Nevan Krogan

Nevan Krogan

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A systems approach to infectious disease.

Nat Rev Genet 2020 Feb 14. Epub 2020 Feb 14.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41576-020-0212-5DOI Listing
February 2020

Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant.

iScience 2020 Jan 28;23(1):100809. Epub 2019 Dec 28.

Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.100809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957872PMC
January 2020

Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly.

Dev Cell 2019 Dec 14;51(6):713-729.e6. Epub 2019 Nov 14.

Howard Hughes Medical Institute, BCM, Houston, TX 77030, USA; Department of Molecular and Human Genetics, BCM, Houston, TX 77030, USA; Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; MD/PhD Medical Scientist Training Program and MHG Graduate program, BCM, Houston, TX 77030, USA; Program in Developmental Biology, BCM, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917859PMC
December 2019

The functional landscape of the human phosphoproteome.

Nat Biotechnol 2019 Dec 9. Epub 2019 Dec 9.

European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/s41587-019-0344-3DOI Listing
December 2019

Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast.

J Biol Chem 2019 Nov 10;294(44):16080-16094. Epub 2019 Sep 10.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada

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http://dx.doi.org/10.1074/jbc.RA119.008515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827322PMC
November 2019

UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity.

Nature 2019 11 23;575(7782):366-370. Epub 2019 Sep 23.

Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.

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http://dx.doi.org/10.1038/s41586-019-1612-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856441PMC
November 2019

Mapping genetic interactions in cancer: a road to rational combination therapies.

Genome Med 2019 10 22;11(1):62. Epub 2019 Oct 22.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 16th Street, Mission Bay Campus, San Francisco, CA, 94158-2140, USA.

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http://dx.doi.org/10.1186/s13073-019-0680-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805649PMC
October 2019

Anti-CRISPR-Associated Proteins Are Crucial Repressors of Anti-CRISPR Transcription.

Cell 2019 Sep 29;178(6):1452-1464.e13. Epub 2019 Aug 29.

Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.07.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754177PMC
September 2019

Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.

Cell Rep 2019 Aug;28(9):2317-2330.e8

Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; QB3, California Institute for Quantitative Biosciences, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728083PMC
August 2019

SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1.

Mol Metab 2019 07 17;25:35-49. Epub 2019 Apr 17.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601363PMC
July 2019

ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.

Cell Host Microbe 2019 07 25;26(1):86-99.e7. Epub 2019 Jun 25.

Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.05.008DOI Listing
July 2019

Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.

Mol Cell 2019 06 1;74(6):1164-1174.e4. Epub 2019 May 1.

J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588463PMC
June 2019

Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress.

Proc Natl Acad Sci U S A 2019 Jun 17;116(23):11291-11298. Epub 2019 May 17.

Department of Medicine, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1904516116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561268PMC
June 2019

Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets.

Antiviral Res 2019 02 11;162:90-100. Epub 2018 Dec 11.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.antiviral.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457457PMC
February 2019

Mapping the protein-protein and genetic interactions of cancer to guide precision medicine.

Curr Opin Genet Dev 2019 02 6;54:110-117. Epub 2019 Jul 6.

Cellular and Molecular Pharmacology, University of California, San Francisco, CA, United States; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, United States; Quantitative Biosciences Institute, University of California, San Francisco, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2019.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746583PMC
February 2019

The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1.

G3 (Bethesda) 2018 12 10;8(12):3931-3944. Epub 2018 Dec 10.

Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158

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http://g3journal.org/lookup/doi/10.1534/g3.118.200767
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http://dx.doi.org/10.1534/g3.118.200767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288840PMC
December 2018

Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.

Cell 2018 12;175(7):1917-1930.e13

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.08.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366944PMC
December 2018

TCO, a Putative Transcriptional Regulator in , Is a Target of the Protein Kinase CK2.

Int J Mol Sci 2018 Dec 28;20(1). Epub 2018 Dec 28.

Department of Biology, American University, 4400 Massachusetts Avenue NW, Washington, DC 20016, USA.

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http://dx.doi.org/10.3390/ijms20010099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337506PMC
December 2018

Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease.

Mol Cell 2018 10 30;72(1):152-161.e7. Epub 2018 Aug 30.

Immunology Program, Sloan Kettering Institute, New York, NY, USA; Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.07.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389330PMC
October 2018

EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion.

Sci Rep 2018 09 5;8(1):13269. Epub 2018 Sep 5.

Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, Ljubljana, SI 1000, Slovenia.

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http://dx.doi.org/10.1038/s41598-018-31482-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125409PMC
September 2018

An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses.

Mol Cell 2018 08;71(4):637-648.e5

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94148, USA; Gladstone Institutes, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329589PMC
August 2018

Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.

Sci Rep 2018 Jul 20;8(1):11001. Epub 2018 Jul 20.

Cardiovascular Research Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1038/s41598-018-29333-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054673PMC
July 2018

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Cell 2018 07;174(3):505-520

Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247911PMC
July 2018

Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.

Cell Metab 2018 03;27(3):616-629.e4

Cardiovascular Research Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020063PMC
March 2018

Genetic Interaction Mapping in Using the Pombe Epistasis Mapper (PEM) System and a ROTOR HDA Colony Replicating Robot in a 1536 Array Format.

Cold Spring Harb Protoc 2018 02 1;2018(2). Epub 2018 Feb 1.

Department Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94518.

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http://dx.doi.org/10.1101/pdb.prot091975DOI Listing
February 2018

High-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast .

Cold Spring Harb Protoc 2018 02 1;2018(2). Epub 2018 Feb 1.

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94518

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http://dx.doi.org/10.1101/pdb.top079905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764749PMC
February 2018

Genetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast.

Cold Spring Harb Protoc 2018 02 1;2018(2). Epub 2018 Feb 1.

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94518.

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http://dx.doi.org/10.1101/pdb.prot091983DOI Listing
February 2018

Transformation of in a 96-Well Format.

Cold Spring Harb Protoc 2018 01 2;2018(1). Epub 2018 Jan 2.

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94518.

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http://dx.doi.org/10.1101/pdb.prot091942DOI Listing
January 2018

DNA Preparation from .

Cold Spring Harb Protoc 2018 01 2;2018(1). Epub 2018 Jan 2.

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94518.

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http://dx.doi.org/10.1101/pdb.prot091959DOI Listing
January 2018

Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes.

Genetics 2018 01 10;208(1):419-431. Epub 2017 Nov 10.

Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Unidad de Genómica Avanzada (Langebio), 36821 Irapuato, Guanajuato, Mexico

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http://dx.doi.org/10.1534/genetics.117.300377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753873PMC
January 2018

Virus-Like Vesicles of Kaposi's Sarcoma-Associated Herpesvirus Activate Lytic Replication by Triggering Differentiation Signaling.

J Virol 2017 08 12;91(15). Epub 2017 Jul 12.

Department of Molecular and Medical Pharmacology, University of California-Los Angeles, Los Angeles, California, USA

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http://dx.doi.org/10.1128/JVI.00362-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651724PMC
August 2017

The Tyrosine Kinase Inhibitor Gefitinib Restricts Mycobacterium tuberculosis Growth through Increased Lysosomal Biogenesis and Modulation of Cytokine Signaling.

ACS Infect Dis 2017 08 5;3(8):564-574. Epub 2017 Jun 5.

School of Public Health, Division of Infectious Diseases and Vaccinology, Li Ka Shing Center, University of California , Berkeley, California 94720, United States.

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http://dx.doi.org/10.1021/acsinfecdis.7b00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728371PMC
August 2017

Genetic interaction mapping in mammalian cells using CRISPR interference.

Nat Methods 2017 Jun 8;14(6):577-580. Epub 2017 May 8.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/nmeth.4286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584685PMC
June 2017

The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity.

Cell 2017 05;169(4):679-692.e14

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217988PMC
May 2017

SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.

Cell Host Microbe 2017 May;21(5):569-579.e6

Gladstone Institute for Virology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490666PMC
May 2017

An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.

Cell 2017 04;169(2):350-360.e12

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Quantitative Biosciences Institute, QBI, University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5616215PMC
April 2017

The histone variant H2A.Z promotes splicing of weak introns.

Genes Dev 2017 04;31(7):688-701

Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco 94158, California, USA.

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http://dx.doi.org/10.1101/gad.295287.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411709PMC
April 2017

PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.

Sci Rep 2017 03 27;7:45394. Epub 2017 Mar 27.

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/srep45394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366948PMC
March 2017

G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands.

Mol Pharmacol 2017 Feb 22;91(2):145-156. Epub 2016 Nov 22.

Department of Psychiatry (N.G.T., M.T.-Z., M.Z.), Department of Cellular and Molecular Pharmacology (M.Z.), California Institute for Quantitative Biosciences (B.W.N., J.R.J., N.J.K.), and Lung Biology Center, Department of Medicine (A.B.S.), University of California, San Francisco, San Francisco, California; J. David Gladstone Institute, San Francisco, California (N.J.K.); and Department of Biochemistry, Stanford University, Stanford, California (D.P.R.).

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http://dx.doi.org/10.1124/mol.116.106369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267521PMC
February 2017

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.

Nat Genet 2017 Feb 19;49(2):193-203. Epub 2016 Dec 19.

Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511375PMC
February 2017

Inhibition of CRISPR-Cas9 with Bacteriophage Proteins.

Cell 2017 Jan 29;168(1-2):150-158.e10. Epub 2016 Dec 29.

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA; Quantitative Biosciences Institute, QBI, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)31683-X.pdf
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http://www.cell.com/cms/attachment/2077323567/2070673332/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741631683
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http://dx.doi.org/10.1016/j.cell.2016.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235966PMC
January 2017

The mTOR Complex Controls HIV Latency.

Cell Host Microbe 2016 Dec;20(6):785-797

Gladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354304PMC
December 2016

Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome.

Mol Cell Biol 2016 11 28;36(22):2768-2781. Epub 2016 Oct 28.

St-Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Centre de Recherche du CHU de Québec-Axe Oncologie, Hôtel-Dieu de Québec, Québec City, Quebec, Canada

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http://dx.doi.org/10.1128/MCB.00112-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086519PMC
November 2016

A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export.

Cell Host Microbe 2016 Nov;20(5):642-653

Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130111PMC
November 2016

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.

Neuron 2016 Nov 27;92(4):813-828. Epub 2016 Oct 27.

Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.09.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199216PMC
November 2016

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells.

Cell Rep 2016 10;17(5):1438-1452

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Innovative Genomics Initiative, University of California, Berkeley, Berkeley, CA 94720, USA; Divisions of Infectious Diseases and Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123761PMC
October 2016

Nonsense-mediated decay regulates key components of homologous recombination.

Nucleic Acids Res 2016 06 21;44(11):5218-30. Epub 2016 Mar 21.

Department of Microbiology & Molecular Genetics, University of California, Davis, CA 95616-8665, USA Department of Molecular & Cellular Biology University of California, Davis, CA 95616-8665, USA

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http://dx.doi.org/10.1093/nar/gkw182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914092PMC
June 2016

Non-degradative Ubiquitination of Protein Kinases.

PLoS Comput Biol 2016 06 2;12(6):e1004898. Epub 2016 Jun 2.

Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890936PMC
June 2016

A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S.

PLoS Genet 2016 06 29;12(6):e1006124. Epub 2016 Jun 29.

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927156PMC
June 2016

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.

Cell Stem Cell 2016 Apr 10;18(4):541-53. Epub 2016 Mar 10.

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; California Institute for Quantitative Biosciences, QB3, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Medicine and Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830697PMC
April 2016

CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing.

Cell Host Microbe 2015 Nov;18(5):560-70

Departments of Medicine, Microbiology, and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648707PMC
November 2015

Comparative mapping of host-pathogen protein-protein interactions.

Curr Opin Microbiol 2015 Oct 10;27:62-8. Epub 2015 Aug 10.

Department of Cellular and Molecular Pharmacology, University of California, Byers Hall, 1700 4th Street, San Francisco, CA 94158, United States; QB3, University of California, Byers Hall, 1700 4th Street, Byers Hall, San Francisco, CA 94158, United States; J. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA 94158, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2015.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659747PMC
October 2015

Prediction of Functionally Important Phospho-Regulatory Events in Xenopus laevis Oocytes.

PLoS Comput Biol 2015 Aug 27;11(8):e1004362. Epub 2015 Aug 27.

European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany and European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom; iBiMED and Department of Health Sciences, University of Aveiro, Aveiro, Portugal.

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http://dx.doi.org/10.1371/journal.pcbi.1004362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552029PMC
August 2015

Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells.

Cell Syst 2015 Aug 26;1(2):141-51. Epub 2015 Aug 26.

Medical Systems Biology, UCC, Medical Faculty Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023010PMC
August 2015

Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection.

Cell Host Microbe 2015 Jul 25;18(1):109-21. Epub 2015 Jun 25.

Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540348PMC
July 2015

Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1.

Biochemistry 2015 Jul 17;54(29):4423-6. Epub 2015 Jul 17.

†Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, United States.

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http://dx.doi.org/10.1021/acs.biochem.5b00504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816488PMC
July 2015