Navin Rao

Navin Rao

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Navin Rao

Navin Rao

Publications by authors named "Navin Rao"

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24Publications

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Accelerating Lead Identification by High Throughput Virtual Screening: Prospective Case Studies from the Pharmaceutical Industry.

J Chem Inf Model 2019 May 13;59(5):2046-2062. Epub 2019 Mar 13.

Discovery Sciences , Janssen Research and Development , Welsh and McKean Roads , Spring House , Pennsylvania 19477 , United States.

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http://dx.doi.org/10.1021/acs.jcim.8b00941DOI Listing
May 2019

IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity.

J Allergy Clin Immunol 2019 Apr 12;143(4):1355-1370.e16. Epub 2018 Oct 12.

Department of Experimental Immunology, Amsterdam University Medical Centers/University of Amsterdam, Amsterdam, The Netherlands; Department of Respiratory Medicine, Amsterdam University Medical Centers/University of Amsterdam, Amsterdam, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183143
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http://dx.doi.org/10.1016/j.jaci.2018.08.051DOI Listing
April 2019

Phenotypic Approaches to Identify Inhibitors of B Cell Activation.

J Biomol Screen 2015 Aug 6;20(7):876-86. Epub 2015 May 6.

Discovery Sciences, Janssen Research and Development LLC, La Jolla, CA, USA.

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http://dx.doi.org/10.1177/1087057115585724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512518PMC
August 2015

Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: a model of relevance to asthma.

Clin Sci (Lond) 2013 Dec;125(11):533-42

Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1042/CS20130092DOI Listing
December 2013

Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness.

Am J Respir Crit Care Med 2010 May 28;181(9):899-907. Epub 2010 Jan 28.

Immunology, Johnson & Johnson PRD, 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1164/rccm.200807-1158OCDOI Listing
May 2010

IRAK1: a critical signaling mediator of innate immunity.

Cell Signal 2008 Feb 23;20(2):269-76. Epub 2007 Aug 23.

Immunology, Johnson & Johnson Pharmaceutical Research and Development, L.L.C., San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.cellsig.2007.08.009DOI Listing
February 2008

TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders.

Inflamm Allergy Drug Targets 2007 Dec;6(4):223-35

Department of Immunology, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.2174/187152807783334300DOI Listing
December 2007

Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.

J Pharmacol Exp Ther 2007 Jun 19;321(3):1154-60. Epub 2007 Mar 19.

Johnson and Johnson Pharmaceutical Research and Development LLC, 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1124/jpet.106.115436DOI Listing
June 2007

A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.

Mol Cell Biol 2005 Aug;25(15):6521-32

Johnson and Johnson Pharmaceutical Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1128/MCB.25.15.6521-6532.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190355PMC
August 2005

Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase.

J Biol Chem 2004 Aug 18;279(34):36132-41. Epub 2004 Jun 18.

Division of Molecular Oncology, Department of Medicine Evanston Northwestern Healthcare Research Institute, Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois 60201, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M404189200
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http://dx.doi.org/10.1074/jbc.M404189200DOI Listing
August 2004

Cbl-mediated ubiquitinylation and negative regulation of Vav.

J Biol Chem 2003 Oct 24;278(40):38495-504. Epub 2003 Jul 24.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M305656200DOI Listing
October 2003

ErbB2 degradation mediated by the co-chaperone protein CHIP.

J Biol Chem 2003 Apr 6;278(16):13829-37. Epub 2003 Feb 6.

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M209640200DOI Listing
April 2003

An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn.

Signal Transduct 2002 Nov;2(1-2):29-39

Brigham and Women's Hospital, Harvard Medical School, Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Boston, MA 02115, USA.

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http://dx.doi.org/10.1002/1615-4061(200205)2:1/2<29::AID-SITA29>3.0.CO;2-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788922PMC
November 2002

The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system.

J Leukoc Biol 2002 May;71(5):753-63

Division of Medical Sciences, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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May 2002

Negative regulation of Lck by Cbl ubiquitin ligase.

Proc Natl Acad Sci U S A 2002 Mar;99(6):3794-9

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.062055999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122603PMC
March 2002