Neil C Henderson

Neil C Henderson

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Neil C Henderson

Neil C Henderson

Publications by authors named "Neil C Henderson"

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Development of mouse models of angiosarcoma driven by p53.

Dis Model Mech 2019 Jul 9;12(7). Epub 2019 Jul 9.

Edinburgh Cancer Research UK Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK

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http://dx.doi.org/10.1242/dmm.038612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679377PMC
July 2019

Fibroblast-specific integrin-alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis.

J Pathol 2019 May 24;248(1):16-29. Epub 2019 Jan 24.

Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/path.5215DOI Listing
May 2019

A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation.

Front Immunol 2018 26;9:264. Epub 2018 Feb 26.

MRC Centre for Inflammation Research, Centre for Multiple Sclerosis Research, BHF Centre for Cardiovascular Science, and Centre for Immunity Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.00264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834440PMC
March 2019

Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.

Am J Pathol 2019 02 16;189(2):258-271. Epub 2018 Nov 16.

Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom; Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440173053
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http://dx.doi.org/10.1016/j.ajpath.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360354PMC
February 2019

Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.

Gastroenterology 2017 07 28;153(1):233-248.e16. Epub 2017 Mar 28.

Birmingham Liver Biomedical Research Unit, National Institute for Health Research, Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511862PMC
July 2017

Skeletal and cardiac muscle pericytes: Functions and therapeutic potential.

Pharmacol Ther 2017 03 2;171:65-74. Epub 2016 Sep 2.

MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726267PMC
March 2017

Longitudinal in vivo bioimaging of hepatocyte transcription factor activity following cholestatic liver injury in mice.

Sci Rep 2017 02 3;7:41874. Epub 2017 Feb 3.

Stem Cell Group, Cardiovascular &Cell Sciences Research Institute, St. George's University of London, Cranmer Terrace, London SW17 0RE, UK.

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http://dx.doi.org/10.1038/srep41874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291111PMC
February 2017

Mesenchymal stromal cells and liver fibrosis: a complicated relationship.

FASEB J 2016 12 6;30(12):3905-3928. Epub 2016 Sep 6.

National Institute for Health Research, Birmingham Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom;

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http://dx.doi.org/10.1096/fj.201600433RDOI Listing
December 2016

Antifibrotics in chronic liver disease: tractable targets and translational challenges.

Lancet Gastroenterol Hepatol 2016 12 10;1(4):328-340. Epub 2016 Nov 10.

Medical Research Council (MRC) Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/S2468-1253(16)30110-8DOI Listing
December 2016

αv integrins: key regulators of tissue fibrosis.

Cell Tissue Res 2016 09 2;365(3):511-9. Epub 2016 May 2.

MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

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http://link.springer.com/10.1007/s00441-016-2407-9
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http://dx.doi.org/10.1007/s00441-016-2407-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010580PMC
September 2016

Recent progress on targeting the αvβ1 integrin for the treatment of tissue fibrosis.

Expert Opin Drug Discov 2016 08 7;11(8):749-51. Epub 2016 Jun 7.

a MRC Centre for Inflammation Research , Queens Medical Research Institute , Edinburgh , UK.

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http://dx.doi.org/10.1080/17460441.2016.1193486DOI Listing
August 2016

Homing in on the hepatic scar: recent advances in cell-specific targeting of liver fibrosis.

F1000Res 2016 19;5. Epub 2016 Jul 19.

MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.12688/f1000research.8822.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955024PMC
August 2016

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis.

Nat Commun 2016 08 18;7:12502. Epub 2016 Aug 18.

Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1038/ncomms12502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992158PMC
August 2016

CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism.

Gut 2016 07 15;65(7):1175-85. Epub 2015 Jun 15.

NIHR Birmingham Liver BRU and Centre for Liver Research, University of Birmingham, Birmingham, UK University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

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http://dx.doi.org/10.1136/gutjnl-2014-308325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941145PMC
July 2016

Acute Liver Injury Is Independent of B Cells or Immunoglobulin M.

PLoS One 2015 25;10(9):e0138688. Epub 2015 Sep 25.

MRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom; Clinical Surgery, The University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138688PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583453PMC
May 2016

Cre-ativity in the liver: transgenic approaches to targeting hepatic nonparenchymal cells.

Hepatology 2015 Jun 13;61(6):2091-9. Epub 2015 Apr 13.

MRC Center for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1002/hep.27606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657490PMC
June 2015

Hepatic stellate cells: central modulators of hepatic carcinogenesis.

BMC Gastroenterol 2015 May 27;15:63. Epub 2015 May 27.

MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, UK.

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http://dx.doi.org/10.1186/s12876-015-0291-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445994PMC
May 2015

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Nat Med 2013 Dec 10;19(12):1617-24. Epub 2013 Nov 10.

1] Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA. [2] Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/nm.3282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855865PMC
December 2013

Origins of fibrosis: pericytes take centre stage.

F1000Prime Rep 2013 Sep 2;5:37. Epub 2013 Sep 2.

MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh 47 Little France Crescent, Edinburgh, EH16 4TJ UK.

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http://dx.doi.org/10.12703/P5-37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768328PMC
September 2013

Integrin-mediated regulation of TGFβ in fibrosis.

Biochim Biophys Acta 2013 Jul 6;1832(7):891-6. Epub 2012 Oct 6.

MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2012.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573259PMC
July 2013

Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation.

Biochim Biophys Acta 2013 Jul 10;1832(7):876-83. Epub 2012 Nov 10.

MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2012.11.002DOI Listing
July 2013

Eosinophils secrete IL-4 to facilitate liver regeneration.

Proc Natl Acad Sci U S A 2013 Jun 28;110(24):9914-9. Epub 2013 May 28.

Department of Genetics and Pathology, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.1304046110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683773PMC
June 2013

Standing down the guard: stellate cells leave quietly.

Gastroenterology 2012 Oct 20;143(4):890-2. Epub 2012 Aug 20.

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http://dx.doi.org/10.1053/j.gastro.2012.08.014DOI Listing
October 2012

Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure.

World J Gastroenterol 2011 Mar;17(11):1457-61

Liver Cell Biology Laboratory, Department of Hepatology, University of Edinburgh, Edinburgh, EH16 4SA, United Kingdom.

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http://dx.doi.org/10.3748/wjg.v17.i11.1457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070019PMC
March 2011

Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells.

Gastroenterology 2009 Jul 21;137(1):320-9. Epub 2009 Feb 21.

MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2009.02.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201985PMC
July 2009

The regulation of inflammation by galectin-3.

Immunol Rev 2009 Jul;230(1):160-71

Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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http://doi.wiley.com/10.1111/j.1600-065X.2009.00794.x
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http://dx.doi.org/10.1111/j.1600-065X.2009.00794.xDOI Listing
July 2009

Hepatic fibrogenesis: from within and outwith.

Toxicology 2008 Dec 7;254(3):130-5. Epub 2008 Sep 7.

The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S0300483X0800399
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http://dx.doi.org/10.1016/j.tox.2008.08.017DOI Listing
December 2008

Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis.

Am J Pathol 2008 Feb 17;172(2):288-98. Epub 2008 Jan 17.

The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.2353/ajpath.2008.070726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2312353PMC
February 2008

Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function.

Am J Pathol 2008 Feb 17;172(2):395-405. Epub 2008 Jan 17.

Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.2353/ajpath.2008.070870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2312371PMC
February 2008

Regulation of alternative macrophage activation by galectin-3.

J Immunol 2008 Feb;180(4):2650-8

Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 49 Little France Crescent, Edinburgh, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.180.4.2650DOI Listing
February 2008

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.

Gut 2007 Jul 21;56(7):982-90. Epub 2006 Dec 21.

Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1136/gut.2006.104372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994347PMC
July 2007

Liver fibrosis: cellular mechanisms of progression and resolution.

Clin Sci (Lond) 2007 Mar;112(5):265-80

MRC/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4TJ, U.K.

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http://dx.doi.org/10.1042/CS20060242DOI Listing
March 2007

Galectin-3 regulates myofibroblast activation and hepatic fibrosis.

Proc Natl Acad Sci U S A 2006 Mar 20;103(13):5060-5. Epub 2006 Mar 20.

Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, 51 Little France Crescent, EH16 4SA Edinburgh, Scotland, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0511167103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458794PMC
March 2006

CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation.

J Biol Chem 2004 Dec 12;279(52):54731-41. Epub 2004 Oct 12.

Lung Inflammation Group, Medical Research Council Centre for Inflammation Research, University of Edinburgh Medical School, Edinburgh EH8 9XD, Scotland, UK.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M408700200
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http://dx.doi.org/10.1074/jbc.M408700200DOI Listing
December 2004

Chemokines in the pathogenesis of liver disease: so many players with poorly defined roles.

Clin Sci (Lond) 2003 Jan;104(1):47-63

MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9AJ, UK.

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http://dx.doi.org/10.1042/DOI Listing
January 2003