Nelleke A Gruis

Nelleke A Gruis

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Nelleke A Gruis

Nelleke A Gruis

Publications by authors named "Nelleke A Gruis"

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73Publications

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High Growth Rate of Pancreatic Ductal Adenocarcinoma in Mutation Carriers.

Cancer Prev Res (Phila) 2018 09 10;11(9):551-556. Epub 2018 Jul 10.

Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0035DOI Listing
September 2018

Prognostic Significance of Promoter Hypermethylation and Diminished Gene Expression of SYNPO2 in Melanoma.

J Invest Dermatol 2015 Sep 28;135(9):2328-2331. Epub 2015 Apr 28.

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.163DOI Listing
September 2015

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.

Nat Genet 2015 Sep 3;47(9):987-995. Epub 2015 Aug 3.

Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1038/ng.3373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557485PMC
September 2015

Histologic features of melanoma associated with CDKN2A genotype.

J Am Acad Dermatol 2015 Mar 13;72(3):496-507.e7. Epub 2015 Jan 13.

Department of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jaad.2014.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333073PMC
March 2015

Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma.

J Natl Cancer Inst 2015 Feb 13;107(2). Epub 2014 Dec 13.

Affiliations of authors: QIMR Berghofer Medical Research Institute, Brisbane, Australia (LGA, ALP, MG, PJ, JMP, JS, VB, SW, KDR, MSS, GWM, NGM, NKH); Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK (CDRE, TMK, DJA); Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark (KW, AMG); Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK (MH, HSn, DTB, JANB); Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (JC, KMB); Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología del Principado de Asturias (IUOPA) Universidad de Oviedo, Oviedo, Spain (VQ, AJR, CLO); Cancer Genomics Research Laboratory, NCI Frederick, SAIC-Frederick Inc., Frederick MD (XZ, KJ); Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands (RvD, NAG); Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden (HO, CI, ÅB, GJ); Translational Genomics Institute, Phoenix, AZ (JMT); University of Sydney at Westmead Millennium Institute, Westmead, Sydney, NSW, Australia (EAH, HSc, GJM); Melanoma Institute Australia, North Sydney, NSW, Australia (EAH, HSc, GJM).

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http://dx.doi.org/10.1093/jnci/dju408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334787PMC
February 2015

Promoter CpG island hypermethylation in dysplastic nevus and melanoma: CLDN11 as an epigenetic biomarker for malignancy.

J Invest Dermatol 2014 Dec 7;134(12):2957-2966. Epub 2014 Jul 7.

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands; The first two and last three authors contributed equally to this work. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.270DOI Listing
December 2014

The effect on melanoma risk of genes previously associated with telomere length.

J Natl Cancer Inst 2014 Oct 17;106(10). Epub 2014 Sep 17.

Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds, Leeds, UK (MMI, DTB, JCT, MHa, JRM, JANB, JHB); Oncogenomics (NKH), Genetic Epidemiology (NGM), Inflammatory Bowel Diseases Laboratory (GLRS), Cancer Control Group (DCW), Statistical Genetics (SM, MHL), and Molecular Epidemiology (GWM), QIMR Berghofer Medical Research Institute, Brisbane, Australia; INSERM, UMR-946, Genetic Variation and Human Diseases Unit, Paris, France (MB, FD); Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France (MB, FD); Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney, Australia (AEC); Department of Oncology, University of Cambridge, Cambridge, UK (AMD, PDPP); Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX (JEL); Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley, Australia (EKM, SVW); Centre for Cancer Biomarkers CCBIO (LAA) and Gade Laboratory for Pathology (AM), Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Pathology, Haukeland University Hospital, Bergen, Norway (LAA); Department of Pathology, Molecular Pathology (PAA) and Department of Dermatology (PH), Oslo University Hospital, Rikshospitalet, Oslo, Norway; Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes, Paris, France (MFA); Department of Dermatology (EA) and Oncogenics Unit (EA, EF), Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv, Israel (EA); Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy (GBS, EFPG); Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital, Genoa, Italy (GBS, EFPG); Division of Cancer Epidemiology and Gene

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https://genepi.qimr.edu.au/contents/p/staff/IlesMM_JNCI_EPUB
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/dju267
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http://dx.doi.org/10.1093/jnci/dju267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196080PMC
October 2014

In-vitro melanoma models: invasive growth is determined by dermal matrix and basement membrane.

Melanoma Res 2014 Aug;24(4):305-14

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/CMR.0000000000000079DOI Listing
August 2014

Acquired melanocytic nevi in childhood and familial melanoma.

JAMA Dermatol 2014 Jan;150(1):35-40

Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1001/jamadermatol.2013.5588DOI Listing
January 2014

Class III β-tubulin, a novel biomarker in the human melanocyte lineage.

Differentiation 2013 Apr-Jun;85(4-5):173-81. Epub 2013 Jul 2.

Department of Otorhinolaryngology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.diff.2013.05.003DOI Listing
November 2013

Surveillance of second-degree relatives from melanoma families with a CDKN2A germline mutation.

Cancer Epidemiol Biomarkers Prev 2013 Oct 29;22(10):1771-7. Epub 2013 Jul 29.

Authors' Affiliations: Department of Dermatology, Medical Statistics and Clinical Epidemiology, Clinical Genetics, Leiden University Medical Center, Leiden; Medical Affairs, Agendia, Amsterdam; Department of Pathology, VU University Medical Center, Amsterdam; The Netherlands Foundation for the Detection of Hereditary Tumors, Leiden; and Department of Gastroenterology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1055-9965.EPI-13-0130DOI Listing
October 2013

A variant in FTO shows association with melanoma risk not due to BMI.

Nat Genet 2013 Apr 3;45(4):428-32, 432e1. Epub 2013 Mar 3.

Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St. James's University Hospital, Leeds, UK.

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https://genepi.qimr.edu.au/contents/p/staff/Iles_etal_Nature
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http://www.nature.com/doifinder/10.1038/ng.2571
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http://dx.doi.org/10.1038/ng.2571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640814PMC
April 2013

Melanocortin 1 receptor (MC1R) variants in high melanoma risk patients are associated with specific dermoscopic ABCD features.

Acta Derm Venereol 2012 Nov;92(6):587-92

Department of Dermatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.2340/00015555-1457DOI Listing
November 2012

Melanocortin 1 receptor function: shifting gears from determining skin and nevus phenotype to fetal growth.

J Invest Dermatol 2012 Aug;132(8):1953-5

Skin Research Laboratory, LUMC, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/jid.2012.216DOI Listing
August 2012

Genome-wide association study identifies three new melanoma susceptibility loci.

Nat Genet 2011 Oct 9;43(11):1108-13. Epub 2011 Oct 9.

Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James’s University Hospital, Leeds, UK.

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http://dx.doi.org/10.1038/ng.959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251256PMC
October 2011

Effectiveness and causes for failure of surveillance of CDKN2A-mutated melanoma families.

J Am Acad Dermatol 2011 Aug 12;65(2):289-296. Epub 2011 May 12.

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jaad.2010.06.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138884PMC
August 2011

Clinical and histologic characteristics of malignant melanoma in families with a germline mutation in CDKN2A.

J Am Acad Dermatol 2011 Aug 12;65(2):281-288. Epub 2011 May 12.

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jaad.2010.06.044DOI Listing
August 2011

Management of melanoma families.

Cancers (Basel) 2010 Apr 16;2(2):549-66. Epub 2010 Apr 16.

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.3390/cancers2020549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835091PMC
April 2010

Absence of germline epimutation of the CDKN2A gene in familial melanoma.

J Invest Dermatol 2009 Mar 25;129(3):781-4. Epub 2008 Sep 25.

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http://dx.doi.org/10.1038/jid.2008.287DOI Listing
March 2009

Genetic testing in familial melanoma: uptake and implications.

Psychooncology 2008 Aug;17(8):790-6

Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/pon.1377DOI Listing
August 2008

Epigenetic regulation identifies RASEF as a tumor-suppressor gene in uveal melanoma.

Invest Ophthalmol Vis Sci 2008 Apr;49(4):1291-8

Department of Ophthalmology, Leiden University Medical Center , Leiden, The Netherlands.

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http://dx.doi.org/10.1167/iovs.07-1135DOI Listing
April 2008

Pyrophosphorolysis detects B-RAF mutations in primary uveal melanoma.

Invest Ophthalmol Vis Sci 2008 Jan;49(1):23-7

Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1167/iovs.07-0722DOI Listing
January 2008

Expression of Wnt5a and its downstream effector beta-catenin in uveal melanoma.

Melanoma Res 2007 Dec;17(6):380-6

Department of Ophthalmology, Skin Research Lab, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/CMR.0b013e3282f1d302DOI Listing
December 2007

Genetics: what advice for patients who present with a family history of melanoma?

Semin Oncol 2007 Dec;34(6):452-9

Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James's Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1053/j.seminoncol.2007.09.006DOI Listing
December 2007

Epigenetic inactivation of RASSF1a in uveal melanoma.

Invest Ophthalmol Vis Sci 2007 Feb;48(2):486-90

Departments of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1167/iovs.06-0781DOI Listing
February 2007

Aberrant DNA methylation in cutaneous malignancies.

Semin Oncol 2005 Oct;32(5):479-87

Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 AL Leiden, The Netherlands.

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http://dx.doi.org/10.1053/j.seminoncol.2005.07.001DOI Listing
October 2005

A mutation hotspot at the p14ARF splice site.

Oncogene 2005 Jun;24(28):4604-8

Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, England.

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http://dx.doi.org/10.1038/sj.onc.1208678DOI Listing
June 2005

Familial melanoma: a complex disorder leading to controversy on DNA testing.

Fam Cancer 2003 ;2(2):109-16

Departments of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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January 2004

Pancreatic carcinoma in carriers of a specific 19 base pair deletion of CDKN2A/p16 (p16-leiden).

Clin Cancer Res 2003 Sep;9(10 Pt 1):3598-605

Departments of Gastroenterology, Leiden University Medical Center, Leiden PB 9600, the Netherlands.

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September 2003

MICA gene polymorphism is not associated with an increased risk for skin cancer.

J Invest Dermatol 2002 Apr;118(4):686-91

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1046/j.1523-1747.2002.01712.xDOI Listing
April 2002