Nenggang Zhang

Nenggang Zhang

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Nenggang Zhang

Nenggang Zhang

Publications by authors named "Nenggang Zhang"

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The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes.

Front Pharmacol 2018 7;9:313. Epub 2018 May 7.

Center for Drug Discovery, Baylor College of Medicine, Houston, TX, United States.

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http://dx.doi.org/10.3389/fphar.2018.00313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949348PMC
May 2018

Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.

J Cancer Sci Ther 2018 22;10(3). Epub 2018 Mar 22.

Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.4172/1948-5956.1000517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959057PMC
March 2018

Biology and insights into the role of cohesin protease separase in human malignancies.

Biol Rev Camb Philos Soc 2017 Nov 8;92(4):2070-2083. Epub 2017 Feb 8.

Departments of Pediatrics and Molecular and Cellular Biology, Texas Children's Cancer Center, Baylor College of Medicine, 1102 Bates St., FC1220, Houston, TX 77030, U.S.A.

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http://dx.doi.org/10.1111/brv.12321DOI Listing
November 2017

Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase.

Bioorg Med Chem Lett 2016 09 1;26(18):4446-4450. Epub 2016 Aug 1.

Department of Chemistry, University of Houston, Houston, TX 77204, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.07.080DOI Listing
September 2016

C-terminus of Sororin interacts with SA2 and regulates sister chromatid cohesion.

Cell Cycle 2015 ;14(6):820-6

a Texas Children's Cancer Center ; Department of Pediatric Hematology/Oncology ; Baylor College of Medicine ; Houston , TX USA.

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http://dx.doi.org/10.1080/15384101.2014.1000206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614265PMC
December 2015

MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERα)-positive mammary adenocarcinomas.

Oncogene 2014 Nov 25;33(48):5511-5522. Epub 2013 Nov 25.

Texas Children's Cancer Center, Department of Pediatric Hematology/Oncology, Houston, TX 77030.

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http://dx.doi.org/10.1038/onc.2013.493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032816PMC
November 2014

Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy.

J Biomol Screen 2014 Jul 13;19(6):878-89. Epub 2014 Feb 13.

Texas Children's Cancer Center, and Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

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http://dx.doi.org/10.1177/1087057114520972DOI Listing
July 2014

Characterization of the interaction between the cohesin subunits Rad21 and SA1/2.

PLoS One 2013 12;8(7):e69458. Epub 2013 Jul 12.

Texas Children' Cancer Center, Department of Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069458PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709894PMC
February 2014

Sororin is a master regulator of sister chromatid cohesion and separation.

Cell Cycle 2012 Jun 1;11(11):2073-83. Epub 2012 Jun 1.

Texas Children's Cancer Center, Department of Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA. nzhang@bcmedu

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http://dx.doi.org/10.4161/cc.20241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368859PMC
June 2012

A cohesin-RAD21 interactome.

Biochem J 2012 Mar;442(3):661-70

Texas Children's Cancer Center, Department of Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, 77030, USA.

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http://biochemj.org/lookup/doi/10.1042/BJ20111745
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http://dx.doi.org/10.1042/BJ20111745DOI Listing
March 2012

Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion.

J Biol Chem 2011 Dec 10;286(48):41826-37. Epub 2011 Oct 10.

Texas Children's Cancer and Hematology Center, Department of Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M111.305888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310079PMC
December 2011

Calpain-1 cleaves Rad21 to promote sister chromatid separation.

Mol Cell Biol 2011 Nov 29;31(21):4335-47. Epub 2011 Aug 29.

Department of Pediatric Hematology/Oncology, Baylor College of Medicine, 1102 Bates Avenue, Suite 1220, Houston, TX 77030.

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http://dx.doi.org/10.1128/MCB.06075-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209327PMC
November 2011

Development and validation of a fluorogenic assay to measure separase enzyme activity.

Anal Biochem 2009 Sep 2;392(2):133-8. Epub 2009 Jun 2.

Department of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ab.2009.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713383PMC
September 2009

Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.

Clin Cancer Res 2009 Apr 7;15(8):2703-10. Epub 2009 Apr 7.

Department of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-08-2454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718850PMC
April 2009

Handcuff for sisters: a new model for sister chromatid cohesion.

Cell Cycle 2009 Feb 10;8(3):399-402. Epub 2009 Feb 10.

Department of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689371PMC
http://dx.doi.org/10.4161/cc.8.3.7586DOI Listing
February 2009

A handcuff model for the cohesin complex.

J Cell Biol 2008 Dec;183(6):1019-31

Department of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1083/jcb.200801157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600748PMC
December 2008

Hormone-induced chromosomal instability in p53-null mammary epithelium.

Cancer Res 2004 Aug;64(16):5608-16

Department of Pediatrics, Hematology-Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-03-0629DOI Listing
August 2004

Linking sister chromatid cohesion and apoptosis: role of Rad21.

Mol Cell Biol 2002 Dec;22(23):8267-77

Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134054PMC
http://dx.doi.org/10.1128/mcb.22.23.8267-8277.2002DOI Listing
December 2002