Publications by authors named "Negar Omidi"

22 Publications

  • Page 1 of 1

Predicting the outcome in confirmed COVID-19 patients with coronary artery disease: a key role for the first chest computed tomography.

Egypt Heart J 2021 Mar 31;73(1):35. Epub 2021 Mar 31.

Research Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Serial chest computed tomography (CT) scans are used to detect coronavirus disease 2019 (COVID-19) pneumonia and monitor the disease course. This study investigates relationship between total severity score by first chest CT and the outcome of coronavirus COVID-19 patients with coronary artery disease (CAD).

Results: A total of 48 patients with a history of CAD (mean age=60.83±3.06 years, 75% male) with positive real-time reverse transcription-polymerase chain reaction for COVID-19 were included. Outcome was defined as acute respiratory distress syndrome or death. The unadjusted and adjusted effects of the CT score on the outcome were reported through odds ratio (OR) with 95% confidence interval (CI). Outcome occurred in 17 (35.5%) patients (8 deaths). The CT score was directly and significantly correlated with the outcome in the univariate analysis (OR 1.38, 95% CI 1.12-1.70; P=0.003) and remained significant after adjustment for diabetes, hypertension, body mass index, and serum level of highly sensitive C-reactive protein (OR 1.51, 95% CI 1.11-2.05; P=0.009). Outcome rate was 24.1% in patients with a CT score <2.5, whereas it was 8.3% in patients with a CT score>2.5.

Conclusions: The first chest CT score could be a robust predictor of adverse events in confirmed COVID-19 patients with coronary artery disease.
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http://dx.doi.org/10.1186/s43044-021-00148-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011044PMC
March 2021

Isolated tricuspid valve surgery; long-term outcomes based on Tehran Heart Center data bank report.

J Cardiothorac Surg 2021 Feb 23;16(1):19. Epub 2021 Feb 23.

Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Given that isolated tricuspid valve (TV) repair or replacement is performed relatively rarely, we sought to evaluate the rate of long-term mortality and readmission following this surgery.

Methods: The current study was conducted in Tehran Heart Center on patients who underwent isolated TV repair or replacement between 2010 and 2018. Totally, 197 patients (repair = 150 vs replacement = 47) were included in our study and were then followed right after surgery for a median of 8 years to assess the incidence of postoperative events, readmission, and all-cause mortality.

Results: The final analysis was conducted on 197 patients at a mean age of 44.4 ± 13.8 years. Most of the patients were female (56.9%). Ejection fraction, TAPSE, and right ventricular function improved in both groups after TV surgery. Length of stay in the intensive care unit per hour and hospitalization per day were higher in the replacement group and compared to the repair group (158.34 vs. 55.11 and 18.21 vs. 9.34, respectively). In-hospital mortality occurred in 20 patients, of whom 15 had TV replacement. Readmission occurred in five (2.5%) patients,all were in the repair group.

Conclusions: The result of this single-center study showed that TV replacement is associated with a higher rate of postoperative events and all-cause mortality compared to TV repair. Whereas, repair group had a higher rate of readmission. Therefore, the overwhelming tendency is toward repair; nonetheless, no hesitation is permissible if a replacement is adjudged to confer a better outcome for the patient.
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http://dx.doi.org/10.1186/s13019-021-01394-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903743PMC
February 2021

Time to Treatment and In-Hospital Major Adverse Cardiac Events Among Patients With ST-Segment Elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary Intervention (PCI) According to the 24/7 Primary PCI Service Registry in Iran: Cross-Sectional Study.

Interact J Med Res 2020 Dec 16;9(4):e20352. Epub 2020 Dec 16.

Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Performing primary percutaneous coronary intervention (PCI) as a preferred reperfusion strategy for patients with ST-segment elevation myocardial infarction (STEMI) may be associated with major adverse cardiocerebrovascular events (MACCEs). Thus, timely primary PCI has been emphasized in order to improve outcomes. Despite guideline recommendations on trying to reduce the door-to-balloon time to <90 minutes in order to reduce mortality, less attention has been paid to other components of time to treatment, such as the symptom-to-balloon time, as an indicator of the total ischemic time, which includes the symptom-to-door time and door-to-balloon time, in terms of clinical outcomes of patients with STEMI undergoing primary PCI.

Objective: We aimed to determine the association between each component of time to treatment (ie, symptom-to-door time, door-to-balloon time, and symptom-to-balloon time) and in-hospital MACCEs among patients with STEMI who underwent primary PCI.

Methods: In this observational study, according to a prospective primary PCI 24/7 service registry, adult patients with STEMI who underwent primary PCI in one of six catheterization laboratories of Tehran Heart Center from November 2015 to August 2019, were studied. The primary outcome was in-hospital MACCEs, which was a composite index consisting of cardiac death, revascularization (ie, target vessel revascularization/target lesion revascularization), myocardial infarction, and stroke. It was compared at different levels of time to treatment (ie, symptom-to-door and door-to-balloon time <90 and ≥90 minutes, and symptom-to-balloon time <180 and ≥180 minutes). Data were analyzed using SPSS software version 24 (IBM Corp), with descriptive statistics, such as frequency, percentage, mean, and standard deviation, and statistical tests, such as chi-square test, t test, and univariate and multivariate logistic regression analyses, and with a significance level of <.05 and 95% CIs for odds ratios (ORs).

Results: Data from 2823 out of 3204 patients were analyzed (mean age of 59.6 years, SD 11.6 years; 79.5% male [n=2243]; completion rate: 88.1%). Low proportions of symptom-to-door time ≤90 minutes and symptom-to-balloon time ≤180 minutes were observed among the study patients (579/2823, 20.5% and 691/2823, 24.5%, respectively). Overall, 2.4% (69/2823) of the patients experienced in-hospital MACCEs, and cardiac death (45/2823, 1.6%) was the most common cardiac outcome. In the univariate analysis, the symptom-to-balloon time predicted in-hospital MACCEs (OR 2.2, 95% CI 1.1-4.4; P=.03), while the symptom-to-door time (OR 1.4, 95% CI 0.7-2.6; P=.34) and door-to-balloon time (OR 1.1, 95% CI 0.6-1.8, P=.77) were not associated with in-hospital MACCEs. In the multivariate analysis, only symptom-to-balloon time ≥180 minutes was associated with in-hospital MACCEs and was a predictor of in-hospital MACCEs (OR 2.3, 95% CI 1.1-5.2; P=.04).

Conclusions: A longer symptom-to-balloon time was the only component associated with higher in-hospital MACCEs in the present study. Efforts should be made to shorten the symptom-to-balloon time in order to improve in-hospital MACCEs.

International Registered Report Identifier (irrid): RR2-10.2196/13161.
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http://dx.doi.org/10.2196/20352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773509PMC
December 2020

Cost-effectiveness analysis of mitral valve repair with the MitraClip delivery system for patients with mitral regurgitation: a systematic review.

Heart Fail Rev 2021 May 24;26(3):587-601. Epub 2020 Nov 24.

Laboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, Canada.

To assess the cost-effectiveness of mitral valve repair with the MitraClip delivery system for patients with mitral regurgitation and heart failure, a systematic literature search was conducted in various electronic databases to January 3, 2020. Eligibility criteria are the population (patients with mitral regurgitation (MR)), intervention (transcatheter mitral valve repair using the MitraClip), comparator (conventional medical treatment), outcomes, and designs (Model-based or trial-based full economic evaluations).The quality of included studies was assessed using the CHEERS checklist. Mortality and survival rate, quality-adjusted life year (QALY), life years gained (LYG), total cost, and the incremental cost-effectiveness ratio (ICER) regarding the use of MitraClip System were considered as the key outcomes. Eight articles were eligible for full-text assessment. Ultimately, a total of seven studies were considered in the current systematic review. Results demonstrated that MitraClip reduces mortality rate and increases survival rate. The mortality rate at 1 year and 10 years was 16.7% versus 29.77% and 70.9% versus 98.8%, respectively. Total cost data based on 2019 USD show that the MitraClip has the highest cost in the USA ($121,390) and the lowest cost in Italy ($33,062). The results showed that in all selected countries, willingness-to-pay (WTP) thresholds are upper than the cost per QALY; also, the highest ICER for the MitraClip is in the USA ($55,600/QALY) and the lowest in Italy ($10,616/QALY). To conclude, evidence from this systematic review suggests that MitraClip Delivery System improved both life expectancy and QALY compared with medical treatment in patients at high surgical risk and it was also a cost-effective treatment option for patients with mitral regurgitation.
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http://dx.doi.org/10.1007/s10741-020-10055-9DOI Listing
May 2021

Prosthetic heart valves and the COVID-19 pandemic era: What should we be concerned about?

J Card Surg 2020 Oct;35(10):2500-2505

Research Department, Tehran Heart Center and Research Development, Tehran University of Medical Sciences, Tehran, Iran.

Background: The disturbance in the international normalized ratio (INR) in patients receiving warfarin therapy is of concern. We aimed to evaluate coagulation features in hospitalized patients under warfarin treatment for prosthetic heart valves during the novel coronavirus disease 2019 (COVID-19) pneumonia pandemic.

Methods: Between 20 February and 28 March 2020, 10 patients (7 males) who were under warfarin therapy for prosthetic heart valves were hospitalized after a diagnosis of COVID-19 in Tehran Heart Center, Tehran, Iran. The clinical, paraclinical, and in-hospital outcomes were described. The patients were followed for 4 weeks.

Results: The median age was 62 years. All the patients received antiviral treatment, either lopinavir/ritonavir or oseltamivir. The serum level of high-sensitivity C-reactive protein ranged between 0.24 and 15.24 mg/dL. Alanine aminotransaminase was normal in all the patients except for two, with levels 1.6 and 4.2 times above normal values. The INR increased in all the patients. One (10%) patient died in the hospital. No bleeding, ischemic, or thrombotic events occurred during the hospital stay and within the 4-week follow-up.

Conclusions: Antiviral therapy in patients with COVID-19 with prosthetic heart valves might be an issue responsible for an uncontrolled INR. Liver injury may happen in a minority of patients. Bridging in these patients during the antiviral treatment might be required and because of significant INR fluctuations, it might be safer to prescribe antiviral treatment in an inpatient setting.
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http://dx.doi.org/10.1111/jocs.14707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597203PMC
October 2020

Twelve-Year History of STEMI Management in Tehran Heart Center: Concomitant Reduction of In-Hospital Mortality and Hospitalization Length.

Arch Iran Med 2020 08 1;23(8):514-521. Epub 2020 Aug 1.

Tehran Heart Center (THC), Tehran University of Medical Sciences, Tehran, Iran.

Background: Cardiovascular-related death remains the major cause of mortality in Iran despite significant improvements in its care. In the present study, we report the in-hospital mortality, hospitalization length, and treatment methods for patients with ST-elevation myocardial infarction (STEMI) in Tehran Heart Center (THC).

Methods: Records pertaining to patients with STEMI from March 2006 to March 2017 were extracted from the databases of THC. Besides a description of temporal trends, multivariable regression analysis was used to find factors associated with in-hospital mortality.

Results: During the study period, 8,295 patients were admitted with STEMI with a mean age of 60.4 ± 12.5 years. Men accounted for 77.5% of the study population. Hospitalization length declined from 8.4 to 5.2 days, and in-hospital mortality was reduced from 8.0% to 3.9% (both P values < 0.001). In a multivariable model adjusted for age, sex, conventional cardiac risk factors, prior cardiac history, and indices of event severity, primary percutaneous coronary intervention (PCI) (OR: 0.280, 95% CI: 0.186 to 0.512; P<0.001), coronary artery bypass graft (CABG) surgery (OR: 0.482, 95% CI: 0.220 to 0.903; P=0.025), and rescue or facilitated PCI (OR: 0.420, 95% CI: 0.071 to 0.812; P=0.001) were all associated with reduced in-hospital mortality in comparison with medical treatment. Furthermore, primary PCI was a crucial protective factor against prolonged length of hospital stay (OR: 0.307, 95% CI: 0.266 to 0.594; P<0.001).

Conclusion: In-hospital mortality and hospitalization length were almost halved during the study period, and primary PCI has now replaced thrombolysis in the management of STEMI.
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http://dx.doi.org/10.34172/aim.2020.53DOI Listing
August 2020

Single Long Stents versus Overlapping Multiple Stents in the Management of Very Long Coronary Lesions: Comparisons of Procedures and Clinical Outcomes.

J Tehran Heart Cent 2019 Jul;14(3):94-102

Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Different percutaneous coronary intervention (PCI) strategies, including the use of single long stents (SLSs) and overlapping multiple stents (OMSs), have been introduced to treat very long coronary lesions (VLCLs). The aim of this study was to compare procedural and long-term clinical outcomes between SLSs and OMSs in patients with VLCLs. In this historical cohort study, 1709 patients who underwent PCI with the new generation of drug-eluting stents (length ≥38 mm) were stratified into the SLS [PROMUS /Resolute/XIENCE (PRX), (=38 mm), n=1121 (65.59%) and BioMime, (≥40 mm), n=124 (7.26%)] and OMS [(59.43±10.80 mm), n=464 (27.2%)] groups and followed up for 440.93±361.32 days. The study endpoints comprised immediate post-PCI outcomes, major adverse cardiovascular events (MACE), the patient-oriented composite endpoint (POCE), and the device-oriented composite endpoint (DOCE) at the long-term follow-up. The mean age of the patients was 59.28±10.60 years, and 69.6% of them were male. Flow grade 3 (P=0.296) and residual stenosis (P=0.533) were statistically similar between all the groups. A lower level of post-PCI troponin was observed in the BioMime group [14.52 (IQR:10.44-22.42) ng/L; P=0.031] than in the PRX and OMS groups [18.63 (IQR:10.51-34.02) ng/L and 18.96 (IQR:11.17-35.34) ng/L; respectively]. Similarly, the PRX and BioMime groups received lower amounts of the contrast agent [206.29±49.15 mL and 208.06±55.23 mL; respectively] than did the OMS group [265.50±74.69 mL; P<0.001]. There were no statistically significant differences in the incidence of MACE [81 (7.2%), 7 (5.6%), and 28 (6.0%); P=0.603], the POCE [141 (12.6%), 13 (10.5%), and 54 (11.6%); P=0.731], and the DOCE [51 (4.5%), 4 (3.2%), and 21 (4.5%); P=0.791] between the PRX, BioMime, and OMS groups, respectively. In the treatment of VLCLs, the SLS and OMSs appear to have similar clinical outcomes. BioMime ultra-long stents may have comparable results to PRX coronary stents.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981347PMC
July 2019

Cost-effectiveness analysis of PCSK9 inhibitors in cardiovascular diseases: a systematic review.

Heart Fail Rev 2020 11;25(6):1077-1088

School of Public Health, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.

Aims: To assess the cost-effectiveness of pro-protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in cardiovascular disease.

Methods And Results: We performed a comprehensive search strategy in electronic databases from January 2015 to January 2019. Out of 475 articles, 16 were entered into the study. Quality-adjusted life year, life years gained (LYG), annual cost, and the incremental cost-effectiveness ratio (ICER) regarding the use of PCSK9 inhibitors were considered as the key outcomes. The cost-effectiveness threshold varied from $45,000 in Spain to $150,000 in the USA. The annual cost of PCSK9 inhibitors for studies undertaken in the USA was in the range of $14,000 to $15,000, while it was about $7000 for other developed countries. The results showed that reduction in the price of PCSK9 inhibitors changed from 20 to 88%. The means of QALY were 0.65 and 0.67 in the Markov and Cardiovascular Disease Policy Modeling (CVDPM) models; also, the ICER means were $197,707 and $625,555 for the Markov and CVDPM model, respectively.

Conclusion: According to the current study, the effectiveness of PCSK9 inhibitors is well documented, although all studies pointed out a higher cost of these inhibitors.

Trial Registration: This study was registered within the International Prospective Register of Systematic Reviews (PROSPERO) database of the University of York (CRD42018088472).
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http://dx.doi.org/10.1007/s10741-019-09874-2DOI Listing
November 2020

A systematic review of the cost-effectiveness of heart valve replacement with a mechanical versus biological prosthesis in patients with heart valvular disease.

Heart Fail Rev 2020 05;25(3):495-503

Laboratory for industrial and applied mathematics (LIAM), Department of mathematics and statistics, York university, Toronto, Canada.

Heart valve disease (HVD) affects 2.5% of the US population and one million individuals aged 65 years and older in the UK. Given its burden, the aim of the present review was to assess the cost-effectiveness of heart valve replacement with mechanical versus biological prosthesis in HVD patients. We performed a systematic search in various electronic databases from January 1990 to June 2019. Five out of 542 articles were entered into the study, from which 2 papers were subsequently excluded not meeting the minimum number of items of the CHEERS checklist. Quality-Adjusted Life Year, Life Years Gained, and the Incremental Cost-Effectiveness Ratio (ICER) regarding the type of replaced heart valve were extracted and reported. Studies were conducted in three different countries (Iran, France, and USA). ICER ranged from $1253 in Iran to €54,634 in France. Survival rate of mitral mechanical versus biological valves at 10 and 20 years was 72.9% versus 76.0% and 51% versus 30%, respectively. Survival rate at 20 years in patients undergoing atrial valve replacement was 20%. Ten- and 20-year death rates for biological valves were higher with respect to mechanical prosthesis (15.5% versus 8.4% at 10 years), with this difference becoming more relevant at 20 years (36.9% versus 13.9%). Due to higher ICER, mortality rate, and lower success rates in the long term for biological prostheses compared to mechanical ones, these appear to be more suitable for older patients (aged ≥ 70 years).
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http://dx.doi.org/10.1007/s10741-019-09897-9DOI Listing
May 2020

The Role of Thyroid Diseases and their Medications in Cardiovascular Disorders: A Review of the Literature.

Curr Cardiol Rev 2020 ;16(2):103-116

Department of Anatomical Sciences, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

The association between thyroid disease and cardiovascular manifestations is significant and undeniable. Previous studies have explained several aspects of the effects of thyroid hormone on the heart and cardiovascular system. Accordingly, both hyper and hypothyroidism can cause important alterations in cardiac rhythm, output and contractility as well as vascular resistance and blood pressure. Since treating the thyroid abnormality, especially in its initial stages, could lead to a significant improvement in most of its resultant cardiovascular disturbances, early suspicion and recognition of thyroid dysfunction, is necessary in patients with cardiovascular manifestations. In this in-depth review, we discuss the physiological roles as well as the effects of abnormal levels of thyroid hormones on the cardiovascular system. We also review the effects of the medications used for the treatment of hyper and hypothyroidism on cardiac function. In the end, we discuss the association between thyroid function and amiodarone, an effective and frequently-used antiarrhythmic drug, because of its well-known effects on the thyroid.
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http://dx.doi.org/10.2174/1573403X15666191008111238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460701PMC
July 2020

Tubular thrombus-in-transit detected initially on computed tomography scan.

Turk Kardiyol Dern Ars 2019 Jun;47(4):331

Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, I.R. Iran.

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http://dx.doi.org/10.5543/tkda.2019.02067DOI Listing
June 2019

Time to Treatment and In-Hospital Major Adverse Cardiac Events Among Patients With ST-Segment Elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary Intervention (PCI) According to the 24/7 Primary PCI Service Registry in Iran: Protocol for a Cross-Sectional Study.

JMIR Res Protoc 2019 Mar 1;8(3):e13161. Epub 2019 Mar 1.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.

Background: Patients with ST-segment elevation myocardial infarction (STEMI) experience major adverse cardiac events (MACEs) following primary percutaneous coronary intervention (PCI). Although the relationship between time to treatment (eg, door-to-balloon time, symptom onset-to-balloon time, and symptom onset-to-door time) and 1-month all-cause mortality was assessed previously, its relationship with in-hospital MACEs and the effect of some clinical characteristics on this relationship were not considered. Furthermore, previous studies that were conducted in developed countries with a different quality of care cannot be applied in Iran, as Iran is a developing country and the studies were not performed according to the 24/7 primary PCI service registry.

Objective: The objective of this study protocol is to determine the relationship between time to treatment and in-hospital MACEs.

Methods: This cross-sectional study will take place at the Tehran Heart Center (THC), which is affiliated with Tehran University of Medical Sciences (TUMS) in Tehran, Iran. Data related to patients with STEMI, who underwent primary PCI between March 2015 and March 2019, that have been prospectively recorded in the THC's 24/7 primary PCI service registry will be analyzed. The study outcome is the occurrence of in-hospital MACEs. Data analysis will be conducted using SPSS for Windows, version 16.0 (SPSS Inc). We will perform chi-square tests, independent-samples t tests, or the Mann-Whitney U test, as well as univariate and multivariate binary logistic regression with a significance level of less than .05 and 95% CI for odds ratios.

Results: From March 2015 to September 2017, 1586 patients were included in the THC service registry, consecutively. We will conduct a retrospective analysis of this registry on patient entries between March 2015 and March 2019 and data will be analyzed and published by the end of 2019.

Conclusions: To our knowledge, this is the first observational study based on the 24/7 primary PCI service registry in Iran. The findings of this study may reveal current problems regarding time to treatment in STEMI management in the THC. Results from this study may help determine appropriate preventive strategies that need to be applied in order to reduce time-to-treatment delays and improve patients' outcomes following primary PCI in the setting of STEMI at the THC and similar clinical centers.

International Registered Report Identifier (irrid): DERR1-10.2196/13161.
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http://dx.doi.org/10.2196/13161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418487PMC
March 2019

CHA2DS2-VASc Score as an Independent Predictor of Suboptimal Reperfusion and Short-Term Mortality after Primary PCI in Patients with Acute ST Segment Elevation Myocardial Infarction.

Medicina (Kaunas) 2019 Feb 1;55(2). Epub 2019 Feb 1.

Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran.

We aimed to demonstrate the clinical utility of CHA2DS2-VASc score in risk assessment of patients with STEMI regarding adverse clinical outcomes particularly no-reflow phenomenon. We designed a retrospective cohort study using the data of Tehran Heart Center registry for acute coronary syndrome. The study included 1331 consecutive patients with STEMI who underwent primary angioplasty. Patients were divided into two groups according to low and high CHA2DS2-VASc score. Angiographic results of reperfusion were inspected to evaluate the association of high CHA2DS2-VASc score and the likelihood of suboptimal TIMI flow. The secondary endpoint of the study was short-term in-hospital mortality of all cause. The present study confirmed that CHA2DS2-VASc model enables us to determine the risk of no-reflow and all-cause in-hospital mortality independently. Odds ratios were 1.59 (1.30⁻2.25) and 1.60 (1.17⁻2.19), respectively. Moreover, BMI, high thrombus grade, and cardiogenic shock were predictors of failed reperfusion (odds were 1.07 (1.01⁻1.35), 1.59 (1.28⁻1.76), and 8.65 (3.76⁻24.46), respectively). We showed that using a cut off value of ≥ two in CHA2DS2-VASc model provides a sensitivity of 69.7% and specificity of 64.4% for discrimination of increased mortality hazards. Area under the curve: 0.72 with 95% CI (0.62⁻0.81). Calculation of CHA2DS2-VASc score applied as a simple risk stratification tool before primary PCI affords great predictive power. Furthermore, incremental values are obtained by using both CHA2DS2-VASc and no-reflow regarding mortality risk assessment.
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http://dx.doi.org/10.3390/medicina55020035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409514PMC
February 2019

Melatonin preconditioning of bone marrow-derived mesenchymal stem cells promotes their engraftment and improves renal regeneration in a rat model of chronic kidney disease.

J Mol Histol 2019 Apr 22;50(2):129-140. Epub 2019 Jan 22.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has shown to be effective in treating chronic kidney disease. However, the effectiveness of this strategy is constrained by low homing and survival rate of transplanted cells in the injured organs. Therefore, developing strategies to improve homing and cell survival rate and therapeutic potential in cell-based therapies seems necessary. The purpose of this study is to evaluate the effect of pretreating BMMSCs with melatonin (MT) on the prosurvival and renoprotective of transplanted cells into the irreversible model of unilateral ureteral obstruction. Adult male Sprague-Dawley rats were randomized into four groups: Sham, UUO, UUO + BMMSCs, and UUO + BMMSCs + MT. The results of our study demonstrated that preconditioning with MT enhanced homing of BMMSCs into the injured kidney. MT reduced the number of TUNEL positive transplanted cells in the UUO + BMMSCs + MT group. The UUO + BMMSCs + MT group showed lower expressions of TGF-β1, α-SMA and TNF-α at both gene and protein levels but higher expression of E-cadherin compared with the UUO + BMMSCs group. In addition, MT preconditioned BMMSCs ameliorated basement membrane disruption and histological status of injured renal tubules and also reduced fibrosis in damaged kidneys. In conclusion, our results show that stem cells pretreated by MT may represent a feasible approach for improving the beneficial effects of stem cell therapy and significantly enhance their survival after transplantation to the injured kidney.
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http://dx.doi.org/10.1007/s10735-019-09812-4DOI Listing
April 2019

Therapeutic effect of perinatal exogenous melatonin on behavioral and histopathological changes and antioxidative enzymes in neonate mouse model of cortical malformation.

Int J Dev Neurosci 2018 08 29;68:1-9. Epub 2018 Mar 29.

Institute of Neuroanatomy, RWTH Aachen University, Aachen, Germany; Giulan Neuroscience Research Center, Department of Anatomical Sciences, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Electronic address:

Background: Melatonin, which is an antioxidant and neuroprotective agent, can be an effective treatment for neurological disorders. We assessed the effect of melatonin administration on histological changes, antioxidant enzyme levels, and behavioral changes in a neonate mouse model of cortical malformation.

Materials And Methods: Cortical malformation was induced by two injections of 15 mg/kg methylazoxymethanol (MAM) on gestational day 15 (E15). Pregnant Balb/c mice were randomly divided into the following six groups: Control (CO), Melatonin (MEL), Luzindole (LUZ), MAM, MEL + MAM1 (co-treatment), and MEL + MAM2 (pretreatment). Melatonin was intraperitoneally injected at a dose of 10 mg/kg daily (from E15 until delivery of from E6 for 20 days after delivery). On postnatal day 31, the activity and anxiety of mice were assessed by open field and elevated plus maze tests, respectively. Histopathological changes in the neonate cortex were studied using hematoxylin and eosin staining and neurofilament immunohistochemistry. Enzyme-linked immunosorbent assays were used to measure the activity of nitric oxide (NO), malondialdehyde (MDA), and antioxidant enzymes, including catalase (CAT), super oxide dismutase (SOD), and glutathione peroxidase (GPX).

Results: In the behavioral assessment of neonate mice, a significant increase in the crossing activity and decrease in anxiety were recorded in groups treated with MAM plus melatonin. In histological examination, heterotopic, dysmorphic, and ectopic cells, as well as dyslamination, were seen in the MAM and LUZ groups. However, these defects were attenuated in the MAM plus melatonin groups. Significant reductions were recorded in the SOD and GPX levels in the MAM and LUZ groups compared to the control, while the NO level was increased in these groups. Groups that received MAM plus melatonin showed significant increases in the levels of SOD and GPX and a significant decrease in the level of NO, compared to the MAM group.

Conclusion: Melatonin increased the crossing activity and decreased the anxiety in the treated mice of the neonate mouse model of cortical malformation. Histologically, the administration of exogenous melatonin in pregnant mice and their neonates had a protective effect on the cerebral cortex of neonates. Also, this effect is elicited by decreasing NO and increasing antioxidative enzymes.
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http://dx.doi.org/10.1016/j.ijdevneu.2018.03.008DOI Listing
August 2018

Management of Cardiovascular Disorders in Patients with Noonan Syndrome: A Case Report.

J Tehran Heart Cent 2017 Oct;12(4):184-187

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

The Noonan syndrome is a rare disorder, one of whose major complications is cardiovascular involvement. A wide spectrum of congenital heart diseases has been observed in this syndrome. The most common cardiac disorder is pulmonary valve stenosis, which has a progressive nature. Hypertrophic cardiomyopathy is less common, but its morbidity and mortality rates are high. We herein introduce a 12-year-old boy with the typical findings of the Noonan syndrome. His symptoms began from infancy, and there was a gradual exacerbation in his respiratory and cardiac manifestations with age. The cardiac involvement included right ventricular outflow tract and pulmonary valve stenosis, hypertrophic cardiomyopathy, and subaortic valve stenosis. Due to the progressive course of the disease, surgical repair was done. Although the patient had a difficult postoperative period, his general condition improved and he was discharged. At 3 months' follow-up, his symptoms showed improvement. Additionally, there was a reduction in the echocardiographic parameters of the outflow tract stenosis gradient as well as a significant improvement in the cardiac hemodynamic indices.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849592PMC
October 2017

Association between ABO blood group and severity of coronary artery disease in unstable angina.

ARYA Atheroscler 2017 Jul;13(4):172-175

Assistant Professor, Department of Cardiology, School of Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: ABO blood groups are genetically transmitted through chromosome 9 at locus 9q34. It is supposed that there is a locus on 9p21, which has a role in developing coronary artery disease.

Methods: Our study population consisted of 309 patients with unstable angina admitted to the Ziaeian Hospital, Tehran, Iran, who underwent coronary angiography. The association between types of blood group (O and non-O) with the severity of coronary artery disease was investigated.

Results: Compared to the non-O groups, the O group had more severe coronary artery involvement (P = 0.004).

Conclusion: Our study supports recent suggestions on the association between blood group and coronary artery disease. Further studies are needed to evaluate the effect of blood group on atherosclerosis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677320PMC
July 2017

Regulatory effect of triiodothyronine on brain myelination and astrogliosis after cuprizone-induced demyelination in mice.

Metab Brain Dis 2016 Apr 4;31(2):425-33. Epub 2016 Jan 4.

Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, 52074, Aachen, Germany.

Chronic demyelination and plaque formation in multiple sclerosis is accompanied by persisting astrogliosis, negatively influencing central nervous system recovery and remyelination. Triiodothyronin (T3) is thought to enhance remyelination in the adult brain by the induction of oligodendrocyte maturation. We investigated additional astrocyte-mediated mechanisms by which T3 might promote remyelination in chronically demyelinated lesions using the cuprizone mouse model. C57BL/6 mice were fed cuprizone for 12 weeks to induce lesions with an impaired remyelination capacity. While the expression of oligodenrocyte progenitor markers, i.e., platelet derived growth factor-α receptor was not affected by T3 administration, myelination status, myelin protein expression as well as total and adult oligodendrocyte numbers were markedly increased compared to cuprizone treated controls. In addition to these effects on oligodendrocyte numbers and function, astrogliosis but not microgliosis was ameliorated by T3 administration. Intermediate filament proteins vimentin and nestin as well as the extracellular matrix component tenascin C were significantly reduced after T3 exposure, indicating additional effects of T3 on astrocytes and astrogliosis. Our data clearly indicate that T3 promotes remyelination in chronic lesions by both enhancing oligodendrocyte maturation and attenuating astrogliosis.
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http://dx.doi.org/10.1007/s11011-015-9781-yDOI Listing
April 2016

Therapeutic value of melatonin post-treatment on CCl-induced fibrotic rat liver.

Can J Physiol Pharmacol 2016 Feb 20;94(2):119-130. Epub 2015 Jul 20.

a Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Poursina Street, Tehran, Iran, 1417613151.

Melatonin is known for being beneficial in targeting liver diseases. This study aimed to investigate whether melatonin post-treatment is capable of rat carbon tetrachloride (CCl)-induced liver fibrosis reduction. Thirty-two male Sprague-Dawley rats were divided into 4 groups: normal; fibrosis with CCl injection (1 mL/kg) twice weekly for 8 weeks; phosphate-buffered saline (PBS); and melatonin (20 mg/kg) for a further 4 weeks on cessation of CCl. At the beginning of week 13, liver tissue samples were used for hematoxylin-eosin (H&E), periodic acid-Schiff (PAS), Masson's trichrome (MT), and Oil Red O staining, quantitative real-time PCR (qRT-PCR) analysis of the matrix metalloproteinase-9 (MMP-9), MMP-13, transforming growth factor-β1 (TGF-β1), Bcl-2, and Bax genes as well as immunofluorescence (IF) of the first 3, and sera for measurement of aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, and hydroxyproline. Chronic administration of CCl followed by considerable increase in tissue disruption, macro- and micro-vesicles, collagen, lipid droplets (LDs), AST, ALT, hydroxyproline, TGF-β1, and Bax, and decrease in glycogen depository, albumin, Bcl-2, MMP-9, and MMP-13; however, the pattern was reverse when it comes to melatonin treatment (for all p < 0.05). Our results reveal the beneficial aspects of melatonin in treatment of liver fibrosis probably via inhibition of TGF-β1expression.
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http://dx.doi.org/10.1139/cjpp-2015-0266DOI Listing
February 2016

Accuracy of Doppler-derived indices in predicting pulmonary vascular resistance in children with pulmonary hypertension secondary to congenital heart disease with left-to-right shunting.

Pediatr Cardiol 2014 Mar 23;35(3):521-9. Epub 2013 Oct 23.

Heart Valve Disease Research Center, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

This study aimed to evaluate the accuracy of Doppler echocardiography-derived indices in children with pulmonary hypertension secondary to congenital heart disease with left-to-right shunting. Doppler-derived indices including the acceleration time corrected (AcTc), deceleration time corrected, deceleration index, peak velocity, heart-rate-corrected inflection time (InTc), and a new index (the acceleration slope [Acc = peak flow velocity/AcTc]) were measured from the pulmonary artery (PA) systolic flow curve before and after 100 % oxygen administration in the main, left, and right PAs of 33 children. The acquired data were compared between low and high pulmonary vascular resistance (PVR) groups and between responders and nonresponders to the vasoreactivity test. The AcTc values differed significantly between the low and high PVR groups before and after oxygen administration in the main (P = 0.032 and <0.001, respectively), right (P = 0.011 and <0.001, respectively), and left (P < 0.001 and <0.001, respectively) PAs. The AcTc cutoff point in the main PA was 3.44 before oxygen administration (81% sensitivity and 91% specificity). The InTc in the main PA and its changes differed significantly between the low and high PVR groups before and after oxygen administration and between the responders and nonresponders (P = 0.016, 0.046, and 0.021, respectively). The velocity changes of the PA in the main PA differed significantly between the responders and nonresponders to oxygen administration (P < 0.001). The Acc and its changes differed significantly between the low and high PVR groups after oxygen administration and between the responders and nonresponders to oxygen administration (P = 0.044 and 0.006, respectively). Doppler echocardiographic examination using PA systolic flow indices in addition to PA reactivity testing is a promising technique for assessing PVR in children with congenital heart disease.
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http://dx.doi.org/10.1007/s00246-013-0818-xDOI Listing
March 2014

Poster presentations.

Authors:
Funda Aksu Hakan Topacoglu Candan Arman Aytul Atac Suleyman Tetik Aida Hasanovic Amela Kulenovic Zakira Mornjakovic Branko Pikula Aida Sarac-Hadzihalilovic Alma Voljevica Belgin Bamac Tuncay Colak Murat Alemdar Gulmine Dundar Macit Selekler Ozgur Dincer Enis Colak Aydin Ozbek Cenk Kilic Kivanc Kamburoglu Tuncer Ozen Vatan Kavak Yalcin Kirici Emin Oztas Handan Altinkaya Soysal Erdogan Unur Nihat Ekinci Omur Karaca Olga Malakhova Murat Kocaoglu Serdar Toker Figen Taser Volkan Kilincoglu Mustafa Fahri Yurtgun Cannur Dalcik Ali Zeybek Marc Baroncini Johann Peltier Patrice Jissendi Jean-Pierre Pruvo Jean-Paul Francke Vincent Prevot Rengin Kosif Yasin Arifoglu Murat Diramali Mustafa Sarsilmaz Evren Kose Murat Ogeturk Burhan Akpinar Ilter Kus Sedat Meydan Alev Kara Zeliha Kurtoglu Ibrahim Tekdemir Alaittin Elhan Orhan Bas Ersan Odaci Hakan Mollaoglu Kagan Ucok Suleyman Kaplan Mehmet Senoglu Vedat Nacitarhan Ergul Belge Kurutas Nimet Senoglu Idris Altun Yalcin Atli Davut Ozbag Sacide Karakas M Dincer Bilgin Ayfer Metin Tellioglu Sercin Ozlem Betul Akcanal Yuksel Yildiz Hakki Gunes Hayrullah Kose Ibrahim Uzum Umit Naci Gundogmus Cigdem Caglayan Velichka Pavlova Mashenka Dimitrova Lilia Georgieva Elena Nikolova Deniz Uzmansel Nail Can Ozturk Canan Yurttas Saylam Erkin Ozgiray Mustafa Orhan Sedat Cagli Mehmet Zileli Derya Ozkan Taylan Akkaya Ayhan Comert Nilgun Balikci Esra Ozdemir Haluk Gumus Zafer Ergul Oskay Kaya Serdar Altun R Erkin Unlu Hakan Orbay Deog-Im Kim Seung-Ho Han Yi-Suk Kim Ho-Jeong Kim Kyu-Seok Lee Omur Elcioglu Hilmi Ozden Gul Guven Nurcan Imre Bulent Yalcin Hasan Ozan Pinar Akyer Mustafa Guvencer Vasfi Karatosun Mandeep Gill Sagoo Rachel Claire Aland Derya Ustuner M Cengiz Ustuner Jafar Ai Seyed Reza Ghazi Seyed Hadi Mansouri Mehmet Cudi Tuncer Mehmet Ufuk Aluclu Ozlen Karabulut Eyup Savas Hatipoglu Hasan Nazaroglu Cigdem Icke Emrah Akbay Turkan Gunay Suleyman Icke Selda Yildiz Fatih Yazar Barcin Orhan Barlas Delia Elena Zahoi Ahmet Kavakli Ufuk Tas Durrin Ozlem Dabak Hilal Irmak Sapmaz Necdet Kocabiyik Cenk Murat Ozer Ayhan Ozcan Levent Elevli Kadir Desdicioglu Ibrahim Alanbay Figen Govsa Canan Y Saylam Ilgaz Akdogan Yilmaz Kiroglu Sule Onur Emine Hilal Evcil Neslihan Cankara Mehmet Ali Malas M Tayyar Kalcioglu Serdar Duman Tufan Ulcay Ahmet Uzun Zulfu Karabulut Cagatay Barut Ozdemir Sevinc Gamze Yurdakan Dundar Kacar Ali Riza Erdogan Hulyam Kurt Bunyamin Demir Mustafa Saltan Dilek Burukoglu Mehmet Cengiz Ustuner Irfan Degirmenci Aliriza Erdogan Ozlem Damar Merih Is Gokhan Bayramoglu Sahin Kabay Onur Uysal Hakan Senturk Aysegul Bayramoglu Cansu Ozbayar Ali Kutlu Mediha Canbek Salih Cenap Cevli Oguz Hancerlioglu Mustafa Koplay Elif Aksakalli Fatih Dikici Aysin Kale Ozcan Gayretli Ilke Ali Gurses Senem Turan Ozdemir Ilker Ercan Emel Bulbul Baskan Mediha Yilmaz Guven Ozkaya Hayriye Saricaoglu Mete Erturk Gulgun Kayalioglu Mehmet Uzel Guler Kahraman Ercan Tanyeli Ali Ihsan Soyluoglu Orhan Tacar Ayda Demirant Murat Bilgin Aziz Karadede Ayfer Aktas E Hilal Evcil Esra Koyuncu Osman Sulak Soner Albay Gulnur Ozguner Ahmet Ozbek Elvan Ozbek A Hakan Ozturk Tuba Demirci Engin Ciftcioglu Mehmet Tevfik Demir Cem Kopuz Esra Eroglu Semin Gedikli Hamit Ozyurek Mehmet Selim Nural Lutfi Incesu Gonul Ogur Engin Kara Baris Celebi Altan Yildiz B Zuhal Altunkaynak Samet Vasfi Kuvat Suleyman Murat Tagil Cumhur Ertekin Hilmi Uysal Fikret Bademkiran Nural Albayrak Ali Firat Esmer Nigar Keles Coskun Muzaffer Sindel Ferah Kizilay Sevket Yalin Nevin Karapinar Mehmet Tokdemir Lokman Karakurt Levent Tumkaya Adnan Korkmaz Bulent Ayas Nusret Ciftci Yuksel Terzi Ozlem Baran Yusuf Nergiz Murat Akkus Ufuk Aluclu Askin Ender Topal Dilek Yuksel Halil Ibrahim Acar Simel Kendir Emre Hekimoglu Deniz Basman Sunay Duman Baris Ozener Can Pelin Ragiba Zagyapan Ayla Kurkcuoglu Mustafa Koc Meral Erdinc Levent Erdinc Ilker Kelle Enver Sancakdar Nil Cetin Selcuk Tunik Ayse Yildirim Iskender Kaplanoglu Ercan Ayaz Necip Ilhan Mehmet Okumus Kasim Zafer Yuksel Harun Ciralik Zeki Yilmaz Yakup Gumusalan Mehmet Gamsizkan Mustafa Kazkayasi Nadire Unver Dogan Ismihan Ilknur Uysal Aylin Karalezli Zeliha Fazliogullari Mustafa Buyukmumcu Mehmet Cem Bozkurt Aynur Emine Cicekcibasi Deniz Demiryurek M Hakan Ozsoy Alp Bayramoglu Eray Tuccar Ozlem Pamukcu Baran Sevda Soker Selen Bahceci Yasemin Nasir Mehmet Tugrul Yilmaz Emine Aynur Cicekcibasi Mahinur Ulusoy Pervin Gunaslan Nuray Bilge Muzaffer Akkaya Abdurrahman Genc Sezer Akcer Yucel Gonul Emine Cosar Gulengul Koken Ilknur Ari Sinan Bakirci Ilker Mustafa Kafa Murat Uysal Ahmet Kagan Karabulut Bahar Keles Dilek Emlik Yavuz Uyar Kayhan Ozturk Neslihan Altuntas Yilmaz Ahmet Salbacak Burkay Kutluhan Kacira Mehmet Arazi Serafettin Demirci Demet Kiresi Serter Gumus Muzaffer Seker Mehmet Uyar Mohammad Ebrahim Astaneh Alireza Khorshid Ramazan Uygur Ahmet Songur Osman Fikret Sonmez Kamil Hakan Dogan Giray Kolcu Madalina Iliescu Petru Bordei Dan Iliescu Camelia Ciobotaru Viorel Lucescu Anatoli Covaleov Constantin Ionescu Miguel Guirao E Páramo R Mutuberria I Sánchez-Montesinos O Roda F Girón Miguel Lopez-Soler Olga Roda Raúl Campos-López Miguel Guirao-Piñeiro Maria Teresa Pascual-Morenilla Indalecio Sanchez-Montesinos Maria Teresa Pascual I Garzon D Serrato R Nieto-Aguilar I Sanchez-Montesinos M Sanchez-Quevedo M Bulent Ozdemir R Hakan Ozean Dilek Bagdatli Esat Adiguzel Zumrut Dogan Ozlem Aycan Nigar Vardi Haldun Sukru Erkal Hakan Ozturk S Mocanu C Stefanescu A Ionescu Raluca Talpes Elena Sapte Constantin Dina Loredana Surdu Ionut Bulbuc M T Medina J Medina M López-Soler Carlos Martin-Oviedo Alejandro Lowy-Benoliel Eva Maranillo Tomas Martinez-Guirado Jose Sañudo Bartolome Scola Teresa Vazquez L A Arráez-Aybar J L Conejo-Menor C C Gonzáles-Gómez A J Torres-García Hisayo Nasu Shoji Chiba M Gutierrez-Semillera Yahya Paksoy Ahmet Kalaycioglu Mehmet Yildirim Ali Ozyasar Omer Ozdogmus Yusuf Ozgur Cakmak Ural Verimli Safiye Cavdar Begum Yildizhan Z Asli Aktan Ikiz Hulya Ucerler Zuhal Ozgur Seher Yilmaz Abdullah Demirtas Ertugrul Mavili Mehtap Hacialiogullari Hatice Susar Seda Arslan Kenan Aycan Vecihi Ozkaya Mara Pilmane Sarmite Boka Gursel Ortug Carlos Ramirez Aran Pascual-Font Francisco Valderrama-Canales Abdulah Kucukalic Eldan Kapur Elvira Talovic Vaclav Baca Robert Grill Zdenek Horak David Kachlik Valer Dzupa Marek Konarik Jakub Knize Petr Veleminsky Tereza Smrzova Michal Otcenasek Jana Chmelova Michal Kheck Michal Kheck Tomas Cupka Lukas Hnatek Floris van der Meijs Pavel Cech Vladimir Musil H Mustafa Ozkan S Kivanc Muratli Hamid Tayefi Ipek Ergur Amac Kiray Muhsin Toktas Ozan Alkoc Tolgahan Acar Ibrahim Uzun Oguz Asian Ozen Abdullah Aycicek Ozan Alper Alkoc Mehmet Unlu Ufuk Corumlu Ihsaniye Coskun Ikiz I Hakan Oygucu Erdogan Sendemir Tuncay Kaner Veli Caglar Olcay Eser Mehmet T Demir Omer Iyigun Gokhan Pirzirenli Ahmet Hilmi Kaya Mennan Ece Aydin Fahrettin Celik Hakan True Sevket Ozkaya Bekir Ugur Ergur Gulsah Zeybek Kadir Bacakoglu Mina Tadjalli Aghdas Poostpasand Seid Hadi Mansouiri Ozra Allahvaisi Jafar Soleimanirad Bahram Nikkhoo Yasukazu Nagato Yasuo Haruki Komazo Yazawa Tutomu Okazaki Munetaka Haida Yutaka Imai Thmineh Peirouvi Mehrzad Mahzad-Sadaghiani Farahnaz Noroozinia Salami Siamak Gholamhosseine Farjah Sima Mola Ewa Biegaj Tymon Skadorwa Konrad Pawlewicz Robert Kapolka Agata Chachulska Joanna Zabicka Aleksandra Krasowska Alicja Prusik Grzegorz Jaczewski Adam Kolesnik M Mohsen Taghavi S Hasan Alavi S Adel Moallem Zahed Safikhani Marzieh Panahi Shahriar Dabiri Majid Asadi Shekaari Rafael Latorre Federico Soria Octavio Lopez-Albors Ricardo Sarria Inacio Ayala Inma Serrano Enrique Perez-Cuadrado Vladimir Musienko Dmitry Tkachenko Neriman Colakoglu Murat Abdulgani Kus Mahdi Jalali Mohammad Reza Nikravesh Abbas Ali Moeen Mohammad Hassan Karimfar Houshang Rafighdoost Shabnam Mohammadi Marina Korneeva Houshang Rafighdoust Kvetuse Lovasova Adriana Bolekova Darina Kluchova Igor Sulla Marina Yurievna Kapitonova Syed Baharom Syed Ahmad Fuad Flossie Jayakaran Ali Reza Shams Fereshteh Aghaee Zohreh Baqer Mohamad Faroki Srijit Das Normadiah Kassim Azian Latiff Frihah Suhaimi Norzana Ghafar Khin Pa Pa Hlaing Israa Maatoq Faizah Othman Muge Kiray Husnu Alper Bagriyanik Cetin Pekcetin Candan Ozogul Mustafa Fidan Farihah Suhaimi Fei Sun Francisco Sanchez-Margallo Francisco Gil Verónica Crisostomo Jesus Uson Gegorio Ramirez Ozan Turamanlar Oguz Kirpiko Alpay Haktanir Salvador Climent Sergio Losilla Maria Climent Levent Sarikcioglu Yesim Senol Fatos B Yildirim Arzu Utuk Jacek Kunicki Parichehr Pasbakhsh Negar Omidi Hamed Omidi Fatemeh Dehghani Nazhvani Seyed Razi Ghalebi Nima Javan Akrami Mohagery Ali Reza Ebrahimzadeh Bideskan Mohammad Mehdi Hassanzadeh Taheri Ali Reza Fazel Cesare Tiengo Veronica Macchi Carla Stecco Andrea Porzionato Franco Mazzoleni Raffaele De Caro Alberto Clemente Aldo Morra Pietro Greco Piero Pavan Arturo Natali Mehmet Demir Mehmet Dokur Niyazi Acer Ayfer Mavi Niki Matveeva Dobrila Lazarova Kostandina Korneti Svetlana Jovevska Dragica Jurkovik Meri Papazova Masoumeh Havasi Naeim Alboghobeish Ahmad Savari Negin Salamat Mozafar Sharifi Hyun-Ho Kwak Kyung-Seok Hu Gyoo-Cheon Kim Bong-Soo Park Hee-Jin Kim Ahmet Sinav Adarsh K Gulati Nidhi K Gulati Hussien Alshammary Seifollah Dehghani Nazhvani Amir Vafafar Tahereh Esmaeilpour Soghra Bahmanpour Leila Elyasi Ahmad Monabbati M Ghanadi Mohammad Reza Paryani Hassan Gilanpour Banino Amirsam Rodrigo Elizondo Omaña Santos Guzmán López Oscar De la Garza Castro Edgar Urrutia Vega Santos Guzman Lopez Freshteh Talebpour Rahim Golmohammadi Golamreza Dashti Mohammad Ali Atlasi Mehdi Mehdizadeh Mohammad Hadi Bahadori Mohammad Taghi Joghataei Leili Hatami Mandana Beigi Boroujeni Jasem Estakhr Ebrahim Esfandiary Mohsen Marzban Mehrdad Bakhtiary Navid Modiry Mokhtar Jafarpur Hassan Mofidpur S Hassan Alavi Alareza Mahmoudian Mohmmad Mohsen Taghavi Mokhtar Jafarpour Ali Reza Mahmoudian Nasrin Sanjarmousavi Ines Doassans Natalia Sorrenti German Decuadro Andres Saibene Marie Poumayrac Sebastian Laza Carina Almiron Maria Elena Vergara Victor Soria Sebastian Lasa Adolfo Perez Gabriela Castro Ana Santa Maria Mansoureh Soleimani Majid Katebi Masoomeh Bakhshayesh Mithat Oner Mehmet Halici Ali Yikilmaz Ahmet Guney Yildirim Turk Mete Edizer Umit Beden Nihal Icten Mohammad Afshar Mohammad Mehdi Hasanzadeh Taheri Adel Moalem Mohammad Jafar Golalipour Azadeh Tamizi Mohammad Ahi Shahram Mohammadpour Ardeshir Maiery Cengiz Acikel Ersin Ulkur Huseyin Karagoz Bahattin Celikoz Kuldip Bedi Partadiredja Ginus Mohammad Jafar Golalipoor Mohammad Reza Mohammadi Poya Jhand Azad Reza Mansourian Kanizreza Hosseinpoor Abbas Ali Keshtkar Raith Alsaffar Babak Kabiri Balajadeh Soraya Ghafari Ramin Azarhosh Seyyed Amirhossein Fazeli Mehrdad Jahanshahi Annen Mohammad Gharravi Banu Alicioglu Hakki Muammer Karakas Ahmet Harma Hun-Mu Yang Sung-Yoon Won Jae-Gi Lee Ju-Young Lee Jeong-Yong Lee Yoo-Ri Kim Wu-Chul Song Ki-Seok Koh Eu-Na Hwang Hyun-Gon Choi Soon-Heum Kim Soo-Young Kim Mi-Sun Hur Enis Ulucam Osman Celbis Da-Hye Kim Hee-Suk Hong Hyun-Joo Kim Jong-Hoon Choi Jong-Tae Park Hyeon-Cheol Kim Hamed Abbasi Seyed Mohammad Hosseinipanah Mohammad Hosseini A Amani H R Ashrafi Mohsen Sadeghimehr Hyun-Ju Kim Vadim Sheverdin Zahra Amani Alireza Ashrafi Ali Reza Ashrafi Hami Javad Mokhtar Jafarpoor Kachap Sebastián Laza Marie Catherine Poumayrac Inés Doassans María Elena Vergara Carina Almirón Víctor Soria Alvaro Rivara Angela Sirilo Diego Freire Angela Cirillo Maria Elena Veragara Vlado Krmek Nikola Krmek Ana Jo-Osvatic Vasilije Nikolic Radivoje Radic R Shane Tubbs Marios Loukas Quentin Fogg Neil Ashwood Serpil Cilingiroglu Cemal Ozbakir Tahereh Mazoochi Vedat Sabanciogullari Cesur Gumus F Hayat Erdil Mehmet Cimen Hesam Moodi Fateme Ghiasi Asghar Akbari Javad Hami Majid Khazei Elham Haghparast Ioannis Mitsakis Aikaterini Anastasiou Menelaos Mitsakis Kyriaki Sianou Roxani Hainoglou Margarida Francisco Charikleia Mitsaki Maria Konstantinidi Stamatia Prapa Igor Leksan Tomislav Mrcela Robert Selthofer Fatemeh Kermanian Alireza Mahmoudian Mahmood Erfanian Ahmadpoor Naser Dalili Amir Hossein Elian Ardesheer Moaiery Zahra Jamalpour Mohammad Reza Nourani Alireza Asgari Mohammad Mehdi Hassanzadeh Taheri Alireza Ebrahimzadeh Seyed Hasan Eftekharvaghefi Abbas Mohammadi Vahid Sheibani Seyed Noureddin Nematollahi-Mahani Mastafa Latifpour Masood Deilami Behzad Soroure-Azimzadeh Fatemeh Nabipour Hamid Najafipour Nouzar Nakhaee Mohammad Yaghoobi Rana Eftekharvaghefi Parvin Salehinejad Hasan Azizi Hamid Reza Riasi Maliheh Nobakht Sara Asalgoo Roshanak Rahbar Norooz Najafzadeh Kazem Moosavizadeh Massood Ezzatabadypour Masoud Majidi Reza Malekpor-Afshar Fariba Karimzade Mahmood Hoseini Mohamad Bayat Ali Gorgi Akram Nezhadi Mehrdad Bakhtiari Homa Rasooli Jazi Maryam Jafaryan Hosein Haghir Mahmood Hosseini Sadegh Rahimi Fatemeh Behnam Rassouli Ali Gorji Aliasghar Habibi Fatemeh Pouya Shahryar Dabiri A Mousavi Saeed Rajabalian A Abolidokht Neda Khanlarkhani Homayoun Naderian Nezamedin Berjis Mohamad Reza Namavar Tahereh Talaei Zohreh Mazaheri Ahmad Monabati Mehmet Ilkay Kosar Kezban Karacan Hamidreza Chegini Hossein Nikzad Egemen Ayhan Sinan Ustundag Salih Murat Akkin Tahir Ogut Parviz Rayegan Mohamad Ali Emami Meibodi Reza Montazer Ghaem Rosa Zargarpoor Seyd Hasan Eftekhar Vaghefi Ghazale Moshkdanian Fateme Poya Hamid Kohestani Roozbeh Rayegan Abarghoeai Parviz Rayegan Abarghoeai Seyed Hasan Eftekhar Vaghefi Abolghasem Amir Mahmodi Ali Poraboli Hamid Reza Kohestani Raena Eftekhar Vaghefi Seyed Hasan Eftekhar Vaghefy Raena Eftekhar Vaghefy Parviz Raygan Abarghoeai Mohamad Saba Anneh Mohammad Gharravi Fatemeh Javadnia Mohsen Zhaleh Dariush Bijan Nezhad Mohammad Reza Gholami Maria Piagkou Vassiliki Kouki Aikaterini Giannoulis Piagkos Stergios Douvetzemis Panagiotis Skandalakis Sophia Anagnostopoulou Nikolaos Papadopoulos H Hamdi Celik Ilkan Tatar Emel Cadalli Tatar Burce Ozgen Mocan Mustafa F Sargon C Cem Denk Homa Rasoolijazi Mohammad Taghi Joghataie Mehrdad Roghani Salin Murat Akkin Gulten Dinc Mustafa Kurklu Sener Ozboluk Mahmut Komurcu Jürgen Koebke Mehmet Bulent Balioglu Mehmet Akif Kaygusuz Ferdi Sefa Bozkus Ozgur Korkmaz Sule Biyik Bayram Mehmet Ali Can Ebrahim Nasiri Koroush Jafar-Kazemi Melina Hosseini Shahin Maghoul Mansooreh Soleimani Abdollah Amini Mohamad Mahdi Hassanzade Mohammad Hossein Davari Tom Van Hoof Germano T Gomes Emmanuel Audenaert Koenraad Verstraete Ingrid Kerckaert Katharina D'Herde Brion Benninger Gil Hedley Florin Mihail Filipoiu Eugen Tarta Mihali Enyedi Cosmin Pantu Razvan Stanciulescu Cezary Skobowiat Jaroslaw Calka Mariusz Majewski Maryam Rezaian Akbar Yaghoobfar Somayeh Hamedi T Shomali

Surg Radiol Anat 2009 Sep;31 Suppl 1:95-229

Division of Histology, Department of Basic Sciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.

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http://dx.doi.org/10.1007/BF03371486DOI Listing
September 2009

The protective effect of vitamin E on locus coeruleus in early model of Parkinson's disease in rat: immunoreactivity evidence.

Iran Biomed J 2008 Oct;12(4):217-22

Dept. of Anatomy, School of Medicine, University of Tehran, Tehran, Iran.

Background: Free radical formation and oxidative stress might play an important role in the pathogenesis of Parkinson's disease (PD). In vitro data indicate that neuromelanin (NM) pigment is formed the excess cytosolic catecholamine that is not accumulated into synaptic vesicles via the vesicular monoamine transporter 2 (VMAT2). We designed this study to investigate the neuroprotective effects of vitamin E in the early model of PD.

Methods: Male rats (n = 40) with unbiased rotational behavior were randomly divided into five groups: sham operated group (SH, n = 8), vehicle-treated SH group (SH + V, n = 8), vitamin E-treated SH group (SH + E, n = 8), vehicle-treated lesion group (L + V, n = 8) and vitamin E-treated lesion group (L + E, n = 8). Unilateral intrastriatal 6-hydroxydopamine (12.5 microl) lesioned rats were treated intramuscularly with alpha-tocopherol acid succinate (24 I.U/kg, intramuscular [i.m.]) 1 h before surgery and three times per week for 2 month post-surgery. To evaluate the vitamin E pretreatment efficacy, tyrosine hydroxylase (TH) immunoreactivity and immunostaining intensity (ISI) for monoamine transporter 2 were used.

Results: TH immunohistochemical analyses showed a reduction of 20 percent in locus coeruleus (LC) cell number of vitamin E pretreated lesioned group but the cell number dropped to 60 percent in the lesioned group. The ISI of the cells was measured for VMAT2 in LC. Lesioned groups: 1) had the lowest VMAT2 ISI of all neurons; 2) There was an inverse relationship between VMAT2 ISI and NM pigment in the locus and 3) Neurons with the highest VMAT2 ISI also had high TH ISI.

Conclusion: The data support the hypothesis that repeated i.m. administration of vitamin E exerts a protective effect on the LC neurons in the early model of PD.
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October 2008