Publications by authors named "Neil Carragher"

78Publications

Novel roles of PRK1 and PRK2 in cilia and cancer biology.

Sci Rep 2020 03 3;10(1):3902. Epub 2020 Mar 3.

University of Edinburgh, Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, Edinburgh, United Kingdom.

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March 2020

Drug Screening Platforms and RPPA.

Adv Exp Med Biol 2019 ;1188:203-226

Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.

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December 2019

A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.

Mol Cancer Ther 2020 02 29;19(2):637-649. Epub 2019 Nov 29.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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February 2020

High content phenotypic screening identifies serotonin receptor modulators with selective activity upon breast cancer cell cycle and cytokine signaling pathways.

Bioorg Med Chem 2020 01 9;28(1):115209. Epub 2019 Nov 9.

Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XR Edinburgh, United Kingdom. Electronic address:

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January 2020

The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells.

BMC Cancer 2019 Nov 19;19(1):1124. Epub 2019 Nov 19.

MRC Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, EH16 4TJ, UK.

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November 2019

Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF.

Cancer Immunol Res 2019 12 15;7(12):2052-2064. Epub 2019 Oct 15.

MRC Centre for Reproductive Health, The University of Edinburgh, Edinburgh, United Kingdom.

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December 2019

N-cadherin stabilises neural identity by dampening anti-neural signals.

Development 2019 11 8;146(21). Epub 2019 Nov 8.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh EH16 4UU, UK

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November 2019

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells.

J Vis Exp 2019 01 29(143). Epub 2019 Jan 29.

Edinburgh Phenotypic Assay Centre, University of Edinburgh; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics, Molecular Medicine, University of Edinburgh.

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January 2019

Evaluation of Machine Learning Classifiers to Predict Compound Mechanism of Action When Transferred across Distinct Cell Lines.

SLAS Discov 2019 03 29;24(3):224-233. Epub 2019 Jan 29.

1 Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.

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March 2019

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells.

Cell Chem Biol 2018 12 4;25(12):1456-1469.e6. Epub 2018 Oct 4.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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December 2018

Concerns, challenges and promises of high-content analysis of 3D cellular models.

Nat Rev Drug Discov 2018 08 6;17(8):606. Epub 2018 Jul 6.

Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary and the Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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August 2018

High-Dimensional Profiling: The Theta Comparative Cell Scoring Method.

Methods Mol Biol 2018 ;1787:171-181

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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February 2019

Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer.

Front Immunol 2017 17;8:2004. Epub 2018 Jan 17.

MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.

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January 2018

Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions.

Assay Drug Dev Technol 2018 01;16(1):51-63

1 Centre for Regenerative Medicine, University of Edinburgh , Edinburgh, United Kingdom .

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January 2018

High-Precision Photothermal Ablation Using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy.

ACS Appl Mater Interfaces 2018 Jan 22;10(4):3341-3348. Epub 2018 Jan 22.

Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Crewe Road South, Edinburgh EH4 2XR, United Kingdom.

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January 2018

Reverse Phase Protein Arrays and Drug Discovery.

Methods Mol Biol 2017 ;1647:153-169

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK.

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April 2018

Reverse Phase Protein Arrays elucidate mechanisms-of-action and phenotypic response in 2D and 3D models.

Drug Discov Today Technol 2017 Mar 30;23:7-16. Epub 2017 May 30.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address:

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March 2017

Accelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screening.

Mol Cell Neurosci 2017 04 4;80:198-207. Epub 2016 Nov 4.

MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK; Institute of Genetics and Molecular Medicine, CRUK Edinburgh Centre, University of Edinburgh, UK. Electronic address:

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April 2017

Screening out irrelevant cell-based models of disease.

Nat Rev Drug Discov 2016 11 12;15(11):751-769. Epub 2016 Sep 12.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.

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November 2016

Development of the Theta Comparative Cell Scoring Method to Quantify Diverse Phenotypic Responses Between Distinct Cell Types.

Assay Drug Dev Technol 2016 09;14(7):395-406

Institute of Genetics and Molecular Medicine, Cancer Research UK Edinburgh Centre, University of Edinburgh , Edinburgh, United Kingdom .

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September 2016

Next-generation phenotypic screening.

Future Med Chem 2016 07 30;8(11):1331-47. Epub 2016 Jun 30.

Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK.

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July 2016

Naturally Inspired Peptide Leads: Alanine Scanning Reveals an Actin-Targeting Thiazole Analogue of Bisebromoamide.

Chembiochem 2016 09 5;17(17):1621-7. Epub 2016 Aug 5.

EaStCHEM School of Chemistry, The University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ, UK.

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September 2016

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches.

Cell Syst 2016 01 27;2(1):38-48. Epub 2016 Jan 27.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland; Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia.

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January 2016

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival.

Cell Rep 2015 Dec 19;13(9):1949-64. Epub 2015 Nov 19.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address:

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December 2015

FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis.

J Exp Med 2015 Aug 10;212(9):1433-48. Epub 2015 Aug 10.

MRC and University of Edinburgh Centre for Reproductive Health, Queen's Medical Research Institute; and Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine; University of Edinburgh, Edinburgh EH16 4TJ, Scotland, UK Department of Developmental and Molecular Biology and Department of Biochemistry, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461

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August 2015

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells.

Proc Natl Acad Sci U S A 2015 Jul 10;112(29):E3800-5. Epub 2015 Jul 10.

Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom;

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July 2015

Palladium-mediated dealkylation of N-propargyl-floxuridine as a bioorthogonal oxygen-independent prodrug strategy.

Sci Rep 2015 Mar 19;5:9329. Epub 2015 Mar 19.

Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK.

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March 2015

The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through β-catenin signaling.

Stem Cell Reports 2015 Apr 5;4(4):551-60. Epub 2015 Mar 5.

The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK. Electronic address:

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April 2015

Quantitative phenotypic and pathway profiling guides rational drug combination strategies.

Front Pharmacol 2014 28;5:118. Epub 2014 May 28.

Edinburgh Cancer Discovery Unit, Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh Edinburgh, UK.

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June 2014

Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine.

J Med Chem 2014 Jun 12;57(12):5395-404. Epub 2014 Jun 12.

Edinburgh Cancer Research UK Centre, and ‡MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Crewe Road South, Edinburgh EH4 2XR, U.K.

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June 2014

Developments in preclinical cancer imaging: innovating the discovery of therapeutics.

Nat Rev Cancer 2014 May 17;14(5):314-28. Epub 2014 Apr 17.

Garvan Institute of Medical Research and The Kinghorn Cancer Centre Sydney, St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, New South Wales 2010, Sydney, Australia.

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May 2014

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery.

Drug Discov Today 2012 Mar;17(5-6):203-14

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, UK.

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March 2012

Advancing cancer drug discovery towards more agile development of targeted combination therapies.

Future Med Chem 2012 Jan;4(1):87-105

Edinburgh Cancer Research UK Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, UK.

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January 2012

The calpain system and cancer.

Nat Rev Cancer 2011 May;11(5):364-74

University of Nottingham, School of Molecular Medical Sciences, Nottingham NG5 1PB, UK.

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May 2011

Live cell in vitro and in vivo imaging applications: accelerating drug discovery.

Pharmaceutics 2011 Apr 4;3(2):141-70. Epub 2011 Apr 4.

Advanced Science & Technology Laboratory, AstraZeneca R&D Charnwood, Loughborough LE11 5RH, UK.

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April 2011

High-content phenotypic profiling of drug response signatures across distinct cancer cells.

Mol Cancer Ther 2010 Jun 8;9(6):1913-26. Epub 2010 Jun 8.

Advanced Science and Technology Laboratory, AstraZeneca R&D Charnwood, Loughborough, United Kingdom.

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June 2010

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development.

Cancer Res 2009 Apr 24;69(7):2714-9. Epub 2009 Mar 24.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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April 2009

Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover.

Authors:
Neil O Carragher

Clin Exp Metastasis 2009 29;26(4):381-97. Epub 2008 Oct 29.

Advanced Science and Technology Laboratory, AstraZeneca Charnwood, Bakewell Road, Loughborough, UK.

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April 2009

Assaying calpain activity.

Authors:
Neil O Carragher

Methods Mol Biol 2007 ;370:109-20

Cell Adhesion-Linked Kinase Laboratory, Beatson Institute for Cancer Research, Bearsden, Glassgow, UK.

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July 2008

Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.

J Cell Sci 2006 Jun;119(Pt 11):2375-85

Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, UK.

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June 2006

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.

Nat Rev Cancer 2005 Jul;5(7):505-15

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom.

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July 2005

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion.

Trends Cell Biol 2004 May;14(5):241-9

The Beatson Institute for Cancer Research, Cancer Research UK, Glasgow G61 1BD, UK.

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May 2004

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.

Curr Biol 2003 Aug;13(16):1442-50

The Beatson Institute for Cancer Research, Cancer Research United Kingdom, Beatson Laboratories, Glasgow G61 1BD, Scotland, United Kingdom.

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August 2003

Calpain: a role in cell transformation and migration.

Int J Biochem Cell Biol 2002 Dec;34(12):1539-43

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, G61 1BD Glasgow, Scotland, UK.

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December 2002

v-Src's hold over actin and cell adhesions.

Nat Rev Mol Cell Biol 2002 Apr;3(4):233-45

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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April 2002