Publications by authors named "Nehme El-Hachem"

37Publications

Assessment of Genetic Drift in Large Pharmacogenomic Studies.

Cell Syst 2020 Oct 15;11(4):393-401.e2. Epub 2020 Sep 15.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Computer Science, University of Toronto, Toronto, ON, Canada; Vector Institute, Toronto, ON, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cels.2020.08.012DOI Listing
October 2020

Repurposing cilostazol for Raynaud's phenomenon.

Curr Med Chem 2020 Sep 3. Epub 2020 Sep 3.

Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut. Lebanon.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/0929867327666200903114154DOI Listing
September 2020

A novel TRAF3IP2 variant causing familial scarring alopecia with mixed features of discoid lupus erythematosus and folliculitis decalvans.

Clin Genet 2020 Aug 29;98(2):116-125. Epub 2020 Jun 29.

Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cge.13767DOI Listing
August 2020

-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect.

BMC Chem 2019 Dec 31;13(1):124. Epub 2019 Oct 31.

1Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13065-019-0640-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824041PMC
December 2019

SIGN: similarity identification in gene expression.

Bioinformatics 2019 11;35(22):4830-4833

Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 1L7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btz485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853666PMC
November 2019

Gene isoforms as expression-based biomarkers predictive of drug response in vitro.

Nat Commun 2017 10 24;8(1):1126. Epub 2017 Oct 24.

Princess Margaret Cancer Centre, University Health Network, 101 College Street, Toronto, ON, Canada, M5G1L7.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-01153-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655668PMC
October 2017

Integrative cancer pharmacogenomics to establish drug mechanism of action: drug repurposing.

Pharmacogenomics 2017 11 23;18(16):1469-1472. Epub 2017 Oct 23.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2017-0132DOI Listing
November 2017

Defining the biological basis of radiomic phenotypes in lung cancer.

Elife 2017 07 21;6. Epub 2017 Jul 21.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.23421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590809PMC
July 2017

AutoDock and AutoDockTools for Protein-Ligand Docking: Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) as a Case Study.

Methods Mol Biol 2017 ;1598:391-403

Department of Biochemistry and Molecular Genetics, American University of Beirut, DTS4-19A, Bliss Street, Riad El Solh, Beirut, 1107 2020, Lebanon.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6952-4_20DOI Listing
March 2018

A HAND to TBX5 Explains the Link Between Thalidomide and Cardiac Diseases.

Sci Rep 2017 05 3;7(1):1416. Epub 2017 May 3.

Departments of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-01641-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431093PMC
May 2017

Integrative Cancer Pharmacogenomics to Infer Large-Scale Drug Taxonomy.

Cancer Res 2017 06 17;77(11):3057-3069. Epub 2017 Mar 17.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-17-0096DOI Listing
June 2017

Safikhani et al. reply.

Nature 2016 11;540(7631):E2-E4

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature19839DOI Listing
November 2016

Safikhani et al. reply.

Nature 2016 11;540(7631):E11-E12

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature20581DOI Listing
November 2016

Safikhani et al. reply.

Nature 2016 11;540(7631):E6-E8

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature20172DOI Listing
November 2016

Assessment of pharmacogenomic agreement.

F1000Res 2016 9;5:825. Epub 2016 May 9.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 1L7, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario, M5S 2E4, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.8705.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926729PMC
July 2016

PharmacoGx: an R package for analysis of large pharmacogenomic datasets.

Bioinformatics 2016 04 9;32(8):1244-6. Epub 2015 Dec 9.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btv723DOI Listing
April 2016

Characterization of Conserved Toxicogenomic Responses in Chemically Exposed Hepatocytes across Species and Platforms.

Environ Health Perspect 2016 Mar 14;124(3):313-20. Epub 2015 Jul 14.

Integrative systems biology, Institut de Recherches Cliniques de Montréal, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1289/ehp.1409157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786983PMC
March 2016

Thiazole derivatives as inhibitors of cyclooxygenases in vitro and in vivo.

Eur J Pharmacol 2015 Mar 21;750:66-73. Epub 2015 Jan 21.

Department of Biochemistry and Molecular Genetics, Faculty of Medicine, AUB, Beirut, PO Box 11-236, Lebanon; Centre de recherche sur l'inflammation, INSERM UMR 1149-Université Paris Diderot, Faculté de Médecine Xavier Bichat, 16 rue Henri Huchard, F-75018 Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2015.01.008DOI Listing
March 2015

Importance of collection in gene set enrichment analysis of drug response in cancer cell lines.

Sci Rep 2014 Feb 13;4:4092. Epub 2014 Feb 13.

1] Bioinformatics and Computational Genomics Laboratory, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec, Canada [2] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep04092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923229PMC
February 2014

Inconsistency in large pharmacogenomic studies.

Nature 2013 Dec 27;504(7480):389-93. Epub 2013 Nov 27.

1] Department of Biostatistics and Computational Biology and Center for Cancer Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [3].

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237165PMC
December 2013

mRMRe: an R package for parallelized mRMR ensemble feature selection.

Bioinformatics 2013 Sep 3;29(18):2365-8. Epub 2013 Jul 3.

Bioinformatics and Computational Biology Laboratory, Integrative Systems Biology Axis, Institut de recherches cliniques de Montréal, Montreal, H2W 1R7, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btt383DOI Listing
September 2013

Identification of new GATA4-small molecule inhibitors by structure-based virtual screening.

Bioorg Med Chem 2011 Mar 18;19(5):1734-42. Epub 2011 Jan 18.

Department of Biochemistry, American University of Beirut, Beirut, Lebanon.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2011.01.022DOI Listing
March 2011