Publications by authors named "Naveed Hussain"

71 Publications

Facile Synthesis of g-CN/MoO Nanohybrid for Efficient Removal of Aqueous Diclofenac Sodium.

Nanomaterials (Basel) 2021 Jun 14;11(6). Epub 2021 Jun 14.

College of Environment and Planning, Henan University, Kaifeng 475004, China.

Graphitic carbon nitride modified by molybdenum trioxide (g-CNMoO) as a nanohybrid was synthesized by co-precipitation method. Here, g-CN/MoO nanohybrid was used for the first time as an adsorbent for the pharmaceutical drug, diclofenac, (an aqueous micropollutant) from water to mitigate its possible environmental toxic effects. Compared to pristine components, the nanohybrid exhibited better adsorptive removal of diclofenac. Adsorption was enhanced with increment in MoO content from 1 to 3 wt %; however further increment in MoO content resulted in lower adsorption capacity due to agglomeration of MoO particles over g-CN. 162 mg g adsorption capacity was achieved for 300 mg L diclofenac in solution with 1 g L adsorbent at pH = 6. Adsorption of diclofenac over g-CN /MoO followed pseudo 2nd order kinetics. Temkin, Langmuir, Dubinin Radushkevich and Freundlich isotherm models were applied on the experimental results concluding that diclofenac adsorption over g-CN/MoO followed the Langmuir isotherm. The adsorption mechanism could be explained by the π-π interaction between aromatic rings of diclofenac and g-CN/MoO (3%) nanohybrid, which is also evident by the FTIR results. This study presents the facile fabrication of a 2nd generation adsorbent for the treatment of diclofenac contaminated water that may as well help achieve the removal of other micropollutants form water.
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http://dx.doi.org/10.3390/nano11061564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231834PMC
June 2021

Fetal gastric area ratio to predict severe neonatal opioid withdrawal syndrome.

J Matern Fetal Neonatal Med 2021 Jun 20:1-5. Epub 2021 Jun 20.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Connecticut, Farmington, CT, USA.

Objective: Neonatal opioid withdrawal syndrome (NOWS) can occur in newborns exposed to opioids in pregnancy. Opioids delay gastric emptying and inhibit gastric motility in adults, but little is known about their effect in the fetus. We sought to assess gastric area ratio (GAR) in opioid-exposed fetuses.

Study Design: Retrospective cohort study including opioid-exposed maternal-neonatal dyads between 2007-2017. Primary outcome: severe NOWS (three consecutive Finnegan scores ≥8 or three scores totaling ≥24 within 96 h of life). GAR: (gastric area)/(transverse abdominal area) × 100. Data analysis was by descriptive, parametric, and non-parametric tests.

Results: Forty-nine maternal-neonatal dyads were included, 67% ( = 33) with severe NOWS. GAR <95th percentile for gestational age was seen in 80% of neonates ( = 39). However, GAR was not different between groups ( = .90) and did not predict severe NOWS.

Conclusion: Fetal GAR was <95th percentile in 80% of opioid-exposed neonates. However, fetal GAR may not predict NOWS treatment.
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http://dx.doi.org/10.1080/14767058.2021.1939302DOI Listing
June 2021

Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome.

J Obstet Gynecol Neonatal Nurs 2021 Sep 8;50(5):539-548. Epub 2021 Jun 8.

Objective: To critically review and summarize current knowledge regarding the assessment of newborns with neonatal abstinence syndrome (NAS).

Data Sources: We searched the following databases for articles on the assessment of newborns with NAS that were published in English between January 2014 and June 2020: PubMed, CINAHL, and PsycINFO. Keywords and Medical Subject Heading terms used to identify relevant research articles included neonatal abstinence syndrome; Finnegan Scale; eat, sleep, console; epigenetics; genetics; pharmacokinetics; and measurement. We independently reviewed articles for inclusion.

Study Selection: We retrieved 435 articles through database searches and 17 through manual reference searches; 31 articles are included in the final review. Excluded articles were duplicates, not relevant to NAS, qualitative studies, and/or of low quality.

Data Extraction: We used the methodology of Whittemore and Knafl to guide this integrative review. We extracted and organized data under the following headings: author, year and country, purpose, study design, participants, measurement, biomarker (if applicable), results, limitations, recommendations, and intervention.

Data Synthesis: The Finnegan Neonatal Abstinence Scale is the most widely used instrument to measure symptoms of NAS in newborns, although it is very subjective. Recently, there has been a transition from the Finnegan Neonatal Abstinence Scale to the eat, sleep, console method, which consists of structured assessment and intervention and has been shown to decrease length of hospital stay and total opioid treatment dose. Researchers examined biomarkers of NAS, including genetic markers and autonomic nervous system responses, on the variation in incidence and differential severity of NAS. In the included articles, women with opioid use disorder who were treated with naltrexone during pregnancy gave birth to newborns without NAS diagnoses. However, most women who were treated with buprenorphine gave birth to newborns with NAS diagnoses.

Conclusion: NAS negatively affects newborns in a multitude of ways, and the objective assessment and measurement of the newborn's response to withdrawal remains understudied and needs further investigation.
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http://dx.doi.org/10.1016/j.jogn.2021.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429083PMC
September 2021

Spammer group detection and diversification of customers' reviews.

PeerJ Comput Sci 2021 9;7:e472. Epub 2021 Apr 9.

Department of Electrical Engineering, COMSATS University Islamabad, Islamabad, Pakistan.

Online reviews regarding different products or services have become the main source to determine public opinions. Consequently, manufacturers and sellers are extremely concerned with customer reviews as these have a direct impact on their businesses. Unfortunately, to gain profit or fame, spam reviews are written to promote or demote targeted products or services. This practice is known as review spamming. In recent years, Spam Review Detection problem (SRD) has gained much attention from researchers, but still there is a need to identify review spammers who often work collaboratively to promote or demote targeted products. It can severely harm the review system. This work presents the Spammer Group Detection (SGD) method which identifies suspicious spammer groups based on the similarity of all reviewer's activities considering their review time and review ratings. After removing these identified spammer groups and spam reviews, the resulting non-spam reviews are displayed using diversification technique. For the diversification, this study proposed Diversified Set of Reviews (DSR) method which selects diversified set of top-k reviews having positive, negative, and neutral reviews/feedback covering all possible product features. Experimental evaluations are conducted on Roman Urdu and English real-world review datasets. The results show that the proposed methods outperformed the existing approaches when compared in terms of accuracy.
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http://dx.doi.org/10.7717/peerj-cs.472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049124PMC
April 2021

Comments: Pendleton's model for improving outcomes through eye donation counseling.

Indian J Ophthalmol 2021 04;69(4):1019-1020

5th Year Medical Student, Clinical Medical Students, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.4103/ijo.IJO_3184_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012926PMC
April 2021

Temporal and seasonal variations in incidence of stage II and III NEC-a 28-year epidemiologic study from tertiary NICUs in Connecticut, USA.

J Perinatol 2021 May 15;41(5):1100-1109. Epub 2021 Feb 15.

Division of Neonatology, Department of Pediatrics, Connecticut Children's Medical Center and University of Connecticut School of Medicine, Farmington, CT, USA.

Objective: To investigate seasonality and temporal trends in the incidence of NEC.

Study Design: A retrospective cohort study from two tertiary NICUs in northern and central Connecticut involving 16,761 infants admitted over a 28-year period. Various perinatal and neonatal risk factors were evaluated by univariate, multivariate, and spectral density analyses.

Results: Incidence of NEC was unchanged over the 28 years of study. Gestational age, birth weight, and birth-months (birth in April/May) were independently associated with stage II or III NEC even after adjusting for confounding factors (p < 0.05). Yearly NEC incidence showed a multi-modal distribution with spectral density spikes approximately every 10 years.

Conclusion(s): Temporal and seasonal factors may play a role in NEC with a peak incidence in infants born in April/May and periodicity spikes approximately every 10 years. These trends suggest non-random and possibly environmental factors influencing NEC.
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http://dx.doi.org/10.1038/s41372-021-00961-7DOI Listing
May 2021

A facile synthesis of bismuth oxychloride-graphene oxide composite for visible light photocatalysis of aqueous diclofenac sodium.

Sci Rep 2020 08 25;10(1):14191. Epub 2020 Aug 25.

Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions, College of Environment and Planning, Henan University, Kaifeng, 475004, China.

In this study, bismuth oxychloride/graphene oxide (BiOCl-GO) composite was fabricated by facile one pot hydrothermal method. The pure BiOCl and BiOCl-GO composite was characterized by X-ray diffraction, Transmission electron microscopy X-ray photoelectron spectroscopy and UV-Vis diffuse reflectance spectroscopy. The synthesized composite was then assessed for photocatalytic degradation of diclofenac sodium (DCF) in visible as well as direct solar light and UV irradiation. Results indicated that the photocatalytic removal efficiency of DCF was significantly affected by dose of catalysts, pH value and source of light. The results reveled that degradation efficiency of BiOCl-GO for DCF reduced from 100 to 34.4% with the increases in DCF initial concentration from 5 mg L to 25 mg L. The solar light degradation of DCF using BiOCl-GO was achieved with apparent rate constant 0.0037 min. The effect of scavengers study revealed that superoxide ions and holes were mainly responsible for DCF degradation. The regeneration study indicates that BiOCl-GO composite can be successfully recycled up to the five cycles. The study revealed the effectiveness of one pot hydrothermal method for the fabrication of BiOCl-GO composite.
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http://dx.doi.org/10.1038/s41598-020-71139-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447784PMC
August 2020

The Effect of Circumcision on Exclusive Breastfeeding, Phototherapy, and Hospital Length of Stay in Term Breastfed Newborns.

Hosp Pediatr 2020 06;10(6):516-522

Connecticut Children's Medical Center, Hartford, Connecticut.

Background And Objectives: Little is known about the effect of circumcision on breastfeeding in the hours and days after the procedure. Factors with the potential to negatively impact breastfeeding success in the newborn period may result in higher rates of jaundice requiring phototherapy and formula supplementation, both of which can potentially extend the length of initial hospitalization. Our objective was to determine the impact of circumcision on rates of exclusive breastfeeding, neonatal jaundice requiring phototherapy, and length of stay at hospital discharge immediately after birth.

Methods: Term male newborn infants whose mothers intended to exclusively breastfeed were included in this retrospective cohort. Bivariate analysis and multivariate logistic regression modeling were used to evaluate target behaviors, comparing infant boys who were circumcised with those who were uncircumcised.

Results: Of the 1109 breastfed male newborns included, 846 (76.6%) were circumcised. There was no significant effect of circumcision status or circumcision timing on the rate of in-hospital formula supplementation. There were no differences in peak bilirubin levels, phototherapy requirement, or length of hospital stay for male newborns based on circumcision status.

Conclusions: Circumcision did not affect the rate of exclusive breastfeeding, neonatal jaundice, phototherapy requirement, or length of hospital stay in this retrospective analysis of breastfed male newborns.
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http://dx.doi.org/10.1542/hpeds.2019-0270DOI Listing
June 2020

Calorie intake is associated with weight gain during transition phase of nutrition in female extremely low birth weight infants.

Biol Sex Differ 2020 04 15;11(1):16. Epub 2020 Apr 15.

Connecticut Children's Medical Center, Hartford, CT, USA.

We sought to determine whether there are sex-based differences in the requirements for calories or protein for optimal growth during the transition phase (TP) when an extremely low birth weight (ELBW) infant, defined as a preterm infant with a birth weight of < 1000 g, is progressing from parenteral to enteral feeds. A retrospective review of ELBW infants born from 2014 to 2016 was performed at a tertiary NICU. Infants with necrotizing enterocolitis, short bowel syndrome, or chromosomal anomalies were excluded. TP was defined as the period when the infant's enteral feeds were increased from 30 up to 120 ml/kg/day while weaning parenteral nutrition (PN). Effects of sex and protein-calorie intake on the change in growth parameters from the beginning to the end of TP were analyzed. Pre-TP growth percentiles and calorie and protein intake were similar in both sexes. There was a significant (r = 0.22, p = 0.026) correlation of total calorie intake with a change in weight percentiles (wt.pc) for the whole group, but on sex-specific analysis, this correlation was more robust and significant only in girls (r = 0.28, p = 0.015). Protein intake did not correlate with the changes in wt.pc in either sex. Despite a similar intake of calories and protein during the TP, we found a significant decrease in wt.pc only in girls. More extensive studies are needed to understand the sex-based differences in caloric needs and metabolic rate in ELBW infants.
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http://dx.doi.org/10.1186/s13293-020-00295-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160909PMC
April 2020

Generation and characterization of dipeptidyl peptidase-IV inhibitory peptides from trypsin-hydrolyzed α-lactalbumin-rich whey proteins.

Food Chem 2020 Jul 1;318:126333. Epub 2020 Feb 1.

Institute of Food Science and Technology, Chinese Academy of Agricultural Science, Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, No. 2 Yuan Ming Yuan West Road, Haidian District, P.O. Box 5109, Beijing 100193, PR China. Electronic address:

Dipeptidyl peptidase-IV (DPP-IV) is an enzyme that break down the antidiabetic hormone glucagon-like peptide-1. Therefore, inhibition of DPP-IV could be an effective strategy to treat Type 2 diabetes (T2D). The α-lactalbumin-rich whey protein concentrate was hydrolyzed by trypsin, and the hydrolysates were then fractionated at a semi-preparative scale using a Superdex Gel filtration Chromatography. The peptides were analyzed by using HPLC coupled with tandem mass spectrometry (RP-HPLC-MS/MS), and their Dipeptidyl peptidase-IV inhibitory activity was determined by the enzymatic assay. Among tested fragments, a potent fragment (LDQWLCEKL), with the half-maximal inhibitory concentration (IC) of 131 μM was obtained. Further analysis shows that the LDQWLCEKL peptide corresponds to the amino acid sequence of f(115-123) in α-lactalbumin. Furthermore, LDQWLCEKL exhibited a typical non-competitive mode of inhibition. The results indicate that α-lactalbumin contains active peptides with DPP-IV inhibitory activity that may be used to prevent and treat T2D.
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http://dx.doi.org/10.1016/j.foodchem.2020.126333DOI Listing
July 2020

Ultrathin Pd-based nanosheets: syntheses, properties and applications.

Nanoscale 2020 Feb 6;12(7):4219-4237. Epub 2020 Feb 6.

Department of Chemistry, Division of Science & Technology, University of Education, Lahore, Pakistan.

Two-dimensional (2D) noble metal-based nanosheets (NSs) have received considerable interest in recent years due to their unique properties and widespread applications. Pd-based NSs, as a typical member of 2D noble metal-based NSs, have been most extensively studied. In this review, we first summarize the research progress on the synthesis of Pd-based NSs, including pure Pd NSs, Pd-based alloy NSs, Pd-based core-shell NSs and Pd-based hybrid NSs. The synthetic strategy and growth mechanism are systematically discussed. Then their properties and applications in catalysis, biotherapy, gas sensing and so on are introduced in detail. Finally, the challenges and opportunities towards the rational design and controlled synthesis of Pd-based NSs are proposed.
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http://dx.doi.org/10.1039/c9nr09557hDOI Listing
February 2020

Replacement reaction-assisted synthesis of silver nanoparticles by jet for conductive ink.

Nanotechnology 2020 Mar 2;31(11):115301. Epub 2019 Dec 2.

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, People's Republic of China.

Synthesis of silver (Ag) nanoparticles with controllable morphology and with high purity remains challenging. In this work, single crystalline Ag nanoparticles with uniform morphology and high purity are successfully synthesized based on the replacement reaction between aqueous Ag nitrate (AgNO) and solid copper (Cu) via jet. We further demonstrate that the developed jet method is facile and morphology-controllable. It is believed that diffusion limited aggregation and oriented attachment mechanisms are responsible for the formation of Ag nanostructures. The synthesized nanoparticles were characterized by different techniques. Finally, the Ag nanoparticles are successfully applied to prepare the conductive ink for flexible electronics and wearable equipment. Furthermore, the conductivity, flexibility and stability of the conductive material are measured. The conductive pattern exhibits lowest resistivity of 6.7 μΩ cm, showing the good conductivity of the prepared conductive material. In addition, the prepared conductive material is flexible in nature and exhibits stability over a long period.
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http://dx.doi.org/10.1088/1361-6528/ab5dfdDOI Listing
March 2020

Facile and High-Yield Replacement Reaction-Assisted Synthesis of Silver Dendrites by Jet for Conductive Ink.

Langmuir 2019 Sep 12;35(38):12400-12406. Epub 2019 Sep 12.

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering , Tsinghua University , Beijing 100084 , China.

Metallic dendrites with uniform morphology, high purity, and large yield remain challenging to synthesize. In this work, single-crystalline silver (Ag) dendrites with uniform morphology, high purity, and large yield are successfully synthesized by employing single replacement reaction between aqueous silver nitrate (AgNO) and solid copper (Cu) by jet. The combined effect of diffusion-limited aggregation and the locally oriented attachment of Ag particles is responsible for the formation of silver dendrites under nonequilibrium conditions. Finally, the potential applications of as-synthesized silver dendrites are demonstrated by successfully preparing silver-based conductive ink for flexible electronics and wearable equipment. The conductive pattern exhibits resistivity of 7.2 μΩ·cm, showing good conductivity of the prepared conductive material. This facile and time-efficient synthetic route can be extended to synthesize other noble metal nanostructures with desired morphologies by adopting selective precursor salt concentrations and substrate metals with proper redox potentials.
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http://dx.doi.org/10.1021/acs.langmuir.9b01860DOI Listing
September 2019

Noble Metal Based Alloy Nanoframes: Syntheses and Applications in Fuel Cells.

Front Chem 2019 3;7:456. Epub 2019 Jul 3.

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, China.

Noble metal nanostructures are being used broadly as catalysts for energy conversion in fuel cells. To overcome the future energy crises, fuel cells are anticipated as clean energy sources because they can be operated at low temperature, their energy conversion is high and their carbon release is almost zero. However, an active and stable electrocatalyst is essential for the electrochemical reactions in fuel cells. Therefore, properties of the nanostructures greatly depend on the shape of the nanostructures. Individual as well as interaction properties are greatly affected by changes in the surface area of the nanostructures. By shape controlled synthesis, properties of the nanostructures could be further enhanced by increasing the surface area or active sites for electrocatalysts. Therefore, an efficient approach is needed for the fabrication of nanostructures to increase their efficiency, activity, or durability in fuel cells by reducing the usage of noble metals. Different types of hollow nanostructures until now have been prepared including nanoboxes, nanocages, nanoshells, nanoframes (NFs), etc. NFs are the hollow unique three-dimensional structure which have no walls-they only contain corners or edges so they have large surface area. In electrocatalytic reactions, the molecules involved in the reaction can easily reach the inner surface of the nanoframes, thus noble metals' utilization efficiency increases. NFs usually have high surface area, greater morphological and compositional stabilities, allowing them to withstand harsh environmental conditions. By considering the current challenges in fabrication of noble metal based alloy NFs as electrocatalysts, this review paper will highlight recent progress, design, and fabrication of noble metal alloy NFs through different strategies-mainly photocatalytic template, electrodeposition, Kirkendall effect, galvanic replacement, chemical/oxidative etching, combination of both and other methods. Then, electrochemical applications of NFs in fuel cells toward formic acid, methanol, ethanol, oxygen reduction reaction as well as bifunctional catalyst will also be highlighted. Finally, we will summarize different challenges in the fabrication of highly proficient nanocatalysts for the fuel cells with low cost, high efficiency and high durability, which are the major issues for the highly commercial use of fuel cells in the future.
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http://dx.doi.org/10.3389/fchem.2019.00456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616278PMC
July 2019

Facile synthesis of g-CN/CeO/FeO nanosheets for DFT supported visible photocatalysis of 2-Chlorophenol.

Sci Rep 2019 07 15;9(1):10202. Epub 2019 Jul 15.

Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions, College of Environment and Planning, Henan University, Keifeng, 475004, China.

Visible light active g-CN/CeO/FeO ternary composite nanosheets were fabricated by facile co-precipitation routes. The density functional theory (DFT) computations investigated changes in geometry and electronic character of g-CN with CeO and FeO addition. Chemical and surface characterizations were explored with XRD, XPS, SEM, TEM, PL, DRS and Raman measurements. DRS and PL spectroscopy evidenced the energy band gap tailoring from 2.68 eV for bulk g-CN and 2.92 eV for CeO to 2.45 eV for the ternary nanocomposite. Efficient electron/hole pair separation, increase in red-ox species and high exploitation of solar spectrum due to band gap tailoring lead to higher degradation efficiency of g-CN/CeO/FeO. Superior sun light photocatalytic breakdown of 2-Chlorophenol was observed with g-CN having CeO loading up to 5 wt%. In case of ternary nanocomposites deposition of 1 wt% FeO over g-CN/CeO binary composite not only showed increment in visible light catalysis as predicted by the DFT studies, but also facilitated magnetic recovery. The g-CN/CeO/FeO nanosheets showed complete mineralization of 25 mg.L 2-CP within 180 min exposure to visible portion of sun light and retained its high activity for 3 consecutive reuse cycles. The free radical scavenging showed superoxide ions and holes played a significant role compared to hydroxyl free radicals while chromatographic studies helped establish the 2-CP degradation mechanism. The kinetics investigations revealed 2.55 and 4.04 times increased rate of reactions compared to pristine FeO and CeO, showing highest rate constant value of 18.2 × 10 min for the ternary nanocomposite. We present very persuasive results that can be beneficial for exploration of further potential of g-CN/CeO/FeO in advance wastewater treatment systems.
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http://dx.doi.org/10.1038/s41598-019-46544-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629633PMC
July 2019

Ice as Solid Electrolyte To Conduct Various Kinds of Ions.

Angew Chem Int Ed Engl 2019 Sep 2;58(36):12569-12573. Epub 2019 Aug 2.

State Key Lab of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.

Water, considered as a universal solvent to dissolve salts, has been extensively studied as liquid electrolyte in electrochemical devices. The water/ice phase transition at around 0 °C presents a common phenomenon in nature, however, the chemical and electrochemical behaviors of ice have rarely been studied. Herein, we discovered that the ice phase provides efficient ionic transport channels and therefore can be applied as generalized solid-state ionic conductor. Solid state ionic conducting ices (ICIs) of Li , Na , Mg , Al , K , Mn , Fe , Co , Ni , Cu , and Zn , frozen from corresponding sulphate solutions, exhibit ionic conductivities ranging from ≈10  S cm (Zn ) to ≈10  S cm (Li ) at temperatures spanning from -20 °C to -5 °C. The discovery of ICIs opens new insight to design and fabrication of solid-state electrolytes that are simple, inexpensive, and versatile.
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http://dx.doi.org/10.1002/anie.201907832DOI Listing
September 2019

One-Pot Synthesis of Heterobimetallic Metal-Organic Frameworks (MOFs) for Multifunctional Catalysis.

Chemistry 2019 Aug 8;25(44):10490-10498. Epub 2019 Jul 8.

Department of Chemistry and Chemical Engineering, Lahore University of Management Sciences (LUMS), Lahore, 54792, Pakistan.

A one-pot synthesis of bimetallic metal-organic frameworks (Co/Fe-MOFs) was achieved by treating stoichiometric amounts of Fe and Co salts with 2-aminoterephthalic acid (NH -BDC). Monometallic Fe (catalyst A) and Co (catalyst F) were also prepared along with mixed-metal Fe/Co catalysts (B-E) by changing the Fe/Co ratio. For mixed-metal catalysts (B-E) SEM energy-dispersive X-ray (EDX) analysis confirmed the incorporation of both Fe and Co in the catalysts. However, a spindle-shaped morphology, typically known for the Fe-MIL-88B structure and confirmed by PXRD analysis, was only observed for catalysts A-D. To test the catalytic potential of mixed-metal MOFs, reduction of nitroarenes was selected as a benchmark reaction. Incorporation of Co enhanced the activity of the catalysts compared with the parent NH -BDC-Fe catalyst. These MOFs were also tested as electrocatalysts for the oxygen evolution reaction (OER) and the best activity was exhibited by mixed-metal Fe/Co-MOF (Fe/Co batch ratio=1). The catalyst provided a current density of 10 mA cm at 410 mV overpotential, which is comparable to the benchmark OER catalyst (i.e., RuO ). Moreover, it showed long-term stability in 1 m KOH. In a third catalytic test, dehydrogenation of sodium borohydride showed high activity (turnover frequency=87 min ) and hydrogen generation rate (67 L min  g catalyst). This is the first example of the synthesis of bimetallic MOFs as multifunctional catalysts particularly for catalytic reduction of nitroarenes and dehydrogenation reactions.
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http://dx.doi.org/10.1002/chem.201901939DOI Listing
August 2019

Placental aromatase expression decreased in severe neonatal opioid withdrawal syndrome.

J Matern Fetal Neonatal Med 2021 Mar 15;34(5):670-676. Epub 2019 May 15.

Department of Obstetrics and Gynecology, University of Connecticut, Farmington, CT, USA.

Severe neonatal opioid withdrawal syndrome (NOWS) cannot be predicted. Placental aromatase metabolizes both methadone and buprenorphine and may contribute to the severity of NOWS. To determine whether placental aromatase mRNA expression differs in methadone- or buprenorphine-exposed placentas and is associated with NOWS severity. Prospective multicenter observational cohort study from July 2016 to December 2017. Inclusion: pregnant, ≥18 years old, singleton fetus, nonanomalous, ≥34 weeks at delivery, documented methadone or buprenorphine use. Exclusion: declined sample collection. Severe NOWS is defined as three consecutive Finnegan scores ≥8 or sum of three consecutive scores ≥24 within 72 hours of birth. Finnegan scoring was correlated with placental mRNA expression and compared to umbilical cord drug and metabolite levels. Data were analyzed using descriptive, parametric, and nonparametric statistics and regression analysis. -Value <.05 was considered significant. Thirty-eight out of 45 (84%) patients were included. Methadone and buprenorphine were used by 29/38 (76%) and 9/38 (24%) of patients, respectively. 19/38 (50%) infants had severe NOWS. Placental aromatase/actin mRNA expression was significantly lower in the placentas of infants with severe NOWS ( = .04). Mean umbilical cord 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP)/methadone ratios were significantly higher in infants with severe NOWS ( = .03). Placental aromatase mRNA expression was weakly to moderately correlated with umbilical cord methadone, buprenorphine, and their metabolite concentrations ( = 0.4-0.8). Placental aromatase mRNA expression was lower and umbilical cord EDDP/methadone ratios were higher in infants with severe NOWS. Additional investigation of placental aromatase in methadone- and buprenorphine-exposed pregnancies is needed.
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http://dx.doi.org/10.1080/14767058.2019.1612870DOI Listing
March 2021

Large Piezoelectric Strain in Sub-10 Nanometer Two-Dimensional Polyvinylidene Fluoride Nanoflakes.

ACS Nano 2019 Apr 25;13(4):4496-4506. Epub 2019 Mar 25.

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering , Tsinghua University , Beijing 100084 , China.

Functional polymers such as polyvinylidene fluoride (PVDF) and its copolymers, which exhibit room-temperature piezoelectricity and ferroelectricity in two-dimensional (2D) limit, are promising candidates to substitute hazardous lead-based piezoceramics for flexible nanoelectronic and electromechanical energy-harvesting applications. However, realization of many polymers including PVDF in ultrathin 2D nanostructures with desired crystal phases and tunable properties remains challenging due to ineffective conventional synthesis methods. Consequently, it has remained elusive to obtain optimized piezoelectric performance of PVDF particularly in sub-10 nm regimes. Taking advantage of its high flexibility and easy processing, we fabricate ultrathin PVDF nanoflakes with thicknesses down to 7 nm by using a hot-pressing method. This thermo-mechanical strategy simultaneously induces robust thermodynamic α to electroactive β-phase transformation, with β fraction as high as 92.8% in sub-10 nm flakes. Subsequently, piezoelectric studies performed by using piezoresponse force microscopy reveal an excellent piezoelectric strain of 0.7% in 7 nm film and the highest piezoelectric coefficient ( d) achieved is -68 pm/V for 50 nm-thick nanoflakes, which is 13% higher than the piezoresponse from 50 nm-thick PZT nanofilms. Our results further suggest thickness modulation as an effective strategy to tune the piezoelectric performance of PVDF and affirm its supremacy over conventional piezoceramics especially at nanoscale. This work aims not only to help understand fundamental piezoelectricity of pure PVDF in sub-10 nm regimes but also provides an opportunity to realize other polymer-based 2D nanocrystals.
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http://dx.doi.org/10.1021/acsnano.9b00104DOI Listing
April 2019

Full-term newborn infant with blistering skin lesions-Caution regarding use of pain medications.

Pediatr Dermatol 2019 May 10;36(3):362-364. Epub 2019 Mar 10.

Department of Pediatrics, Division of Neonatology, University of Connecticut, Farmington, Connecticut.

Multiple opioids are known to trigger mast cell degranulation. We report the case of a neonate with blistering skin lesions at birth who died of multi-organ failure after administration of morphine. Given the excessive histamine release and potential complications associated with morphine administration, alternative opioids and adjuvants should be considered in infants presenting with evidence of bullous or infiltrative skin lesions until mastocytosis is ruled out.
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http://dx.doi.org/10.1111/pde.13794DOI Listing
May 2019

Delayed Achievement of Oral Feedings Is Associated with Adverse Neurodevelopmental Outcomes at 18 to 26 Months Follow-up in Preterm Infants.

Am J Perinatol 2020 04 1;37(5):483-490. Epub 2019 Mar 1.

Division of Neonatology, Department of Pediatrics, Connecticut Children's Medical Center, University of Connecticut School of Medicine, Hartford, Connecticut.

Objective: This study aimed to compare neurodevelopmental outcomes in preterm infants at 18 to 26 months corrected age (CA) who did versus did not achieve full oral feedings at 40 weeks postmenstrual age (PMA).

Study Design: This retrospective study included infants born between 2010 and 2015 with gestational age <32 weeks and followed between 18 and 26 months CA. Achievement of full oral feedings was defined as oral intake >130 mL/kg/d for >72 hours by 40 weeks PMA. Incidence of cognitive, language, or motor delay, or cerebral palsy at 18 to 26 months CA was compared in multivariable analyses for infants in the two feeding groups.

Results: Of 372 included infants, those achieving full oral feedings had lower incidence of any adverse neurodevelopmental outcome ( < 0.001) compared with those who did not achieve full oral feedings. In multivariable analyses, achievement of full oral feedings by 40 weeks PMA was associated with decreased odds of cognitive, language, and motor delays, cerebral palsy, and any adverse neurodevelopmental outcome at follow-up.

Conclusion: Achievement of full oral feedings by 40 weeks PMA was associated with better adjusted neurodevelopmental outcomes at 18 to 26 months CA. Inability to fully feed orally at 40 weeks PMA may be a simple, clinically useful marker for risk of adverse neurodevelopmental outcomes.
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http://dx.doi.org/10.1055/s-0039-1681059DOI Listing
April 2020

Promoting a highly stable lithium metal anode by superficial alloying with an ultrathin indium sheet.

Chem Commun (Camb) 2019 Jan;55(11):1592-1595

Department of Materials Science and Technology, China University of Geosciences, Beijing, 100083, P. R. China.

Lithium dendrite growth remains one of the major hindrances for its practical application. Here, we develop an ultrathin indium sheet to construct a stabilized lithium-rich hybrid anode with fast interfacial ion transport. The artificial alloy layer demonstrates an enhanced ionic conductivity that is an order of magnitude higher than that of the pristine solid electrolyte interphase. With the reduced diffusion barrier and improved charge transfer at the artificial interface, the hybrid anode realizes uniform lithium electrodeposition and considerable dendrite suppression. When coupled with LiNi5Co3Mn2O2 cathodes, this hybrid anode shows impressive reversibility.
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http://dx.doi.org/10.1039/c8cc08934eDOI Listing
January 2019

Boosting the Electrocatalytic Water Oxidation Performance of CoFeO Nanoparticles by Surface Defect Engineering.

ACS Appl Mater Interfaces 2019 Jan 17;11(4):3978-3983. Epub 2019 Jan 17.

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering , Tsinghua University , Beijing 100084 , China.

Spinel oxides have attracted widespread interest for electrocatalytic applications owing to their unique crystal structure and properties. The surface structure of spinel oxides significantly influences the electrocatalytic performance of spinel oxides. Herein, we report a Li reduction strategy that can quickly tune the surface structure of CoFeO (CFO) nanoparticles and optimize its electrocatalytic oxygen evolution reaction (OER) performance. Results show that a large number of defective domains have been successfully introduced at the surface of CFO nanopowders after Li reduction treatment. The defective CFO nanoparticles demonstrate significantly improved electrocatalytic OER activity. The OER potential observed a negative shift from 1.605 to 1.513 V at 10 mA cm, whereas the Tafel slope is greatly decreased to 42.1 mV dec after 4 wt % Li reduction treatment. This efficient Li reduction strategy can also be applied to engineer the surface defect structure of other material systems and broaden their applications.
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http://dx.doi.org/10.1021/acsami.8b19265DOI Listing
January 2019

Postnatal Growth Restriction Is Reduced If Birth Weight Is Used for Nutritional Calculations in ELBW Infants.

Int J Pediatr 2018 11;2018:2045370. Epub 2018 Nov 11.

University of Health Sciences, Farmington, CT, USA.

Since fluid and nutrition needs and delivery in ELBW infants are calculated based on their body weights, there could be a measurable difference in fluid, nutrition, and protein intake calculations based on birth weight (BW) or current weight of the infant, especially in the first two weeks of life. Theoretically, the use of current daily weight (CW) for calculations may result in decreased fluid, nutrition, and protein delivery as well as a cumulative protein deficit (cPD) over the first two weeks of life until the infant regains birth weight. However, there have been no clinical studies comparing the clinical and nutritional impact of these two strategies is unknown. . The aims of this study were to quantify the amount of protein intake and to compare growth parameters at hospital discharge (as measured by discharge weight and head circumference percentiles) when using two different methodologies (BW vesrsus current daily weight until BW is regained) for calculating fluid and protein intake in the first two weeks after birth in ELBW infants. . A retrospective review of infants weighing ≤ 1kg at birth was conducted from January 2005 to December 2009 (Phase 1; P1) and January 2012 to December 2014 (Phase 2; P2) in a tertiary care NICU. At this center, in P1 (2005-09) CW was exclusively used for calculating fluid, calorie, and protein administration till BW was regained. In P2 (2012-14), BW was exclusively used for all calculations. Both P1 and P2 periods were compared and analyzed for differences in demographics, nutritional intake, comorbid conditions, and growth outcomes. . We studied 146 infants with 84 and 62 infants in P1 and P2 periods, respectively. The mean gestational age was lower during Phase 1 (25.74 ±1.32 vs. 26.47 ±1.82 weeks. P value =0.01). However, the birth weights were not different between the two periods. When the multiple-regression analysis was done using a discharge weight of >10 percentile as the dependent variable, protein intake before regaining of BW (OR of 4.126 with 95 CI of 2.03-8.36, a P value of 0.00) and AGA status at birth (OR of 8.37 with 95 CI of 2.67-26.24) remained significant factors. Compared to P1, babies in P2 received 1g/kg/day more protein till BW was regained. % of babies who were appropriate for gestational age (AGA) for head circumference at birth became by discharge, to % (p=0.03). Similarly, % , % (p=<0.0001). The number of days it took to regain BW was 9.6 days in P1 vs. 7 days in P2 (p=<0.0001). . Basing nutrition calculations in ELBW on birth weight rather than current daily weight until the birth weight is regained resulted in significantly greater protein delivery, a significant decrease in the incidence of failure to thrive and smaller head circumference percentiles at discharge in ELBW infants.
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http://dx.doi.org/10.1155/2018/2045370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252204PMC
November 2018

Stress Oximetry: Description of a Test to Determine Readiness for Discontinuing Oxygen Therapy in Infants with Chronic Lung Disease.

Int J Pediatr 2018 9;2018:8151678. Epub 2018 Sep 9.

Division of Neonatology, University of Connecticut Health Center, Farmington, CT 06030, USA.

Background: In infants with CLD there are no objective tests to monitor an infant's progress towards weaning out of oxygen inhalation therapy (OIT). A test involving staged maneuvers of increasing respiratory stress while decreasing oxygen support, termed Stress Oximetry (StressOx), has been used at our center for weaning OIT.

Objective: To report the clinical utility of "StressOx" in evaluating readiness for discontinuing OIT in infants with CLD.

Methods: A retrospective review was done of StressOx tests administered at our center from 2002-2008. StressOx was performed based on a consistent clinical protocol in all eligible infants on OIT. OIT was generally discontinued after infant had passed two StressOx tests and subsequently infants were monitored for a minimum of 7 days to determine successful weaning.

Results: There were 279 infants with 899 tests that met inclusion criteria. An average of 3 tests per infant was done, one week apart. The test had a specificity of 97.4% and a positive predictive value of 99.6% in determining success of discontinuing OIT.

Conclusions: StressOx appears to be a clinically useful test that may help in determining an infant's ability to successfully wean out of OIT. Further validation of this test is warranted.
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http://dx.doi.org/10.1155/2018/8151678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151215PMC
September 2018

Synergistic potential of Zingiber officinale and Curcuma longa to ameliorate diabetic-dyslipidemia.

Pak J Pharm Sci 2018 Mar;31(2):491-498

Department of Food Sciences and Human Nutrition, UVAS, Lahore, Pakistan.

To find the cure of world's one of the leading morbid and mortal disorders; diabetes mellitus and its most prevalent complication, 'diabetic-dyslipidemia', is one of the leading health challenges of 21st century. The use of phytomedicine is a glimmer of hope in this scenario. Studies of current decade have shown that methanolic extracts of Zingiber officinale and Curcuma longa have highly effective therapeutic potentials against the aforesaid disorders, however, which of the extracts has more potential is still unclear. Furthermore, synergistic effect of the extracts has never been studied. Forty-eight Albino adult rats of either sex were randomly divided into eight groups. A-D groups were containing healthy rats while E-H groups were of induced diabetic-dyslipidemic rats. For forty-two days, rats of each group were given either distilled water or Zingiber officinale methanolic extract (ZOME) or Curcuma longa methanolic extract (CLME) or ZOME+CLME therapies at dose rate of 300mg/100 mL dist. HO/kg body wt/day. FPG and lipid profiles were estimated before and after the trial, and were statistically analyzed by one-way ANOVA along with Post-hoc Tukey's multiple comparison tests. Although, ZOME and CLME significantly (P<0.05) lowered fasting plasma glucose (FPG) levels and controlled lipid profiles in diabetic-dyslipidemic rats; yet, synergistic therapy of both extracts (ZOME+CLME) most significantly (P<0.05) controlled all parameters of diabetic-dyslipidemia (78.00±1.06mg/dL FPG, 62.00±0.58mg/dL TG, 66.50±0.76mg/dL cholesterol, 32.00±0.36mg/dL HDL, 22.43±0.64 mg/dL LDL, and 12.40±0.12mg/dL VLDL). Our findings may be useful to formulate new medicines having multiple potentials to control diabetes mellitus, dyslipidemia, and diabetic-dyslipidemia.
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March 2018

Ice Melting to Release Reactants in Solution Syntheses.

Angew Chem Int Ed Engl 2018 03 14;57(13):3354-3359. Epub 2018 Feb 14.

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.

Aqueous solution syntheses are mostly based on mixing two solutions with different reactants. It is shown that freezing one solution and melting it in another solution provides a new interesting strategy to mix chemicals and to significantly change the reaction kinetics and thermodynamics. For example, a precursor solution containing a certain concentration of AgNO was frozen and dropped into a reductive NaBH solution at about 0 °C. The ultra-slow release of reactants was successfully achieved. An ice-melting process can be used to synthesize atomically dispersed metals, including cobalt, nickel, copper, rhodium, ruthenium, palladium, silver, osmium, iridium, platinum, and gold, which can be easily extended to other solution syntheses (such as precipitation, hydrolysis, and displacement reactions) and provide a generalized method to redesign the interphase reaction kinetics and ion diffusion in wet chemistry.
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http://dx.doi.org/10.1002/anie.201711128DOI Listing
March 2018

Ultra-low-temperature growth of CdS quantum dots on g-CN nanosheets and their photocatalytic performance.

Dalton Trans 2018 Jan;47(5):1417-1421

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.

CdS quantum dots deposited on carbon nitride (g-CN) nanosheets have been synthesized by ultra-low temperature (-60 °C) liquid phase precipitation reactions. The obtained CdS quantum dots were uniformly distributed on the surface of the g-CN nanosheets with an average diameter of 5 nm. Correspondingly, CdS/g-CN exhibits a highly enhanced photocatalytic performance.
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http://dx.doi.org/10.1039/c7dt04355dDOI Listing
January 2018

Ultrathin two-dimensional metals with fully exposed (111) facets.

Chem Commun (Camb) 2017 Dec;54(2):160-163

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.

Large-size ultrathin two-dimensional (2D) metals with a fully exposed (111) surface have been synthesized by a heat-pressing process. As a result of the compact (111) surface arrangement, an ultrathin Pt 5 nm 2D metal exhibits a superior methanol electro-oxidation performance than an as-sputtered Pt 5 nm thin film (1.8, 2.2 and 5.0 times higher specific activity under different scanning cycles).
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http://dx.doi.org/10.1039/c7cc07923kDOI Listing
December 2017

Racial/Ethnic Disparities in Morbidity and Mortality for Preterm Neonates Admitted to a Tertiary Neonatal Intensive Care Unit.

J Racial Ethn Health Disparities 2018 08 25;5(4):867-874. Epub 2017 Oct 25.

Division of Neonatology, Department of Pediatrics, Connecticut Children's Medical Center, Farmington, CT, USA.

Objective: The objective of this study was to assess whether in-hospital morbidity or mortality differed by race/ethnicity for preterm neonates admitted to the neonatal intensive care unit (NICU).

Study Design: In a retrospective cohort study, preterm infants, < 37 weeks, were admitted to the NICU from 1994 to 2009. Exclusions included structural anomalies and aneuploidy. Primary outcome was in-hospital mortality (IHM). Secondary outcomes were respiratory distress syndrome (RDS), interventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), and retinopathy of prematurity (ROP). Sub-analysis of very preterm (VPT) infants, < 28 weeks, was performed. Five racial/ethnic groups (REGs) were compared: White, Black, Hispanic, Asian, and Mixed. Associations were modeled by logistic regression. White neonates (WNs) were the referent group. Unadjusted and adjusted odds ratios and 95% confidence intervals for remaining REGs were reported. p value was significant at 5% for overall tests and at Bonferroni-corrected level < 0.0125 for between-race comparisons with WNs.

Results: Four thousand nine hundred fifty-five preterm neonates were identified; 153 were excluded leaving 4802 for analysis. After controlling covariates that were chosen a priori, there was no difference across REGs for IHM (all between-race comparison p values > 0.0125). There was a significant difference in RDS among Black neonates (BNs) (aOR 0.57, 95% CI 0.45-0.73; p < 0.001) and Hispanic neonates (HNs) (aOR 0.67, 95% CI 0.50-0.89; p = 0.005) compared to WNs. The risk of ROP was significantly different across REGs with HNs having a 70% increase in ROP (aOR 1.70, 95% CI 1.15-2.49; p = 0.008) and Mixed neonates (MNs) experiencing a 55% reduction (aOR 0.45, 95% CI 0.29-0.68; p < 0.001) compared to WNs. There was no difference in IVH or NEC across REGs (all p values > 0.0125). In the VPT cohort sub-analysis, BNs experienced a significant 59% reduction in IHM compared to WNs (BNs aOR 0.41, 95% CI 0.22-0.73; p = 0.003). MNs experienced a 46% reduction in ROP compared to WNs (aOR 0.54, 95% CI 0.35-0.81; p = 0.004). There was no difference in RDS, IVH, or NEC in very preterm infants across REGs (all between comparison p values > 0.0125).

Conclusion: In preterm neonates, in-hospital mortality does not significantly differ across racial and ethnic groups. However, in very preterm infants, in-hospital mortality for Black neonates is improved. There are morbidity differences (RDS, ROP) seen among racial/ethnic groups.
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http://dx.doi.org/10.1007/s40615-017-0433-2DOI Listing
August 2018
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