aug 3;89(2):110-4. Epub 2015 Jun 3.

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2015.05.018DOI Listing
August 2015

Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.

J Clin Oncol 2015 Aug 29;33(22):2472-80. Epub 2015 Jun 29.

Erin L. Stewart, Celine Mascaux, Nhu-An Pham, Shingo Sakashita, Jenna Sykes, Lucia Kim, Naoki Yanagawa, Ghassan Allo, Kota Ishizawa, Dennis Wang, Chang-Qi Zhu, Ming Li, Christine Ng, Ni Liu, Melania Pintilie, Petra Martin, Tom John, Igor Jurisica, Natasha B. Leighl, Benjamin G. Neel, Thomas K. Waddell, Frances A. Shepherd, Geoffrey Liu, Ming-Sound Tsao, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Lucia Kim, Inha University College of Medicine, Incheon, South Korea; and Tom John, Austin Hospital, Heidelberg, Australia.

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http://jco.ascopubs.org/content/33/22/2472.full.pdf
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http://200.40.135.66:90/toc/0873/2015/0873-20150801-22-09.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.60.1492
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http://dx.doi.org/10.1200/JCO.2014.60.1492DOI Listing
August 2015

CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration.

Mol Cancer Res 2015 Jul 17;13(7):1119-29. Epub 2015 Mar 17.

Program in Molecular Structure and Function, Hospital For Sick Children, Toronto, Ontario, Canada. Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0165-TDOI Listing
July 2015

Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact.

Nat Commun 2014 Nov 28;5:5469. Epub 2014 Nov 28.

1] Department of Molecular Structure and Function, The Hospital For Sick Children, 686 Bay Street, Toronto, Ontario, Canada M5G0A4 [2] Princess Margaret Cancer Centre, 101 College Street, Toronto, Ontario, Canada M5G 1L7 [3] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5G 0A4.

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http://dx.doi.org/10.1038/ncomms6469DOI Listing
November 2014

Proteomic profiles of human lung adeno and squamous cell carcinoma using super-SILAC and label-free quantification approaches.

Proteomics 2014 Mar;14(6):795-803

Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pmic.201300382DOI Listing
March 2014

Primary tumor xenografts of human lung adeno and squamous cell carcinoma express distinct proteomic signatures.

J Proteome Res 2011 Jan 24;10(1):161-74. Epub 2010 Sep 24.

Program in Molecular Structure and Function, Hospital For Sick Children, University Health Network, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Canada.

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http://dx.doi.org/10.1021/pr100491eDOI Listing
January 2011

The ability to form primary tumor xenografts is predictive of increased risk of disease recurrence in early-stage non-small cell lung cancer.

Clin Cancer Res 2011 Jan 16;17(1):134-41. Epub 2010 Nov 16.

Melbourne Centre for Clinical Sciences, Ludwig Institute for Cancer Research, Melbourne, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2224DOI Listing
January 2011

Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma.

Mol Cancer 2010 Feb 1;9:24. Epub 2010 Feb 1.

Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1186/1476-4598-9-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824633PMC
February 2010

Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft models.

Int J Cancer 2009 Jan;124(2):280-6

Ontario Cancer Institute, Princess Margaret Hospital, and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ijc.23912DOI Listing
January 2009

Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.

Cancer Chemother Pharmacol 2008 Apr 20;61(4):669-81. Epub 2007 Jun 20.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 610 University Ave., 5th Floor, Rm 203, M5G 2M9, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00280-007-0522-8DOI Listing
April 2008

Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models.

Pancreas 2007 Oct;35(3):e16-26

Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://pdfs.journals.lww.com/pancreasjournal/2007/10000/Diss
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/mpa.0b013e318095a747DOI Listing
October 2007

Quantitative image analysis of immunohistochemical stains using a CMYK color model.

Diagn Pathol 2007 Feb 27;2. Epub 2007 Feb 27.

Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Canada.

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http://diagnosticpathology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/1746-1596-2-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810239PMC
February 2007

Integrin-linked kinase inhibitor KP-392 demonstrates clinical benefits in an orthotopic human non-small cell lung cancer model.

J Thorac Oncol 2006 Oct;1(8):771-9

Division of Thoracic Surgery, Toronto General Hospital, University Health Network and the Department of Surgery and Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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October 2006

Altered mitochondrial structure and motion dynamics in living cells with energy metabolism defects revealed by real time microscope imaging.

Microsc Microanal 2004 Apr;10(2):247-60

Richardson Technologies Inc. at The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1017/S143192760404005XDOI Listing
April 2004

Oxidative stress is generated via the mitochondrial respiratory chain during plant cell apoptosis.

Cytometry A 2003 Aug;54(2):109-17

Division of Experimental Therapeutics, Department of Medical Oncology and Haematology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Canada.

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http://dx.doi.org/10.1002/cyto.a.10054DOI Listing
August 2003