Neil Walker

Neil Walker

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Neil Walker

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Demonstration of a Fair Level of Agreement Between Escalation Scores Reported by Hospital Managers and Analysis of Stress-Related Hospital Metrics.

Health Serv Res Manag Epidemiol 2019 Jan-Dec;6:2333392818819291. Epub 2019 Mar 15.

Nuffield Department of Primary Care Health Science, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1177/2333392818819291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421601PMC
March 2019

An examination of user costs in relation to smokers using a cessation service based in the UK.

BMC Health Serv Res 2018 03 15;18(1):182. Epub 2018 Mar 15.

Institute of Primary Care & Public Health, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1186/s12913-018-2985-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856222PMC
March 2018

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.

Diabetologia 2018 Jan 5;61(1):147-157. Epub 2017 Oct 5.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, NIHR Oxford Biomedical Research Centre, Nuffield Department of Medicine, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1007/s00125-017-4440-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719131PMC
January 2018

Challenges of Capacity and Development for Health System Sustainability.

Healthc Pap 2018 01;17(3):18-27

Vice President, System Transformation, North Simcoe Muskoka Local Health Integration Network, Orillia, ON.

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http://dx.doi.org/10.12927/hcpap.2018.25505DOI Listing
January 2018

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.

Wellcome Open Res 2017 5;2:28. Epub 2017 Oct 5.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus,Cambridge, CB2 0XY, UK.

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https://wellcomeopenresearch.org/articles/2-28/v3
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http://dx.doi.org/10.12688/wellcomeopenres.11300.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531165PMC
October 2017

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

JCI Insight 2017 Aug 17;2(16). Epub 2017 Aug 17.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.93739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621870PMC
August 2017

Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study.

BMJ Open 2015 Dec 8;5(12):e009799. Epub 2015 Dec 8.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1136/bmjopen-2015-009799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679899PMC
December 2015

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls.

Nat Genet 2015 Jul 8;47(7):839-46. Epub 2015 Jun 8.

1] JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. [2] Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754941PMC
July 2015

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.

PLoS Genet 2015 Jun 24;11(6):e1005272. Epub 2015 Jun 24.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1005272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481316PMC
June 2015

Impacts of removing badgers on localised counts of hedgehogs.

PLoS One 2014 15;9(4):e95477. Epub 2014 Apr 15.

National Wildlife Management Centre, Animal Health and Veterinary Laboratories Agency, New Haw, Addlestone, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095477PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988185PMC
May 2015

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients.

Diabetologia 2015 Apr 6;58(4):781-90. Epub 2015 Feb 6.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, WT/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK,

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http://dx.doi.org/10.1007/s00125-015-3509-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351433PMC
April 2015

Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes.

Hum Mol Genet 2015 Mar 25;24(6):1774-90. Epub 2014 Nov 25.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK,

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http://hmg.oxfordjournals.org/content/early/2014/11/25/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu581
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http://dx.doi.org/10.1093/hmg/ddu581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381751PMC
March 2015

Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D).

Trials 2015 Mar 11;16:86. Epub 2015 Mar 11.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1186/s13063-015-0583-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369347PMC
March 2015

A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations.

Genet Epidemiol 2014 Dec 4;38(8):661-70. Epub 2014 Nov 4.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1002/gepi.21853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258092PMC
December 2014

Returning findings within longitudinal cohort studies: the 1958 birth cohort as an exemplar.

Emerg Themes Epidemiol 2014 4;11:10. Epub 2014 Aug 4.

Director of Cohorts and Longitudinal Studies Enhancement Resources (CLOSER), Centre for Longitudinal Studies, Institute of Education, London, UK.

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http://dx.doi.org/10.1186/1742-7622-11-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131774PMC
August 2014

Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial.

BMJ Open 2014 Jun 4;4(6):e005559. Epub 2014 Jun 4.

Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge, UK.

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http://dx.doi.org/10.1136/bmjopen-2014-005559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054640PMC
June 2014

Crosstalk between transposase subunits during cleavage of the mariner transposon.

Nucleic Acids Res 2014 May 12;42(9):5799-808. Epub 2014 Mar 12.

School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1093/nar/gku172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027188PMC
May 2014

A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples.

BMC Genomics 2014 Apr 11;15:274. Epub 2014 Apr 11.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, CB2 0XY, Cambridge, UK.

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http://dx.doi.org/10.1186/1471-2164-15-274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029094PMC
April 2014

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

Diabetologia 2014 Feb 22;57(2):366-72. Epub 2013 Nov 22.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0XY, UK.

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http://link.springer.com/10.1007/s00125-013-3113-8
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http://dx.doi.org/10.1007/s00125-013-3113-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890035PMC
February 2014

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.

J Immunol 2013 Mar 15;190(6):2554-66. Epub 2013 Feb 15.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1202914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614027PMC
March 2013

Seven newly identified loci for autoimmune thyroid disease.

Hum Mol Genet 2012 Dec 24;21(23):5202-8. Epub 2012 Aug 24.

Department of Medical Genetics, Cambridge Institute for Medical Research, Juvenile Diabetes Research Foundation/ Wellcome Trust Diabetes and Inflammation Laboratory, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK.

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http://dx.doi.org/10.1093/hmg/dds357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490518PMC
December 2012

Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes.

Diabetes 2012 Nov 13;61(11):3012-7. Epub 2012 Aug 13.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Department of Medical Genetics, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.2337/db11-1694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478521PMC
November 2012

Effectiveness of biosecurity measures in preventing badger visits to farm buildings.

PLoS One 2011 29;6(12):e28941. Epub 2011 Dec 29.

The Food & Environment Research Agency, Sand Hutton, York, Yorkshire, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028941PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248415PMC
April 2012

FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection.

Diabetes 2011 Nov;60(11):3081-4

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.2337/db11-0638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198057PMC
November 2011

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.

Diabetes Metab Res Rev 2011 Nov;27(8):838-43

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1002/dmrr.1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816329PMC
November 2011

Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct.

Diabetes 2011 Oct 10;60(10):2635-44. Epub 2011 Aug 10.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetesand Inflammation Laboratory, Cambridge Institute for Medical Research, Departmentof Medical Genetics, University of Cambridge, Cambridge, U.K.

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http://dx.doi.org/10.2337/db11-0131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178284PMC
October 2011

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

PLoS Genet 2011 Aug 4;7(8):e1002216. Epub 2011 Aug 4.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1002216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150451PMC
August 2011

Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes.

Diabetes 2011 May 25;60(5):1624-31. Epub 2011 Mar 25.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.2337/db10-1656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292339PMC
May 2011

Evidence of association with type 1 diabetes in the SLC11A1 gene region.

BMC Med Genet 2011 Apr 27;12:59. Epub 2011 Apr 27.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1186/1471-2350-12-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114708PMC
April 2011

Reduced expression of IFIH1 is protective for type 1 diabetes.

PLoS One 2010 Sep 9;5(9). Epub 2010 Sep 9.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936573PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012646PLOS
September 2010

Diagnostic accuracy and optimal use of three tests for tuberculosis in live badgers.

PLoS One 2010 Jun 17;5(6):e11196. Epub 2010 Jun 17.

Centre for Emerging, Endemic and Exotic Diseases, Royal Veterinary College, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011196PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887451PMC
June 2010

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

Authors:
Nick Craddock Matthew E Hurles Niall Cardin Richard D Pearson Vincent Plagnol Samuel Robson Damjan Vukcevic Chris Barnes Donald F Conrad Eleni Giannoulatou Chris Holmes Jonathan L Marchini Kathy Stirrups Martin D Tobin Louise V Wain Chris Yau Jan Aerts Tariq Ahmad T Daniel Andrews Hazel Arbury Anthony Attwood Adam Auton Stephen G Ball Anthony J Balmforth Jeffrey C Barrett Inês Barroso Anne Barton Amanda J Bennett Sanjeev Bhaskar Katarzyna Blaszczyk John Bowes Oliver J Brand Peter S Braund Francesca Bredin Gerome Breen Morris J Brown Ian N Bruce Jaswinder Bull Oliver S Burren John Burton Jake Byrnes Sian Caesar Chris M Clee Alison J Coffey John M C Connell Jason D Cooper Anna F Dominiczak Kate Downes Hazel E Drummond Darshna Dudakia Andrew Dunham Bernadette Ebbs Diana Eccles Sarah Edkins Cathryn Edwards Anna Elliot Paul Emery David M Evans Gareth Evans Steve Eyre Anne Farmer I Nicol Ferrier Lars Feuk Tomas Fitzgerald Edward Flynn Alistair Forbes Liz Forty Jayne A Franklyn Rachel M Freathy Polly Gibbs Paul Gilbert Omer Gokumen Katherine Gordon-Smith Emma Gray Elaine Green Chris J Groves Detelina Grozeva Rhian Gwilliam Anita Hall Naomi Hammond Matt Hardy Pile Harrison Neelam Hassanali Husam Hebaishi Sarah Hines Anne Hinks Graham A Hitman Lynne Hocking Eleanor Howard Philip Howard Joanna M M Howson Debbie Hughes Sarah Hunt John D Isaacs Mahim Jain Derek P Jewell Toby Johnson Jennifer D Jolley Ian R Jones Lisa A Jones George Kirov Cordelia F Langford Hana Lango-Allen G Mark Lathrop James Lee Kate L Lee Charlie Lees Kevin Lewis Cecilia M Lindgren Meeta Maisuria-Armer Julian Maller John Mansfield Paul Martin Dunecan C O Massey Wendy L McArdle Peter McGuffin Kirsten E McLay Alex Mentzer Michael L Mimmack Ann E Morgan Andrew P Morris Craig Mowat Simon Myers William Newman Elaine R Nimmo Michael C O'Donovan Abiodun Onipinla Ifejinelo Onyiah Nigel R Ovington Michael J Owen Kimmo Palin Kirstie Parnell David Pernet John R B Perry Anne Phillips Dalila Pinto Natalie J Prescott Inga Prokopenko Michael A Quail Suzanne Rafelt Nigel W Rayner Richard Redon David M Reid Renwick Susan M Ring Neil Robertson Ellie Russell David St Clair Jennifer G Sambrook Jeremy D Sanderson Helen Schuilenburg Carol E Scott Richard Scott Sheila Seal Sue Shaw-Hawkins Beverley M Shields Matthew J Simmonds Debbie J Smyth Elilan Somaskantharajah Katarina Spanova Sophia Steer Jonathan Stephens Helen E Stevens Millicent A Stone Zhan Su Deborah P M Symmons John R Thompson Wendy Thomson Mary E Travers Clare Turnbull Armand Valsesia Mark Walker Neil M Walker Chris Wallace Margaret Warren-Perry Nicholas A Watkins John Webster Michael N Weedon Anthony G Wilson Matthew Woodburn B Paul Wordsworth Allan H Young Eleftheria Zeggini Nigel P Carter Timothy M Frayling Charles Lee Gil McVean Patricia B Munroe Aarno Palotie Stephen J Sawcer Stephen W Scherer David P Strachan Chris Tyler-Smith Matthew A Brown Paul R Burton Mark J Caulfield Alastair Compston Martin Farrall Stephen C L Gough Alistair S Hall Andrew T Hattersley Adrian V S Hill Christopher G Mathew Marcus Pembrey Jack Satsangi Michael R Stratton Jane Worthington Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem Ouwehand Miles Parkes Nazneen Rahman John A Todd Nilesh J Samani Peter Donnelly

Nature 2010 Apr;464(7289):713-20

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http://dx.doi.org/10.1038/nature08979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892339PMC
April 2010

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.

Nat Genet 2010 Jan 6;42(1):68-71. Epub 2009 Dec 6.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820243PMC
January 2010

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.

Nat Genet 2009 Sep 23;41(9):1011-5. Epub 2009 Aug 23.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, UK.

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http://www.nature.com/articles/ng.434
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http://dx.doi.org/10.1038/ng.434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749506PMC
September 2009

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

Nat Genet 2009 Jun 10;41(6):703-7. Epub 2009 May 10.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://www.nature.com/articles/ng.381
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http://dx.doi.org/10.1038/ng.381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889014PMC
June 2009

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.

Science 2009 Apr 5;324(5925):387-9. Epub 2009 Mar 5.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1167728
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http://dx.doi.org/10.1126/science.1167728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707798PMC
April 2009

The use of post-operative reverse camber shoes following scarf osteotomy.

Foot Ankle Surg 2008 23;14(4):190-3. Epub 2008 May 23.

Wessex Orthopaedic Rotation, Queen Alexandra Hospital, Cosham, Portsmouth, United Kingdom.

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http://dx.doi.org/10.1016/j.fas.2008.02.002DOI Listing
March 2009

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

Nat Genet 2008 Dec 2;40(12):1399-401. Epub 2008 Nov 2.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635556PMC
December 2008

Shared and distinct genetic variants in type 1 diabetes and celiac disease.

N Engl J Med 2008 Dec 10;359(26):2767-77. Epub 2008 Dec 10.

Juvenile Diabetes Research Foundation-Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://www.nejm.org/doi/abs/10.1056/NEJMoa0807917
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http://dx.doi.org/10.1056/NEJMoa0807917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840835PMC
December 2008

PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.

Diabetes 2008 Jun 27;57(6):1730-7. Epub 2008 Feb 27.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db07-11
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http://dx.doi.org/10.2337/db07-1131DOI Listing
June 2008

Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.

Diabetes 2008 Jun 10;57(6):1753-6. Epub 2008 Mar 10.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://diabetes.diabetesjournals.org/content/early/2008/03/1
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http://diabetes.diabetesjournals.org/content/57/6/1753.full.
Web Search
http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db07-14
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http://dx.doi.org/10.2337/db07-1402DOI Listing
June 2008

Severe facial edema at high altitude.

J Travel Med 2008 Mar-Apr;15(2):130-2

Department of Plastic and Reconstructive Surgery, Royal Hospital Haslar, Gosport, UK.

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https://academic.oup.com/jtm/article-lookup/doi/10.1111/j.17
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http://dx.doi.org/10.1111/j.1708-8305.2008.00192.xDOI Listing
April 2008

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.

Nature 2007 Dec 14;450(7171):887-92. Epub 2007 Nov 14.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1038/nature06406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703779PMC
December 2007

Audit of elective paediatric clinic referrals from primary care February 2002-September 2006.

J Pediatr Orthop B 2007 Nov;16(6):447-50

Queen Alexandra Hospital, Cosham, Portsmouth, UK.

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http://dx.doi.org/10.1097/BPB.0b013e3282e61ad2DOI Listing
November 2007

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

Authors:
Paul R Burton David G Clayton Lon R Cardon Nick Craddock Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem H Ouwehand Nilesh J Samani John A Todd Peter Donnelly Jeffrey C Barrett Dan Davison Doug Easton David M Evans Hin-Tak Leung Jonathan L Marchini Andrew P Morris Chris C A Spencer Martin D Tobin Antony P Attwood James P Boorman Barbara Cant Ursula Everson Judith M Hussey Jennifer D Jolley Alexandra S Knight Kerstin Koch Elizabeth Meech Sarah Nutland Christopher V Prowse Helen E Stevens Niall C Taylor Graham R Walters Neil M Walker Nicholas A Watkins Thilo Winzer Richard W Jones Wendy L McArdle Susan M Ring David P Strachan Marcus Pembrey Gerome Breen David St Clair Sian Caesar Katharine Gordon-Smith Lisa Jones Christine Fraser Elaine K Green Detelina Grozeva Marian L Hamshere Peter A Holmans Ian R Jones George Kirov Valentina Moskivina Ivan Nikolov Michael C O'Donovan Michael J Owen David A Collier Amanda Elkin Anne Farmer Richard Williamson Peter McGuffin Allan H Young I Nicol Ferrier Stephen G Ball Anthony J Balmforth Jennifer H Barrett Timothy D Bishop Mark M Iles Azhar Maqbool Nadira Yuldasheva Alistair S Hall Peter S Braund Richard J Dixon Massimo Mangino Suzanne Stevens John R Thompson Francesca Bredin Mark Tremelling Miles Parkes Hazel Drummond Charles W Lees Elaine R Nimmo Jack Satsangi Sheila A Fisher Alastair Forbes Cathryn M Lewis Clive M Onnie Natalie J Prescott Jeremy Sanderson Christopher G Matthew Jamie Barbour M Khalid Mohiuddin Catherine E Todhunter John C Mansfield Tariq Ahmad Fraser R Cummings Derek P Jewell John Webster Morris J Brown Mark G Lathrop John Connell Anna Dominiczak Carolina A Braga Marcano Beverley Burke Richard Dobson Johannie Gungadoo Kate L Lee Patricia B Munroe Stephen J Newhouse Abiodun Onipinla Chris Wallace Mingzhan Xue Mark Caulfield Martin Farrall Anne Barton Ian N Bruce Hannah Donovan Steve Eyre Paul D Gilbert Samantha L Hilder Anne M Hinks Sally L John Catherine Potter Alan J Silman Deborah P M Symmons Wendy Thomson Jane Worthington David B Dunger Barry Widmer Timothy M Frayling Rachel M Freathy Hana Lango John R B Perry Beverley M Shields Michael N Weedon Andrew T Hattersley Graham A Hitman Mark Walker Kate S Elliott Christopher J Groves Cecilia M Lindgren Nigel W Rayner Nicolas J Timpson Eleftheria Zeggini Melanie Newport Giorgio Sirugo Emily Lyons Fredrik Vannberg Adrian V S Hill Linda A Bradbury Claire Farrar Jennifer J Pointon Paul Wordsworth Matthew A Brown Jayne A Franklyn Joanne M Heward Matthew J Simmonds Stephen C L Gough Sheila Seal Michael R Stratton Nazneen Rahman Maria Ban An Goris Stephen J Sawcer Alastair Compston David Conway Muminatou Jallow Melanie Newport Giorgio Sirugo Kirk A Rockett Suzannah J Bumpstead Amy Chaney Kate Downes Mohammed J R Ghori Rhian Gwilliam Sarah E Hunt Michael Inouye Andrew Keniry Emma King Ralph McGinnis Simon Potter Rathi Ravindrarajah Pamela Whittaker Claire Widden David Withers Niall J Cardin Dan Davison Teresa Ferreira Joanne Pereira-Gale Ingeleif B Hallgrimsdo'ttir Bryan N Howie Zhan Su Yik Ying Teo Damjan Vukcevic David Bentley Matthew A Brown Alastair Compston Martin Farrall Alistair S Hall Andrew T Hattersley Adrian V S Hill Miles Parkes Marcus Pembrey Michael R Stratton Sarah L Mitchell Paul R Newby Oliver J Brand Jackie Carr-Smith Simon H S Pearce R McGinnis A Keniry P Deloukas John D Reveille Xiaodong Zhou Anne-Marie Sims Alison Dowling Jacqueline Taylor Tracy Doan John C Davis Laurie Savage Michael M Ward Thomas L Learch Michael H Weisman Mathew Brown

Nat Genet 2007 Nov 21;39(11):1329-37. Epub 2007 Oct 21.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1038/ng.2007.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680141PMC
November 2007

The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.

BMC Med Genet 2007 Nov 28;8:71. Epub 2007 Nov 28.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2350-8-71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217539PMC
November 2007

Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes.

Diabetes 2007 Oct 2;56(10):2616-21. Epub 2007 Jul 2.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.2337/db07-0652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493063PMC
October 2007

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Nat Genet 2007 Sep 5;39(9):1074-82. Epub 2007 Aug 5.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, UK.

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http://www.nature.com/doifinder/10.1038/ng2102
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http://dx.doi.org/10.1038/ng2102DOI Listing
September 2007

Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes.

J Leukoc Biol 2007 Mar 5;81(3):581-3. Epub 2007 Jan 5.

Juvenile Diabetes Research Foundation/Wellcome Trust, Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1189/jlb.0906577DOI Listing
March 2007

No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility.

Diabetes Metab Res Rev 2006 Sep-Oct;22(5):356-60

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 2XY UK.

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http://dx.doi.org/10.1002/dmrr.628DOI Listing
November 2006

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.

Nat Genet 2006 Jun 14;38(6):617-9. Epub 2006 May 14.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1038/ng1800DOI Listing
June 2006

Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.

J Allergy Clin Immunol 2006 Jun 3;117(6):1306-13. Epub 2006 Apr 3.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK.

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http://dx.doi.org/10.1016/j.jaci.2005.12.1354DOI Listing
June 2006

No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases.

Diabetes 2006 May;55(5):1525-8

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, U.K.

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http://dx.doi.org/10.2337/db05-1452DOI Listing
May 2006

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.

BMC Genet 2006 Apr 20;7:22. Epub 2006 Apr 20.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1186/1471-2156-7-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479364PMC
April 2006

Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

BMC Med Genet 2006 Mar 6;7:20. Epub 2006 Mar 6.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Rd, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1186/1471-2350-7-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420277PMC
March 2006

Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.

Diabetes 2006 Feb;55(2):559-62

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK.

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http://dx.doi.org/10.2337/diabetes.55.02.06.db05-0826DOI Listing
February 2006

Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes.

BMC Genet 2006 Feb 22;7:12. Epub 2006 Feb 22.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1186/1471-2156-7-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402321PMC
February 2006

Population structure, differential bias and genomic control in a large-scale, case-control association study.

Nat Genet 2005 Nov 9;37(11):1243-6. Epub 2005 Oct 9.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, CB2 2XY, UK.

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http://www.nature.com/articles/ng1653
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http://dx.doi.org/10.1038/ng1653DOI Listing
November 2005

No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes.

Biochem Biophys Res Commun 2005 Jun;331(2):435-41

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.203DOI Listing
June 2005

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.

Am J Hum Genet 2005 May 17;76(5):773-9. Epub 2005 Mar 17.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/Medical Research Council Building, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1086/429843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199367PMC
May 2005

Regression mapping of association between the human leukocyte antigen region and Graves disease.

Am J Hum Genet 2005 Jan 22;76(1):157-63. Epub 2004 Nov 22.

Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, and Birmingham Heartlands Hospital, Birmingham B9 5SS, United Kingdom.

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http://dx.doi.org/10.1086/426947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1196419PMC
January 2005

T1DBase, a community web-based resource for type 1 diabetes research.

Nucleic Acids Res 2005 Jan;33(Database issue):D544-9

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1093/nar/gki095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC540049PMC
January 2005

Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.

Diabetes 2004 Oct;53(10):2709-12

Juvenile Diabetes Research Foundation/Wellcome Trust DiabetesInflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, WT/MRC building, Addenbrooke's Hospital, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.2337/diabetes.53.10.2709DOI Listing
October 2004

Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene.

Hum Mol Genet 2004 Aug 2;13(15):1633-9. Epub 2004 Jun 2.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK.

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http://dx.doi.org/10.1093/hmg/ddh169DOI Listing
August 2004

Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping.

BMC Biotechnol 2004 Jul 27;4:15. Epub 2004 Jul 27.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes, Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1186/1472-6750-4-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514612PMC
July 2004

Prospective validity of measuring angina severity with Canadian Cardiovascular Society class: The ACRE study.

Can J Cardiol 2004 Mar;20(3):305-9

Department of Epidemiology and Public Health, University College London Medical School, London, UK.

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March 2004

Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.

Diabetes 2004 Feb;53(2):505-9

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, U.K.

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http://dx.doi.org/10.2337/diabetes.53.2.505DOI Listing
February 2004

The determinants and effect of shared care on patient outcomes and psychiatric admissions - an inner city primary care cohort study.

Soc Psychiatry Psychiatr Epidemiol 2004 Feb;39(2):154-63

Department of Public Health Research, Westminster Primary Care Trust, Westminster Primary Care Trust Headquarters, 15 Marylebone Road, London NW1 5JD, UK.

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http://dx.doi.org/10.1007/s00127-004-0721-0DOI Listing
February 2004

Association of intercellular adhesion molecule-1 gene with type 1 diabetes.

Lancet 2003 Nov;362(9397):1723-4

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, CB2 2XY, Cambridge, UK.

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http://dx.doi.org/10.1016/S0140-6736(03)14847-7DOI Listing
November 2003

Successful palliation and significant remission of cutaneous calcinosis in CREST syndrome with carbon dioxide laser.

Dermatol Surg 2003 Sep;29(9):968-70

Department of Dermatology, The Churchill, Oxford Radcliffe Hospitals, Old Road, Headington, Oxford OX3 7LJ, United Kingdom.

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http://dx.doi.org/10.1046/j.1524-4725.2003.29261.xDOI Listing
September 2003