Nathalie Y R Agar

Nathalie Y R Agar

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Nathalie Y R Agar

Nathalie Y R Agar

Publications by authors named "Nathalie Y R Agar"

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Rapid MALDI mass spectrometry imaging for surgical pathology.

NPJ Precis Oncol 2019 4;3:17. Epub 2019 Jul 4.

2Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 USA.

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http://dx.doi.org/10.1038/s41698-019-0089-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609678PMC
July 2019

Quantitative Wide-Field Imaging Techniques for Fluorescence Guided Neurosurgery.

Front Surg 2019 6;6:31. Epub 2019 Jun 6.

Department of Neurosurgery, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States.

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http://dx.doi.org/10.3389/fsurg.2019.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563771PMC
June 2019

Metal Oxide Laser Ionization Mass Spectrometry Imaging (MOLI MSI) Using Cerium(IV) Oxide.

Anal Chem 2019 May 8;91(10):6800-6807. Epub 2019 May 8.

Department of Neurosurgery , Brigham and Women's Hospital, Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.analchem.9b00894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826256PMC
May 2019

Genetically Encoded Fluorescent Proteins Enable High-Throughput Assignment of Cell Cohorts Directly from MALDI-MS Images.

Anal Chem 2019 Mar 6;91(6):3810-3817. Epub 2019 Mar 6.

Department of Chemistry and Chemical Biology and Barnett Institute of Chemical and Biological Analysis , Northeastern University , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.analchem.8b03454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827431PMC
March 2019

Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.

J Neurooncol 2018 Nov 20;140(2):269-279. Epub 2018 Aug 20.

Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road, Suite C5086, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1007/s11060-018-2978-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244779PMC
November 2018

Prostate cancer diagnosis and characterization with mass spectrometry imaging.

Prostate Cancer Prostatic Dis 2018 09 5;21(3):297-305. Epub 2017 Dec 5.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41391-017-0011-z
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http://dx.doi.org/10.1038/s41391-017-0011-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988647PMC
September 2018

In Vitro Liquid Extraction Surface Analysis Mass Spectrometry (ivLESA-MS) for Direct Metabolic Analysis of Adherent Cells in Culture.

Anal Chem 2018 04 2;90(8):4987-4991. Epub 2018 Apr 2.

Department of Cancer Biology , Dana-Farber Cancer Institute, Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.analchem.8b00530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196362PMC
April 2018

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Cancer Cell 2017 10 28;32(4):411-426.e11. Epub 2017 Sep 28.

The David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929990PMC
October 2017

Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling.

Cell Commun Signal 2017 09 18;15(1):34. Epub 2017 Sep 18.

Center for Skull Base and Pituitary Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12964-017-0189-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604305PMC
September 2017

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents.

Nat Commun 2017 06 6;8:15623. Epub 2017 Jun 6.

Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms15623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467173PMC
June 2017

Imaging and Mapping of Tissue Constituents at the Single-Cell Level Using MALDI MSI and Quantitative Laser Scanning Cytometry.

Methods Mol Biol 2015 ;1346:133-49

Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-2987-0_10DOI Listing
August 2016

Label-Free Neurosurgical Pathology with Stimulated Raman Imaging.

Cancer Res 2016 06 12;76(12):3451-62. Epub 2016 Apr 12.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911248PMC
June 2016

Translational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases.

J Clin Oncol 2016 Mar 1;34(9):945-52. Epub 2016 Feb 1.

Rachel A. Freedman, Rebecca S. Gelman, Christina Herold, Nicole Ryabin, Sarah Farooq, Elizabeth Lawler, Ian E. Krop, Eric P. Winer, and Nancy U. Lin, Dana-Farber Cancer Institute; Beverly Moy, Massachusetts General Hospital; Alarice Lowe and Nathalie Y.R. Agar, Brigham and Women's Hospital, Boston, MA; Jeffrey S. Wefel, Kenneth R. Hess, and Nuhad Ibrahim, The University of Texas MD Anderson Cancer Center; Polly A. Niravath and Mothaffar F. Rimawi, Baylor College of Medicine, Houston, TX; Michelle E. Melisko, University of California, San Francisco, San Francisco, CA; Roisin M. Connolly and Antonio C. Wolff, Johns Hopkins University, Baltimore, MD; Catherine H. Van Poznak, University of Michigan, Ann Arbor, MI; Shannon L. Puhalla, University of Pittsburgh Cancer Institute and Magee-Women's Hospital, Pittsburgh, PA; Kimberly L. Blackwell, Duke University Medical Center, Durham, NC; and Minetta C. Liu, Mayo Clinic, Rochester, MN.

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http://jco.ascopubs.org/content/early/2016/01/28/JCO.2015.63
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.63.0343
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http://dx.doi.org/10.1200/JCO.2015.63.0343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070554PMC
March 2016

MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation.

Proc Natl Acad Sci U S A 2015 Aug 27;112(32):9978-83. Epub 2015 Jul 27.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115

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http://www.pnas.org/content/112/32/9978.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1423101112
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http://dx.doi.org/10.1073/pnas.1423101112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538649PMC
August 2015

Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making.

Int J Mass Spectrom 2015 Feb;377:690-698

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 ; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 ; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115.

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http://dunnlab.bwh.harvard.edu/wp-content/uploads/2015/05/Ca
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http://linkinghub.elsevier.com/retrieve/pii/S138738061400250
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http://dx.doi.org/10.1016/j.ijms.2014.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379512PMC
February 2015

Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery.

Proc Natl Acad Sci U S A 2014 Jul 30;111(30):11121-6. Epub 2014 Jun 30.

Department of Cancer Biology, Harvard Medical School and Dana-Farber Cancer Institute, Boston, MA 02115;Neurosurgery, andRadiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1404724111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121790PMC
July 2014

Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.

Proteomics 2014 May 17;14(10):1152-7. Epub 2014 Apr 17.

Department of Chemistry and Chemical Biology, Barnett Institute, Northeastern University, Boston, MA, USA; Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA; Department of Biochemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, USA; Department of Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, USA.

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http://dx.doi.org/10.1002/pmic.201300450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507715PMC
May 2014

Reconstruction and Feature Selection for Desorption Electrospray Ionization Mass Spectroscopy Imagery.

Proc SPIE Int Soc Opt Eng 2014 Mar;9036:90360D

Department of Electrical and Computer Engineering, the University of Alabama, Birmingham.

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http://dx.doi.org/10.1117/12.2043273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187386PMC
March 2014

Recursive feature elimination for brain tumor classification using desorption electrospray ionization mass spectrometry imaging.

Conf Proc IEEE Eng Med Biol Soc 2012 ;2012:5258-61

Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1109/EMBC.2012.6347180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649005PMC
August 2013

A compressive sensing approach for glioma margin delineation using mass spectrometry.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:5682-5

Schools of Electrical & Computer and Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1109/IEMBS.2011.6091375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640451PMC
June 2012

Classification of astrocytomas and oligodendrogliomas from mass spectrometry data using sparse kernel machines.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:7965-8

School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1109/IEMBS.2011.6091964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644033PMC
May 2012

Classifying human brain tumors by lipid imaging with mass spectrometry.

Cancer Res 2012 Feb 2;72(3):645-54. Epub 2011 Dec 2.

Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, Indiana 47907, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-2465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271168PMC
February 2012

Development of stereotactic mass spectrometry for brain tumor surgery.

Neurosurgery 2011 Feb;68(2):280-89; discussion 290

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1227/NEU.0b013e3181ff9cbbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678259PMC
February 2011

Tissue preparation for the in situ MALDI MS imaging of proteins, lipids, and small molecules at cellular resolution.

Methods Mol Biol 2010 ;656:415-31

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://link.springer.com/10.1007/978-1-60761-746-4_24
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http://dx.doi.org/10.1007/978-1-60761-746-4_24DOI Listing
December 2010

Discrimination of human astrocytoma subtypes by lipid analysis using desorption electrospray ionization imaging mass spectrometry.

Angew Chem Int Ed Engl 2010 Aug;49(34):5953-6

Department of Chemistry and Center for Analytical Instrumentation and Development, Purdue University, West Lafayette, IN 47907, USA.

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http://doi.wiley.com/10.1002/anie.201001452
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http://dx.doi.org/10.1002/anie.201001452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021787PMC
August 2010

Transformative effects of higher magnetic field in Fourier transform ion cyclotron resonance mass spectrometry.

J Am Soc Mass Spectrom 2010 Jul 31;21(7):1218-22. Epub 2010 Mar 31.

Department of Chemistry and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA.

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http://dx.doi.org/10.1016/j.jasms.2010.03.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902155PMC
July 2010

Imaging of meningioma progression by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.

Anal Chem 2010 Apr;82(7):2621-5

Surgical Molecular Imaging Laboratory, Department of Neurosurgery, 221, Longwood Avenue, BLI-137, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/ac100113wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852177PMC
April 2010

The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth.

J Biol Chem 2010 Mar 11;285(11):8472-80. Epub 2010 Jan 11.

Department of Neurosurgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M109.069450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832996PMC
March 2010

Biphenyl dioxygenase from an arctic isolate is not cold adapted.

Appl Environ Microbiol 2008 Jun 18;74(12):3908-11. Epub 2008 Apr 18.

Department of Microbiology and Immunology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1128/AEM.02928-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446576PMC
June 2008

Matrix solution fixation: histology-compatible tissue preparation for MALDI mass spectrometry imaging.

Anal Chem 2007 Oct 7;79(19):7416-23. Epub 2007 Sep 7.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/ac071460eDOI Listing
October 2007

Isolation of a natural inhibitor of human malignant glial cell invasion: inter alpha-trypsin inhibitor heavy chain 2.

Cancer Res 2006 Feb;66(3):1464-72

Brain Tumour Research Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1913DOI Listing
February 2006

Molecular basis for the substrate selectivity of bicyclic and monocyclic extradiol dioxygenases.

Biochem Biophys Res Commun 2005 Dec 8;338(1):215-22. Epub 2005 Sep 8.

Department of Microbiology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.

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http://dx.doi.org/10.1016/j.bbrc.2005.08.219DOI Listing
December 2005

Reactivity of toluate dioxygenase with substituted benzoates and dioxygen.

J Bacteriol 2002 Aug;184(15):4096-103

Department of Microbiology and Immunology, University of British Columbia, Vancouver BC V6T 1Z3, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135208PMC
http://dx.doi.org/10.1128/jb.184.15.4096-4103.2002DOI Listing
August 2002