Publications by authors named "Nazanin Rahimi"

3 Publications

  • Page 1 of 1

Acute and subacute toxicities of biogenic tellurium nanorods in mice.

Regul Toxicol Pharmacol 2017 Nov 18;90:222-230. Epub 2017 Sep 18.

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran; Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

The current study was performed to evaluate the acute and subacute toxicities of biogenic tellurium nanorods (Te NRs). The Te NRs were prepared using Pseudomonas pseudoalcaligenes strain Te in a culture medium containing KTeO (1 mM) and their physiochemical properties were investigated using TEM, EDX and XRD. The median lethal dose (LD) of Te NRs and potassium tellurite (KTeO) were determined in mice and the subacute toxicity was also evaluated. The experimental design involved certain general toxicological, haematological, serum and histopathological investigations. The TEM and XRD analyses showed that the biogenic nanoparticles were rod-shaped and hexagonal. The toxicological evaluation showed that the LD values of Te NRs and KTeO were 60 and 12.5 mg/kg, respectively. Higher doses of Te NRs (6 mg/kg) and KTeO (1.25 mg/kg) were accompanied by signs of toxicity, including lower body weight, elevation in MDA and depletion in GSH content, SOD and CAT activity, and changes in biochemistry parameters. No obvious histopathological changes were observed in the treatment with Te NRs. In conclusion, the biogenic Te NRs were less toxic as compared to KTeO, and the no-observed-adverse-effect level (NOAEL) dose of Te NRs in 14 days subacute toxicity study was lower than 1.2 mg/kg.
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November 2017

A novel PCBD gene mutation in an Iranian patient with hyperphenylalaninemia.

Clin Lab 2013 ;59(7-8):925-8

Medical Genetics Lab. of Dr. Zeinali, Kawsar's Human Genetic Research Center, Tehran, Iran.

Background: Neonatal screening for PKU is carried out nationally and our center is one of the referral centers for molecular analysis of PKU in Iran. Hyperphenylalaninemias are common disorders of phenyalanine catabolism. Six genes, including PAH, PTPS, DHPR, GTPCH, SR, and PCBD, independently play a role in this disorder.

Methods: A 2-year-old boy was referred to our center for genetic diagnosis of PKU. PAH gene was sequenced but no mutation was found. Using the STR based linkage mapping approach, BH4-metabolizing genes were screened.

Result: A pattern of autozygosity by descent (ABD) suggested that the PCBD gene may be involved in this family. The PCBD gene was sequenced and a homozygous T > C substitution (X105Q) was found in the termination codon.

Conclusions: Although most of the reported mutations in PCBD gene are single substitutions or premature stop codons causing a benign or transient form of BH4 deficiency, this novel mutation was found in the stop codon.
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November 2013

Electrochemical hydrogen evolution of multi-walled carbon nanotube/micro-hybrid composite decorated with Ni nanoparticles as catalyst through electroless deposition process.

Mater Sci Eng C Mater Biol Appl 2013 Aug 1;33(6):3173-9. Epub 2013 Apr 1.

Nano Chemical Engineering, Department, Shiraz University, Shiraz, Iran.

Hydrogen evolution of multi-walled nanotube (MWCNT)/micro-hybrid polymer composite, decorated with Ni nanoparticles through electroless deposition process is studied by the electrochemical method. Cyclic voltammetry (CV) is utilized to clearly study the electrochemical hydrogen storage/evolution behavior of the composite through a potential window ranging from -1.60 to +0.60 V (vs. Ag/AgCl). Hydrogen adsorption/desorption peaks are positioned at -1.52 and -0.05 V, respectively. Chronoamperometry is also applied to estimate active surface area (0.145 m(2)g(-1)) of the composite as well as the diffusion coefficient (3.4×10(-11) m(2) s(-1)) of adsorbed hydrogen process. According to the chrono-charge/discharge technique, the capacity of fabricated Ni-MWCNT/micro-hybrid composite is estimated to be 2.98 wt.% during charging for a certain time (40 min).
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August 2013