Publications by authors named "Nazife Aşıkgarip"

5 Publications

  • Page 1 of 1

Comparison of the effects of intravitreal ranibizumab and aflibercept on retinal vessel diameters in patients with diabetic macular edema.

Photodiagnosis Photodyn Ther 2021 Apr 1;34:102282. Epub 2021 Apr 1.

University of Health Sciences, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.

Purpose: To evaluate and compare the effects of intravitreal ranibizumab and aflibercept treatment on retinal vessel diameters in patients with diabetic macular edema (DME).

Methods: Thirty initial-treatment naïve patients with DME who received three loading doses at monthly intervals of intravitreal ranibizumab or aflibercept were retrospectively reviewed. The diameters of the central retinal artery and vein sections at a distance of 1500 microns from the optical disc boundary were measured and evaluated at baseline and after the first, second, and third month of the treatment, using infrared images from optical coherence tomography (OCT) (Heidelberg Engineering, Heidelberg, Germany).

Results: In the superotemporal artery (STA) measurements, the mean basal vessel diameter decreased from 110.00 ± 17.25 μm to 102.60 ± 16.90 μm (p = 0.001) in the third month of the treatment in the ranibizumab group. In the aflibercept group, measurements of the basal STA vessel diameter decreased from 110.20 ± 21.25 μm to 103.93 ± 19.03 μm (p = 0.001) at the third month. The mean basal inferotemporal artery (ITA) vessel diameter was significantly decreased at the third month in both ranibizumab (p = 0.001) and aflibercept groups (p = 0.005). In the superotemporal vein (STV) and inferotemporal vein (ITV) measurements, vessel diameters were found significantly decreased at the end of the third month compared with basal measurements in both the ranibizumab (p = 0.001; p = 0.001, respectively) and aflibercept (p = 0.001; p = 0.004, respectively) treatment groups. The retinal vessel measurements were not found to differ significantly between the two intravitreal treatment agents (p > 0.05).

Conclusion: Both intravitreal ranibizumab and aflibercept agents cause a significant narrowing in the retinal vessel diameters in patients with DME after three loading doses at monthly intervals.
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http://dx.doi.org/10.1016/j.pdpdt.2021.102282DOI Listing
April 2021

Evaluation of Nasopharyngeal and Conjunctival Swab Samples of Hospitalised Patients with Confirmed COVID-19.

Ocul Immunol Inflamm 2021 Mar 4:1-4. Epub 2021 Mar 4.

Department of Emergency Medicine, Kırşehir Ahi Evran University School of Medicine, Kırşehir, Turkey.

Purpose: To evaluate the results of conjunctival and nasopharyngeal swab tests in patients with confirmed COVID-19.

Methods: This prospective study included 45 patients who were hospitalized for confirmed COVID-19. Nasopharyngeal swab samples were obtained from the patients before hospitalization. Only one eye of each patient was randomly selected for-conjunctival sampling. All participants underwent a complete slit-lamp examination. Conjunctival and nasopharyngeal swab samples were analyzed by reversetranscriptase-polymerase-chain reaction (RT-PCR).

Results: Twenty seven (60%) of the patients were male and 18 (40%) were female. Conjunctival swab was positive in only one (2.22%) patient. None of the COVID-19 patients showed ocular changes and symptoms. There were no abnormalities of the ocular surface, anterior chamber or posterior segment at slit-lamp examination.

Conclusions: The RT-PCR was not high positive in the conjunctiva as in nasopharyngeal swabs. Ocular changes were not common in COVID-19 patients.
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http://dx.doi.org/10.1080/09273948.2020.1838558DOI Listing
March 2021

Retinal Vessel Diameter Changes in COVID-19 Infected Patients.

Ocul Immunol Inflamm 2021 Jan 26:1-7. Epub 2021 Jan 26.

Department of Medical Microbiology, Amasya University School of Medicine, Amasya, Turkey.

: To evaluate the longitudinal changes in retinal vessel diameters in patients with coronavirus disease 2019 (COVID-19).: This study included 25 patients with COVID-19 (Group 1) and 25 healthy subjects (Group 2). The diameters of peripapillary temporal and nasal retinal arteries and veins were measured at baseline and at 4 months after remission.: The baseline diameters of the inferior temporal vein and the artery were increased in group 1 compared to controls ( = .007 and = .041, respectively). There was also an increase in the diameters of the inferior and superior nasal veins and arteries in group 1 at baseline ( = .001, = .019, = .037, and = .008, respectively). Retinal vessel diameters decreased after remission in all quadrants in comparison to baseline measurements (all < .05).: Increased retinal vessel diameters were measured in COVID-19 patients during the disease. Measurement of retinal vessel diameters may be a noninvasive method of estimating the vascular risk.
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http://dx.doi.org/10.1080/09273948.2020.1853783DOI Listing
January 2021

Localized retinal nerve fiber layer defect in patients with COVID-19.

Arq Bras Oftalmol 2020 Nov-Dec;83(6):562-563

Department of Opthalmology, Kırşehir Ahi Evran University School of Medicine, Kırşehir, Turkey.

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http://dx.doi.org/10.5935/0004-2749.20200109DOI Listing
January 2021

Evaluation of choroidal thickness and choroidal vascularity index during pregnancy.

Can J Ophthalmol 2021 Jan 6. Epub 2021 Jan 6.

Kırşehir Ahi Evran University School of Medicine, Department of Gynecology and Obstetrics, Kırşehir, Turkey.

Objective: To assess the choroidal structural characteristics in the first and third trimesters in pregnant women using enhanced depth imaging optical coherence tomography and binarization method.

Design: Prospective study.

Participants: Twenty-five eyes of 25 pregnant women in the first trimester (group 1) and 25 eyes of 25 pregnant women in the third trimester (group 2) were examined. Healthy age-matched 25 participants were enrolled as a control group (group 3).

Methods: The choroidal thickness (CT) was measured at 3 points; subfoveal, 1500 μm nasal to the fovea, and 1500 μm temporal to the fovea. Total choroidal area, luminal area, stromal area, stroma/lumen ratio, and choroidal vascularity index (CVI) were measured by Image-J software.

Results: The mean subfoveal and nasal CT were statistically significantly increased in group 1 compared with controls (p = 0.005 and p = 0.004, respectively). The mean temporal CT was statistically significantly increased in group 1 compared with groups 2 and 3 (group 1 vs group 2, p = 0.043; group 1 vs group 3, p = 0.011). The mean total choroidal area, stromal area, and luminal area were significantly increased in groups 1 and 2 compared with control group (p < 0.001, p < 0.001, p < 0.001, and p < 0.001, p = 0.002, p = 0.002, respectively). There were no statistically significant differences among groups in terms of mean stroma/lumen ratio and CVI (p = 0.148 and p = 0.312, respectively).

Conclusions: There was a significant increase in subfoveal, temporal, and nasal CT in the first trimester. Total choroidal, stromal, and luminal areas were significantly increased in the first and third trimesters.
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http://dx.doi.org/10.1016/j.jcjo.2020.12.002DOI Listing
January 2021