Nathaniel W Snyder

Nathaniel W Snyder

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Nathaniel W Snyder

Publications by authors named "Nathaniel W Snyder"

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Association of serum androgens and coronary artery calcium scores in women.

Fertil Steril 2019 Sep 11;112(3):586-593. Epub 2019 Jun 11.

Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.fertnstert.2019.04.024DOI Listing
September 2019

Should we consider subcellular compartmentalization of metabolites, and if so, how do we measure them?

Curr Opin Clin Nutr Metab Care 2019 Sep;22(5):347-354

A.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MCO.0000000000000580DOI Listing
September 2019

Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria.

J Cell Physiol 2019 Sep 6. Epub 2019 Sep 6.

Department of Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.29160DOI Listing
September 2019

Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer.

Mol Cancer Res 2019 Aug 20;17(8):1710-1720. Epub 2019 May 20.

Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-18-1233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679739PMC
August 2019

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate.

Cell Metab 2019 Jul 30;30(1):174-189.e5. Epub 2019 May 30.

Institute for Diabetes, Obesity & Metabolism, University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.05.005DOI Listing
July 2019

Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females.

Cell Rep 2019 May;27(9):2772-2784.e6

Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608748PMC
May 2019

Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry.

Anal Biochem 2019 Mar 31;568:65-72. Epub 2018 Dec 31.

AJ Drexel Autism Institute, Drexel University, 3020 Market St Suite 560, Philadelphia, PA, 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2018.12.023DOI Listing
March 2019

Gestational Diabetes Alters the Metabolomic Profile in 2nd Trimester Amniotic Fluid in a Sex-Specific Manner.

Int J Mol Sci 2018 Sep 10;19(9). Epub 2018 Sep 10.

Center for Research in Reproduction and Women's Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.mdpi.com/1422-0067/19/9/2696
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http://dx.doi.org/10.3390/ijms19092696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165183PMC
September 2018

Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction.

Horm Behav 2018 06 18;102:93-104. Epub 2018 May 18.

Epigenetics Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yhbeh.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261494PMC
June 2018

Artefactual formation of pyruvate from in-source conversion of lactate.

Rapid Commun Mass Spectrom 2018 May 8. Epub 2018 May 8.

AJ Drexel Autism Institute, Drexel University, 3020 Market St Suite 560, Philadelphia, PA, 19104.

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http://doi.wiley.com/10.1002/rcm.8159
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http://dx.doi.org/10.1002/rcm.8159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312753PMC
May 2018

Low apolipoprotein A-I levels in Friedreich's ataxia and in frataxin-deficient cells: Implications for therapy.

PLoS One 2018 15;13(2):e0192779. Epub 2018 Feb 15.

Penn/CHOP Center of Excellence in Friedreich's Ataxia, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192779PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813973PMC
April 2018

Bioorthogonal pro-metabolites for profiling short chain fatty acylation.

Chem Sci 2018 Feb 8;9(5):1236-1241. Epub 2017 Dec 8.

Chemical Biology Laboratory , Center for Cancer Research , National Cancer Institute , National Institutes of Health , Frederick , MD 21702 , USA . Email:

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http://dx.doi.org/10.1039/c7sc00247eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885804PMC
February 2018

Metabolic tracing analysis reveals substrate-specific metabolic deficits in platelet storage lesion.

Transfusion 2017 11 23;57(11):2683-2689. Epub 2017 Aug 23.

A.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/trf.14292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787404PMC
November 2017

Relationship of SULT1A1 copy number variation with estrogen metabolism and human health.

J Steroid Biochem Mol Biol 2017 11 1;174:169-175. Epub 2017 Sep 1.

Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09600760173024
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http://dx.doi.org/10.1016/j.jsbmb.2017.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675753PMC
November 2017

Stable isotope labeling by essential nutrients in cell culture (SILEC) for accurate measurement of nicotinamide adenine dinucleotide metabolism.

Analyst 2017 Nov;142(23):4431-4437

Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://xlink.rsc.org/?DOI=C7AN01378G
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http://dx.doi.org/10.1039/c7an01378gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849469PMC
November 2017

Susceptibility to traumatic stress sensitizes the dopaminergic response to cocaine and increases motivation for cocaine.

Neuropharmacology 2017 Oct 1;125:295-307. Epub 2017 Aug 1.

Drexel University College of Medicine, Department of Neurobiology and Anatomy, 2900 W Queen Lane, Philadelphia PA, 19129, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.07.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585061PMC
October 2017

Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure.

Biomark Med 2017 Jul 23;11(7):547-556. Epub 2017 May 23.

Penn Superfund Research Program & Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.2217/bmm-2017-0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619144PMC
July 2017

Coenzyme A thioester formation of 11- and 15-oxo-eicosatetraenoic acid.

Prostaglandins Other Lipid Mediat 2017 05 24;130:1-7. Epub 2017 Feb 24.

A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446925PMC
May 2017

Differences in testosterone and its precursors by sex of the offspring in meconium.

J Steroid Biochem Mol Biol 2017 03 18;167:78-85. Epub 2016 Nov 18.

AJ Drexel Autism Institute, Drexel University, 3020 Market St, Suite 560, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292277PMC
March 2017

FluxFix: automatic isotopologue normalization for metabolic tracer analysis.

BMC Bioinformatics 2016 Nov 25;17(1):485. Epub 2016 Nov 25.

AJ Drexel Autism Institute, Drexel University, Philadelphia, PA, 19104, USA.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12859-016-1360-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123363PMC
November 2016

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch.

Cell Rep 2016 10;17(4):1037-1052

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175409PMC
October 2016

Serum apolipoprotein A-1 quantification by LC-MS with a SILAC internal standard reveals reduced levels in smokers.

Bioanalysis 2015 22;7(22):2895-911. Epub 2015 Sep 22.

Center of Excellence in Environmental Toxicology & Penn SRP Center, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4155/bio.15.195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737526PMC
September 2016

Diisopropylethylamine/hexafluoroisopropanol-mediated ion-pairing ultra-high-performance liquid chromatography/mass spectrometry for phosphate and carboxylate metabolite analysis: utility for studying cellular metabolism.

Rapid Commun Mass Spectrom 2016 08;30(16):1835-45

Penn SRP and Center for Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1002/rcm.7667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970762PMC
August 2016

Translational metabolomics in cancer research.

Biomark Med 2015 1;9(9):821-34. Epub 2015 Sep 1.

Penn SRP Center & Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania, PA 19104, USA.

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http://dx.doi.org/10.2217/bmm.15.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718447PMC
July 2016

Stable isotopes and LC-MS for monitoring metabolic disturbances in Friedreich's ataxia platelets.

Bioanalysis 2015 ;7(15):1843-55

Center of Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4155/bio.15.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620983PMC
May 2016

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism.

J Vis Exp 2016 Apr 4(110):e53941. Epub 2016 Apr 4.

Center for Cancer Pharmacology, University of Pennsylvania; Center for Excellence in Environmental Toxicology, University of Pennsylvania;

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http://dx.doi.org/10.3791/53941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841355PMC
April 2016

Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure.

Bioanalysis 2015 ;7(9):1157-73

1Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.4155/bio.15.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487641PMC
February 2016

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.

Circulation 2016 Feb 27;133(8):706-16. Epub 2016 Jan 27.

From Cardiovascular Institute University of Pennsylvania Perelman School of Medicine, Smilow Translational Research Center, Philadelphia, PA (K.C.B., J.B., A.J., K.B.M., J.E.R.); A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA (N.W.S.); and Center of Cancer Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (M.A., C.M., A.J.W., L.L.W., I.A.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.017545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779339PMC
February 2016

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells.

Immunity 2016 Feb;44(2):380-90

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.01.021DOI Listing
February 2016

Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes.

Biochem Pharmacol 2015 Aug 29;96(3):247-55. Epub 2015 May 29.

Meakins-Christie Laboratories, Centre for Translational Biology, McGill University Health Centre, 1001 Decarie Blvd, Montreal, QC H4A 3J1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830392PMC
August 2015

15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways.

Chem Biol Interact 2015 Jun 4;234:144-53. Epub 2014 Nov 4.

University of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA 15261, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00092797140032
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http://dx.doi.org/10.1016/j.cbi.2014.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414684PMC
June 2015

Rotenone Stereospecifically Increases (S)-2-Hydroxyglutarate in SH-SY5Y Neuronal Cells.

Chem Res Toxicol 2015 May 8;28(5):948-54. Epub 2015 Apr 8.

∥A.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/tx500535cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721232PMC
May 2015

ATM couples replication stress and metabolic reprogramming during cellular senescence.

Cell Rep 2015 May 30;11(6):893-901. Epub 2015 Apr 30.

Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431925PMC
May 2015

Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture.

Anal Biochem 2015 Apr 6;474:59-65. Epub 2015 Jan 6.

Penn SRP Center and Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2014.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413507PMC
April 2015

Ultrasensitive quantification of serum estrogens in postmenopausal women and older men by liquid chromatography-tandem mass spectrometry.

Steroids 2015 Apr 29;96:140-52. Epub 2015 Jan 29.

Center of Excellence in Environmental Toxicology and Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2015.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369926PMC
April 2015

Metabolism of propionic acid to a novel acyl-coenzyme A thioester by mammalian cell lines and platelets.

J Lipid Res 2015 Jan 25;56(1):142-50. Epub 2014 Nov 25.

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M055384
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http://dx.doi.org/10.1194/jlr.M055384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274062PMC
January 2015

Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.

J Biol Chem 2014 Sep 12;289(39):26895-903. Epub 2014 Aug 12.

From the Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.591354
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http://dx.doi.org/10.1074/jbc.M114.591354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175330PMC
September 2014

Stable isotope dilution liquid chromatography/mass spectrometry analysis of cellular and tissue medium- and long-chain acyl-coenzyme A thioesters.

Rapid Commun Mass Spectrom 2014 Aug;28(16):1840-8

Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, and Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104-4863, USA.

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http://dx.doi.org/10.1002/rcm.6958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286313PMC
August 2014

Cellular uptake and antiproliferative effects of 11-oxo-eicosatetraenoic acid.

J Lipid Res 2013 Nov 14;54(11):3070-7. Epub 2013 Aug 14.

Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1194/jlr.M040741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793611PMC
November 2013

Untargeted metabolomics from biological sources using ultraperformance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS).

J Vis Exp 2013 May 20(75):e50433. Epub 2013 May 20.

Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania.

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http://dx.doi.org/10.3791/50433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711276PMC
May 2013

11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid.

Chem Res Toxicol 2011 Dec 30;24(12):2227-36. Epub 2011 Sep 30.

Center for Cancer Pharmacology and Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1021/tx200336fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242474PMC
December 2011