Publications by authors named "Neiva Leite"

58 Publications

Influence of Insulin Application Time and High-Intensity Intermittent Exercise on Hypoglycemic Risk in Adolescents With Type 1 Diabetes.

Pediatr Exerc Sci 2021 Jul 26:1-7. Epub 2021 Jul 26.

Federal University of Paraná.

Purpose: The study analyzed the influence of exercise on hypoglycemia episodes postexercise and in the subsequent 24 hours in children and adolescents with type 1 diabetes.

Methods: Thirty young people performed the same protocol of physical exercises for 1 hour (Ex1h) and 2 hours (Ex2h) after the administration of insulin. They performed 30 minutes of exercise on a cycle ergometer with a load of 60% of maximal oxygen uptake, interspersed with maximum intensity sprints lasting 10 seconds every 5 minutes.

Results: Regarding the occurrence of hypoglycemia, in the 8 hours following the exercises, there was no occurrence in Ex1h (χ2 = 0.001; P = .0001) and a greater proportion for Ex2h (n = 71 episodes, 53.8%), while Ex1h had a higher number of nocturnal hypoglycemic episodes (n = 60, 71.4%) compared with Ex2h (n = 31, 23.1%, χ2 = 49.521, P = .0001), Ex1h triggered a lower number of hypoglycemia (n = 84) than Ex2h (n = 134, χ2 = 11.504, P = .001). There was a greater reduction in the average amount of fast-acting insulin administered the day after Ex1h compared with Ex2h (P = .031).

Conclusions: Intermittent exercise performed 1 hour after insulin administration shows a lower risk of hypoglycemia within 8 hours after exercise, as well as a reduction in insulin the following day.
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http://dx.doi.org/10.1123/pes.2020-0150DOI Listing
July 2021

Effects and Responsiveness of a Multicomponent Intervention on Body Composition, Physical Fitness, and Leptin in Overweight/Obese Adolescents.

Int J Environ Res Public Health 2021 07 7;18(14). Epub 2021 Jul 7.

Graduate Program in Human Movement Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90690-200, Brazil.

Physical exercise reduces the biochemical markers of obesity, but the effects of multicomponent interventions on these markers should be explored. The present study aimed to elucidate how overweight/obese adolescents respond to a multicomponent program approach on body composition, physical fitness, and inflammatory markers, using a quasi-experimental study with 33 overweight/obesity adolescents (control group (CG) = 16; intervention group (IG) = 17). The intervention consisted of 24 weeks with physical exercises and nutritional and psychological guidance. Both groups were evaluated at the pre/post-intervention moments on body mass index (BMI); body fat (%Fat); waist circumference (WC); waist/hip ratio (WHR); waist-to-height ratio (WHtR), cardiorespiratory fitness (CRF); abdominal strength, flexibility; leptin; interleukin 6; interleukin 10; and tumor necrosis factor-alpha. Mixed-analysis of variance and generalized estimation equations were used for statistical analysis. There was an interaction effect between groups and time on %Fat ( = 0.002), WC ( = 0.023), WHR ( < 0.001), WHtR ( = 0.035), CRF ( = 0.050), and leptin ( = 0.026). Adolescents were classified as 82.4% responders for %Fat, 70.6% for WC, 88.2% for WHR, and 70.6% for CRF. Further, there was an association between changes in %Fat ( = 0.033), WC ( = 0.032), and WHR ( = 0.033) between responders and non-responders with CRF in the IG. There was a positive effect on body composition, physical fitness, and leptin. In addition, reductions in body composition parameters were explained by CRF improvements.
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http://dx.doi.org/10.3390/ijerph18147267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305247PMC
July 2021

Excess adiposity and low physical fitness hamper Supine-to-Stand test performance among sedentary adolescents.

J Pediatr (Rio J) 2021 Mar 11. Epub 2021 Mar 11.

Universidade Federal do Paraná, Departamento de Educação Física, Curitiba, PR, Brazil; Universidade do Porto, Faculdade de Desporto, Porto, Portugal. Electronic address:

Objective: The aim of this study was to analyze the relationship between body adiposity and physical fitness with performance in the Supine-to-Stand test (STS-test) in sedentary adolescents.

Methods: Sixty-two adolescents, of both sexes, between 10 and 16 years old, participated in the study. Body mass (BM), height, waist circumference (WC), fat mass (FM), fat-free mass (FFM), right and left handgrip strength (HGS-right, HGS-left), abdominal resistance (ABDO), flexibility (FLEX), and cardiorespiratory fitness (VO) were measured. Body mass index (BMI), z-score BMI (BMI-z), tri-ponderal mass index (TMI) and waist-to-height ratio (WHtR) were calculated. The STS-test was applied to evaluate the STS-MC by the movement patterns in the execution of the test. The STS-time in seconds (s) was categorized into terciles: fast (FG < 2.0 s), intermediate (IG = 2.0-2.6 s) and slow (SG > 2.6 s). One-way ANOVA, Chi-square, Spearman's correlation coefficient as well as non-parametric tests were used, with significance p ≤ 0.05.

Results: The SG presented higher BMI, BMI-z, TMI, WHtR, FM, %FM, as well as lower averages for %FFM, HGS-right, HGS-left, FLEX, ABDO, VO, VO relative to BM (VO) in relation to GF. The BMI, BMI-z, TMI, WC, WHtR and FM showed moderate and direct correlations with STS-time and inverse with STS-MC (p < 0.01). HGS-right, HGS-left, ABDO, and VO showed moderate and an inverse correlation with STS-time (p < 0.05). The VO was moderate and with direct correlations to STS-MC (p < 0.01).

Conclusion: It is concluded that excess fat and low physical fitness hamper STS-test performance. Therefore, the STS-test can be used for screening students to assess MC.
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http://dx.doi.org/10.1016/j.jped.2021.01.007DOI Listing
March 2021

Predicting Cardiorespiratory Fitness Using the 20-m Shuttle Run Test: New Insights Using Nonlinear Allometry.

Med Sci Sports Exerc 2021 08;53(8):1624-1629

Department of Physical Education, Federal University of Paraná, Curitiba, BRAZIL.

Purpose: Recently, doubts have been raised concerning the validity of the 20-m shuttle run test (20mSRT) to predict cardiorespiratory fitness (CRF) in youth. Despite these doubts, authors continue to provide powerful evidence that CRF can be predicted reliably using the 20mSRT albeit using contrasting models. Therefore, we aimed to compare a new linear model with an alternative allometric model to predict CRF (peak oxygen uptake, V˙O2peak) using the 20mSRT.

Methods: The study included 148 adolescents (43% girls) age 13.37 ± 1.84 yr. Adolescents were randomly assigned to validation (n = 91) and cross-validation (n = 57) groups. V˙O2peak was measured using a gas analyzer in both maximal exercise tests in the laboratory and the 20mSRT. Multiple linear regression methods were applied to develop the linear models using the 20mSRT (laps), body mass index, and body fat percentage. Alternative allometric models were also proposed/fitted using the 20mSRT (laps), height, and body mass.

Results: The criterion validity values of both the linear and the allomeric models were found to be acceptable, with R2 = 82.5% and 82.7% respectively, providing reassuring evidence that the 20mSRT can be used with confidence to predict CRF. However, the allometric model identified a height-to-mass ratio, not dissimilar to the inverse body mass index (known to be a measure of leanness), to be associated with CRF. The allometric model also revealed that the rise in energy cost (V˙O2peak) with increasing laps was exponential. This will more accurately reflect the nonlinear rise in energy demand of shuttle running as the test progresses to exhaustion.

Conclusions: These observations provided powerful evidence that allometric models are more than satisfactory in terms of both criterion and construct validity when predicting CRF (V˙O2peak) using the 20mSRT.
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http://dx.doi.org/10.1249/MSS.0000000000002637DOI Listing
August 2021

Altered metabolomic profiling of overweight and obese adolescents after combined training is associated with reduced insulin resistance.

Sci Rep 2020 10 9;10(1):16880. Epub 2020 Oct 9.

Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas (UNICAMP), Av. ÉricoVeríssimo, 701, Campinas, São Paulo, Brazil.

Exercise training and a healthy diet are the main non-pharmacological strategies for treating chronic conditions, such as obesity and insulin resistance (IR), in adolescents. However, the isolated metabolic changes caused by exercise training without dietary intervention have not yet been established. We investigated how combined training (CT) without dietary intervention altered the concentrations of serum metabolites, biochemical, anthropometric and functional parameters in overweight and obese adolescents. Thirty-seven adolescents (14.6 ± 1.05 years), of both sexes, were randomly assigned to the control group (CG, n = 19) or the training group (TG, n = 18). The CT was composed by resistance training and aerobic training performed in the same session (~ 60 min), three times a week, for 12 weeks. All assessments were performed pre and post-intervention. Metabolomics analyses were conducted using nuclear magnetic resonance spectroscopy (H NMR) in a 600 MHz spectrometer. There was a decrease in body weight (BW), body mass index (BMI), waist circumference (WC), % body fat (%BF), fasting glucose, insulin levels, and insulin resistance (IR), by HOMA-IR, in the TG. An increase in fat-free mass (FFM) was also observed in the CG. The metabolic changes were given mainly by changes in the levels of metabolites 2-oxoisocaproate (↓TG), 3-hydroxyisobutyrate (↑CG and ↓TG), glucose (↓TG), glutamine (↓CG and ↑TG) and pyruvate (↓TG). These findings demonstrate the positive effects of CT program without dietary intervention on metabolomic profile, body composition, biochemical markers, and glucose metabolism in overweight and obese adolescents.
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http://dx.doi.org/10.1038/s41598-020-73943-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547065PMC
October 2020

Hypertensive Measures In Schoolchildren: Risk Of Central Obesity And Protective Effect Of Moderate-To-Vigorous Physical Activity.

Arq Bras Cardiol 2020 07 7;115(1):42-49. Epub 2020 Aug 7.

Universidade Federal do Paraná, Curitiba, PR, Brasil.

Background The proportion of arterial hypertension (AH) has increased in children and adolescents and is associated with several comorbidities. Objective To verify the association of arterial hypertension with central and general obesity as well as according to the level of physical activity in schoolchildren. Methods 336 children and adolescents aged 11 to 17 participated in the study. Height, body weight, waist circumference (WC) and blood pressure (BP) were measured. The body mass index z-score (BMI-z) was calculated. The level of physical activity was assessed by the short form of the International Physical Activity Questionnaire (IPAQ) according to the practice of moderate-to-vigorous physical activities (AF-mv). Students with systolic (SBP) and/or diastolic blood pressure (DBP) higher than the 95thpercentile according to sex, age and height or ≥120/80 were considered hypertensive. Statistical tests of t-Student, Chi-square, Mann-Whitney and binary logistic regression model were used, considering the significance level of p<0.05. Results It was found that 40.5% of the students had AH, 35.11% were overweight (12.5% obese), 13.39% had high WC and 40.2% were considered insufficiently active in AF-mv. The chances of AH were related to high WC (OR = 6.11; 95% CI: 2.59¬-14.42) and overweight (OR = 2.91; 95% CI: 1.76-4.79). In addition, adolescents who practiced AF-mv had a lower risk of high DBP (OR = 0.33; 95% CI: 0.15-0.72). Conclusion Central obesity was the best predictor of AH in children and adolescents, as well as general obesity and males. The practice of AF-mv demonstrated a protective effect on high DBP in schoolchildren. (Arq Bras Cardiol. 2020; 115(1):42-49).
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http://dx.doi.org/10.36660/abc.20180391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384320PMC
July 2020

Validation of equations to estimate the peak oxygen uptake in adolescents from 20 metres shuttle run test.

J Sports Sci 2020 Nov 25;38(22):2588-2596. Epub 2020 Jul 25.

Department of Physical Education, Federal University of Paraná , Curitiba, Brazil.

This study aimed to develop new prediction models from directly determined peak of oxygen uptake (VO) in adolescents using 20-metre shuttle run test (20 m-SR) and to compare the new models with previously published equations. This study included 148 adolescents (43% girls), aged 13.37 ± 1.84 years old. Adolescents were randomly assigned to validation (n = 91) and cross-validation (n = 57) groups. VO was measured using a gas analyser in both maximal exercise tests in the laboratory as well as by 20 m-SR. The multiple linear regression method was applied to develop the models using BMI, BMI-z score and body fat percentage (%FM). The proposed models presented better predictive performance (R2 = 75.6% to 78.9%) and a lower absolute percentage error (%error = 10.51 to 11.78%) than the previously published equations (R2 = 38.8% to 69.1%; %error = 13.13% to 21.54%). The Model with BMI-z was the best fit equation in girls, and the model with BMI-z and %FM in boys. Therefore, it is recommended that the equations developed in the present study be used in future research and projects in the school environment to estimate VO in adolescents by the 20 m-SR test.
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http://dx.doi.org/10.1080/02640414.2020.1794255DOI Listing
November 2020

Different amounts of moderate to vigorous physical activity and change in glycemic variability in adolescents with type 1 diabetes: is there dose-response relationship?

Arch Endocrinol Metab 2020 May-Jun;64(3):312-318

Programa de Pós-Graduação Interdisciplinar em Desenvolvimento Comunitário. Departamento de Educação Física, Universidade Estadual do Centro-Oeste (Unicentro), Irati, PR, Brasil.

Objective: To identify the level of physical activity and glycemic variability of adolescents with type 1 diabetes mellitus and to compare glycemic variability on days with different amounts of moderate to vigorous physical activity (MVPA).

Subjects And Methods: A sample of 34 subjects aged 10 to 15 years, 18 (52.94%) female; age: 13.04 ± 1.94; HbA1c: 9.76 ± 1.51. Physical activity was measured by wGT3X accelerometer. The glucose data were obtained using continuous glucose monitoring, and the following glycemic variability measures were calculated: standard deviation (SD), low blood glucose index (LBGI), high blood glucose index (HBGI), mean amplitude of glycemic excursions (MAGE), glycemic risk assessment in diabetes equation (GRADE) and coefficient of variation (CV). The most and least active days (the days with greater and lesser time dedicated to physical activities of moderate to vigorous intensity, respectively) were identified. In addition, based on the whole period of accelerometer use, daily means of time spent in MVPA were identified among participants, who were then divided into three groups: up to 100 minutes; from 101 to 200 minutes and above 201 minutes. Then, the measures of glycemic variability were compared among the most and least active days and among the groups too.

Results: The amount of MVPA was significantly different between the days evaluated (237.49 ± 93.29 vs. 125.21 ± 58.10 minutes), but glycemic variability measures did not present a significant difference.

Conclusion: Despite the significant differences in the amount of MVPA between the two days evaluated, the glycemic variability did not change significantly. Arch Endocrinol Metab. 2020;64(3):312-8.
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http://dx.doi.org/10.20945/2359-3997000000254DOI Listing
June 2020

Validity and accuracy of body fat prediction equations using anthropometrics measurements in adolescents.

Eat Weight Disord 2021 Apr 19;26(3):879-886. Epub 2020 May 19.

Department of Physical Education, Federal University of Paraná, Curitiba, PR, Brazil.

Background: The pediatric relative fat mass (RFM) has been recently presented and validated as an index for estimating percentage body fat (%BF) in North American children and adolescents. Similar to body mass index (BMI) and tri-ponderal mass index (TMI), RFM uses anthropometric measures (i.e., weight, height and waist circumference) to estimate body composition. The primary purpose of this study was to validate the newly developed RFM equation for %BF prediction in Southern Brazilian adolescents; as secondary objective, we compared %BF estimation from BMI- and TMI-derived equations.

Methods: A total of 631 individuals (434 boys) aged 11 to 18 were analyzed. Bland-Altman analyses were used to determine concordance between predicted equations and %BF measured by DXA; results are presented using mean difference (i.e., bias) and standard deviation. Sensitivity and specificity were calculated for %BF percentile classifications.

Results: RFM underestimated %BF in 65.2% of boys (- 4.3 ± 2.8%) and 84.8% of girls (- 5.3 ± 2.7%). In contrast, TMI overestimated %BF in 62.9% of boys (4.0 ± 2.9%) and 56.3% (3.5 ± 3.0%) of girls. The performance of BMI showed mixed results; %BF was overestimated in 68.4% of boys (5.0 ± 4.0%) and underestimated in 67.5% of girls (- 3.9 ± 2.6%), all p < 0.001. Although, RFM had the highest specificity for %BF percentile classifications, sensitivity was low and inferior to BMI and TMI.

Conclusion: TMI was superior to RFM and BMI in predicting %BF in Southern Brazilian adolescents. Using RFM, BMI or TMI equations for %BF prediction without a population-specific correction factor may lead to incorrect interpretations. We suggest that correction factors should be investigated to improve the accuracy of these surrogate indices for body composition assessment.

Level Of Evidence: Level V, cross sectional descriptive study.
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http://dx.doi.org/10.1007/s40519-020-00918-3DOI Listing
April 2021

Scaling left ventricular mass in adolescent female soccer players.

BMC Pediatr 2020 04 13;20(1):157. Epub 2020 Apr 13.

Department of Kinesiology and Health Education, University of Texas, Austin, USA.

Background: The aim of the study was to examine the contribution of chronological age (CA), skeletal maturation, training experience and concurrent body size descriptors, to inter-individual variance in left ventricular mass (LVM) among female adolescent soccer players.

Methods: The sample included 228 female soccer players 11.8-17.1 years. Training experience defined as years of participation in competitive soccer (range 2-9 years), was obtained by interview. Stature, body mass and skinfolds (triceps, medial calf) were measured. Fat mass was estimated; Fat-free mass was derived. LVM was assessed by echocardiography. Skeletal maturity status was as the difference of skeletal age (SA, Fels method) minus CA.

Results: Fat-free mass was the most prominent single predictor of LVM (R = 36.6%). It was associated with an allometric coefficient close to linearity (k = 0.924, 95%CI: 0.737 to 1.112). A significant multiplicative allometric model including body mass, fat-free mass, CA, training experience and skeletal maturity status was also obtained (R = 0.684; R = 46.2%).

Conclusion: Stature has limitations as a valid size descriptor of LVM. Body mass, fat-free mass, training experience, CA, body mass and skeletal maturity status were relevant factors contributing to inter-individual variability in LVM.
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http://dx.doi.org/10.1186/s12887-020-02043-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153237PMC
April 2020

Effect of combined interval training on the cardiorespiratory fitness in heart failure patients: a systematic review and meta-analysis.

Braz J Phys Ther 2020 Jan - Feb;24(1):8-19. Epub 2019 Apr 20.

Physical Education Department, Research Nucleus of Quality of Life, Universidade Federal Paraná (UFPR), Curitiba, PR, Brazil; Ciafel, Porto University, Porto, Portugal.

Background: The combination of interval training and resistance training has showed interesting results in chronic heart failure patients, corroborating the benefits of physiological adaptations of both protocols.

Objective: To evaluate the effect of the combination of interval training and resistance training program when compared to interval training alone and/or without intervention group on cardiorespiratory fitness in patients with chronic heart failure.

Methods: We search MEDLINE via PubMed, ScienceDirect, Sportdiscus, BIREME and Scielo, from their inception to December 2018. Were included both randomized and non-randomized controlled trials comparing the effect of combined training, interval training alone and/or WI group on VO (expressed in ml/kg/min), in people with chronic heart failure patients. The meta-analysis was conducted via Review Manager v 5.3 software, using random effect model.

Results: Ten articles were selected (nine randomized controlled trial), involving 401 participants. Six studies compared combined training with interval training and six studies compared combined training with the without intervention group. Eighty percent of the trials presented moderate risk of bias and twenty percent low risk of bias. Data showed significant difference and major increase in VO in favor to combined training group compared to interval training group (SMD=0.25; CI=0.04-0.46) and without intervention group (SMD=0.46; CI=0.29-0.64), respectively.

Conclusion: The combination of interval training and resistance training showed more effective in increasing cardiorespiratory fitness in patients with heart failure than interval training alone and non-exercise therapy. However, further studies should be conducted to increase the understanding of this combined training method.
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http://dx.doi.org/10.1016/j.bjpt.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994317PMC
April 2020

PREDICTIVE EQUATIONS OF MAXIMUM OXYGEN CONSUMPTION BY SHUTTLE RUN TEST IN CHILDREN AND ADOLESCENTS: A SYSTEMATIC REVIEW.

Rev Paul Pediatr 2019 Apr-Jun;37(2):241-251. Epub 2019 Mar 18.

Universidade Federal do Paraná, Curitiba, PR, Brazil.

Objective: To systematically review the literature as for the level of evidence of predictive equations of VO2peak through the 20-meter shuttle run test (20m-SRT) in children and adolescents.

Data Sources: Searches were conducted independently by two researchers, according to the procedures adopted by PRISMA, in the electronic databases MEDLINE via PubMed, ScienceDirect, Web of Science, LILACS and SciELO, for articles published until September 2017 in English and Portuguese. The inclusion criteria were: original studies, abstract available, using predictive equations of VO2peak through 20m-SRT, conducted with adolescents and/or children, non-athletes, and mentioning correlation analysis between predicted and measured VO2peak. The level of evidence of equations was based on the risk of bias of the studies using the following criteria: sample number, sample characteristics, and statistical analysis.

Data Synthesis: Eighteen studies were selected, in which fifteen equations were found and analyzed. The studies had been conducted with samples composed of subjects of both sexes, aged 8 to 19 years. Equations of Léger and Matsuzaka had their level of evidence classified as high, and estimation ranged between r=0.54-0.90 and r=0.65-0.90. Equations by Ruiz, Barnett and Matsuzaka had their level of evidence classified as moderate, and estimation ranged between r=0.75-0.96, r=0.66-0.84 and r=0.66-0.89, respectively.

Conclusions: Matsuzaka's equation presented satisfactory parameters for estimates of VO2peak in children and adolescents. Although not explored in equations, body adiposity and pubertal stage are significantly associated with cardiorespiratory fitness in children and adolescents.
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http://dx.doi.org/10.1590/1984-0462/;2019;37;2;00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651308PMC
January 2020

Adiposity and adipocytokines: the moderator role of cardiorespiratory fitness and pubertal stage in girls.

J Pediatr Endocrinol Metab 2019 Mar;32(3):239-246

Project Sport Brazil (PROESP-Br), Post Graduation Program in Human Movement Sciences, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Background Cardiorespiratory fitness (CRF) and pubertal stages have been related to many health outcomes, including obesity and adipocytokines. Thus, the present study aimed to analyze the moderator role of CRF and pubertal stage in the relationship between adiposity and adipocytokines in girls. Method This cross-sectional study was performed with 42 pre-pubertal girls aged from 7 to 11 years and 54 post-pubertal girls aged from 13 to 17 years. Blood samples were collected to determine the serum levels of leptin and adiponectin, and then the leptin/adiponectin ratio (L/A ratio) was calculated. CRF, anthropometric and body composition indicators were assessed. For statistical analysis, descriptive statistics and several linear regression models were used. The moderation analysis was tested using the PROCESS macro. Results An interaction between body mass index (BMI) and CRF (β: -0.70; confidence interval [CI]: -1.29, -0.12), as well as between BMI and pubertal stage (β: 0.79; CI: 0.28, 1.30) with leptin, was found. Regarding the L/A ratio, an interaction was found only in BMI × CRF (β: -0.56; CI: -1.06, -0.06). Using a combined interaction (CRF and pubertal stage), the results showed a positive association between BMI with leptin and L/A ratio only in low CRF, pre-pubertal and post-pubertal stages. Conclusion This study suggests a protective role of high levels of CRF in the relationship between BMI and adipocytokines. Despite the effect of pubertal stage, the results suggest that youth should be engaged in physical activity in order to improve CRF levels and consequently improve cardiometabolic health.
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http://dx.doi.org/10.1515/jpem-2018-0407DOI Listing
March 2019

12-Week aerobic exercise and nutritional program minimized the presence of the 64Arg allele on insulin resistance.

J Pediatr Endocrinol Metab 2018 Sep;31(9):1033-1042

Physical Education Department, Federal University of Paraná, Curitiba, Brazil.

Background: The objective of the study was to investigate the response of 64Arg allele carriers of the ADRB3 gene (Trp64Arg polymorphism) in the anthropometric, cardiorespiratory and metabolic variables in overweight adolescents after a 12-week aerobic exercise and nutritional program.

Methods: A total of 92 overweight adolescents, 10-16 years old and of both genders, participated. Body composition, waist circumference (WC), pubertal stage status, blood pressure, glucose, insulin and lipid profile and direct maximal oxygen uptake were assessed at baseline and after 12 weeks of a training program. The homeostasis metabolic assessments [homeostasis model assessment of insulin resistance (HOMA-IR)] and quantitative insulin sensitivity check index (QUICKI) were determined and the Trp64Arg polymorphism of the ADRB3 gene was investigated by Taqman single nucleotide polymorphism (SNP) genotyping assays. Exercise sessions consisted of 100-min aerobic exercise and 20-min stretching, 3 times a week, totalizing 36 sessions. Multivariate analysis of variance (MANOVA), analysis of covariance (ANCOVA) and effect size were used for variables, with p<0.05 considered significant.

Results: In baseline, HOMA-IR was higher in carriers of the 64Arg allele and decreased more after 12 weeks than in non-carriers (p=0.01). The anthropometric, physical fitness and metabolic profiles had similar responses after training in carriers and non-carriers.

Conclusions: Overweight adolescents present changes in body composition and physical fitness, independent of Trp64Arg genotypes. However, a 12-week aerobic exercise and nutritional program promoted greater reductions in insulin resistance in carriers of the 64Arg allele.
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http://dx.doi.org/10.1515/jpem-2018-0066DOI Listing
September 2018

Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents.

Genet Mol Biol 2018 Oct-Dec;41(4):735-741. Epub 2018 Nov 23.

Laboratório de Polimorfismos e Ligação, Departamento de Genética, Universidade Federal do Paraná (UFPR) Curitiba, PR, Brazil.

Genes can influence lipid profile and anthropometric variables related to obesity. The present study aimed to verify if variants of the APOE, APOB, ADIPOQ, HSD11β1, and PLIN4 genes are associated with lipid levels or anthropometric variables in a sample comprised of 393 Euro-Brazilian children and adolescents. DNA was genotyped by TaqMan allelic discrimination assay. The ε4 and ε2 alleles of the APOE gene were associated respectively with lower high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels (p=0.015 and p=0.012, respectively), while the ε3 allele was associated with higher abdominal circumference (p=0.0416) and excess weight (p=0.0001). The G allele (rs846910) of the HSD11β1 gene was also associated with excess weight (p=0.039). No other association was found. Our results indicate that the ε4 and ε2 alleles could contribute to lower HDL-C and LDL-C levels, respectively, furthermore, the ε3 allele and the G allele (rs846910) of HSD11β1 gene may be risk factors for excess of weight.These findings are very important because we observed that some genetic variants influence the lipid profile and anthropometric variables early in life.
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http://dx.doi.org/10.1590/1678-4685-GMB-2017-0195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415595PMC
November 2018

Association between Toll-like receptors (TLR) and NOD-like receptor (NLR) polymorphisms and lipid and glucose metabolism.

Gene 2019 Feb 24;685:211-221. Epub 2018 Nov 24.

Department of Genetics, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, Paraná, Brazil.

Recent evidences had shown activation of TLR (toll-like receptors) and NLR (nod-like receptors) in response to imbalance in nutrients intake, such as lipid and glucose. The main aim of this study was to investigate possible associations between 11 SNPs in TLR2, TLR4, NLRC4, CARD8 and NEK7 genes and lipid and glucose metabolism. Sample was composed by healthy children and adolescents (n = 158) and adults (n = 115). DNA extraction was obtained by salting-out and sample genotyping by matrix-assisted laser desorption ionization time-of-flight mass spectrometry based system. LDL-cholesterol, HDL-cholesterol, triglycerides, total cholesterol, glucose and insulin were measured by standard automated methods. Means were compared by t-test or Mann-Whitney test. Univariate and multivariate logistic regression were used to verify association between polymorphisms and lipid and glucose markers. Seven polymorphisms in 5 genes were associated with lipid and glucose parameters. For lipid parameters, the following associations were found: higher LDL-C levels and C allele of rs1554973 (TLR4) and G allele of rs6671879 (NEK7); higher HDL-cholesterol levels and A allele of rs13105517 (TLR2); higher total cholesterol and TT genotype of rs3804099 (TLR2) and G allele of rs6671879 (NEK7); higher triglycerides levels and G allele of rs455060 (NLRC4). For glucose parameters associations were found between C allele of rs7258674 (CARD8) and higher glucose levels, and between C allele of rs212704 (NLRC4) and G allele of rs455060 (NLRC4) and insulin levels. These findings indicate a relationship between polymorphisms of TLRs and NLRs genes and markers of lipid and glucose metabolism.
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http://dx.doi.org/10.1016/j.gene.2018.11.065DOI Listing
February 2019

rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents.

J Obes 2018 26;2018:3134026. Epub 2018 Apr 26.

Department of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, Brazil.

Purpose: The rs9939609 SNP (T > A) in gene is associated with obesity and type 2 diabetes. The present study aimed at verifying whether this SNP influenced biochemical outcomes of children and adolescents who are overweight/obese submitted to a program of physical exercise and also if there was influence on basal levels of these biochemical variables.

Methods: The sample was composed by 432 children and adolescents grouped in three ways (obese, overweight, and normal weight); of these, 135 children and adoloescents who are obese and overweight were submitted to a physical exercise program for 12 weeks. All were genotyped by TaqMan SNP genotyping assay.

Results: The children and adolescents who are overweight/obese and carriers of AA genotype had higher levels of insulin (=0.03) and HOMA (=0.007) and lower levels of glucose (=0.003), but the SNP did not modulate the response to physical exercise.

Conclusions: In our study, the rs9939609 AA genotype was associated with parameters related to insulin metabolism but did not interact with physical exercise.
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http://dx.doi.org/10.1155/2018/3134026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944237PMC
September 2019

FTO rs9939609 A allele influences anthropometric outcome in response to dietary intervention, but not in response to physical exercise program.

Eur J Nutr 2019 Feb 13;58(1):325-334. Epub 2017 Dec 13.

Department of Genetics, Polymorphism and Linkage Laboratory, Federal University of Paraná, Curitiba, Brazil.

Purpose: The fat mass and obesity-associated (FTO) gene is involved in energy homeostasis. The A allele of the rs9939609 (SNP; T>A) is associated with obesity and higher food intake, while its effect in energy expenditure remains unclear. The aim of this study is to examine whether FTO rs9939609 is associated with the anthropometric outcomes of a physical exercise program and a dietary intervention.

Methods: We studied two independent samples. The first was composed by children and adolescents in which overweight and obese individuals were submitted to a physical exercise program (n = 136) and normal weight participants served as a control group (n = 172). The second sample was composed by obese women submitted to a hypocaloric dietary intervention (n = 126).

Results: Physical exercise and dietary intervention were effective, independently of genotype. We found no association of FTO rs9939609 with obesity in children and adolescents (p = 0.67). The rs9939609 affected the response to dietary intervention in obese women: A allele carriers reduced 2.7 cm less of abdominal circumference (AC) than homozygous TT (p = 0.04), while no effect was observed in response to physical exercise in overweight and obese children and adolescents.

Conclusions: The A allele is associated with a worse outcome in response to the hypocaloric dietary intervention regarding abdominal circumference reduction; the same allele did not show interaction with any anthropometric outcomes in response to the exercise program applied.
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http://dx.doi.org/10.1007/s00394-017-1596-7DOI Listing
February 2019

Trp64Arg polymorphism of the ADRB3 gene associated with maximal fat oxidation and LDL-C levels in non-obese adolescents.

J Pediatr (Rio J) 2018 Jul - Aug;94(4):425-431. Epub 2017 Sep 21.

Universidade Federal do Paraná (UFPR), Departamento de Educação Física, Curitiba, PR, Brazil.

Objective: To analyze the association between the Trp64Arg polymorphism of the ADRB3 gene, maximal fat oxidation rates and the lipid profile levels in non-obese adolescents.

Methods: 72 schoolchildren, of both genders, aged between 11 and 17 years, participated in the study. The anthropometric and body composition variables, in addition to total cholesterol, HDL-c, LDL-c, triglycerides, insulin, and basal glycemia, were evaluated. The sample was divided into two groups according to the presence or absence of the polymorphism: non-carriers of the Arg64 allele, i.e., homozygous (Trp64Trp: n=54), and carriers of the Arg64 allele (Trp64Arg+Arg64Arg: n=18), in which the frequency of the Arg64 allele was 15.2%. The maximal oxygen uptake and peak of oxygen uptake during exercise were obtained through the symptom-limited, submaximal treadmill test. Maximal fat oxidation was determined according to the ventilatory ratio proposed in Lusk's table.

Results: Adolescents carrying the less frequent allele (Trp64Arg and Arg64Arg) had higher LDL-c levels (p=0.031) and lower maximal fat oxidation rates (p=0.038) when compared with non-carriers (Trp64Trp).

Conclusions: Although the physiological processes related to lipolysis and lipid metabolism are complex, the presence of the Arg 64 allele was associated with lower rates of FATMAX during aerobic exercise, as well as with higher levels of LDL-c in adolescents.
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http://dx.doi.org/10.1016/j.jped.2017.07.010DOI Listing
September 2018

Sleep deprivation and drowsiness of medical residents and medical students.

Rev Col Bras Cir 2016 Dec;43(6):438-444

Quality of Life Center, Federal University of Paraná, Curitiba, Paraná, Brazil.

Objective: to evaluate sleep quality and daytime sleepiness of residents and medical students.

Methods: we applied a socio-demographic questionnaire, the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) to a population of residents and medical students.

Results: hundred five residents and 101 undergraduate medical students participated. Residents presented higher mean PSQI (6.76±2.81) with poorer sleep quality when compared with undergraduates (5.90±2.39); Both had similar measures of sleepiness by ESS (p=0.280), but residents showed lower duration and lower subjective sleep quality.

Conclusion: medical students and residents presented sleep deprivation, indicating the need for preventive actions in the medical area.
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http://dx.doi.org/10.1590/0100-69912016006005DOI Listing
December 2016

Physical Activity Levels of Adolescents with Type 1 Diabetes Physical Activity in T1D.

Pediatr Exerc Sci 2017 05 4;29(2):213-219. Epub 2017 Jan 4.

1 Federal University of Paraná.

The aim of this study was to evaluate the level of physical activity and cardiorespiratory fitness in teenagers with type 1 diabetes mellitus (T1D) in comparison with healthy scholar participants. Total of 154 teenagers (T1D = 45 and CON = 109). Height, weight, cardiorespiratory fitness (VO), and the level of physical activity by the Bouchard's Physical Activity Record were measured, and glycated hemoglobin (HbA1c) in T1D. The VO was lower in the T1D (38.38 ± 7.54) in comparison with the CON (42.44 ± 4.65; p < .05). The VO had correlation with the amount of time of moderate-to-vigorous physical activity (r = .63; p = .0001) and an inverse correlation with sedentary activities (r= -0.46; p = .006). In the T1D the levels of HbA1c had an inverse correlation with the amount of time of moderate-to-vigorous physical activity (r= -0.34; p = .041) and correlation with the BMI z-score (r = .43; p = .017). Only 37,8% of the participants in the T1D reached the adequate amount of daily moderate-to-vigorous intensity physical activity, in the CON 81,7% reached the WHO's recommendation.

Conclusion: T1D had less cardiorespiratory capacity then healthy controls, the teenagers of T1D with lower BMI z-score and that dedicated a greater time in moderate-to-vigorous intensity physical activity demonstrated a better glycemic control.
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http://dx.doi.org/10.1123/pes.2016-0199DOI Listing
May 2017

Effects of aquatic exercise on muscle strength and functional performance of individuals with osteoarthritis: a systematic review.

Rev Bras Reumatol Engl Ed 2016 Nov - Dec;56(6):530-542. Epub 2016 Oct 4.

Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil.

Water-based exercises are recommended for people with osteoarthritis (OA), due to the beneficial effects on physical function, quality of life and symptom reduction. However, the effects on muscle strength are still controversial. The aim of this review was to assess and compare the effects of aquatic exercise programs on muscle strength and physical function in people with OA. A systematic search was performed at Pubmed, Scopus and Web of Science databases. Clinical trials with interventions involving aquatic exercises for individuals with OA were included. The methodological quality of the studies was evaluated using the PEDro scale. 296 studies were found and twelve were selected: six studies comparing water-based exercises with land-based exercise, and six comparing water-based exercise groups with the control group. Exercise programs included muscle strengthening, aerobic, balance, flexibility and stretching exercises. Duration of the program, weekly frequency, intensity and progression varied between studies. Beneficial effects of aquatic exercise were found on physical function. However, only two of five studies that assessed muscle strength observed positive effect of aquatic exercise. Although it is difficult to compare studies and establish guidelines for the standardized protocol formulation, it was observed that water-based exercises can be effective on improving physical function and increasing muscle strength, since they are well-structured, with exercise intensity and overload controlled.
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http://dx.doi.org/10.1016/j.rbre.2016.09.003DOI Listing
October 2018

Effects of 12 weeks of combined training without caloric restriction on inflammatory markers in overweight girls.

J Sports Sci 2016 Oct 6;34(20):1902-12. Epub 2016 Feb 6.

c Faculty of Physical Education , State University of Campinas , Campinas , Brazil.

The objective of the present study was to investigate the effects of combined training without caloric restriction on inflammatory markers in overweight girls. Thirty-three girls (13-17 years) were assigned into overweight training (n = 17) or overweight control (n = 16) groups. Additionally, a normal-weight group (n = 15) was used as control for the baseline values. The combined training programme consisted of six resistance exercises (three sets of 6-10 repetitions at 60-70% 1 RM) followed by 30 min of aerobic exercise (walking/running) at 50-80% VO2peak, performed in the same 60 min session, 3 days/weeks, for 12 weeks. Body composition, dietary intake, aerobic fitness (VO2peak), muscular strength (1 RM), glycaemia, insulinemia, lipid profile and inflammatory markers (C-reactive protein, interleukin-6, tumour necrosis factor-alpha, interleukin-10, leptin, resistin and adiponectin) were measured before and after intervention. There was a significant decrease in body fat (P < 0.01) and increase in fat-free mass (P < 0.01), VO2peak (P < 0.01), 1 RM for leg press (P < 0.01) and bench press (P < 0.01) in the overweight training group. Concomitantly, this group presented significant decreases in serum concentrations of C-reactive protein (P < 0.05) and leptin (P < 0.05), as well as in insulin resistance (P < 0.05) after the experimental period. In conclusion, 12 weeks of combined training without caloric restriction reduced inflammatory markers associated with obesity in overweight girls.
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http://dx.doi.org/10.1080/02640414.2016.1142107DOI Listing
October 2016

[Influence of polymorphisms of the beta-2 adrenergic receptor on the presence of exercise-induced bronchospasm in adolescents].

Rev Paul Pediatr 2016 Jan-Mar;34(1):24-9. Epub 2015 Oct 9.

Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil.

Objective: To determine the influence of polymorphisms of the beta-2 adrenergic receptor (ADRB2) in triggering exercise-induced bronchospasm (EIB) in adolescents.

Methods: The subjects were divided into two groups: present EIB (EIB+) (n=45) and absent EIB (EIB-) (n=115). The bronchial provocation test with exercise was performed with a protocol that consisted of walking/running for at least eight minutes at high intensity, i.e., >85% of maximum heart rate, considering EIB+ as a 10% decrease in forced expiratory volume in one second (FEV1). The genotyping of the ADRB2 gene was performed by the Taqman method, using the Step One Plus system. Independent t-test, Mann-Whitney and Chi-square tests, as well as Spearman's correlation coefficient were used for the statistical analysis.

Results: Age, body weight, height, FEV1, FVC and FEV1/FVC ratio were lower in the EIB+ group when compared to EIB- (p<0.05). There were no significant differences in the proportion of the allele at position 27 and Arg16Gly and Gln27Glu genotypes between the EIB+ and EIB- groups (p=0.26; p=0.97 and p=0.43, respectively). However, there was a trend towards statistical significance regarding the greater proportion of the Gly16 allele for the EIB+ when compared to the EIB- group (p=0.08).

Conclusions: The presence of polymorphisms associated with the Glu27 allele and Arg16Gly and Gln27Glu genotypes had no influence on EIB. However, the statistical trend towards greater frequency of the Gly16 allele in individuals with EIB+ can be considered evidence of the influence of polymorphisms of the ADBR2 gene on EIB in adolescents.
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http://dx.doi.org/10.1016/j.rpped.2015.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795718PMC
May 2018

Association between adiposity indicators, metabolic parameters and inflammatory markers in a sample of female adolescents.

Arch Endocrinol Metab 2015 Aug;59(4):325-34

Universidade Federal do Paraná, Curitiba, PR, BR.

Objective: The aim of this study was to investigate the association between total and abdominal adiposity with metabolic parameters and inflammatory markers, in female adolescents.

Subjects And Methods: The sample consisted of 53 adolescents aged 13 to 17 years from a public school in Curitiba, Brazil. The adiposity indicators studied were body mass index (BMI), waist circumference (WC), trunk fat mass (TKFM), total fat mass (TFM) and body fat percentage (BF%) measured by dual-energy X-ray absorptiometry. The metabolic and inflammatory parameters studied were systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, insulin, homeostasis model assessment index for insulin resistance (HOMA-IR), lipids, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), leptin, adiponectin and resistin.

Results: Eighty percent of WC variation, 87% of TKFM and TFM, and 73% of BF% were predicted by BMI variation. There was a significant positive correlation between all indicators of adiposity with SBP, DBP, insulin, HOMA-IR, CRP and leptin. Triglycerides were positively correlated with BMI and WC, and adiponectin correlated negatively with BMI. TNF-α, IL-6, glucose, total cholesterol, and high- and low-density lipoprotein cholesterol did not correlate to the studied variables.

Conclusion: BMI showed a significant association with most of the parameters studied, and WC was slightly better than BMI to predict insulin resistance in this specific population.
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http://dx.doi.org/10.1590/2359-3997000000070DOI Listing
August 2015

ADIPOQ single nucleotide polymorphism: Association with adiponectin and lipoproteins levels restricted to men.

Meta Gene 2015 Sep 17;5:98-104. Epub 2015 Jun 17.

Polymorphism and Linkage Laboratory, Department of Genetics, Federal University of Paraná, Brazil.

Adiponectin is an adipokine inversely correlated with obesity, which has beneficial effect on insulin resistance and lipid metabolism. Considering its potential as a therapeutic target in the metabolic disorder contexts, and in order to add knowledge in the area, our study evaluated the ADIPOQ 276G > T polymorphism effect on adiponectin levels, and on lipoproteins of clinical interest in a population sample composed of 211 healthy individuals. Significant effects were observed only among men: the carriers of heterozygous genotype (GT) showed high levels of adiponectin (p = 0.018), while the rare homozygous genotype (TT) gave its carriers a negative phenotype, represented by higher levels of low density lipoprotein cholesterol (LDL-C) (p = 0.004 and p = 0.005) and total cholesterol (TC) (p = 0.010 and p = 0.005) compared to carriers of other genotypes (GG and GT respectively), the independent effect of SNP on LDL-C and TC levels was confirmed by multiple regression analysis (p = 0.008 and p = 0.044). We found no evidence of correlation between circulating adiponectin levels and biochemical markers, which suggests, therefore, an SNP 276G > T independent effect on adiponectin levels and on lipoprotein metabolism in men enrolled in this study.
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http://dx.doi.org/10.1016/j.mgene.2015.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484719PMC
September 2015

Ankle dorsiflexion may play an important role in falls in women with fibromyalgia.

Clin Biomech (Bristol, Avon) 2015 Jul 2;30(6):593-8. Epub 2015 Apr 2.

Physical Education Department/Center for Motor Behaviour Studies, Federal University of Paraná, Curitiba, Paraná, Brazil. Electronic address:

Background: Fibromyalgia is a chronic pain condition, which involves reduced range of motion. This leads to gait changes and high incidence of falls. The understanding of the gait patterns in subjects with fibromyalgia and their relationship with falls may be useful when designing intervention programs. The purpose of this study was to evaluate the range of motion of the hip and ankle joints during gait in women with and without fibromyalgia. Further, we determined the relationship between joint range of motion and falls in this population.

Methods: Middle-aged women (16 with fibromyalgia and 16 as control group) were recruited. Pain intensity, physical activity level, and fall prevalence were assessed. Three dimensional gait analysis provided temporal and joint kinematic variables.

Findings: In general, hip and ankle range of motion were similar between groups, except that fibromyalgia group showed higher plantar flexion during toe-off (P<0.05) and reduced dorsiflexion during stance phase (P<0.05). Additionally, in the fibromyalgia group the higher number of falls was correlated to reduced dorsiflexion during stance phase. This limitation in dorsiflexion was related to longer length of time with fibromyalgia symptoms.

Interpretation: Women with fibromyalgia showed a higher number of falls, reduced dorsiflexion during stance phase, and increased plantar flexion during toe-off. Also, the higher number of falls reported in the fibromyalgia group was related to reduced dorsiflexion during stance phase, which was correlated to a longer length of time living with fibromyalgia symptoms. These data suggest that improving ankle kinematics in patients with fibromyalgia may help prevent falls and improve mobility.
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http://dx.doi.org/10.1016/j.clinbiomech.2015.03.026DOI Listing
July 2015

[Smoking, alcohol consumption and sleep time of industrial workers in the state of Paraná in Brazil].

Rev Salud Publica (Bogota) 2014 Jul-Aug;16(4):491-504

Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil,

Objective: This study was aimed at verifying smoking, alcohol consumption and sleep time associated with sociodemographic factors in physically active industrial workers in the state of Paraná in Brazil.

Methods: Nine hundred and seven subjects volunteered (71% men and 29% women) to answer a questionnaire aimed at assessing their quality of life and health (QVS-80). The volunteers included 389 physically active workers. The Chi-square test and Chi-square test for linear trend were used for analyzing the data so collected (p<0.05).

Results: Physical activity (PA) prevalence was higher amongst men (49%) compared to women (22%) (p<0.01). Younger women (p<0.01) having a higher educational level (p<0.01) trended to engage in PA (p<0.01). Smoking was identified in 15% of the active workers; this was associated with age (p<0.05) and educational level (p<0.01) in male workers. Alcohol abuse was present in 8% of men and 3% of women (p<0.05). Inadequate sleep time was associated with increased age (p<0.01) in both genders and lower family income (p<0.05) in women.

Conclusion: Physically active workers had lower tobacco and alcohol consumption compared to physically inactive workers in previous studies.
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December 2016

[Gait characteristics of women with fibromyalgia: a premature aging pattern].

Rev Bras Reumatol 2014 Sep-Oct;54(5):335-41. Epub 2014 Jul 6.

Setor de Ciências Biológicas, Centro de Estudos do Comportamento Motor, Universidade Federal do Paraná, Curitiba, PR, Brasil.

Background: Fibromyalgia is a condition which involves chronic pain. Middle-aged individuals with fibromyalgia seem to exhibit changes in gait pattern, which may prematurely expose them to a gait pattern which resembles that found in the elderly population.

Objective: To determine the 3D spatial (linear and angular) gait parameters of middle-aged women with fibromyalgia and compare to elderly women without this condition.

Methods: 25 women (10 in the fibromyalgia group and 15 in the elderly group) volunteered to participate in the study. Kinematics was performed using an optoelectronic system, and linear and angular kinematic variables were determined.

Results: There was no difference in walking speed, stride length, cadence, hip, knee and ankle joints range of motion between groups, except the pelvic rotation, in which the fibromyalgia group showed greater rotation (P<0.05) compared to the elderly group. Also, there was a negative correlation with pelvic rotation and gluteus pain (r = -0.69; P<0.05), and between pelvic obliquity and greater trochanter pain (r = -0.69; P<0.05) in the fibromyalgia group.

Conclusion: Middle-aged women with fibromyalgia showed gait pattern resemblances to elderly, women, which is characterized by reduced lower limb ROM, stride length and walking speed.
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http://dx.doi.org/10.1016/j.rbr.2013.11.003DOI Listing
December 2016
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