Nezam Afdhal

Nezam Afdhal

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Nezam Afdhal

Publications by authors named "Nezam Afdhal"

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Changing demographics among populations prescribed HCV treatment, 2013-2017.

Am J Manag Care 2019 Jul;25(7):319-323

University of Hawaii, 642 Ulukahiki St #103, Kailua, HI 96734. Email:

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July 2019

Liver Fibrosis Determination.

Gastroenterol Clin North Am 2019 06 1;48(2):281-289. Epub 2019 Apr 1.

Department of Medicine, Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street, Suite 4A, Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08898553193000
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http://dx.doi.org/10.1016/j.gtc.2019.02.002DOI Listing
June 2019

A Pathophysiologic Approach Combining Genetics and Insulin Resistance to Predict the Severity of Nonalcoholic Fatty Liver Disease.

Hepatol Commun 2018 Dec 1;2(12):1467-1478. Epub 2018 Nov 1.

Division of Gastroenterology and Hepatology Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA.

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http://dx.doi.org/10.1002/hep4.1267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287585PMC
December 2018

The impact of individual patient data in a network meta-analysis: An investigation into parameter estimation and model selection.

Res Synth Methods 2018 Sep 15;9(3):441-469. Epub 2018 Aug 15.

National Centre of Pharmacoeconomics, St. James's Hospital, Dublin 8, Ireland.

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http://dx.doi.org/10.1002/jrsm.1305DOI Listing
September 2018

Serum Activity of Macrophage-Derived Adenosine Deaminase 2 Is Associated With Liver Fibrosis in Nonalcoholic Fatty Liver Disease.

Clin Gastroenterol Hepatol 2018 07 21;16(7):1170-1172. Epub 2017 Nov 21.

Division of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565173136
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http://dx.doi.org/10.1016/j.cgh.2017.11.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962372PMC
July 2018

On-treatment HCV RNA in patients with varying degrees of fibrosis and cirrhosis in the SOLAR-1 trial.

Antivir Ther 2016 18;21(6):541-546. Epub 2016 Feb 18.

Department of Hepatology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.3851/IMP3037DOI Listing
January 2018

Neurologic Manifestations of Hepatitis C Virus Infection.

Clin Liver Dis 2017 08 26;21(3):535-542. Epub 2017 Apr 26.

Division of Gastroenterology & Hepatology, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cld.2017.03.008DOI Listing
August 2017

The Optimal Timing of Hepatitis C Therapy in Transplant Eligible Patients With Child B and C Cirrhosis: A Cost-Effectiveness Analysis.

Transplantation 2017 05;101(5):987-995

1 Division of Gastroenterology/Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. 2 Harvard Medical School, Boston, MA. 3 Liver Unit, Department of Internal Medicine, Hospital Valle Hebron and Ciberehd del Institut Carlos III, Barcelona, Spain. 4 Hepatology, University Clinic for Visceral Surgery and Medicine, Inselspital, University of Berne, Switzerland. 5 Division of Gastroenterology/Hepatology, Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1097/TP.0000000000001400DOI Listing
May 2017

Before or After Transplantation? A Review of the Cost Effectiveness of Treating Waitlisted Patients With Hepatitis C.

Transplantation 2017 05;101(5):933-937

1 Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI. 2 Division of Gastroenterology/Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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http://Insights.ovid.com/crossref?an=00007890-201705000-0001
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http://dx.doi.org/10.1097/TP.0000000000001611DOI Listing
May 2017

Evaluation of proton pump inhibitor use on treatment outcomes with ledipasvir and sofosbuvir in a real-world cohort study.

Hepatology 2016 12 5;64(6):1893-1899. Epub 2016 Oct 5.

Division of Gastroenterology/Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/hep.28782DOI Listing
December 2016

Effect of Registries and Cohort Studies on HCV Treatment.

Gastroenterology 2016 09 25;151(3):387-90. Epub 2016 Jul 25.

Hôpital Saint-Antoine, Service d'Hépatologie and UPMC University of Paris, Paris, France.

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http://dx.doi.org/10.1053/j.gastro.2016.07.024DOI Listing
September 2016

The Performance of Vibration Controlled Transient Elastography in a US Cohort of Patients With Nonalcoholic Fatty Liver Disease.

Am J Gastroenterol 2016 05 15;111(5):677-84. Epub 2016 Mar 15.

Department of Medicine, Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ajg.2016.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860094PMC
May 2016

Fibrosis Assessment in Nonalcoholic Fatty Liver Disease (NAFLD) in 2016.

Dig Dis Sci 2016 May 26;61(5):1356-64. Epub 2016 Mar 26.

Liver Center, Department of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis St #8e, Boston, MA, 0221, USA.

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http://dx.doi.org/10.1007/s10620-016-4079-4DOI Listing
May 2016

Performance of an Optimized Paper-Based Test for Rapid Visual Measurement of Alanine Aminotransferase (ALT) in Fingerstick and Venipuncture Samples.

PLoS One 2015 28;10(5):e0128118. Epub 2015 May 28.

Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America; Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128118PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447376PMC
April 2016

Serum Ammonia in Associated With Transplant-free Survival in Hospitalized Patients With Acutely Decompensated Cirrhosis.

J Clin Gastroenterol 2016 Apr;50(4):345-50

*Division of Gastroenterology†Department of Medicine‡Decision Support, Beth Israel Deaconess Medical Center, Boston, MA.

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http://dx.doi.org/10.1097/MCG.0000000000000443DOI Listing
April 2016

Poor Inter-test Reliability Between CK18 Kits as a Biomarker of NASH.

Dig Dis Sci 2016 Mar 13;61(3):905-12. Epub 2015 Oct 13.

Division of Gastroenterology/Liver Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street, Suite 4 A, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s10620-015-3916-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761280PMC
March 2016

Direct costs of care for hepatocellular carcinoma in patients with hepatitis C cirrhosis.

Cancer 2016 Mar 30;122(6):852-8. Epub 2015 Dec 30.

Division of Gastroenterology/Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.29855DOI Listing
March 2016

Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection.

N Engl J Med 2015 Dec 17;373(27):2608-17. Epub 2015 Nov 17.

From Queen Mary University of London (G.R.F.), University College London (W.R.), King's College Hospital (W.R.), and Institute of Liver Studies (K.A.) - all in London; Beth Israel Deaconess Medical Center, Boston (N.A.); Alfred Health and Monash University (S.K.R.) and St. Vincent's Hospital (A.T.), Melbourne, VIC, and Monash Health and Monash University, Clayton, VIC (S.P.) - all in Australia; James J. Peters Veterans Affairs Medical Center, Bronx (N.B.), and Icahn School of Medicine at Mount Sinai, New York (N.B.) - both in New York; Auckland Clinical Studies, Auckland (E.J.G.), and Christchurch Clinical Studies Trust and University of Otago, Christchurch (C.A.M.S.) - both in New Zealand; Texas Liver Institute, University of Texas Health Science Center, San Antonio (E.L.); Liver Institute of Virginia, Richmond (M.L.S.); University of Ottawa, Ottawa (C.C.), and Vancouver Infectious Diseases Centre, Vancouver, BC (B.C.) - both in Canada; Kaiser Permanente (W.J.T.), Ruane Medical (P.R.), and Cedars-Sinai Medical Center (T.T.T.), Los Angeles, and Gilead Sciences, Foster City (H.M., H.D.-S., L.H., J.W., J.M., A.O., D.M.B., J.G.M.) - all in California; Hôpital Saint Joseph, Marseilles (M.B.), and Service d'Hépatologie, Hôpital Beaujon, INSERM UMR 1149, Université Paris Diderot, Clichy (T.A.) - both in France; University Hospital Leipzig, Leipzig (T.B.), and Johann Wolfgang Goethe University, Frankfurt (S.Z.) - both in Germany; Santa Maria Annunziata Hospital, Florence (F.M.), and Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo (A.M.) - both in Italy; Henry Ford Health System, Detroit (S.C.G.); Duke University School of Medicine, Durham, NC (K.P.); Rush University Medical Center, Chicago (N.R.); and Johns Hopkins University, Baltimore (M.S.).

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http://www.natap.org/2015/AASLD/nejmoa1512610.pdf
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http://www.nejm.org/doi/abs/10.1056/NEJMoa1512612
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http://dx.doi.org/10.1056/NEJMoa1512612DOI Listing
December 2015

Cost-Effective Evaluation of Nonalcoholic Fatty Liver Disease With NAFLD Fibrosis Score and Vibration Controlled Transient Elastography.

Am J Gastroenterol 2015 Sep 25;110(9):1298-304. Epub 2015 Aug 25.

Division of Gastroenterology/Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.nature.com/articles/ajg2015241
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http://dx.doi.org/10.1038/ajg.2015.241DOI Listing
September 2015

Treatment with ledipasvir and sofosbuvir improves patient-reported outcomes: Results from the ION-1, -2, and -3 clinical trials.

Hepatology 2015 Jun 18;61(6):1798-808. Epub 2015 Mar 18.

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA.

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http://dx.doi.org/10.1002/hep.27724DOI Listing
June 2015

Vibration-controlled transient elastography: a practical approach to the noninvasive assessment of liver fibrosis.

Curr Opin Gastroenterol 2015 May;31(3):192-8

Department of Medicine, Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MOG.0000000000000169DOI Listing
May 2015

Accuracy of fibroscan, compared with histology, in analysis of liver fibrosis in patients with hepatitis B or C: a United States multicenter study.

Clin Gastroenterol Hepatol 2015 Apr 18;13(4):772-9.e1-3. Epub 2014 Dec 18.

Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1016/j.cgh.2014.12.014DOI Listing
April 2015

Contemporary assessment of hepatic fibrosis.

Clin Liver Dis 2015 Feb 14;19(1):123-34. Epub 2014 Oct 14.

Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cld.2014.09.007DOI Listing
February 2015

Low likelihood of intracranial hemorrhage in patients with cirrhosis and altered mental status.

Clin Gastroenterol Hepatol 2015 Jan 4;13(1):165-9. Epub 2014 Jun 4.

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.cgh.2014.05.022DOI Listing
January 2015

FibroScan (vibration-controlled transient elastography): where does it stand in the United States practice.

Clin Gastroenterol Hepatol 2015 Jan 5;13(1):27-36. Epub 2014 Jun 5.

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15423565140081
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http://dx.doi.org/10.1016/j.cgh.2014.04.039DOI Listing
January 2015

A Fixed-Dose Combination of Sofosbuvir and Ledipasvir for Hepatitis C Virus Genotype 1.

Authors:
Nezam H Afdhal

Gastroenterol Hepatol (N Y) 2014 Dec;10(12):815-7

Director of Hepatology Beth Israel Deaconess Medical Center Professor of Medicine Harvard Medical School Boston, Massachusetts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980816PMC
December 2014

Simple non-invasive biomarkers of advanced fibrosis in the evaluation of non-alcoholic fatty liver disease.

Gastroenterol Rep (Oxf) 2014 Nov 7;2(4):276-80. Epub 2014 Jul 7.

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA USA; Division of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1093/gastro/gou034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219143PMC
November 2014

Reply: To PMID 24126097.

Gastroenterology 2014 Jul 27;147(1):255-6. Epub 2014 May 27.

Glaxo Smith Kline, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1053/j.gastro.2014.05.030DOI Listing
July 2014

Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection.

N Engl J Med 2014 Apr 11;370(16):1483-93. Epub 2014 Apr 11.

From Beth Israel Deaconess Medical Center, Boston (N.A.); University of Pennsylvania, Philadelphia (K.R.R.); University of Florida, Gainesville (D.R.N.); Texas Liver Institute, University of Texas Health Science Center, San Antonio (E.L.), and the North Texas Research Institute, Arlington (R.G.) - both in Texas; Henry Ford Health Systems, Detroit (S.C.G.); Center for Liver Diseases, School of Medicine, University of Miami, Miami (E.S.); ID Care, Hillsborough, NJ (R.N.); Atlanta Gastroenterology Associates, Atlanta (N.G.); Quality Medical Research, Nashville (R.H.), and Gastro One, Germantown (Z.H.Y.) - both in Tennessee; Quest Clinical Research, San Francisco (J.L.), Scripps Clinic, La Jolla (P.J.P.), and Gilead Sciences, Foster City (G.M.S., Y.Z., H.D.-S., J.C.Y., P.S.P., W.T.S., J.G.M.) - all in California; Saint Louis University, St. Louis (A.M.D.); University of New Mexico, Albuquerque (S.A.); Duke University Medical Center, Durham, NC (A.J.M.); Johns Hopkins Medical Center, Baltimore (M.S.); and Indiana University School of Medicine, Indianapolis (P.K.).

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http://dx.doi.org/10.1056/NEJMoa1316366DOI Listing
April 2014

Utilization of FibroScan in clinical practice.

Curr Gastroenterol Rep 2014 Feb;16(2):372

Liver Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis street Suite 8E, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s11894-014-0372-6DOI Listing
February 2014

Serum biomarkers and transient elastography as predictors of advanced liver fibrosis in a United States cohort: the Boston children's hospital experience.

J Pediatr 2013 Oct 5;163(4):1058-64.e2. Epub 2013 Jun 5.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2013.04.044DOI Listing
October 2013

FibroScan in the Diagnosis of Hepatitis C Virus Infection.

Authors:
Nezam H Afdhal

Gastroenterol Hepatol (N Y) 2013 Aug;9(8):533-5

Director of Hepatology Beth Israel Deaconess Medical Center Professor of Medicine Harvard Medical School Boston, Massachusetts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980999PMC
August 2013

Eltrombopag in patients with chronic liver disease.

Expert Opin Pharmacother 2013 Apr 4;14(5):669-78. Epub 2013 Mar 4.

University of Genoa, Department of Internal Medicine, Gastroenterology Unit, Viale Benedetto XV, No. 6,16132, Genoa, Italy.

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http://www.tandfonline.com/doi/full/10.1517/14656566.2013.77
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http://dx.doi.org/10.1517/14656566.2013.775249DOI Listing
April 2013

Biopsy no more; changing the screening and diagnostic algorithm for hepatitis C.

Clin Gastroenterol Hepatol 2013 Mar 20;11(3):309-10. Epub 2012 Dec 20.

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http://dx.doi.org/10.1016/j.cgh.2012.12.003DOI Listing
March 2013

Stability of liver fibrosis among HCV-infected injection drug users.

Antivir Ther 2012 15;17(5):813-21. Epub 2012 Mar 15.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.3851/IMP2085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699312PMC
January 2013

Fibroscan (transient elastography) for the measurement of liver fibrosis.

Authors:
Nezam H Afdhal

Gastroenterol Hepatol (N Y) 2012 Sep;8(9):605-7

Director of Hepatology Beth Israel Deaconess Medical Center Professor of Medicine Harvard Medical School Boston, Massachusetts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594956PMC
September 2012

Management of nonalcoholic fatty liver disease: a 60-year-old man with probable nonalcoholic fatty liver disease: weight reduction, liver biopsy, or both?

Authors:
Nezam H Afdhal

JAMA 2012 Aug;308(6):608-16

Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2012.8402DOI Listing
August 2012

Clinical utility of interleukin-28B testing in patients with genotype 1.

Hepatology 2012 Jul;56(1):367-72

Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.1002/hep.25793DOI Listing
July 2012

Hepatitis C viral infection in difficult-to-treat populations: An overview.

Authors:
Nezam H Afdhal

Clin Liver Dis (Hoboken) 2012 Jul 23;1(3):63-64. Epub 2012 Jul 23.

Liver Center, Beth Israel Deaconess Medical Center, Boston, MA.

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http://dx.doi.org/10.1002/cld.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499269PMC
July 2012

Evaluation of liver lesions.

Clin Liver Dis 2012 May;16(2):271-83

Department of Medicine, Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S108932611200019
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http://dx.doi.org/10.1016/j.cld.2012.03.001DOI Listing
May 2012

Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition.

J Hepatol 2012 Mar 23;56(3):549-56. Epub 2011 Oct 23.

Department of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.jhep.2011.09.015DOI Listing
March 2012

Tolvaptan, an oral vasopressin antagonist, in the treatment of hyponatremia in cirrhosis.

J Hepatol 2012 Mar 23;56(3):571-8. Epub 2011 Oct 23.

GI Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clínic, University of Barcelona, Barcelona, Catalunya, Spain.

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http://dx.doi.org/10.1016/j.jhep.2011.08.020DOI Listing
March 2012

Editorial: staging liver fibrosis in hepatitis C: a challenge for this decade.

Am J Gastroenterol 2011 Dec;106(12):2121-2

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http://dx.doi.org/10.1038/ajg.2011.343DOI Listing
December 2011

Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C.

Hepatology 2011 Nov 24;54(5):1559-69. Epub 2011 Aug 24.

Division of Gastroenterology & Hepatology, Hepatitis C Center, Department of Medicine, University of Colorado Denver & National Jewish Hospital, Denver, CO, USA.

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http://doi.wiley.com/10.1002/hep.24556
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http://dx.doi.org/10.1002/hep.24556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206734PMC
November 2011

Circulating microRNAs as biomarkers for hepatocellular carcinoma.

J Clin Gastroenterol 2011 Apr;45(4):355-60

Department of Hematology and Oncology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA 92675, USA.

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http://dx.doi.org/10.1097/MCG.0b013e3181f18ac2DOI Listing
April 2011

Ubiquitin-proteasome profiling for enhanced detection of hepatocellular carcinoma in patients with chronic liver disease.

J Gastroenterol Hepatol 2011 Apr;26(4):751-8

Quest Diagnostics Nichols Institute, San Juan Capistrano, California 92675, USA.

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http://dx.doi.org/10.1111/j.1440-1746.2010.06491.xDOI Listing
April 2011

Chronic hepatitis B: integrating long-term treatment data and strategies to improve outcomes in clinical practice.

Gastroenterol Hepatol (N Y) 2011 Mar;7(3 Suppl 4):1-16

Beth Israel Deaconess Medical Center Boston, Massachusetts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337661PMC
March 2011