Publications by authors named "Neil Carragher"

78Publications

Integrative analysis of multi-platform reverse-phase protein array data for the pharmacodynamic assessment of response to targeted therapies.

Authors:
Adam Byron Stephan Bernhardt Bérèngere Ouine Aurélie Cartier Kenneth G Macleod Neil O Carragher Vonick Sibut Ulrike Korf Bryan Serrels Leanne de Koning

Sci Rep 2020 12 15;10(1):21985. Epub 2020 Dec 15.

Department of Translational Research, Institut Curie, PSL Research University, 26 rue d'Ulm, 75005, Paris, France.

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December 2020

Brain microenvironment-driven resistance to immune and targeted therapies in acral melanoma.

Authors:
Rebecca Jane Lee Garima Khandelwal Franziska Baenke Alessio Cannistraci Kenneth Macleod Piyushkumar Mundra Garry Ashton Amit Mandal Amaya Viros Gabriela Gremel Elena Galvani Matthew Smith Neil Carragher Nathalie Dhomen Crispin Miller Paul Lorigan Richard Marais

ESMO Open 2020 08;5(4)

Molecular Oncology Group, CRUK Manchester Institute, The University of Manchester, Nether Alderley, Macclesfield, UK

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August 2020

The retinal tyrosine kinome of diabetic Akimba mice highlights potential for specific Src family kinase inhibition in retinal vascular disease.

Authors:
Jurgen Sergeys Inge Van Hove Tjing-Tjing Hu Carolin Temps Neil O Carragher Asier Unciti-Broceta Jean H M Feyen Lieve Moons Michael Porcu

Exp Eye Res 2020 08 23;197:108108. Epub 2020 Jun 23.

Oxurion NV, 3001, Heverlee, Belgium. Electronic address:

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August 2020

High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery.

Authors:
Rebecca E Hughes Richard J R Elliott Alison F Munro Ashraff Makda J Robert O'Neill Ted Hupp Neil O Carragher

SLAS Discov 2020 Aug 22;25(7):770-782. Epub 2020 May 22.

MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK.

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August 2020

Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site.

Authors:
Umesh Kalathiya Monikaben Padariya Marcos Mayordomo Małgorzata Lisowska Judith Nicholson Ashita Singh Maciej Baginski Robin Fahraeus Neil Carragher Kathryn Ball Juergen Haas Alison Daniels Ted R Hupp Javier Antonio Alfaro

J Clin Med 2020 May 14;9(5). Epub 2020 May 14.

International Centre for Cancer Vaccine Science, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.

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May 2020

Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy.

Authors:
Andrea Martello Angela Lauriola David Mellis Elisa Parish John C Dawson Lisa Imrie Martina Vidmar Noor Gammoh Tijana Mitić Mairi Brittan Nicholas L Mills Neil O Carragher Domenico D'Arca Andrea Caporali

EMBO Rep 2020 07 26;21(7):e48192. Epub 2020 Apr 26.

University/BHF Centre for Cardiovascular Science, QMRI, University of Edinburgh, Edinburgh, UK.

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July 2020

Combined targeting of MEK and the glucocorticoid receptor for the treatment of RAS-mutant multiple myeloma.

Authors:
Priya Sriskandarajah Alexis De Haven Brandon Kenneth MacLeod Neil O Carragher Vladimir Kirkin Martin Kaiser Steven R Whittaker

BMC Cancer 2020 Mar 30;20(1):269. Epub 2020 Mar 30.

Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.

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March 2020

Novel roles of PRK1 and PRK2 in cilia and cancer biology.

Authors:
Hitesh Patel Jun Li Ana Herrero Jakob Kroboth Adam Byron Alex Von Kriegsheim Valerie Brunton Neil Carragher Toby Hurd Margaret Frame

Sci Rep 2020 03 3;10(1):3902. Epub 2020 Mar 3.

University of Edinburgh, Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, Edinburgh, United Kingdom.

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March 2020

Drug Screening Platforms and RPPA.

Authors:
John C Dawson Scott J Warchal Neil O Carragher

Adv Exp Med Biol 2019 ;1188:203-226

Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.

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December 2019

A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.

Authors:
John C Dawson Bryan Serrels Adam Byron Morwenna T Muir Ashraff Makda Amaya García-Muñoz Alex von Kriegsheim Daniel Lietha Neil O Carragher Margaret C Frame

Mol Cancer Ther 2020 02 29;19(2):637-649. Epub 2019 Nov 29.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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February 2020

High content phenotypic screening identifies serotonin receptor modulators with selective activity upon breast cancer cell cycle and cytokine signaling pathways.

Authors:
Scott J Warchal John C Dawson Emelie Shepherd Alison F Munro Rebecca E Hughes Ashraff Makda Neil O Carragher

Bioorg Med Chem 2020 01 9;28(1):115209. Epub 2019 Nov 9.

Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XR Edinburgh, United Kingdom. Electronic address:

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January 2020

The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells.

Authors:
Maria E Camacho-Moll Joni Macdonald L H J Looijenga Michael P Rimmer Roland Donat John A Marwick C J Shukla Neil Carragher Anne Jørgensen Rod T Mitchell

BMC Cancer 2019 Nov 19;19(1):1124. Epub 2019 Nov 19.

MRC Centre for Reproductive Health, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, EH16 4TJ, UK.

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November 2019

Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF.

Authors:
Takanori Kitamura Yu Kato Demi Brownlie Daniel Y H Soong Gaël Sugano Nicolle Kippen Jiufeng Li Dahlia Doughty-Shenton Neil Carragher Jeffrey W Pollard

Cancer Immunol Res 2019 12 15;7(12):2052-2064. Epub 2019 Oct 15.

MRC Centre for Reproductive Health, The University of Edinburgh, Edinburgh, United Kingdom.

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December 2019

N-cadherin stabilises neural identity by dampening anti-neural signals.

Authors:
Karolina Punovuori Rosa P Migueles Mattias Malaguti Guillaume Blin Kenneth G Macleod Neil O Carragher Tim Pieters Frans van Roy Marc P Stemmler Sally Lowell

Development 2019 11 8;146(21). Epub 2019 Nov 8.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh EH16 4UU, UK

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November 2019

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis.

Authors:
Harvey W Smith Alison Hirukawa Virginie Sanguin-Gendreau Ipshita Nandi Catherine R Dufour Dongmei Zuo Kristofferson Tandoc Matthew Leibovitch Salendra Singh Jonathan P Rennhack Matthew Swiatnicki Cynthia Lavoie Vasilios Papavasiliou Carolin Temps Neil O Carragher Asier Unciti-Broceta Paul Savage Mark Basik Vincent van Hoef Ola Larsson Caroline L Cooper Ana Cristina Vargas Calderon Jane Beith Ewan Millar Christina Selinger Vincent Giguère Morag Park Lyndsay N Harris Vinay Varadan Eran R Andrechek Sandra A O'Toole Ivan Topisirovic William J Muller

Nat Commun 2019 07 1;10(1):2901. Epub 2019 Jul 1.

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, QC, H3A 1A3, Canada.

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July 2019

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells.

Authors:
Takanori Kitamura Dahlia Doughty-Shenton Jeffrey W Pollard Neil O Carragher

J Vis Exp 2019 01 29(143). Epub 2019 Jan 29.

Edinburgh Phenotypic Assay Centre, University of Edinburgh; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics, Molecular Medicine, University of Edinburgh.

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January 2019

A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors.

Authors:
Alessio De Simone Charis Georgiou Harris Ioannidis Arun A Gupta Jordi Juárez-Jiménez Dahlia Doughty-Shenton Elizabeth A Blackburn Martin A Wear Jonathan P Richards Paul N Barlow Neil Carragher Malcolm D Walkinshaw Alison N Hulme Julien Michel

Chem Sci 2019 Jan 23;10(2):542-547. Epub 2018 Oct 23.

University of Edinburgh , Joseph Black Building, King's Buildings, David Brewster Road , Edinburgh , Scotland EH9 3FJ , UK . Email:

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January 2019

Evaluation of Machine Learning Classifiers to Predict Compound Mechanism of Action When Transferred across Distinct Cell Lines.

Authors:
Scott J Warchal John C Dawson Neil O Carragher

SLAS Discov 2019 03 29;24(3):224-233. Epub 2019 Jan 29.

1 Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.

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March 2019

Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging.

Authors:
Mandy Johnstone Navneet A Vasistha Miruna C Barbu Owen Dando Karen Burr Edward Christopher Sophie Glen Christelle Robert Rana Fetit Kenneth G Macleod Matthew R Livesey David St Clair Douglas H R Blackwood Kirsty Millar Neil O Carragher Giles E Hardingham David J A Wyllie Eve C Johnstone Heather C Whalley Andrew M McIntosh Stephen M Lawrie Siddharthan Chandran

Mol Psychiatry 2019 02 6;24(2):294-311. Epub 2018 Nov 6.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

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February 2019

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells.

Authors:
Sana Sarvi Richard Crispin Yuting Lu Lifan Zeng Thomas D Hurley Douglas R Houston Alex von Kriegsheim Che-Hong Chen Daria Mochly-Rosen Marco Ranzani Marie E Mathers Xiaowei Xu Wei Xu David J Adams Neil O Carragher Mayumi Fujita Lynn Schuchter Asier Unciti-Broceta Valerie G Brunton E Elizabeth Patton

Cell Chem Biol 2018 12 4;25(12):1456-1469.e6. Epub 2018 Oct 4.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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December 2018

Concerns, challenges and promises of high-content analysis of 3D cellular models.

Authors:
Neil Carragher Filippo Piccinini Anna Tesei O Joseph Trask Marc Bickle Peter Horvath

Nat Rev Drug Discov 2018 08 6;17(8):606. Epub 2018 Jul 6.

Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary and the Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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August 2018

High-Dimensional Profiling: The Theta Comparative Cell Scoring Method.

Authors:
Scott J Warchal John C Dawson Neil O Carragher

Methods Mol Biol 2018 ;1787:171-181

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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February 2019

Blocking distinct interactions between Glioblastoma cells and their tissue microenvironment: A novel multi-targeted therapeutic approach.

Authors:
Melanie Mettang Viola Meyer-Pannwitt Georg Karpel-Massler Shaoxia Zhou Neil O Carragher Karl Josef Föhr Bernd Baumann Lisa Nonnenmacher Stefanie Enzenmüller Meike Dahlhaus Markus D Siegelin Sebastien Stroh Daniel Mertens Pamela Fischer-Posovszky E Marion Schneider Marc-Eric Halatsch Klaus-Michael Debatin Mike-Andrew Westhoff

Sci Rep 2018 04 3;8(1):5527. Epub 2018 Apr 3.

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

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April 2018

Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer.

Authors:
Takanori Kitamura Dahlia Doughty-Shenton Luca Cassetta Stamatina Fragkogianni Demi Brownlie Yu Kato Neil Carragher Jeffrey W Pollard

Front Immunol 2017 17;8:2004. Epub 2018 Jan 17.

MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.

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January 2018

Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions.

Authors:
Eoghan O'Duibhir Jasmin Paris Hannah Lawson Catarina Sepulveda Dahlia Doughty Shenton Neil O Carragher Kamil R Kranc

Assay Drug Dev Technol 2018 01;16(1):51-63

1 Centre for Regenerative Medicine, University of Edinburgh , Edinburgh, United Kingdom .

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January 2018

High-Precision Photothermal Ablation Using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy.

Authors:
Belén Rubio-Ruiz Ana M Pérez-López Thomas L Bray Martin Lee Alan Serrels Martín Prieto Manuel Arruebo Neil O Carragher Víctor Sebastián Asier Unciti-Broceta

ACS Appl Mater Interfaces 2018 Jan 22;10(4):3341-3348. Epub 2018 Jan 22.

Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Crewe Road South, Edinburgh EH4 2XR, United Kingdom.

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January 2018

Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action.

Authors:
Jessica M Hearn George M Hughes Isolda Romero-Canelón Alison F Munro Belén Rubio-Ruiz Zhe Liu Neil O Carragher Peter J Sadler

Metallomics 2018 01;10(1):93-107

Department of Chemistry, University of Warwick, UK.

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January 2018

TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p.

Authors:
Jonathan Berrout Eleni Kyriakopoulou Lavanya Moparthi Alexandra S Hogea Liza Berrout Cristina Ivan Mihaela Lorger John Boyle Chris Peers Stephen Muench Jacobo Elies Gomez Xin Hu Carolyn Hurst Thomas Hall Sujanitha Umamaheswaran Laura Wesley Mihai Gagea Michael Shires Iain Manfield Margaret A Knowles Simon Davies Klaus Suhling Yurema Teijeiro Gonzalez Neil Carragher Kenneth Macleod N Joan Abbott George A Calin Nikita Gamper Peter M Zygmunt Zahra Timsah

Nat Commun 2017 10 16;8(1):947. Epub 2017 Oct 16.

School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK.

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October 2017

Reverse Phase Protein Arrays and Drug Discovery.

Authors:
Kenneth G Macleod Bryan Serrels Neil O Carragher

Methods Mol Biol 2017 ;1647:153-169

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK.

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April 2018

Reverse Phase Protein Arrays elucidate mechanisms-of-action and phenotypic response in 2D and 3D models.

Authors:
Michael Pawlak Neil O Carragher

Drug Discov Today Technol 2017 Mar 30;23:7-16. Epub 2017 May 30.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address:

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March 2017

Empirical drug discovery: a view from the proteome.

Authors:
Jonathan A Lee Neil O Carragher Ellen L Berg

Drug Discov Today Technol 2017 Mar;23:1-5

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March 2017

Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array.

Authors:
Marina Partolina Hazel C Thoms Kenneth G MacLeod Giovanny Rodriguez-Blanco Matthew N Clarke Anuroop V Venkatasubramani Rima Beesoo Vladimir Larionov Vidushi S Neergheen-Bhujun Bryan Serrels Hiroshi Kimura Neil O Carragher Alexander Kagansky

Cell Death Discov 2017 6;3:16077. Epub 2017 Mar 6.

Synthetic Epigenetics Laboratory, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh , Edinburgh, UK.

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March 2017

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma.

Authors:
Maria Romina Girotti Filipa Lopes Natasha Preece Dan Niculescu-Duvaz Alfonso Zambon Lawrence Davies Steven Whittaker Grazia Saturno Amaya Viros Malin Pedersen Bart M J M Suijkerbuijk Delphine Menard Robert McLeary Louise Johnson Laura Fish Sarah Ejiama Berta Sanchez-Laorden Juliane Hohloch Neil Carragher Kenneth Macleod Garry Ashton Anna A Marusiak Alberto Fusi John Brognard Margaret Frame Paul Lorigan Richard Marais Caroline Springer

Cancer Cell 2017 03;31(3):466

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March 2017

Accelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screening.

Authors:
Eoghan O'Duibhir Neil O Carragher Steven M Pollard

Mol Cell Neurosci 2017 04 4;80:198-207. Epub 2016 Nov 4.

MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK; Institute of Genetics and Molecular Medicine, CRUK Edinburgh Centre, University of Edinburgh, UK. Electronic address:

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April 2017

Screening out irrelevant cell-based models of disease.

Authors:
Peter Horvath Nathalie Aulner Marc Bickle Anthony M Davies Elaine Del Nery Daniel Ebner Maria C Montoya Päivi Östling Vilja Pietiäinen Leo S Price Spencer L Shorte Gerardo Turcatti Carina von Schantz Neil O Carragher

Nat Rev Drug Discov 2016 11 12;15(11):751-769. Epub 2016 Sep 12.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.

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November 2016

Development of the Theta Comparative Cell Scoring Method to Quantify Diverse Phenotypic Responses Between Distinct Cell Types.

Authors:
Scott J Warchal John C Dawson Neil O Carragher

Assay Drug Dev Technol 2016 09;14(7):395-406

Institute of Genetics and Molecular Medicine, Cancer Research UK Edinburgh Centre, University of Edinburgh , Edinburgh, United Kingdom .

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September 2016

Next-generation phenotypic screening.

Authors:
Scott J Warchal Asier Unciti-Broceta Neil O Carragher

Future Med Chem 2016 07 30;8(11):1331-47. Epub 2016 Jun 30.

Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK.

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July 2016

Naturally Inspired Peptide Leads: Alanine Scanning Reveals an Actin-Targeting Thiazole Analogue of Bisebromoamide.

Authors:
Heather J Johnston Sarah K Boys Ashraff Makda Neil O Carragher Alison N Hulme

Chembiochem 2016 09 5;17(17):1621-7. Epub 2016 Aug 5.

EaStCHEM School of Chemistry, The University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ, UK.

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September 2016

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches.

Authors:
Kate M Byrne Naser Monsefi John C Dawson Andrea Degasperi Jimi-Carlo Bukowski-Wills Natalia Volinsky Maciej Dobrzyński Marc R Birtwistle Mikhail A Tsyganov Anatoly Kiyatkin Katarzyna Kida Andrew J Finch Neil O Carragher Walter Kolch Lan K Nguyen Alex von Kriegsheim Boris N Kholodenko

Cell Syst 2016 01 27;2(1):38-48. Epub 2016 Jan 27.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland; Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia.

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January 2016

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

Authors:
Craig Fraser John C Dawson Reece Dowling Douglas R Houston Jason T Weiss Alison F Munro Morwenna Muir Lea Harrington Scott P Webster Margaret C Frame Valerie G Brunton E Elizabeth Patton Neil O Carragher Asier Unciti-Broceta

J Med Chem 2016 05 4;59(10):4697-710. Epub 2016 May 4.

University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh , Edinburgh EH16 4TJ, United Kingdom.

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May 2016

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival.

Authors:
Georgios Kanellos Jing Zhou Hitesh Patel Rachel A Ridgway David Huels Christine B Gurniak Emma Sandilands Neil O Carragher Owen J Sansom Walter Witke Valerie G Brunton Margaret C Frame

Cell Rep 2015 Dec 19;13(9):1949-64. Epub 2015 Nov 19.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address:

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December 2015

FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis.

Authors:
Bin-Zhi Qian Hui Zhang Jiufeng Li Tianfang He Eun-Jin Yeo Daniel Y H Soong Neil O Carragher Alison Munro Alvin Chang Anne R Bresnick Richard A Lang Jeffrey W Pollard

J Exp Med 2015 Aug 10;212(9):1433-48. Epub 2015 Aug 10.

MRC and University of Edinburgh Centre for Reproductive Health, Queen's Medical Research Institute; and Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine; University of Edinburgh, Edinburgh EH16 4TJ, Scotland, UK Department of Developmental and Molecular Biology and Department of Biochemistry, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461

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August 2015

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells.

Authors:
Jessica M Hearn Isolda Romero-Canelón Alison F Munro Ying Fu Ana M Pizarro Mathew J Garnett Ultan McDermott Neil O Carragher Peter J Sadler

Proc Natl Acad Sci U S A 2015 Jul 10;112(29):E3800-5. Epub 2015 Jul 10.

Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom;

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July 2015

Palladium-mediated dealkylation of N-propargyl-floxuridine as a bioorthogonal oxygen-independent prodrug strategy.

Authors:
Jason T Weiss Neil O Carragher Asier Unciti-Broceta

Sci Rep 2015 Mar 19;5:9329. Epub 2015 Mar 19.

Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK.

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March 2015

The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through β-catenin signaling.

Authors:
Nils Olof Lindström Neil Oliver Carragher Peter Hohenstein

Stem Cell Reports 2015 Apr 5;4(4):551-60. Epub 2015 Mar 5.

The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK. Electronic address:

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April 2015

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.

Authors:
Maria Romina Girotti Filipa Lopes Natasha Preece Dan Niculescu-Duvaz Alfonso Zambon Lawrence Davies Steven Whittaker Grazia Saturno Amaya Viros Malin Pedersen Bart M J M Suijkerbuijk Delphine Menard Robert McLeary Louise Johnson Laura Fish Sarah Ejiama Berta Sanchez-Laorden Juliane Hohloch Neil Carragher Kenneth Macleod Garry Ashton Anna A Marusiak Alberto Fusi John Brognard Margaret Frame Paul Lorigan Richard Marais Caroline Springer

Cancer Cell 2015 Jan 11;27(1):85-96. Epub 2014 Dec 11.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK. Electronic address:

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January 2015

N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture.

Authors:
Jason T Weiss Craig Fraser Belén Rubio-Ruiz Samuel H Myers Richard Crispin John C Dawson Valerie G Brunton E Elizabeth Patton Neil O Carragher Asier Unciti-Broceta

Front Chem 2014 29;2:56. Epub 2014 Jul 29.

Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh Edinburgh, UK.

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August 2014

Quantitative phenotypic and pathway profiling guides rational drug combination strategies.

Authors:
John C Dawson Neil O Carragher

Front Pharmacol 2014 28;5:118. Epub 2014 May 28.

Edinburgh Cancer Discovery Unit, Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh Edinburgh, UK.

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June 2014

Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine.

Authors:
Jason T Weiss John C Dawson Craig Fraser Witold Rybski Carmen Torres-Sánchez Mark Bradley E Elizabeth Patton Neil O Carragher Asier Unciti-Broceta

J Med Chem 2014 Jun 12;57(12):5395-404. Epub 2014 Jun 12.

Edinburgh Cancer Research UK Centre, and ‡MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Crewe Road South, Edinburgh EH4 2XR, U.K.

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June 2014

Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society.

Authors:
Rehan Akbani Karl-Friedrich Becker Neil Carragher Ted Goldstein Leanne de Koning Ulrike Korf Lance Liotta Gordon B Mills Satoshi S Nishizuka Michael Pawlak Emanuel F Petricoin Harvey B Pollard Bryan Serrels Jingchun Zhu

Mol Cell Proteomics 2014 Jul 28;13(7):1625-43. Epub 2014 Apr 28.

¶Center for Biomolecular Science and Engineering, University of California, Santa Cruz, California;

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July 2014

Developments in preclinical cancer imaging: innovating the discovery of therapeutics.

Authors:
James R W Conway Neil O Carragher Paul Timpson

Nat Rev Cancer 2014 May 17;14(5):314-28. Epub 2014 Apr 17.

Garvan Institute of Medical Research and The Kinghorn Cancer Centre Sydney, St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, New South Wales 2010, Sydney, Australia.

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May 2014

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach.

Authors:
Jason T Weiss John C Dawson Kenneth G Macleod Witold Rybski Craig Fraser Carmen Torres-Sánchez E Elizabeth Patton Mark Bradley Neil O Carragher Asier Unciti-Broceta

Nat Commun 2014 ;5:3277

Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK.

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November 2015

Inhibition of NF-κB signaling ablates the invasive phenotype of glioblastoma.

Authors:
Mike-Andrew Westhoff Shaoxia Zhou Lisa Nonnenmacher Georg Karpel-Massler Claudia Jennewein Matthias Schneider Marc-Eric Halatsch Neil O Carragher Bernd Baumann Alexander Krause Thomas Simmet Max G Bachem Christian R Wirtz Klaus-Michael Debatin

Mol Cancer Res 2013 Dec 21;11(12):1611-23. Epub 2013 Oct 21.

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Eythstrasse 24, D-89075 Ulm, Germany.

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December 2013

High-content analysis to leverage a robust phenotypic profiling approach to vascular modulation.

Authors:
Beverley J Isherwood Rebecca E Walls Mark E Roberts Thomas M Houslay Sandra R Brave Simon T Barry Neil O Carragher

J Biomol Screen 2013 Dec 9;18(10):1246-59. Epub 2013 Oct 9.

1Discovery Sciences, AstraZeneca R&D, UK.

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December 2013

Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment.

Authors:
Vebjorn Ljosa Peter D Caie Rob Ter Horst Katherine L Sokolnicki Emma L Jenkins Sandeep Daya Mark E Roberts Thouis R Jones Shantanu Singh Auguste Genovesio Paul A Clemons Neil O Carragher Anne E Carpenter

J Biomol Screen 2013 Dec 17;18(10):1321-9. Epub 2013 Sep 17.

1Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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December 2013

Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells.

Authors:
Albana Gattelli Ivan Nalvarte Anne Boulay Tim C Roloff Martin Schreiber Neil Carragher Kenneth K Macleod Michaela Schlederer Susanne Lienhard Lukas Kenner Maria I Torres-Arzayus Nancy E Hynes

EMBO Mol Med 2013 Sep 19;5(9):1335-50. Epub 2013 Jul 19.

Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.

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September 2013

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer.

Authors:
Max Nobis Ewan J McGhee Jennifer P Morton Juliane P Schwarz Saadia A Karim Jean Quinn Mike Edward Andrew D Campbell Lynn C McGarry T R Jeffry Evans Valerie G Brunton Margaret C Frame Neil O Carragher Yingxiao Wang Owen J Sansom Paul Timpson Kurt I Anderson

Cancer Res 2013 Aug 7;73(15):4674-86. Epub 2013 Jun 7.

The Beatson Institute for Cancer Research, Glasgow; Section of Dermatology, School of Medicine, University of Glasgow, Glasgow, UK.

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August 2013

Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue.

Authors:
Max Nobis Neil O Carragher Ewan J McGhee Jennifer P Morton Owen J Sansom Kurt I Anderson Paul Timpson

FEBS J 2013 Nov 28;280(21):5177-97. Epub 2013 Jun 28.

The Beatson Institute for Cancer Research, Glasgow, UK.

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November 2013

Dasatinib inhibits mammary tumour development in a genetically engineered mouse model.

Authors:
Saadia A Karim Helen Creedon Hitesh Patel Neil O Carragher Jennifer P Morton William J Muller Thomas Rj Evans Barry Gusterson Owen J Sansom Valerie G Brunton

J Pathol 2013 Aug;230(4):430-40

Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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August 2013

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery.

Authors:
Neil O Carragher Valerie G Brunton Margaret C Frame

Drug Discov Today 2012 Mar;17(5-6):203-14

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, UK.

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March 2012

Advancing cancer drug discovery towards more agile development of targeted combination therapies.

Authors:
Neil O Carragher Asier Unciti-Broceta David A Cameron

Future Med Chem 2012 Jan;4(1):87-105

Edinburgh Cancer Research UK Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, UK.

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January 2012

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion.

Authors:
Ewan J McGhee Jennifer P Morton Alex Von Kriegsheim Juliane P Schwarz Saadia A Karim Neil O Carragher Owen J Sansom Kurt I Anderson Paul Timpson

Small GTPases 2011 Jul 1;2(4):239-244. Epub 2011 Jul 1.

The Beatson Institute for Cancer Research; Glasgow; Edinburgh, UK.

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July 2011

The calpain system and cancer.

Authors:
Sarah J Storr Neil O Carragher Margaret C Frame Tim Parr Stewart G Martin

Nat Rev Cancer 2011 May;11(5):364-74

University of Nottingham, School of Molecular Medical Sciences, Nottingham NG5 1PB, UK.

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May 2011

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53.

Authors:
Paul Timpson Ewan J McGhee Jennifer P Morton Alex von Kriegsheim Juliane P Schwarz Saadia A Karim Brendan Doyle Jean A Quinn Neil O Carragher Mike Edward Michael F Olson Margaret C Frame Valerie G Brunton Owen J Sansom Kurt I Anderson

Cancer Res 2011 Feb 25;71(3):747-57. Epub 2011 Jan 25.

The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, United Kingdom.

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February 2011

Live cell in vitro and in vivo imaging applications: accelerating drug discovery.

Authors:
Beverley Isherwood Paul Timpson Ewan J McGhee Kurt I Anderson Marta Canel Alan Serrels Valerie G Brunton Neil O Carragher

Pharmaceutics 2011 Apr 4;3(2):141-70. Epub 2011 Apr 4.

Advanced Science & Technology Laboratory, AstraZeneca R&D Charnwood, Loughborough LE11 5RH, UK.

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April 2011

High-content phenotypic profiling of drug response signatures across distinct cancer cells.

Authors:
Peter D Caie Rebecca E Walls Alexandra Ingleston-Orme Sandeep Daya Tom Houslay Rob Eagle Mark E Roberts Neil O Carragher

Mol Cancer Ther 2010 Jun 8;9(6):1913-26. Epub 2010 Jun 8.

Advanced Science and Technology Laboratory, AstraZeneca R&D Charnwood, Loughborough, United Kingdom.

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June 2010

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530.

Authors:
Tim P Green Mike Fennell Robin Whittaker Jon Curwen Vivien Jacobs Jack Allen Armelle Logie Judith Hargreaves D Mark Hickinson Robert W Wilkinson Paul Elvin Brigitte Boyer Neil Carragher Patrick A Plé Alun Bermingham Geoffrey A Holdgate Walter H J Ward Laurent F Hennequin Barry R Davies Gerard F Costello

Mol Oncol 2009 Jun 7;3(3):248-61. Epub 2009 Feb 7.

Cancer and Infection Research Area, AstraZeneca, Alderley Park, Macclesfield Cheshire, SK10 4TG, UK.

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June 2009

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development.

Authors:
Alan Serrels Paul Timpson Marta Canel Juliane P Schwarz Neil O Carragher Margaret C Frame Valerie G Brunton Kurt I Anderson

Cancer Res 2009 Apr 24;69(7):2714-9. Epub 2009 Mar 24.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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April 2009

Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover.

Authors:
Neil O Carragher

Clin Exp Metastasis 2009 29;26(4):381-97. Epub 2008 Oct 29.

Advanced Science and Technology Laboratory, AstraZeneca Charnwood, Bakewell Road, Loughborough, UK.

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April 2009

Assaying calpain activity.

Authors:
Neil O Carragher

Methods Mol Biol 2007 ;370:109-20

Cell Adhesion-Linked Kinase Laboratory, Beatson Institute for Cancer Research, Bearsden, Glassgow, UK.

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July 2008

Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.

Authors:
Yolanda Calle Neil O Carragher Adrian J Thrasher Gareth E Jones

J Cell Sci 2006 Jun;119(Pt 11):2375-85

Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, UK.

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June 2006

AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins.

Authors:
Heather J Spence Lynn McGarry Catherine S Chew Neil O Carragher Linda A Scott-Carragher Zhengqiang Yuan Daniel R Croft Michael F Olson Margaret Frame Bradford W Ozanne

Mol Cell Biol 2006 Feb;26(4):1480-95

Invasion and Metastasis Laboratory, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom.

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February 2006

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.

Authors:
Gordon W McLean Neil O Carragher Egle Avizienyte Jeff Evans Valerie G Brunton Margaret C Frame

Nat Rev Cancer 2005 Jul;5(7):505-15

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom.

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July 2005

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion.

Authors:
Neil O Carragher Margaret C Frame

Trends Cell Biol 2004 May;14(5):241-9

The Beatson Institute for Cancer Research, Cancer Research UK, Glasgow G61 1BD, UK.

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May 2004

Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis.

Authors:
Nicola Ferri Neil O Carragher Elaine W Raines

Am J Pathol 2004 May;164(5):1575-85

Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA.

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May 2004

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.

Authors:
Neil O Carragher M Andrew Westhoff Valerie J Fincham Michael D Schaller Margaret C Frame

Curr Biol 2003 Aug;13(16):1442-50

The Beatson Institute for Cancer Research, Cancer Research United Kingdom, Beatson Laboratories, Glasgow G61 1BD, Scotland, United Kingdom.

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August 2003

Calpain: a role in cell transformation and migration.

Authors:
Neil O Carragher Margaret C Frame

Int J Biochem Cell Biol 2002 Dec;34(12):1539-43

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, G61 1BD Glasgow, Scotland, UK.

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December 2002

v-Src's hold over actin and cell adhesions.

Authors:
Margaret C Frame Valerie J Fincham Neil O Carragher John A Wyke

Nat Rev Mol Cell Biol 2002 Apr;3(4):233-45

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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April 2002