Neil Howell

Neil Howell

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Neil Howell

Neil Howell

Publications by authors named "Neil Howell"

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Discontinuation of Aspirin in Heartmate 3 Left Ventricular Assist Device.

ASAIO J 2019 Aug;65(6):631-633

From the University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom.

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http://dx.doi.org/10.1097/MAT.0000000000000859DOI Listing
August 2019

Arteriovenous fistula creation in a patient without a pulse: Vascular access in patients with left ventricular assist devices.

J Vasc Access 2019 Jan 31:1129729819826029. Epub 2019 Jan 31.

1 Department of Renal Surgery, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1177/1129729819826029DOI Listing
January 2019

The interval between brainstem death and cardiac assessment influences the retrieval of hearts for transplantation.

Eur J Cardiothorac Surg 2018 06;53(6):1135-1143

Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Wythenshawe Hospital, Manchester, UK.

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https://academic.oup.com/ejcts/article/53/6/1135/4821888
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http://dx.doi.org/10.1093/ejcts/ezx513DOI Listing
June 2018

MutPred mutational load analysis shows mildly deleterious mitochondrial DNA variants are not more prevalent in Alzheimer's patients, but may be under-represented in healthy older individuals.

Mitochondrion 2017 05 7;34:141-146. Epub 2017 Apr 7.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom; Centre for Human Metabonomics, North-West University, Potchefstroom, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2017.04.002DOI Listing
May 2017

The effect of left ventricular assist device therapy in patients with heart failure and mixed pulmonary hypertension.

Int J Artif Organs 2017 03 15;40(2):67-73. Epub 2017 Mar 15.

University Hospitals Birmingham NHS Foundation Trust, Edgbaston, Birmingham - UK.

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http://dx.doi.org/10.5301/ijao.5000556DOI Listing
March 2017

Extracorporeal Life Support: Physiological Concepts and Clinical Outcomes.

J Card Fail 2017 Feb 27;23(2):181-196. Epub 2016 Oct 27.

University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK.

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http://dx.doi.org/10.1016/j.cardfail.2016.10.012DOI Listing
February 2017

The Physiology of Continuous-Flow Left Ventricular Assist Devices.

J Card Fail 2017 Feb 29;23(2):169-180. Epub 2016 Oct 29.

University Hospital Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1016/j.cardfail.2016.10.015DOI Listing
February 2017

National administrative data produces an accurate and stable risk prediction model for short-term and 1-year mortality following cardiac surgery.

Int J Cardiol 2016 Jan 23;203:196-203. Epub 2015 Oct 23.

Quality and Outcomes Research Unit, University Hospital Birmingham, UK; Department Cardiothoracic Surgery, University Hospital Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2015.10.086DOI Listing
January 2016

Ventricular assist device: destination UK.

Heart 2015 Jul 12;101(14):1083-4. Epub 2015 May 12.

Queen Elizabeth Hospital Birmingham, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

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http://dx.doi.org/10.1136/heartjnl-2015-307737DOI Listing
July 2015

Coronary ostial compromise in aortic valve replacement: an avoidable complication.

Asian Cardiovasc Thorac Ann 2015 Jun 18;23(5):535-42. Epub 2015 Feb 18.

Department of Cardiothoracic Surgery, Papworth Hospital NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.1177/0218492315573105DOI Listing
June 2015

Surgical management of left ventricular outflow obstruction in hypertrophic cardiomyopathy.

Echo Res Pract 2015 Mar 9;2(1):R37-44. Epub 2015 Mar 9.

Department of Cardiology, New Queen Elizabeth Hospital Birmingham , Mindelsohn Way, Edgbaston, Birmingham, B15 2GW , UK.

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http://dx.doi.org/10.1530/ERP-15-0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676463PMC
March 2015

Clinical outcomes of Carbomedics Top Hat valve with a robust follow-up system.

Asian Cardiovasc Thorac Ann 2015 Jan 24;23(1):11-6. Epub 2014 Apr 24.

Department of Cardiac Surgery, University Hospitals Birmingham, UK

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http://dx.doi.org/10.1177/0218492314529954DOI Listing
January 2015

The role of HIFs in ischemia-reperfusion injury.

Hypoxia (Auckl) 2014 30;2:107-115. Epub 2014 Jul 30.

College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.2147/HP.S49720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045060PMC
July 2014

Relationship between plasma, atrial and ventricular perhexiline concentrations in humans: insights into factors affecting myocardial uptake.

Br J Clin Pharmacol 2014 May;77(5):789-95

Departments of Clinical Pharmacology and Cardiology, Basil Hetzel Institute, The Queen Elizabeth Hospital, Woodville, SA, Australia; The Discipline of Surgery, University of Adelaide, Adelaide, SA, Australia; Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, Birmingham, UK.

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http://doi.wiley.com/10.1111/bcp.12254
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http://dx.doi.org/10.1111/bcp.12254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004399PMC
May 2014

The new EuroSCORE II does not improve prediction of mortality in high-risk patients undergoing cardiac surgery: a collaborative analysis of two European centres.

Eur J Cardiothorac Surg 2013 Dec 27;44(6):1006-11; discussion 1011. Epub 2013 Mar 27.

Department of Cardiothoracic Surgery, University Hospital Birmingham-Queen Elizabeth, Birmingham, UK.

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http://dx.doi.org/10.1093/ejcts/ezt174DOI Listing
December 2013

The European Association for Cardio-Thoracic Surgery (EACTS) database: an introduction.

Eur J Cardiothorac Surg 2013 Sep 19;44(3):e175-80. Epub 2013 Jun 19.

Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/ejcts/ezt303DOI Listing
September 2013

A systematic review of risk prediction in adult cardiac surgery: considerations for future model development.

Eur J Cardiothorac Surg 2013 May 19;43(5):e121-9. Epub 2013 Feb 19.

Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands.

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https://academic.oup.com/ejcts/article-lookup/doi/10.1093/ej
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http://dx.doi.org/10.1093/ejcts/ezt044DOI Listing
May 2013

Prediction of in-hospital death following aortic valve replacement: a new accurate model.

Eur J Cardiothorac Surg 2013 Apr 22;43(4):704-8. Epub 2012 Aug 22.

School of Health and Population Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1093/ejcts/ezs457DOI Listing
April 2013

Reply to the editor.

J Thorac Cardiovasc Surg 2013 Feb;145(2):610-1

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http://dx.doi.org/10.1016/j.jtcvs.2012.11.003DOI Listing
February 2013

Putting the record straight on aprotinin as safe and effective: results from a mixed treatment meta-analysis of trials of aprotinin.

J Thorac Cardiovasc Surg 2013 Jan 11;145(1):234-40. Epub 2012 Aug 11.

Department of Cardiac Surgery, University Hospital Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1016/j.jtcvs.2012.07.018DOI Listing
January 2013

Subtle changes in renal function are associated with differences in late survival following adult cardiac surgery.

Eur J Cardiothorac Surg 2012 Apr;41(4):e38-42

Department of Cardiac Surgery, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

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https://academic.oup.com/ejcts/article-lookup/doi/10.1093/ej
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http://dx.doi.org/10.1093/ejcts/ezr329DOI Listing
April 2012

Changes in cardiac substrate transporters and metabolic proteins mirror the metabolic shift in patients with aortic stenosis.

PLoS One 2011 18;6(10):e26326. Epub 2011 Oct 18.

Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026326PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196577PMC
February 2012

Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients.

Diab Vasc Dis Res 2010 Jul 26;7(3):213-5. Epub 2010 Jul 26.

Cardiovascular Medicine Group, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1177/1479164110376207DOI Listing
July 2010

Titin isoform expression in aortic stenosis.

Clin Sci (Lond) 2009 Aug 14;117(6):237-42. Epub 2009 Aug 14.

Department of Cardiovascular Medicine, University of Birmingham, Birmingham, U.K.

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http://dx.doi.org/10.1042/CS20080248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419140PMC
August 2009

Mild renal dysfunction predicts in-hospital mortality and post-discharge survival following cardiac surgery.

Eur J Cardiothorac Surg 2008 Aug 23;34(2):390-5; discussion 395. Epub 2008 May 23.

Department of Cardiothoracic Surgery, University Hospital Birmingham, UK.

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http://dx.doi.org/10.1016/j.ejcts.2008.04.017DOI Listing
August 2008

Bleeding in cardiac surgery: the use of aprotinin does not affect survival.

J Thorac Cardiovasc Surg 2008 Mar;135(3):495-502

Department of Cardiothoracic Surgery, University Hospital Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1016/j.jtcvs.2007.11.045DOI Listing
March 2008

Relative rates of evolution in the coding and control regions of African mtDNAs.

Mol Biol Evol 2007 Oct 21;24(10):2213-21. Epub 2007 Jul 21.

MIGENIX Corp., San Diego, CA, USA.

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http://dx.doi.org/10.1093/molbev/msm147DOI Listing
October 2007

Patient-prosthesis mismatch does not affect survival following aortic valve replacement.

Eur J Cardiothorac Surg 2006 Jul 24;30(1):10-4. Epub 2006 May 24.

Department of Cardiothoracic Surgery, University Hospital NHS Foundation Trust, Birmingham, UK.

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http://dx.doi.org/10.1016/j.ejcts.2006.03.046DOI Listing
July 2006

Does the mitochondrial genome play a role in the etiology of Alzheimer's disease?

Hum Genet 2006 Apr 12;119(3):241-54. Epub 2006 Jan 12.

Mitochondrial Research Group, School of Neurology, Neurobiology, and Psychiatry, The University of Newcastle upon Tyne, and Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1007/s00439-005-0123-8DOI Listing
April 2006

Mitochondrial DNA and survival after sepsis: a prospective study.

Lancet 2005 Dec;366(9503):2118-21

University Department of Surgical & Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/S0140-6736(05)67890-7DOI Listing
December 2005

mtDNA mutations and common neurodegenerative disorders.

Trends Genet 2005 Nov 8;21(11):583-6. Epub 2005 Sep 8.

Migenix Corporation, San Diego, CA 92130, USA.

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http://www.cell.com/trends/genetics/pdf/S0168-9525(05)00255-
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http://linkinghub.elsevier.com/retrieve/pii/S016895250500255
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http://dx.doi.org/10.1016/j.tig.2005.08.012DOI Listing
November 2005

Development of 17alpha-estradiol as a neuroprotective therapeutic agent: rationale and results from a phase I clinical study.

Ann N Y Acad Sci 2005 Jun;1052:116-35

MIGENIX Corporation, 12780 High Bluff Dr., San Diego, CA 92130, USA.

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http://dx.doi.org/10.1196/annals.1347.008DOI Listing
June 2005

Co-segregation and heteroplasmy of two coding-region mtDNA mutations within a matrilineal pedigree.

Hum Genet 2005 Jan 3;116(1-2):28-32. Epub 2004 Nov 3.

MitoKor Inc., 12780 High Bluff Drive, Suite 210, San Diego, CA 92130, USA.

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http://dx.doi.org/10.1007/s00439-004-1203-xDOI Listing
January 2005

Assigning pathogenicity to mitochondrial tRNA mutations: when "definitely maybe" is not good enough.

Trends Genet 2004 Dec;20(12):591-6

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle-upon-Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.tig.2004.09.014DOI Listing
December 2004

African Haplogroup L mtDNA sequences show violations of clock-like evolution.

Mol Biol Evol 2004 Oct 9;21(10):1843-54. Epub 2004 Jun 9.

MitoKor Inc., San Diego, California, USA.

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http://dx.doi.org/10.1093/molbev/msh184DOI Listing
October 2004

An evolutionary perspective on pathogenic mtDNA mutations: haplogroup associations of clinical disorders.

Mitochondrion 2004 Sep 1;4(5-6):791-8. Epub 2004 Oct 1.

MitoKor, 12780 High Bluff Drive, Suite 210, San Diego, CA, USA.

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http://dx.doi.org/10.1016/j.mito.2004.07.041DOI Listing
September 2004

Comparative genomics and the evolution of human mitochondrial DNA: assessing the effects of selection.

Am J Hum Genet 2004 Feb 7;74(2):229-38. Epub 2004 Jan 7.

Mitochondrial Research Group, School of Neurology, Neurobiology, and Psychiatry, The Medical School, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1181921PMC
http://dx.doi.org/10.1086/381505DOI Listing
February 2004

A novel sporadic mutation in cytochrome c oxidase subunit II as a cause of rhabdomyolysis.

Neuromuscul Disord 2004 Feb;14(2):162-6

Mitochondrial Research Group, Department of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, Framlington Place, NE2 4HH, UK.

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February 2004

Genotypes from patients indicate no paternal mitochondrial DNA contribution.

Ann Neurol 2003 Oct;54(4):521-4

School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/ana.10673DOI Listing
October 2003

LHON and other optic nerve atrophies: the mitochondrial connection.

Authors:
Neil Howell

Dev Ophthalmol 2003 ;37:94-108

MitoKor, San Diego, Calif., USA.

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September 2003

Low penetrance of the 14484 LHON mutation when it arises in a non-haplogroup J mtDNA background.

Am J Med Genet A 2003 Jun;119A(2):147-51

MitoKor, San Diego, California 92121, USA.

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http://dx.doi.org/10.1002/ajmg.a.20135DOI Listing
June 2003

X-inactivation pattern in multiple tissues from two Leber's hereditary optic neuropathy (LHON) patients.

Am J Med Genet A 2003 May;119A(1):37-40

Department of Neurological and Psychiatric Sciences, University of Padova, Italy.

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http://dx.doi.org/10.1002/ajmg.a.10211DOI Listing
May 2003

Changes in the human mitochondrial genome after treatment of malignant disease.

Mutat Res 2003 Apr;525(1-2):19-27

Department of Neurology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/s0027-5107(02)00313-5DOI Listing
April 2003

Lightning strikes twice: Leber hereditary optic neuropathy families with two pathogenic mtDNA mutations.

J Neuroophthalmol 2002 Dec;22(4):262-9

MitoKor, San Diego, California 92121, USA.

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December 2002

A high frequency of mtDNA polymorphisms in HeLa cell sublines.

Mutat Res 2002 Apr;501(1-2):19-28

MitoKor, 11494 Sorrento Valley Road, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/s0027-5107(01)00304-9DOI Listing
April 2002