Publications by authors named "Navid Kalani"

16 Publications

  • Page 1 of 1

Gender Differences in COVID-19 Deceased Cases in Jahrom City, South of Iran.

Bull Emerg Trauma 2021 Apr;9(2):80-85

Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.

Objective: To evaluate the clinical and epidemiological features of deceased patients and comparing the discrepancies between male and female patients based on high prevalence of coronavirus disease 2019 (COVID-19), its irreversible effects and the rising ‎mortality rate in Jahrom city.

Methods: This is a descriptive-analytical retrospective study that was conducted from the beginning of March 2020 to the end of November 2020. The study population were included all patients with COVID-19 who admitted to Peymaniyeh Hospital in Jahrom and died of COVID-19. Clinical and demographic data were collected from medical records and analyzed by SPSS software.

Results: In this study, 61 patients (57.54%) were men and 45 patients (42.36%) were women. The mean age was 68.7±18.33 in men and 68.82±14.24 in women. The mean hospitalization length was 9.69±7.75 days in men and 9.69±7.75 days in women patients. There was no statistically significant difference between men and women patients (>0.05). The results showed that 17 (27.87%) men and 28 (45.9%) of women patients had hypertension and the prevalence of this disease was significantly higher in women than men (=0.01). In this study, 7 (11.48%) men and 13 (21.31%) women had hyperlipidemia. The frequency of hyperlipidemia in women cases was significantly higher than in men patients (=0.024). Men cases' diastolic blood pressure (mean=77.53) was significantly higher than women's diastolic blood pressure at the same time with a mean of 71.42 (<0.05).

Conclusion: The findings of the study represented the mortality rate in men which is higher than women patients. The prevalence of underlying diseases such as hypertension and hyperlipidemia were higher in women than men. Despite higher mortality among women, symptoms such as fever and dyspnea were less common in women than men.
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http://dx.doi.org/10.30476/BEAT.2021.89206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195831PMC
April 2021

COVID-19 as a worldwide selective event and bitter taste receptor polymorphisms: An ecological correlational study.

Int J Biol Macromol 2021 Apr 11;177:204-210. Epub 2021 Feb 11.

Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran. Electronic address:

Background: Given the observed olfactory and gustatory dysfunctions in patients with COVID-19 and recent findings on taste receptors possible important activities in the immune system, we elected to estimate the correlation between COVID-19 mortality and polymorphism of a particular type of bitter taste receptor gene called TAS2R38, in a worldwide epidemiological point of view.

Methods: Pooled rate of each of the rs713598, rs1726866, rs10246939, and PAV/AVI polymorphisms of the TAS2R38 gene was obtained in different countries using a systematic review methodology and its relationship with the mortality of COVID-19. Data were analyzed by the comprehensive meta-analysis software and SPSS.

Results: There was only a significant reverse Pearson correlation in death counts and PAV/AVI ratio, p = 0.047, r = -0.503. Also, a significant reverse correlation of PAV/AVI ratio and death rate was seen, r = -0.572 p = 0.021. rs10246939 ratio had a significant positive correlation with death rate, r = 0.851 p = 0.031. Further analysis was not significant. Our results showed that the higher presence of PAV allele than AVI, and a higher rate of G allele than A in rs10246939 polymorphism in a country, could be associated with lower COVID-19 mortality. While assessing all three polymorphisms showed a huge diversity worldwide.

Conclusion: Due to extraoral activities of bitter taste receptor genes, especially in mucosal immunity, this gene seems to be a good candidate for future studies on COVID-19 pathophysiology. Also, the high worldwide diversity of TAS2R38 genes polymorphism and its possible assassination with mortality raises concerns about the efficiency of vaccine projects in different ethnicities.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.02.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043766PMC
April 2021

Worldwide ACE (I/D) polymorphism may affect COVID-19 recovery rate: an ecological meta-regression.

Endocrine 2020 06 15;68(3):479-484. Epub 2020 Jun 15.

Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.

With the emergence of the Novel Coronavirus (2019-nCoV), researchers worldwide have started detecting the probable pathogenesis of the disease. The renin-angiotensin system (RAS) and angiotensin-converting enzymes have received a good deal of attention as possible pathways involved in 2019-nCoV pathogenesis. As the experiments seeking to find potential medications acting on these pathways are being conducted in the early phases, having an ecological worldview on the relationship between the prevalence of COVID-19 disease and the genetic differences in the genes involved in the RAS system could be valuable for the field. In this regard, we conducted a meta-analysis study of the prevalence of ACE (I/D) genotype in countries most affected by the COVID-19. In the meta-analysis, 48,758 healthy subjects from 30 different countries were evaluated in 116 studies, using the Comprehensive Meta-analysis software. The I/D allele frequency ratio was pooled by a random-effect model. The COVID-19 prevalence data of death and recovery rates were evaluated as the latitudes for the meta-regression analysis. Our results demonstrated that with the increase of the I/D allele frequency ratio, the recovery rate significantly increased (point estimate: 0.48, CI 95%: 0.05-0.91, p = 0.027). However, there was no significant difference in the case of death rate (point estimate: 1.74, CI 95%: 4.5-1.04, p = 0.22). This ecological perspective coupled with many limitations does not provide a direct clinical relevance between the COVID-19 and RAS system, but it shows potential pathophysiological associations. Our results raise concerns about ethnic and genetic differences that could affect the effectiveness of the currently investigated RAS-associated medications in different regions.
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http://dx.doi.org/10.1007/s12020-020-02381-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294766PMC
June 2020

Diagnostic Accuracy of Physical Examination and History Taking in Traumatic Rib Fracture; A Single Center Experience.

Bull Emerg Trauma 2020 Apr;8(2):111-114

Department of Emergency Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

Objective: To evaluate the diagnostic accuracy of history taking and physical examination in the patients with traumatic rib fractures.

Methods: In a cross-sectional study, all patients with multiple traumas who referred to the emergency department were evaluated for the mechanism of injury, chief complaints, vital signs and oxygen saturation. History taking and physical examination were performed according to Barbara Bates reference. Fracture was diagnosed based on chest x-ray results and CT scan, if needed. The results were analyzed by receiver operating characteristic (ROC) curves and area under the curve (AUC) analysis.

Results: Isolated rib fractures of thoracic bones were found in 8 out of 99 subjects with mean age of 33.4±19.43 years. In the sensitivity analysis of history taking and physical exam tests, the highest sensitivity was chest tenderness and deformity with 100% sensitivity for each one and the lowest was for the dyspnea with 28.10%; however, the highest sensitivity was for dyspnea with 62.50% sensitivity; and pulmonary hearing aid and chest deformity were not specific (0%). For heart rate, AUC analysis was significant. Heart rate above 80/min was associated with 87.5% sensitivity and 62.5% specificity for rib fractures.

Conclusion: Proper and physical examination and history taking can help to detect rib fractures with high sensitivity and specificity denoting to the importance of the issue; while, radiographic or surgical approval is required to diagnose rib fractures.
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http://dx.doi.org/10.30476/BEAT.2020.46451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211385PMC
April 2020

The Prevalence of Allergic Rhinitis among Iranian Children: A Systematic Review and Meta-Analysis.

Endocr Metab Immune Disord Drug Targets 2020 ;20(2):189-197

Lung Diseases and Allergy Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Background: The prevalence of allergic rhinitis in the world is 10-15%, and it is currently the most common chronic disease among children. There is no comprehensive statistics about the prevalence of allergic rhinitis among Iranian children, therefore, this systematic review and metaanalysis was conducted to evaluate the prevalence of allergic rhinitis among the Iranian children.

Methods: The present study was conducted based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. The data was collected using key words including allergic rhinitis, prevalence, epidemiology, child OR children, pediatrics and Iran, in international databases including PubMed, Scopus, Web of Science, Cochrane, Embase, and three national databases including Magiran, Iran Medex, and Scientific Information Databank (SID) till December 2018. The STROBE checklist was used for quality assessment. The data were analyzed using STATA software version 12.1.

Results: The prevalence of allergic rhinitis in children and adolescents were 18% (99.7% CI: 10-28% with publication bias of 0.174) and 25% (99.8% CI: 17-33 with publication bias of 0.617) respectively. The prevalence of allergic rhinitis in males was estimated to be 27% (99.4% CI: 17-36) with publication bias of 0.538 and in females was 23% (99.4% CI: 14-31) with publication bias of 0.926.

Conclusion: The prevalence of allergic rhinitis is approximately high among Iranian children and adolescents; thus, educational strategies should be considered to decrease the prevalence of this disease in Iran.
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http://dx.doi.org/10.2174/1871530319666190515100735DOI Listing
November 2020

The Effect of Ondansetron and Dexamethasone on Nausea and Vomiting under Spinal Anesthesia.

World J Plast Surg 2017 Jan;6(1):88-93

Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Background: During abdominal surgery under regional anesthesia, nausea may happen due to several contributing factors. This study compared the effects of ondansetron and dexamethasone on nausea and vomiting under spinal anesthesia.

Methods: One hundred and twenty patients of 15 to 35 years old with ASA class I and II were enrolled. Before administering either ondansetron or dexamethasone, blood pressure and heart rate of the patients were recorded. The patients received 70 mg of 5% lidocaine for spinal anesthesia. Patients who received 6 mg of ondansetron were considered as group A, while group B received 8 mg of dexamethasone. The level of nausea and vomiting, blood pressure, heart rate and respiratory rate of each patient was measured at 1, 5, 10, 15 and 30 minutes after spinal anesthesia and during recovery (every 5 minutes).

Results: There was a significant difference between nausea and vomiting between the two groups after spinal anesthesia within the first and fifth minutes. There was no significant difference between nausea and vomiting between the two groups within 10, 15 and 30 minutes and during recovery at 5, 10, 15 and 30 minutes.

Conclusion: Dexamethasone and ondansetron were shown to equally reduce the incidence of nausea and vomiting under spinal anesthesia and can be recommended as a good choice for prevention of nausea and vomiting during surgeries.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339615PMC
January 2017

Comparison of the Analgesic Effect of Paracetamol and Magnesium Sulfate during Surgeries.

World J Plast Surg 2016 Sep;5(3):280-286

Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: New drugs are increasingly used to induce analgesia during surgeries. This study compared the analgesic effects of paracetamol and magnesium sulfate.

Methods: Sixty patients with American Society of Anesthesiologists (ASA) class I or II patients who were candidates for surgery of the lower limbs were randomly divided into three equal groups who were age and gender matched. Group 1 received paracetamol, and group 2, the magnesium sulfate during surgery and group 3 as the control. Pain intensities were measured and recorded using the Visual Analog Scale before surgery, in the recovery room, and 6, 12, and 18 hours after surgery.

Results: Pain intensities (7.10, 5.80, and 4.10) were higher in the control group; 6, 12, and 18 hours after surgery compared to the paracetamol (6.45, 4.15, 2.50) and the magnesium groups (7.25, 4.55, and 2.05), but the difference was not statistically significant.

Conclusion: Paracetamol and magnesium sulfate were shown to have postoperative analgesic effects and reduce the quantity of narcotic use after surgery.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109390PMC
September 2016

The Preventive Role of Low-Dose Intravenous Ketamine on Postoperative Shivering in Children: A Placebo Randomized Controlled Trial.

Anesth Pain Med 2016 Jun 9;6(3):e32172. Epub 2016 May 9.

Department of Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Postoperative shivering is a major problem in children undergoing general anesthesia.

Objectives: The aim of the present study was to investigate the role of low-dose intravenous ketamine for prevention of shivering after induction of general anesthesia in children who had undergone tonsillectomy.

Patients And Methods: This was a randomized, double-blinded, placebo-controlled trial including 80 children, of American society of anesthesiologists (ASA) physical status I or II, scheduled for tonsillectomy under general anesthesia who were randomly assigned to an intravenous ketamine (0.5 mg/kg, n = 40; group K) group or matched dose placebo (n = 40; group N) group. Surgical and demographic data, unexpected side effects, and the occurrence of shivering for each child were assessed by a blinded observer at the following time points: T0, in the recovery room; T10, at 10 minutes; T20, at 20 minutes; T30, and at 30 minutes.

Results: With regards to the demographic and surgical data, no significant differences between the two study groups were observed (P ≥ 0.05). Shivering intensity in children who had received ketamine was significantly lower than children who had not received ketamine, at T0, T10, T20, and T30 after arrival (P < 0.05). There were no significant differences in hallucination, nausea, vomiting, hemodynamic dysfunction, blurred vision, and seizure in the K group compared with the N group (P ≥ 0.05).

Conclusions: Administration of intravenous ketamine at a dosage of 0.5 mg/kg immediately after anesthesia induction had a preventive effect on shivering intensity without hemodynamic alterations in children undergoing general anesthesia for tonsillectomy.
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http://dx.doi.org/10.5812/aapm.32172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013751PMC
June 2016

Effect of Hydroalcoholic Extract of Rosmarinus officinalis L. Leaf on Anxiety in Mice.

J Evid Based Complementary Altern Med 2016 Oct 6;21(4):NP85-90. Epub 2016 Apr 6.

Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.

In today's stressful world, psychopathy (especially anxiety) is receiving increased importance. Most of the drugs used to treat this disease have several side effects. Medicinal plants derived from natural products have fewer side effects and can be used in the treatment of this disease. The aim of this study was to evaluate the effect of the hydroalcoholic extract of Rosmarinus officinalis L. on anxiety in mice. In this experimental study, 50 male mice were randomly divided into 5 groups. To evaluate anxiety, the Elevated Plus Maze test was performed. The control group received normal saline, the positive control group received diazepam (1 mg/kg) as intraperitoneal injection, and the experimental groups received doses of 100, 200, and 400 mg/kg body weight of rosemary extract. The data were analyzed using SPSS 15 and ANOVA statistical tests. The results show that rosemary extract dose-dependently increases the mice spending time and the entries number of mice in plus maze open arms (indicating less stress). This effect at a dose of 400 mg/kg was similar to diazepam, which, in comparison to the control group, was statistically significant (P < .01), while the evaluation of locomotor activity in treated groups, compared with the control groups, showed no significant difference (P > .05). On the other hand, the rosemary extract, similar to the standard drug diazepam, showed an anti-anxiety effect. This effect is probably due to the presence of flavonoids in this plant and their antioxidant property.
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http://dx.doi.org/10.1177/2156587216642101DOI Listing
October 2016

Effect of Self-Care Education by Face-to-Face Method on the Quality of Life in Hemodialysis Patients (Relying on Ferrans and Powers Questionnaire).

Glob J Health Sci 2015 Oct 20;8(6):121-7. Epub 2015 Oct 20.

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Introdution: One of the most common methods to control chronic renal failure, Hemodialysis creates numerous changes in the style and the quality of life in patients. Educating patients is one of effective factors to improve the quality of life. The present study aims to investigate influences of self-care education by face-to-face method on determining quality of life in hemodialysis patients in Jahrom, Iran, during 2014-2015.

Methods: This is a quasi-experimental, single-blind study in which 50 patients undergoing hemodialysis at Shahaid Mottahari Hospital, Jahrom. The patients were placed in two groups of 25 individuals: the face to face educational group and the control group. The control group received only routine care in hemodialysis unit. The face to face educational group received 8 instruction sessions of 60 minutes before starting dialysis and received an instruction booklet. Data collection tools were a questionnaire consisting of demographic characteristics, a checklist of needs assessment for hemodialysis patients and a quality of life questionnaire, whose reliability and validity were previously approved. The questionnaires were completed face to face, before and after the intervention.

Results: The results show that the research units did not have any significant difference in terms of demographic variables. Also increase in various aspects of the quality of life compared with the control group is observed after the intervention in the face to face educational group (p<0.001).

Discussion & Conclusion: Given the results, representation of adequate training in hemodialysis ward can cause improve in physical function, mental health and thus increase the quality of life in hemodialysis patients, through raising the awareness level.
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http://dx.doi.org/10.5539/gjhs.v8n6p121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954909PMC
October 2015

The Prevalence of Substance use and Associated Risk Factors Among University Students in the City of Jahrom, Southern Iran.

Int J High Risk Behav Addict 2015 Jun 20;4(2):e22381. Epub 2015 Jun 20.

Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.

Background: Substance use among college students in Iran is a serious problem. Determining the pattern of substance use among University students is an important issue for implementing prevention and treatment programs.

Objectives: The present survey attempts to determine the prevalence of substance usage and associated risk factors among the students of Jahrom University of Medical Sciences and Islamic Azad University of Jahrom, Jahrom, Iran.

Patients And Methods: This cross-sectional study was carried out from December 2012 to February 2013 and included 1149 randomly selected students of two Jahrom universities. A standard questionnaire was used for data gathering. Data were analyzed using the SPSS version 15 for Windows. T-test and Chi-square T-test and Chi-square and Logestic regression tests were used for data analysis.

Results: Tobacco (28.3%), alcohol (13.0%), and cannabis and marijuana (5.2%) were the most common substances used by the students. The prevalence of substance use among the male students was significantly higher (OR: 1.5, 95%CI: 1.42 - 2.68, P < 0.001). The risk of at least single episode of substance usage was higher among the students which were living alone (OR: 3.03, 95%CI: 1.74 - 5.28, P < 0.001) The most important motivators for beginning substance use were curiosity, in 46.4%, and seeking pleasure, in 28.8%.

Conclusions: Substance usage is considered as a risk factor for students' health among University students in Iran. Design of educational courses addressing the detrimental effects and dire consequences of substance usage could help to improve control programs. Universities could improve their drug abuse control programs by focusing on the high risk groups determined by relevant studies.
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http://dx.doi.org/10.5812/ijhrba.4(2)2015.22381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464575PMC
June 2015

The role of benznidazole with cyanocobalamin and ascorbic acid in treating the chronic phase of Chagas disease.

Rev Soc Bras Med Trop 2014 Sep-Oct;47(5):669

Department of Gynecology and Obstetrics, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.1590/0037-8682-0089-2014DOI Listing
May 2015

The potential role of intrathecal nefopam in the management of neuropathic pain.

Korean J Pain 2014 Jul 30;27(3):301-2. Epub 2014 Jun 30.

Department of Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.

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http://dx.doi.org/10.3344/kjp.2014.27.3.301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099247PMC
July 2014

Combined use of ascorbic acid and cyanocobalamin in clearance of Trypanosoma cruzi.

Expert Rev Clin Pharmacol 2014 Jul 24;7(4):401-2. Epub 2014 May 24.

Department of Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.

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http://dx.doi.org/10.1586/17512433.2014.922868DOI Listing
July 2014