Neeltje A Kootstra

Neeltje A Kootstra

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Neeltje A Kootstra

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CD32CD4 T Cells Are Highly Enriched for HIV DNA and Can Support Transcriptional Latency.

Cell Rep 2020 Feb;30(7):2284-2296.e3

Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.01.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050565PMC
February 2020

HIV-negative Men Who Have Sex with Men have higher CD8+ T-cell Counts and Lower CD4+/CD8+ T-cell Ratios compared to HIV-negative Heterosexual Men.

J Infect Dis 2020 Jan 31. Epub 2020 Jan 31.

Amsterdam UMC, University of Amsterdam, Departments of Global Health and Internal Medicine, Amsterdam Infection and Immunity Institute and Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1093/infdis/jiaa048DOI Listing
January 2020

The Role of Macrophages in HIV-1 Persistence and Pathogenesis.

Front Microbiol 2019 5;10:2828. Epub 2019 Dec 5.

Laboratory for Viral Immune Pathogenesis, Department of Experimental Immunology, Amsterdam UMC, Amsterdam Infection & Immunity Institute, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fmicb.2019.02828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906147PMC
December 2019

Deep sequencing identifies hepatitis B virus core protein signatures in chronic hepatitis B patients.

Antiviral Res 2018 10 16;158:213-225. Epub 2018 Aug 16.

Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01663542183001
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http://dx.doi.org/10.1016/j.antiviral.2018.08.009DOI Listing
October 2018

CNS penetration of ART in HIV-infected children.

J Antimicrob Chemother 2018 02;73(2):484-489

Department of Pediatric Infectious Diseases, Emma Children's Hospital/Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/jac/dkx396DOI Listing
February 2018

The Neutralizing Antibody Response in an Individual with Triple HIV-1 Infection Remains Directed at the First Infecting Subtype.

AIDS Res Hum Retroviruses 2016 Oct/Nov;32(10-11):1135-1142. Epub 2016 Feb 24.

1 Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam , Amsterdam, the Netherlands .

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http://dx.doi.org/10.1089/aid.2015.0324DOI Listing
December 2017

Dynamics of the Immune Response in Acute Hepatitis B Infection.

Open Forum Infect Dis 2017 20;4(4):ofx231. Epub 2017 Dec 20.

Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1093/ofid/ofx231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739046PMC
December 2017

Acquisition of wild-type HIV-1 infection in a patient on pre-exposure prophylaxis with high intracellular concentrations of tenofovir diphosphate: a case report.

Lancet HIV 2017 11 14;4(11):e522-e528. Epub 2017 Sep 14.

Department of Infectious Diseases, Amsterdam Infection and Immunity Institute (AI&II), Academic Medical Center, University of Amsterdam, Netherlands; Department of Global Health and Amsterdam Institute for Global Health and Development, Academic Medical Center, University of Amsterdam, Netherlands.

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http://dx.doi.org/10.1016/S2352-3018(17)30132-7DOI Listing
November 2017

Inflammatory and Neuronal Biomarkers Associated With Retinal Thinning in Pediatric HIV.

Invest Ophthalmol Vis Sci 2017 11;58(13):5985-5992

Department of Hematology, Immunology and Infectious Diseases, Emma Children's Hospital/Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1167/iovs.17-22252DOI Listing
November 2017

Immune responses in DAA treated chronic hepatitis C patients with and without prior RG-101 dosing.

Antiviral Res 2017 Oct 24;146:139-145. Epub 2017 Aug 24.

Dep. of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands; Dep. of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2017.08.016DOI Listing
October 2017

Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets.

Nature 2016 12 7;540(7633):448-452. Epub 2016 Dec 7.

Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nature20567DOI Listing
December 2016

Hepatitis B Virus Protein X Induces Degradation of Talin-1.

Viruses 2016 10 19;8(10). Epub 2016 Oct 19.

Department of Blood-borne Infections, Sanquin Research, 1006 AD Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/v8100281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086613PMC
October 2016

Difference in Aortic Stiffness Between Treated Middle-Aged HIV Type 1-Infected and Uninfected Individuals Largely Explained by Traditional Cardiovascular Risk Factors, With an Additional Contribution of Prior Advanced Immunodeficiency.

J Acquir Immune Defic Syndr 2016 09;73(1):55-62

*Department of Global Health, Amsterdam Institute for Global Health and Development and Academic Medical Center, Amsterdam, the Netherlands;†Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands;‡Division of Infectious Diseases, Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, the Netherlands;§HIV Monitoring Foundation, Amsterdam, the Netherlands;‖Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands;¶Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands;#Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; and**Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.

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http://pdfs.journals.lww.com/jaids/2016/09010/Difference_in_
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http://dx.doi.org/10.1097/QAI.0000000000001024DOI Listing
September 2016

Liver fibrosis in HIV-infected individuals on long-term antiretroviral therapy: associated with immune activation, immunodeficiency and prior use of didanosine.

AIDS 2016 07;30(11):1771-80

aDepartment of Global Health, Academic Medical Center and Amsterdam Institute for Global Health and Development bAcademic Medical Center, Division of Infectious Diseases and Center for Infection and Immunity Amsterdam cHIV Monitoring Foundation dDepartment of Neurology, Academic Medical Center eDepartment of Experimental Immunology, Academic Medical Center fDepartment of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/QAD.0000000000001119DOI Listing
July 2016

Higher Prevalence of Hypertension in HIV-1-Infected Patients on Combination Antiretroviral Therapy Is Associated With Changes in Body Composition and Prior Stavudine Exposure.

Clin Infect Dis 2016 07 3;63(2):205-13. Epub 2016 May 3.

Department of Global Health, Academic Medical Center, and Amsterdam Institute for Global Health and Development Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity Amsterdam, Academic Medical Center HIV Monitoring Foundation.

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http://dx.doi.org/10.1093/cid/ciw285DOI Listing
July 2016

ADAR1 Facilitates HIV-1 Replication in Primary CD4+ T Cells.

PLoS One 2015 2;10(12):e0143613. Epub 2015 Dec 2.

Department of Experimental Immunology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143613PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667845PMC
June 2016

DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner.

PLoS One 2015 7;10(12):e0144229. Epub 2015 Dec 7.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infection and Immunity (CINIMA) at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144229PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979971PMC
June 2016

Mutations in CypA Binding Region of HIV-1 Capsid Affect Capsid Stability and Viral Replication in Primary Macrophages.

AIDS Res Hum Retroviruses 2016 Apr 20;32(4):390-8. Epub 2015 Oct 20.

Laboratory of Viral Immune Pathogenesis, Department of Experimental Immunology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam , Amsterdam, the Netherlands .

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http://dx.doi.org/10.1089/AID.2014.0361DOI Listing
April 2016

Determinants of reduced cognitive performance in HIV-1-infected middle-aged men on combination antiretroviral therapy.

AIDS 2016 Apr;30(7):1027-38

aDepartment of Global Health, Academic Medical Center and Amsterdam Institute for Global Health and Development bDepartment of Neurology cDepartment of Radiology dDivision of Infectious Diseases, Department of Internal Medicine, Center for Infection and Immunity Amsterdam (CINIMA) eDepartment of Experimental Immunology fDepartment of Medical Psychology, Academic Medical Center gDepartment of Psychology, University of Amsterdam hPublic Health Service Amsterdam, Infectious Diseases Research iDepartment of Neurology, Onze Lieve Vrouwe Gasthuis jDutch HIV Monitoring Foundation, Amsterdam, The Netherlands. *See "Acknowledgements" section for details concerning the AGEhIV Study Group.

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http://pdfs.journals.lww.com/aidsonline/2016/04240/Determina
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/QAD.0000000000001017DOI Listing
April 2016

Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.

Medicine (Baltimore) 2016 Mar;95(12):e3093

From the Department of Pediatric Hematology, Immunology and Infectious Diseases, (YWVD, CB, SC, JATS, HJS, TWK, DP); Psychosocial Department (JATS), Emma Children's Hospital/Academic Medical Center; Neurochemistry Laboratory and Biobank (CET), Department of Clinical Chemistry, VU University Medical Center and Neurocampus Amsterdam, the Netherlands; Neurology (JK), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland; Department of Experimental Immunology (NAK); Department of Global Health and Amsterdam Institute of Global Health and Development (PR), Academic Medical Center; HIV Monitoring Foundation (PR); Department of Internal Medicine (PR), Division of Infectious Diseases, Center for Infection and Immunity Amsterdam (CINIMA); and Department of Radiology (CBLMM, MWAC), Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/MD.0000000000003093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998374PMC
March 2016

Hepatitis B Virus Pregenomic RNA Is Present in Virions in Plasma and Is Associated With a Response to Pegylated Interferon Alfa-2a and Nucleos(t)ide Analogues.

J Infect Dis 2016 Jan 27;213(2):224-32. Epub 2015 Jul 27.

Department of Clinical Virology, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/infdis/jiv397DOI Listing
January 2016

Minor Contribution of Chimeric Host-HIV Readthrough Transcripts to the Level of HIV Cell-Associated gag RNA.

J Virol 2016 01 11;90(2):1148-51. Epub 2015 Nov 11.

Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1128/JVI.02597-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702708PMC
January 2016

G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA.

Virology 2015 Dec 29;486:94-104. Epub 2015 Sep 29.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam 1105AZ, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.09.007DOI Listing
December 2015

Adaptation of HIV-1 to rhTrim5α-mediated restriction in vitro.

Virology 2015 Dec 27;486:239-47. Epub 2015 Oct 27.

Department of Experimental Immunology, Laboratory of Viral Immune and Pathogenesis at the Academic Medical Center of the University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.09.017DOI Listing
December 2015

Phosphodiesterase 8a supports HIV-1 replication in macrophages at the level of reverse transcription.

PLoS One 2014 8;9(10):e109673. Epub 2014 Oct 8.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infection and Immunity (CINIMA) at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109673PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190361PMC
October 2015

MicroRNAs: role and therapeutic targets in viral hepatitis.

Antivir Ther 2014 18;19(6):533-41. Epub 2014 Mar 18.

Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.3851/IMP2766DOI Listing
August 2015

Viral evolution in HLA-B27-restricted CTL epitopes in human immunodeficiency virus type 1-infected individuals.

J Gen Virol 2015 Aug 14;96(8):2372-2380. Epub 2015 Apr 14.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1099/vir.0.000148DOI Listing
August 2015

An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B.

Liver Int 2015 Jul 21;35(7):1824-32. Epub 2015 Jan 21.

Department of Gastroenterology and Hepatology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/liv.12768DOI Listing
July 2015

SAMHD1 degradation enhances active suppression of dendritic cell maturation by HIV-1.

J Immunol 2015 May 30;194(9):4431-7. Epub 2015 Mar 30.

Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; and

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http://dx.doi.org/10.4049/jimmunol.1403016DOI Listing
May 2015

HIV-1 replication fitness of HLA-B*57/58:01 CTL escape variants is restored by the accumulation of compensatory mutations in gag.

PLoS One 2013 5;8(12):e81235. Epub 2013 Dec 5.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081235PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855271PMC
March 2015

Next-generation sequencing of microRNAs in primary human polarized macrophages.

Genom Data 2014 Dec 27;2:181-3. Epub 2014 Jun 27.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.gdata.2014.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535945PMC
December 2014

Genetic variation in Trex1 affects HIV-1 disease progression.

AIDS 2014 Nov;28(17):2517-21

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infection and Immunity (CINIMA) at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/QAD.0000000000000436DOI Listing
November 2014

HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels.

J Hepatol 2014 Oct 10;61(4):730-7. Epub 2014 May 10.

Department of Gastroenterology and Hepatology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.05.004DOI Listing
October 2014

Fetal exposure to HIV-1 alters chemokine receptor expression by CD4+T cells and increases susceptibility to HIV-1.

Sci Rep 2014 Oct 24;4:6690. Epub 2014 Oct 24.

1] Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Academic Medical Centre (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands [2] Department of Experimental Immunology, AMC, UvA, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/srep06690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208038PMC
October 2014

The presence of CXCR4-using HIV-1 prior to start of antiretroviral therapy is an independent predictor of delayed viral suppression.

PLoS One 2013 1;8(10):e76255. Epub 2013 Oct 1.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076255PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787987PMC
July 2014

HIV-1 isolation from infected peripheral blood mononuclear cells.

Methods Mol Biol 2014 ;1087:187-96

Viral Evolution and Transmission Unit, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1007/978-1-62703-670-2_15DOI Listing
May 2014

Low level of HIV-1 evolution after transmission from mother to child.

Sci Rep 2014 May 28;4:5079. Epub 2014 May 28.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1038/srep05079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381489PMC
May 2014

Next-generation sequencing of microRNAs uncovers expression signatures in polarized macrophages.

Physiol Genomics 2014 Feb 10;46(3):91-103. Epub 2013 Dec 10.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands;

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http://dx.doi.org/10.1152/physiolgenomics.00140.2013DOI Listing
February 2014

Chimeric HIV-1 envelope glycoproteins with potent intrinsic granulocyte-macrophage colony-stimulating factor (GM-CSF) activity.

PLoS One 2013 2;8(4):e60126. Epub 2013 Apr 2.

Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060126PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615126PMC
October 2013

Identification of a new genotype of Torque Teno Mini virus.

Virol J 2013 Oct 30;10:323. Epub 2013 Oct 30.

Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/1743-422X-10-323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819664PMC
October 2013

The hepatitis B virus x protein inhibits thymine DNA glycosylase initiated base excision repair.

PLoS One 2012 8;7(11):e48940. Epub 2012 Nov 8.

Department of Blood-borne Infections, Center for Infection and Immunity Amsterdam (CINIMA), Sanquin, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048940PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493593PMC
July 2013

Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons.

Sci Rep 2012 23;2:763. Epub 2012 Oct 23.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam-CINIMA at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/srep00763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478582PMC
March 2013

Gag sequence variation in a human immunodeficiency virus type 1 transmission cluster influences viral replication fitness.

J Gen Virol 2013 Feb 7;94(Pt 2):354-359. Epub 2012 Nov 7.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1099/vir.0.048371-0DOI Listing
February 2013

HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism.

PLoS One 2012 6;7(3):e32534. Epub 2012 Mar 6.

Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032534PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295759PMC
August 2012

Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia.

PLoS One 2012 7;7(2):e30990. Epub 2012 Feb 7.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infection and Immunity Amsterdam, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030990PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274517PMC
July 2012

HIV-1 envelope diversity 1 year after seroconversion predicts subsequent disease progression.

AIDS 2012 Jul;26(12):1517-22

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/QAD.0b013e328354f539DOI Listing
July 2012

Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection.

Blood 2012 Mar 11;119(9):2024-32. Epub 2012 Jan 11.

Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2011-06-364828DOI Listing
March 2012

Protein X of hepatitis B virus: origin and structure similarity with the central domain of DNA glycosylase.

PLoS One 2011 5;6(8):e23392. Epub 2011 Aug 5.

Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023392PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153941PMC
February 2012

Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages.

Virology 2011 Nov 13;420(1):32-42. Epub 2011 Sep 13.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infection and Immunity at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.virol.2011.08.013DOI Listing
November 2011

Macrophages and HIV-1.

Curr Opin HIV AIDS 2011 Sep;6(5):385-90

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam at Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/COH.0b013e3283497203DOI Listing
September 2011

Comparison of in vivo and in vitro evolution of CCR5 to CXCR4 coreceptor use of primary human immunodeficiency virus type 1 variants.

Virology 2011 Apr 4;412(2):269-77. Epub 2011 Feb 4.

Dept of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA) at Academic Medical Center of University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.virol.2011.01.010DOI Listing
April 2011

Genetic composition of replication competent clonal HIV-1 variants isolated from peripheral blood mononuclear cells (PBMC), HIV-1 proviral DNA from PBMC and HIV-1 RNA in serum in the course of HIV-1 infection.

Virology 2010 Sep 17;405(2):492-504. Epub 2010 Jul 17.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Department of Medical Microbiology, part of the Center for Infectious Diseases and Immunity Amsterdam (CINIMA) at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.virol.2010.06.029DOI Listing
September 2010

Donor variation in in vitro HIV-1 susceptibility of monocyte-derived macrophages.

Virology 2009 Aug 16;390(2):205-11. Epub 2009 Jun 16.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center of The University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.virol.2009.05.027DOI Listing
August 2009

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells.

Haematologica 2009 May 31;94(5):670-8. Epub 2009 Mar 31.

Department of Plasma Proteins, Sanquin Research, Plesmanlaan 125, Amsterdam, The Netherlands.

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http://dx.doi.org/10.3324/haematol.13427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675679PMC
May 2009

Polymorphisms in the regulatory region of the Cyclophilin A gene influence the susceptibility for HIV-1 infection.

PLoS One 2008 18;3(12):e3975. Epub 2008 Dec 18.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003975PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2599883PMC
February 2009

Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection.

AIDS 2009 Jan;23(1):19-28

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/QAD.0b013e32831db247DOI Listing
January 2009

Isolation and propagation of HIV-1 on peripheral blood mononuclear cells.

Nat Protoc 2008 ;3(3):363-70

Sanquin Research, Landsteiner Laboratory, Department of Experimental Immunology and Center of Infection and Immunity Amsterdam (CINIMA), University of Amsterdam, Amsterdam Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nprot.2008.3DOI Listing
November 2008

Molecular evolution of human immunodeficiency virus type 1 upon transmission between human leukocyte antigen disparate donor-recipient pairs.

PLoS One 2008 Jun 18;3(6):e2422. Epub 2008 Jun 18.

Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infectious Diseases and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002422PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409968PMC
June 2008

The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection.

PLoS Pathog 2008 Feb;4(2):e18

Department of Clinical Viro Immunology, Sanquin Research, Landsteiner Laboratory, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.0040018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222955PMC
February 2008

The presence of the Trim5alpha escape mutation H87Q in the capsid of late stage HIV-1 variants is preceded by a prolonged asymptomatic infection phase.

AIDS 2007 Oct;21(15):2015-23

Department of Clinical Viro Immunology, Sanquin Research, Landsteiner Laboratory, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/QAD.0b013e3282effa87DOI Listing
October 2007

Efficient transduction of simian cells by HIV-1-based lentiviral vectors that contain mutations in the capsid protein.

Mol Ther 2007 May 13;15(5):930-7. Epub 2007 Feb 13.

Department of Clinical Viro Immunology, Sanquin Research, Landsteiner Laboratory, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/mt.sj.6300091DOI Listing
May 2007

Isolation, propagation, and titration of human immunodeficiency virus type 1 from peripheral blood of infected individuals.

Methods Mol Biol 2005 ;304:17-24

Department of Clinical Vitro-Immunology, Sanquin Research at CLB, Academical Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1385/1-59259-907-9:017DOI Listing
September 2005

Determination of cell tropism of HIV-1.

Methods Mol Biol 2005 ;304:317-25

Department of Clinical Viro-Immunology Sanquin Research at CLB, Academical Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1385/1-59259-907-9:317DOI Listing
September 2005

Determination of co-receptor usage of HIV-1.

Methods Mol Biol 2005 ;304:327-32

Department of Clinical Viro-Immunology Sanquin Research at CLB, Academical Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1385/1-59259-907-9:327DOI Listing
September 2005

Gene therapy with viral vectors.

Annu Rev Pharmacol Toxicol 2003 10;43:413-39. Epub 2002 Jan 10.

Laboratory of Genetics, The Salk Institute, La Jolla, California 92037-1099, USA.

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http://dx.doi.org/10.1146/annurev.pharmtox.43.100901.140257DOI Listing
September 2003

Efficient production of human FVIII in hemophilic mice using lentiviral vectors.

Mol Ther 2003 May;7(5 Pt 1):623-31

Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1016/s1525-0016(03)00073-xDOI Listing
May 2003

Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells.

Proc Natl Acad Sci U S A 2003 Feb 23;100(3):1298-303. Epub 2003 Jan 23.

Laboratory of Genetics and Infectious Disease Laboratory, The Salk Institute, La Jolla, CA 92037-1099, USA.

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http://dx.doi.org/10.1073/pnas.0337541100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298767PMC
February 2003

Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes.

Mol Ther 2002 Sep;6(3):349-58

Children's Institute for Surgical Science, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1006/mthe.2002.0681DOI Listing
September 2002