Neil Isaacs

Neil Isaacs

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Neil Isaacs

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A history of experimental phasing in macromolecular crystallography.

Authors:
Neil Isaacs

Acta Crystallogr D Struct Biol 2016 Mar 1;72(Pt 3):293-5. Epub 2016 Mar 1.

Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, Scotland.

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http://dx.doi.org/10.1107/S205979831501476XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784660PMC
March 2016

Crystal structure of a Trypanosoma brucei metacaspase.

Proc Natl Acad Sci U S A 2012 May 23;109(19):7469-74. Epub 2012 Apr 23.

Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1200885109
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http://dx.doi.org/10.1073/pnas.1200885109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358904PMC
May 2012

High-throughput identification of purification conditions leads to preliminary crystallization conditions for three inner membrane proteins.

Mol Membr Biol 2011 Oct-Nov;28(7-8):445-53

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.3109/09687688.2011.628954DOI Listing
February 2012

New insights into the structure of the reaction centre from Blastochloris viridis: evolution in the laboratory.

Biochem J 2012 Feb;442(1):27-37

WestCHEM, School of Chemistry, College of Science and Engineering, University of Glasgow, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, UK.

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http://dx.doi.org/10.1042/BJ20111540DOI Listing
February 2012

Outer membrane protein A of bovine and ovine isolates of Mannheimia haemolytica is surface exposed and contains host species-specific epitopes.

Infect Immun 2011 Nov 6;79(11):4332-41. Epub 2011 Sep 6.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK.

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http://dx.doi.org/10.1128/IAI.05469-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257919PMC
November 2011

The 2011 Joint Sino-U.K. Protein Symposium.

Biochem Soc Trans 2011 Oct;39(5):1311-2

School of Life Sciences, Peking University, Beijing 100871, China.

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http://dx.doi.org/10.1042/BST0391311DOI Listing
October 2011

Mapping lipid and detergent molecules at the surface of membrane proteins.

Biochem Soc Trans 2011 Jun;39(3):775-9

Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University Place, Glasgow, U.K.

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http://dx.doi.org/10.1042/BST0390775DOI Listing
June 2011

Autotransporter passenger domain secretion requires a hydrophobic cavity at the extracellular entrance of the β-domain pore.

Biochem J 2011 May;435(3):577-87

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1042/BJ20101548DOI Listing
May 2011

Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor.

J Biol Chem 2010 Dec 5;285(50):39249-59. Epub 2010 Oct 5.

Westchem School of Chemistry, University of Glasgow, Glasgow G12 8TA, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.156679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998157PMC
December 2010

Expression, purification, crystallization and initial X-ray diffraction analysis of thiol peroxidase from Yersinia pseudotuberculosis.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Dec 25;66(Pt 12):1606-9. Epub 2010 Nov 25.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, Glasgow G12 8QQ, Scotland.

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http://dx.doi.org/10.1107/S1744309110039679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998365PMC
December 2010

Crystallization and initial X-ray diffraction analysis of a mannose-binding lectin from champedak.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 May 30;66(Pt 5):592-4. Epub 2010 Apr 30.

Glasgow Biomedical Research Centre, Faculty of Biomedical and Life Sciences, Glasgow G12 8QQ, Scotland.

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http://dx.doi.org/10.1107/S1744309110011760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864700PMC
May 2010

Crystal structures of all-alpha type membrane proteins.

Eur Biophys J 2010 Apr 14;39(5):723-55. Epub 2009 Oct 14.

Westchem, Department of Chemistry, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK.

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http://dx.doi.org/10.1007/s00249-009-0546-6DOI Listing
April 2010

Crystallization and preliminary structural studies of champedak galactose-binding lectin.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Sep 22;65(Pt 9):895-7. Epub 2009 Aug 22.

Division of Molecular and Cellular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland.

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http://dx.doi.org/10.1107/S1744309109029303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795594PMC
September 2009

Structure-function dissection of D6, an atypical scavenger receptor.

Methods Enzymol 2009 ;460:245-61

Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Center, Glasgow University, Glasgow, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S007668790905212
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http://dx.doi.org/10.1016/S0076-6879(09)05212-4DOI Listing
August 2009

A protocol for high throughput methods for the expression and purification of inner membrane proteins.

Mol Membr Biol 2008 Dec;25(8):599-608

Department of Chemistry, Faculty of Biological Life Sciences, University of Glasgow, Glasgow, Scotland, UK.

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http://dx.doi.org/10.1080/09687680802510289DOI Listing
December 2008

Multiple roles for the C-terminal tail of the chemokine scavenger D6.

J Biol Chem 2008 Mar 17;283(12):7972-82. Epub 2008 Jan 17.

Division of Immunology, Infection and Inflammation, Glasgow University, Glasgow G12 8TA, Scotland, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M710128200
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http://dx.doi.org/10.1074/jbc.M710128200DOI Listing
March 2008

Residual structure in disordered peptides and unfolded proteins from multivariate analysis and ab initio simulation of Raman optical activity data.

Proteins 2008 Feb;70(3):823-33

WestCHEM, Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.

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http://dx.doi.org/10.1002/prot.21593DOI Listing
February 2008

Mitochondrial peroxiredoxins.

Subcell Biochem 2007 ;44:295-315

Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.

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http://dx.doi.org/10.1007/978-1-4020-6051-9_14DOI Listing
February 2008

Raman optical activity and circular dichroism reveal dramatic differences in the influence of divalent copper and manganese ions on prion protein folding.

Biochemistry 2008 Feb 19;47(8):2510-7. Epub 2008 Jan 19.

WestChem, Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.

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http://dx.doi.org/10.1021/bi7022893DOI Listing
February 2008

Crystallization and preliminary X-ray diffraction analysis of P30, the transmembrane domain of pertactin, an autotransporter from Bordetella pertussis.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Jul 15;63(Pt 7):593-5. Epub 2007 Jun 15.

Department of Chemistry and WestChem, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, Scotland.

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http://dx.doi.org/10.1107/S1744309107028308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2335132PMC
July 2007

Solid phase immunoadsorption for therapeutic and analytical studies on neuropathy-associated anti-GM1 antibodies.

Glycobiology 2007 Mar 4;17(3):294-303. Epub 2006 Dec 4.

Division of Clinical Neurosciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1093/glycob/cwl074DOI Listing
March 2007

Brominated lipids identify lipid binding sites on the surface of the reaction center from Rhodobacter sphaeroides.

Biochemistry 2007 Mar 23;46(11):2909-16. Epub 2007 Feb 23.

Department of Chemistry, WestCHEM.

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http://dx.doi.org/10.1021/bi062154iDOI Listing
March 2007

Delineation of protein structure classes from multivariate analysis of protein Raman optical activity data.

J Mol Biol 2006 Oct 22;363(1):19-26. Epub 2006 Aug 22.

WestCHEM, Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1016/j.jmb.2006.08.038DOI Listing
October 2006

Overexpression, purification and crystallization of a choline-binding protein CbpI from Streptococcus pneumoniae.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Jul 10;62(Pt 7):672-5. Epub 2006 Jun 10.

Department of Chemistry and WestCHEM, Glasgow Biomedical Research Centre (GBRC), University of Glasgow, 120 University Place, Glasgow G12 8TA, Scotland.

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http://dx.doi.org/10.1107/S1744309106020616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242943PMC
July 2006

Purification, crystallization and preliminary X-ray diffraction analysis of RafE, a sugar-binding lipoprotein from Streptococcus pneumoniae.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Jul 26;62(Pt 7):676-9. Epub 2006 Jun 26.

Department of Chemistry and WestCHEM, Glasgow Biomedical Research Centre (GBRC), University of Glasgow, 120 University Place, Glasgow G12 8TA, Scotland.

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http://scripts.iucr.org/cgi-bin/paper?S1744309106021695
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http://dx.doi.org/10.1107/S1744309106021695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242947PMC
July 2006

A310 helical turn is essential for the proliferation-inhibiting properties of macrophage inflammatory protein-1 alpha (CCL3).

Blood 2006 Feb 18;107(4):1284-91. Epub 2005 Oct 18.

Division of Immunology, Infection and Inflammation, University of Glasgow, University Avenue, Glasgow G12 8QQ, Scotland, United Kingdom.

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http://dx.doi.org/10.1182/blood-2005-08-3112DOI Listing
February 2006

Raman optical activity of proteins, carbohydrates and glycoproteins.

Chirality 2006 Feb;18(2):103-15

WestCHEM, Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1002/chir.20225DOI Listing
February 2006

Creating permanent 3D arrangements of isolated cells using holographic optical tweezers.

Lab Chip 2005 Nov 30;5(11):1224-8. Epub 2005 Sep 30.

Department of Electrical and Electronic Engineering, University of Glasgow, Glasgow, UK G12 8QQ.

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http://dx.doi.org/10.1039/b509218cDOI Listing
November 2005

Bovine mitochondrial peroxiredoxin III forms a two-ring catenane.

Structure 2005 Nov;13(11):1661-4

Department of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, United Kingdom.

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http://dx.doi.org/10.1016/j.str.2005.07.021DOI Listing
November 2005

Raman optical activity: a tool for protein structure analysis.

Structure 2005 Oct;13(10):1409-19

WestCHEM, Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.

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http://dx.doi.org/10.1016/j.str.2005.07.009DOI Listing
October 2005

Polypeptide and carbohydrate structure of an intact glycoprotein from Raman optical activity.

J Am Chem Soc 2005 May;127(17):6142-3

Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1021/ja051048lDOI Listing
May 2005

The structure and function of bacterial light-harvesting complexes.

Mol Membr Biol 2004 May-Jun;21(3):183-91

Division of Biochemistry and Molecular Biology Institute of Biomedical & Life Sciences, University of Glasgow Glasgow, UK.

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http://dx.doi.org/10.1080/09687680410001697224DOI Listing
December 2004

Expression, purification and X-ray characterization of residues 18-230 from the pneumococcal histidine triad protein A (PhtA) from Streptococcus pneumoniae.

Acta Crystallogr D Biol Crystallogr 2004 May 21;60(Pt 5):926-8. Epub 2004 Apr 21.

Division of Infection and Immunity (IBLS), University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, Scotland.

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http://dx.doi.org/10.1107/S0907444904004573DOI Listing
May 2004

Crystallization and preliminary crystallographic studies of the D59A mutant of MicA, a YycF response-regulator homologue from Streptococcus pneumoniae.

Acta Crystallogr D Biol Crystallogr 2004 May 21;60(Pt 5):950-1. Epub 2004 Apr 21.

IBLS, Division of Infection and Immunity, University of Glasgow, Glasgow G12 8QQ, Scotland.

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http://dx.doi.org/10.1107/S0907444904005712DOI Listing
May 2004

Purification and biochemical characterization of the D6 chemokine receptor.

Biochem J 2004 Apr;379(Pt 2):263-72

The Beatson Institute for Cancer Research, Cancer Research U.K. Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1042/BJ20031266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224083PMC
April 2004

Synthetic disialylgalactose immunoadsorbents deplete anti-GQ1b antibodies from autoimmune neuropathy sera.

Brain 2004 Mar 11;127(Pt 3):680-91. Epub 2004 Feb 11.

Clinical Neurosciences Division, University of Glasgow and Department of Neurology, Southern General Hospital, Glasgow, Scotland.

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http://brain.oxfordjournals.org/content/brain/127/3/680.full
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http://www.brain.oupjournals.org/cgi/doi/10.1093/brain/awh08
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http://dx.doi.org/10.1093/brain/awh083DOI Listing
March 2004

Disruption of a specific molecular interaction with a bound lipid affects the thermal stability of the purple bacterial reaction centre.

Biochim Biophys Acta 2004 Jan;1608(1):11-22

Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, BS8 1TD Bristol, UK.

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http://dx.doi.org/10.1016/j.bbabio.2003.09.014DOI Listing
January 2004

Rings, ellipses and horseshoes: how purple bacteria harvest solar energy.

Photosynth Res 2004 ;81(3):207-14

Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK,

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http://dx.doi.org/10.1023/B:PRES.0000036883.56959.a9DOI Listing
January 2004

Crystal structure of the RC-LH1 core complex from Rhodopseudomonas palustris.

Science 2003 Dec;302(5652):1969-72

Department of Chemistry, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1126/science.1088892DOI Listing
December 2003

The structural basis of light-harvesting in purple bacteria.

FEBS Lett 2003 Nov;555(1):35-9

Faculty of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1016/s0014-5793(03)01102-5DOI Listing
November 2003

Purification, crystallization and preliminary X-ray analysis of the Enterococcus faecalis protein EF0377.

Acta Crystallogr D Biol Crystallogr 2003 Apr 25;59(Pt 4):755-7. Epub 2003 Mar 25.

IBLS Infection and Immunity, University of Glasgow, Scotland.

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http://dx.doi.org/10.1107/s0907444903003718DOI Listing
April 2003

Cloning, overexpression, purification, crystallization and preliminary diffraction analysis of the receiver domain of MicA.

Acta Crystallogr D Biol Crystallogr 2003 Apr 25;59(Pt 4):758-60. Epub 2003 Mar 25.

Department of Chemistry, University of Glasgow, Scotland.

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http://dx.doi.org/10.1107/s090744490300372xDOI Listing
April 2003

The structure and thermal motion of the B800-850 LH2 complex from Rps.acidophila at 2.0A resolution and 100K: new structural features and functionally relevant motions.

J Mol Biol 2003 Mar;326(5):1523-38

Department of Synchrotron Radiation, CCLRC Daresbury Laboratory, Keckwick Lane, Warrington, Cheshire WA4 4AD, UK.

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http://dx.doi.org/10.1016/s0022-2836(03)00024-xDOI Listing
March 2003

Protein-lipid interactions in the purple bacterial reaction centre.

Biochim Biophys Acta 2002 Oct;1565(2):206-14

Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK.

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http://dx.doi.org/10.1016/s0005-2736(02)00570-9DOI Listing
October 2002