Publications by authors named "Nehru Viji Sankaranarayanan"

21Publications

Studies on fragment-based design of allosteric inhibitors of human factor XIa.

Bioorg Med Chem 2020 Sep 13;28(23):115762. Epub 2020 Sep 13.

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, United States; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA 23219, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2020.115762DOI Listing
September 2020

Discovering small-molecule therapeutics against SARS-CoV-2.

Drug Discov Today 2020 08 20;25(8):1535-1544. Epub 2020 Jun 20.

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA 2321, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2020.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305878PMC
August 2020

Combinatorial virtual library screening analysis of antithrombin binding oligosaccharide motif generation by heparan sulfate 3--Sulfotransferase 1.

Comput Struct Biotechnol J 2020 1;18:933-941. Epub 2020 Apr 1.

Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, United States.

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http://dx.doi.org/10.1016/j.csbj.2020.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183009PMC
April 2020

Rigorous analysis of free solution glycosaminoglycan dynamics using simple, new tools.

Glycobiology 2020 Jul;30(8):516-527

Institute for Structural Biology, Drug Discovery and Development, 800 E. Leigh Street, Suite 212, Richmond, VA 23219, USA.

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http://dx.doi.org/10.1093/glycob/cwaa015DOI Listing
July 2020

Perspective on computational simulations of glycosaminoglycans.

Wiley Interdiscip Rev Comput Mol Sci 2019 Mar-Apr;9(2). Epub 2018 Sep 10.

Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1002/wcms.1388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504973PMC
September 2018

On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients.

J Med Chem 2019 06 28;62(11):5501-5511. Epub 2019 May 28.

Department of Medicinal Chemistry , Virginia Commonwealth University , Richmond , Virginia 23298 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818412PMC
June 2019

Mucoadhesive role of tamarind xyloglucan on inflammation attenuates ulcerative colitis.

J Funct Foods 2018 Aug 24;47:1-10. Epub 2018 May 24.

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan.

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https://linkinghub.elsevier.com/retrieve/pii/S17564646183025
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http://dx.doi.org/10.1016/j.jff.2018.05.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289526PMC
August 2018

A synthetic glycosaminoglycan mimetic blocks HSV-1 infection in human iris stromal cells.

Antiviral Res 2019 01 24;161:154-162. Epub 2018 Nov 24.

Department of Microbiology & Immunology, College of Graduate Studies, Midwestern University, Downers Grove, IL 60515, USA. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2018.11.007DOI Listing
January 2019

Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics.

ACS Med Chem Lett 2018 Aug 16;9(8):797-802. Epub 2018 Jul 16.

Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23219, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088358PMC
August 2018

So you think computational approaches to understanding glycosaminoglycan-protein interactions are too dry and too rigid? Think again!

Curr Opin Struct Biol 2018 06 9;50:91-100. Epub 2018 Jan 9.

Department of Medicinal Chemistry & Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037615PMC
June 2018

A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules.

PLoS One 2017 9;12(2):e0171619. Epub 2017 Feb 9.

Institute for Structural Biology, Drug Discovery and Development and Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171619PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300208PMC
August 2017

Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics.

J Med Chem 2017 01 5;60(2):641-657. Epub 2017 Jan 5.

Department of Medicinal Chemistry, and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University , Richmond, Virginia 23219, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01474DOI Listing
January 2017

Transforming growth factor-β2 is sequestered in preterm human milk by chondroitin sulfate proteoglycans.

Am J Physiol Gastrointest Liver Physiol 2015 Aug 4;309(3):G171-80. Epub 2015 Jun 4.

Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois; Department of Pediatrics, Morsani College of Medicine, University of South Florida Health, Tampa, Florida; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida Health, Tampa, Florida;

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http://dx.doi.org/10.1152/ajpgi.00126.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525106PMC
August 2015

Designing "high-affinity, high-specificity" glycosaminoglycan sequences through computerized modeling.

Methods Mol Biol 2015 ;1229:289-314

Department of Medicinal Chemistry, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, 800 E. Leigh Street, Suite 212, Richmond, VA, 23298, USA.

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http://dx.doi.org/10.1007/978-1-4939-1714-3_24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452111PMC
June 2015

Toward a robust computational screening strategy for identifying glycosaminoglycan sequences that display high specificity for target proteins.

Glycobiology 2014 Dec 21;24(12):1323-33. Epub 2014 Jul 21.

Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, 800 E. Leigh Street, Suite 212, Richmond, VA 23219, USA

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http://dx.doi.org/10.1093/glycob/cwu077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296175PMC
December 2014