Publications by authors named "Nathanael S Gray"

100Publications

Discovery of Covalent MKK4/7 Dual Inhibitor.

Cell Chem Biol 2020 Sep 7. Epub 2020 Sep 7.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2020.08.014DOI Listing
September 2020

Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities.

Cell Chem Biol 2020 Aug 4. Epub 2020 Aug 4.

Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Frankfurt 60438, Germany; Structural Genomics Consortium, BMLS, Goethe-University Frankfurt, Frankfurt 60438, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2020.07.014DOI Listing
August 2020

Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing.

Cell Chem Biol 2020 Aug 4. Epub 2020 Aug 4.

Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; Department of Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2020.07.011DOI Listing
August 2020

Discovery of a series of benzopyrimidodiazepinone TNK2 inhibitors via scaffold morphing.

Bioorg Med Chem Lett 2020 Oct 31;30(19):127456. Epub 2020 Jul 31.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 360 Longwood Ave, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2020.127456DOI Listing
October 2020

Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis.

Cancer Res 2020 Aug 19;80(16):3319-3330. Epub 2020 Jun 19.

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-2416DOI Listing
August 2020

Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface.

ACS Med Chem Lett 2020 Jun 3;11(6):1269-1273. Epub 2020 Apr 3.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.0c00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294706PMC
June 2020

Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6-benzo[]pyrimido[5,4-][1,4]diazepin-6-one Scaffold.

J Med Chem 2020 Jul 9;63(14):7817-7826. Epub 2020 Jul 9.

Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.0c00596DOI Listing
July 2020

Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations.

Angew Chem Int Ed Engl 2020 Jun 8. Epub 2020 Jun 8.

Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1002/anie.202003500DOI Listing
June 2020

Structure and Characterization of a Covalent Inhibitor of Src Kinase.

Front Mol Biosci 2020 19;7:81. Epub 2020 May 19.

Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States.

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http://dx.doi.org/10.3389/fmolb.2020.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248381PMC
May 2020

Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13.

J Med Chem 2020 Jul 25;63(13):6708-6726. Epub 2020 Jun 25.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01929DOI Listing
July 2020

Development of CDK2 and CDK5 Dual Degrader TMX-2172.

Angew Chem Int Ed Engl 2020 Aug 3;59(33):13865-13870. Epub 2020 Jun 3.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/anie.202004087DOI Listing
August 2020

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs.

Cells 2020 Apr 27;9(5). Epub 2020 Apr 27.

Department of Systems Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.3390/cells9051083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290497PMC
April 2020

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.

Cell 2020 Apr 20;181(3):702-715.e20. Epub 2020 Apr 20.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.03.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397863PMC
April 2020

Defining and Targeting Adaptations to Oncogenic KRAS Inhibition Using Quantitative Temporal Proteomics.

Cell Rep 2020 Mar;30(13):4584-4599.e4

Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.03.021DOI Listing
March 2020

Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.

Cell Chem Biol 2020 May 3;27(5):525-537.e6. Epub 2020 Mar 3.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2020.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286548PMC
May 2020

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging.

Cell 2020 03 27;180(5):968-983.e24. Epub 2020 Feb 27.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.02.012DOI Listing
March 2020

Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.

J Clin Invest 2020 Jun;130(6):2966-2977

Roddenberry Center for Stem Cell Biology and Medicine, Gladstone Institutes, San Francisco, California, USA.

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http://dx.doi.org/10.1172/JCI133753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259992PMC
June 2020

Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.

J Med Chem 2020 02 30;63(4):1624-1641. Epub 2020 Jan 30.

Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493195PMC
February 2020

Benzopyrimidodiazepinone inhibitors of TNK2.

Bioorg Med Chem Lett 2020 02 7;30(4):126948. Epub 2020 Jan 7.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 360 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bmcl.2020.126948DOI Listing
February 2020

A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation.

J Biol Chem 2020 Feb 30;295(6):1694-1703. Epub 2019 Dec 30.

Department of Microbiology and Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115

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http://dx.doi.org/10.1074/jbc.RA119.011132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008383PMC
February 2020

Exploring Targeted Degradation Strategy for Oncogenic KRAS.

Cell Chem Biol 2020 01 26;27(1):19-31.e6. Epub 2019 Dec 26.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.12.006DOI Listing
January 2020

Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling.

Cell Chem Biol 2020 01 16;27(1):66-73.e7. Epub 2019 Dec 16.

Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980747PMC
January 2020

Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.

Cell Syst 2020 01 4;10(1):66-81.e11. Epub 2019 Dec 4.

Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA; Harvard Ludwig Center, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000271PMC
January 2020

Development and Characterization of a Wee1 Kinase Degrader.

Cell Chem Biol 2020 01 14;27(1):57-65.e9. Epub 2019 Nov 14.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980656PMC
January 2020

Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation.

Cell Chem Biol 2019 11 17;26(11):1486-1500. Epub 2019 Oct 17.

Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886688PMC
November 2019

Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold.

ACS Med Chem Lett 2019 Oct 13;10(10):1443-1449. Epub 2019 Sep 13.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792166PMC
October 2019

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.

Cell Rep 2019 10;29(1):118-134.e8

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, MA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918830PMC
October 2019

Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.

Bioorg Med Chem Lett 2019 08 23;29(15):1985-1993. Epub 2019 May 23.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886737PMC
August 2019

Quinoline and thiazolopyridine allosteric inhibitors of MALT1.

Bioorg Med Chem Lett 2019 07 20;29(14):1694-1698. Epub 2019 May 20.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 360 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bmcl.2019.05.040DOI Listing
July 2019

JNK2 Is Required for the Tumorigenic Properties of Melanoma Cells.

ACS Chem Biol 2019 07 17;14(7):1426-1435. Epub 2019 May 17.

Department of Translational Molecular Pathology , The University of Texas M. D. Anderson Cancer Center , Houston , Texas 77030 , United States.

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http://dx.doi.org/10.1021/acschembio.9b00083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181303PMC
July 2019

Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.

Cell Chem Biol 2019 06 11;26(6):818-829.e9. Epub 2019 Apr 11.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456193007
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http://dx.doi.org/10.1016/j.chembiol.2019.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634314PMC
June 2019

Peptide-based covalent inhibitors of MALT1 paracaspase.

Bioorg Med Chem Lett 2019 06 29;29(11):1336-1339. Epub 2019 Mar 29.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 360 Longwood Ave, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.03.046DOI Listing
June 2019

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.

Cell Chem Biol 2019 06 21;26(6):792-803.e10. Epub 2019 Mar 21.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biology Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588464PMC
June 2019

A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers.

J Biol Chem 2019 05 11;294(21):8664-8673. Epub 2019 Mar 11.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.006805
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http://dx.doi.org/10.1074/jbc.RA118.006805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544847PMC
May 2019

Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6.

Angew Chem Int Ed Engl 2019 05 29;58(19):6321-6326. Epub 2019 Mar 29.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1002/anie.201901336DOI Listing
May 2019

Identification of small molecule inhibitors targeting the Zika virus envelope protein.

Antiviral Res 2019 04 13;164:147-153. Epub 2019 Feb 13.

Department of Microbiology and Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2019.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675404PMC
April 2019

Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).

J Biol Chem 2019 03 24;294(12):4511-4519. Epub 2019 Jan 24.

From the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115,

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.005428
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http://dx.doi.org/10.1074/jbc.RA118.005428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433055PMC
March 2019

Small Molecules Targeting the Flavivirus E Protein with Broad-Spectrum Activity and Antiviral Efficacy in Vivo.

ACS Infect Dis 2019 03 14;5(3):460-472. Epub 2019 Jan 14.

Department of Microbiology, Blavatnik Institute , Harvard Medical School , 77 Avenue Louis Pasteur , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.8b00322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548335PMC
March 2019

Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells.

Stem Cell Reports 2018 10 20;11(4):929-943. Epub 2018 Sep 20.

Department of Experimental and Clinical Biomedical Sciences, Università degli Studi di Firenze, viale G.B. Morgagni, 50, Firenze 50134, Italy; Istituto Toscano Tumori (ITT), Firenze 50134, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178886PMC
October 2018

First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia.

J Med Chem 2018 09 11;61(18):8353-8373. Epub 2018 Sep 11.

KU-KIST Graduate School of Converging Science and Technology , Korea University , 145 Anam-ro, Seongbuk-gu , Seoul 02841 , Republic of Korea.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b00882
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http://dx.doi.org/10.1021/acs.jmedchem.8b00882DOI Listing
September 2018

Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors.

J Med Chem 2018 09 23;61(17):7560-7572. Epub 2018 Aug 23.

The Norwegian Structural Biology Centre, Department of Chemistry , UiT The Arctic University of Norway , N-9037 Tromsø , Norway.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01847DOI Listing
September 2018

Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein.

ACS Infect Dis 2018 09 29;4(9):1395-1406. Epub 2018 Aug 29.

Department of Microbiology and Immunobiology , Harvard Medical School , 77 Avenue Louis Pasteur , Boston , Massachusetts 02115 , United States.

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http://pubs.acs.org/doi/10.1021/acsinfecdis.8b00127
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http://dx.doi.org/10.1021/acsinfecdis.8b00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392429PMC
September 2018

Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.

J Clin Invest 2018 10 19;128(10):4397-4412. Epub 2018 Jul 19.

Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI99436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159983PMC
October 2018

BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer.

Cancer Res 2018 09 16;78(18):5203-5215. Epub 2018 Jul 16.

Hematology-Oncology Division, Department of Medicine, and Cancer Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139052PMC
September 2018

Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.

Cell 2018 07;174(2):300-311.e11

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084792PMC
July 2018

How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion.

Elife 2018 07 12;7. Epub 2018 Jul 12.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.

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http://dx.doi.org/10.7554/eLife.36461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056230PMC
July 2018

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8.

ACS Med Chem Lett 2018 Jun 18;9(6):540-545. Epub 2018 Mar 18.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, United States.

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https://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00011
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http://dx.doi.org/10.1021/acsmedchemlett.8b00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004574PMC
June 2018

Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo.

ACS Chem Biol 2018 06 30;13(6):1551-1559. Epub 2018 May 30.

Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , United States.

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http://pubs.acs.org/doi/10.1021/acschembio.8b00154
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http://dx.doi.org/10.1021/acschembio.8b00154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130198PMC
June 2018

Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).

J Med Chem 2018 05 24;61(9):4249-4255. Epub 2018 Apr 24.

Department of Biological Chemistry & Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01655
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http://dx.doi.org/10.1021/acs.jmedchem.7b01655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294449PMC
May 2018

It Takes Two To Target: A Study in KRAS Dimerization.

Biochemistry 2018 04 12;57(16):2289-2290. Epub 2018 Apr 12.

Department of Cancer Biology , Dana-Farber Cancer Institute , Boston , Massachusetts 02215 , United States.

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http://dx.doi.org/10.1021/acs.biochem.8b00376DOI Listing
April 2018

Kinase inhibitors: the road ahead.

Nat Rev Drug Discov 2018 05 16;17(5):353-377. Epub 2018 Mar 16.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States.

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http://dx.doi.org/10.1038/nrd.2018.21DOI Listing
May 2018

Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition.

Proc Natl Acad Sci U S A 2018 03 5;115(12):E2801-E2810. Epub 2018 Mar 5.

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1707929115
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http://dx.doi.org/10.1073/pnas.1707929115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866536PMC
March 2018

ERK5 is activated by oncogenic BRAF and promotes melanoma growth.

Oncogene 2018 05 27;37(19):2601-2614. Epub 2018 Feb 27.

Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1038/s41388-018-0164-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945581PMC
May 2018