Nathalie Janel

Nathalie Janel

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Nathalie Janel

Publications by authors named "Nathalie Janel"

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Down syndrome and infertility: what support should we provide?

J Assist Reprod Genet 2019 Jun 9;36(6):1063-1067. Epub 2019 May 9.

EA7404-GIG, UFR des sciences de la Santé Simone Veil, UVSQ, F-78180, Montigny le Bretonneux, France.

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http://dx.doi.org/10.1007/s10815-019-01457-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603116PMC
June 2019

Hypothesis and Theory: Circulating Alzheimer's-Related Biomarkers in Type 2 Diabetes. Insight From the Goto-Kakizaki Rat.

Front Neurol 2019 26;10:649. Epub 2019 Jun 26.

Univ Paris Diderot-Sorbonne Paris Cité, Laboratoire Processus Dégénératifs, Stress et Vieillissement, Unité de Biologie Fonctionnelle et Adaptative (BFA), UMR 8251 CNRS, Paris, France.

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http://dx.doi.org/10.3389/fneur.2019.00649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606723PMC
June 2019

LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice.

Mol Neurobiol 2019 Feb 30;56(2):963-975. Epub 2018 May 30.

Sorbonne Paris Cité, Biologie Fonctionnelle et Adaptative (BFA), Université Paris Diderot, UMR 8251, 75205, Paris, France.

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http://dx.doi.org/10.1007/s12035-018-1113-xDOI Listing
February 2019

Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia.

Redox Biol 2018 10 25;19:200-209. Epub 2018 Aug 25.

Université Paris Diderot, Sorbonne Paris Cité, Biologie Fonctionnelle et Adaptative (BFA), UMR 8251, F-75205 Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183050
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http://dx.doi.org/10.1016/j.redox.2018.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122394PMC
October 2018

Effect of lyophilized prune extract on hyperhomocysteinemia in mice.

Food Chem Toxicol 2017 May 10;103:183-187. Epub 2017 Mar 10.

Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative (BFA), UMR 8251 CNRS, F-75205 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2017.03.018DOI Listing
May 2017

Impact of Dyrk1A level on alcohol metabolism.

Biochim Biophys Acta 2016 09 20;1862(9):1495-503. Epub 2016 May 20.

Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative (BFA), UMR 8251 CNRS, F-75205 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.05.011DOI Listing
September 2016

Effect of cadmium administration in hyperhomocysteinemic mice due to cystathionine beta synthase deficiency.

Exp Toxicol Pathol 2016 Jun 7;68(6):365-70. Epub 2016 May 7.

Univ. Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative (BFA), UMR 8251 CNRS, F-75205 Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09402993163005
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http://dx.doi.org/10.1016/j.etp.2016.05.001DOI Listing
June 2016

Hepatoprotective effects of lycopene on liver enzymes involved in methionine and xenobiotic metabolism in hyperhomocysteinemic rats.

Food Funct 2016 Jun 27;7(6):2862-9. Epub 2016 May 27.

Département des Sciences Agro-alimentaire, Faculté SNV, université Saad Dahlab (Blida1), Algeria.

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http://dx.doi.org/10.1039/c6fo00095aDOI Listing
June 2016

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

Cell Cycle 2014 28;13(14):2221-9. Epub 2014 May 28.

INSERM U1016; Institut Cochin; Faculté de Médecine Cochin; Université Paris Descartes; Paris, France.

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http://dx.doi.org/10.4161/cc.29250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111677PMC
December 2015

The iron component of particulate matter is antiapoptotic: A clue to the development of lung cancer after exposure to atmospheric pollutants?

Biochimie 2015 Nov 28;118:195-206. Epub 2015 Sep 28.

Université Paris Diderot, Sorbonne Paris Cité, Unit of Functional and Adaptive Biology, CNRS UMR 8251, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2015.09.030DOI Listing
November 2015

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models.

Front Behav Neurosci 2015 20;9:267. Epub 2015 Oct 20.

Université Paris Diderot, Sorbonne Paris Cité, Adaptive Functional Biology, UMR Centre National de la Recherche Scientifique 8251 Paris, France ; Université Pierre-et-Marie-Curie Paris, 06 UMR S 1127, Centre National de la Recherche Scientifique UMR 7225, Institut National de la Santé et de la Recherche Médicale, U 1127, Sorbonne Universités, Institut du Cerveau et de la Moelle Epiniere Paris, France.

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http://dx.doi.org/10.3389/fnbeh.2015.00267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611057PMC
November 2015

DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome.

Endocrinology 2015 Mar 9;156(3):1171-80. Epub 2014 Dec 9.

Inserm U1016 (D.K., L.R., A.C., M.H., R.S., M.P.), 75014 Paris France; Imagine Institute (D.K., A.C., M.P.), Paris, France; Pediatric Endocrinology, Gynaecology and Diabetology Unit (D.K., M.P.), Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; Diabetes and Obesity Research Laboratory (M.M.), Institut d'Investigacions Biomèdiques August Pi I Sunyer, 08036 Barcelona, Spain; Unité de Biologie Fonctionnelle et Adaptative (N.J., J.-M.D.), Centre National de Recherche Scientifique 4413, Université Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France; and Université Paris Descartes-Sorbonne Paris Cité (M.P.), 75006 Paris, France.

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http://dx.doi.org/10.1210/en.2014-1329DOI Listing
March 2015

Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise.

J Mol Neurosci 2015 Feb 13;55(2):318-23. Epub 2014 May 13.

Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative (BFA), Université Paris Diderot, UMR 8251 CNRS, 75205, Paris, France.

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http://dx.doi.org/10.1007/s12031-014-0324-5DOI Listing
February 2015

One-carbon cycle alterations induced by Dyrk1a dosage.

Mol Genet Metab Rep 2014 21;1:487-492. Epub 2014 Nov 21.

Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative (BFA), UMR 8251 CNRS, F-75205 Paris, France.

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http://dx.doi.org/10.1016/j.ymgmr.2014.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121348PMC
November 2014

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage.

Neurobiol Dis 2014 Sep 4;69:65-75. Epub 2014 May 4.

Univ Paris Diderot, Sorbonne Paris Cité, Adaptive Functional Biology, UMR CNRS 8251, 75205 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.04.016DOI Listing
September 2014

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass.

Diabetologia 2014 May 30;57(5):960-9. Epub 2014 Jan 30.

INSERM U1016, Institut Cochin, Faculté de Médecine Cochin, Université Paris Descartes, 24 Rue du Faubourg St Jacques, 75014, Paris, France,

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http://dx.doi.org/10.1007/s00125-014-3174-3DOI Listing
May 2014

A high-performance liquid chromatography assay for Dyrk1a, a Down syndrome-associated kinase.

Anal Biochem 2014 Mar 25;449:172-8. Epub 2013 Dec 25.

Unit of Functional and Adaptative Biology (BFA), Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR 8251, 75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2013.12.024DOI Listing
March 2014

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans.

Mol Nutr Food Res 2014 Feb 14;58(2):278-88. Epub 2013 Sep 14.

Human Pharmacology and Clinical Neurosciences Research Group-Neurosciences Program, IMIM-Hospital del Mar Research Institute, Barcelona, Spain; Cardiovascular Risk and Nutrition Research Group-Inflammatory and Cardiovascular Disorders Program, IMIM-Hospital del Mar Research Institute, and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Barcelona, Spain; University Pompeu Fabra, CEXS-UPF, Barcelona, Spain.

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http://dx.doi.org/10.1002/mnfr.201300325DOI Listing
February 2014

Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a.

J Neurosci 2014 Jan;34(4):1138-47

Institut National de la Santé et de la Recherche Médicale U901, Marseille, 13009, France, Université Aix-Marseille UMR S901, Marseille, 13009, France, INMED, Marseille, 13009, France, and Université Paris Diderot, Sorbonne Paris Cité, Adaptive Functional Biology, EAC Centre National de la Recherche Scientifique 4413, Paris, 75205, France.

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http://dx.doi.org/10.1523/JNEUROSCI.2852-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953590PMC
January 2014

Development of DANDYs, new 3,5-diaryl-7-azaindoles demonstrating potent DYRK1A kinase inhibitory activity.

J Med Chem 2013 Dec 19;56(23):9569-85. Epub 2013 Nov 19.

Institut de Chimie des Substances Naturelles, Centre de Recherche de Gif, UPR 2301, CNRS , Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.

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http://dx.doi.org/10.1021/jm401049vDOI Listing
December 2013

DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.

Mol Genet Metab 2013 Nov 20;110(3):371-7. Epub 2013 Jul 20.

Université Paris Diderot, Sorbonne Paris Cité, Unit of Functional and Adaptive Biology (BFA), EAC-CNRS 4413, Case 7104, 75205 Paris cedex 13, France.

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http://dx.doi.org/10.1016/j.ymgme.2013.07.014DOI Listing
November 2013

Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice.

Biochim Biophys Acta 2013 Jun 18;1832(6):718-28. Epub 2013 Feb 18.

Univ Paris Diderot, Sorbonne Paris Cité, Unit of Functional and Adaptative Biology, EAC-CNRS 4413, 75013 Paris, France.

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http://dx.doi.org/10.1016/j.bbadis.2013.02.008DOI Listing
June 2013

Mice deficient in cystathionine beta synthase display increased Dyrk1A and SAHH activities in brain.

J Mol Neurosci 2013 May 15;50(1):1-6. Epub 2012 Jun 15.

Unit of Functional and Adaptative Biology, University of Paris Diderot, Sorbonne Paris Cité, EAC-CNRS 4413, 75013 Paris, France.

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http://dx.doi.org/10.1007/s12031-012-9835-0DOI Listing
May 2013

Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice.

Eur J Nutr 2013 Apr 17;52(3):1243-50. Epub 2012 Aug 17.

Laboratoire BFA, Unit of Functional and Adaptive Biology (BFA), Université Paris Diderot-CNRS EAC 4413, Paris 7, Case 7104, 3 rue Marie-Andrée Lagroua Weill Hallé, 75205, Paris cedex 13, France.

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http://dx.doi.org/10.1007/s00394-012-0435-0DOI Listing
April 2013

Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice.

Mol Neurobiol 2013 Feb 26;47(1):105-16. Epub 2012 Aug 26.

Unit of Functional and Adaptive Biology (BFA), Univ Paris Diderot, Sorbonne Paris Cité, EAC-CNRS 4413, Case 7104, 75205, Paris, cedex 13, France.

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http://dx.doi.org/10.1007/s12035-012-8326-1DOI Listing
February 2013

Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf2 dependent mechanism.

Mol Genet Metab 2012 Mar 2;105(3):484-8. Epub 2011 Dec 2.

Univ Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), Case 7104, 75205 Paris cedex 13, France.

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http://dx.doi.org/10.1016/j.ymgme.2011.11.194DOI Listing
March 2012

Protection and reversal of hepatic fibrosis by red wine polyphenols in hyperhomocysteinemic mice.

J Nutr Biochem 2011 Sep 24;22(9):856-64. Epub 2010 Dec 24.

Unit of Functional and Adaptive Biology (BFA), Université Paris Diderot-CNRS EAC 4413, Case 7104, 75205 Paris Cedex 13, France.

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http://dx.doi.org/10.1016/j.jnutbio.2010.07.010DOI Listing
September 2011

Effect of red wine polyphenol dietary supplementation on two phase II enzymes in liver of hyperhomocysteinemic mice.

Food Chem Toxicol 2011 Aug 28;49(8):1764-9. Epub 2011 Apr 28.

Laboratory of Gene Dysregulation and Differentiation, Univ. Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), 75205 Paris cedex 13, France.

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http://dx.doi.org/10.1016/j.fct.2011.04.024DOI Listing
August 2011

Early reduction of circulating homocysteine levels in Goto-Kakizaki rat, a spontaneous nonobese model of type 2 diabetes.

Biochim Biophys Acta 2011 Jun 5;1812(6):699-702. Epub 2011 Apr 5.

Laboratory of Gene Dysregulation and Differentiation, Université Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), Case 7104, 75205 Paris Cedex 13, France.

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https://linkinghub.elsevier.com/retrieve/pii/S09254439110006
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http://dx.doi.org/10.1016/j.bbadis.2011.03.011DOI Listing
June 2011

Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats.

Mol Cell Biochem 2011 Jan 12;347(1-2):63-70. Epub 2010 Oct 12.

Univ Paris Diderot-CNRS EAC 4413, unité de Biologie Fonctionnelle et Adaptative, Case 7104, 75205, Paris cedex 13, France.

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http://dx.doi.org/10.1007/s11010-010-0612-5DOI Listing
January 2011

Cadmium alters the biotransformation of carcinogenic aromatic amines by arylamine N-acetyltransferase xenobiotic-metabolizing enzymes: molecular, cellular, and in vivo studies.

Environ Health Perspect 2010 Dec 1;118(12):1685-91. Epub 2010 Sep 1.

Université Paris Diderot-Paris 7, Unité de Biologie Fonctionnelle et Adaptative, Centre National de la Recherche Scientifique, Paris, France.

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http://dx.doi.org/10.1289/ehp.1002334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002187PMC
December 2010

Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats.

Int J Cardiol 2010 Nov 10;145(2):306-307. Epub 2009 Nov 10.

University Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2009.10.043DOI Listing
November 2010

Calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor I kappa B alpha.

Mol Genet Metab 2009 Jun 26;97(2):114-20. Epub 2009 Feb 26.

Université Paris Diderot-CNRS, Unit of Functional and Adaptive Biology (BFA), Case 7104, 75205 Paris cedex 13, France.

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http://dx.doi.org/10.1016/j.ymgme.2009.02.005DOI Listing
June 2009

Resveratrol supplementation worsen the dysregulation of genes involved in hepatic lipid homeostasis observed in hyperhomocysteinemic mice.

Food Chem Toxicol 2009 Jan 7;47(1):230-6. Epub 2008 Nov 7.

Université Paris Diderot-Paris 7, Case 7104, 2 Place Jussieu, 75251 Paris Cedex 05, EA 3508, Paris, France.

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http://dx.doi.org/10.1016/j.fct.2008.11.005DOI Listing
January 2009

Effect of hyperhomocysteinemia on the protein kinase DYRK1A in liver of mice.

Biochem Biophys Res Commun 2009 Jan 6;378(3):673-7. Epub 2008 Dec 6.

EA 3508 - case 7104, Univ Paris Diderot, 75205 Paris cedex 13, France.

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http://dx.doi.org/10.1016/j.bbrc.2008.11.126DOI Listing
January 2009

Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver.

Biochim Biophys Acta 2008 Jul-Aug;1782(7-8):482-8. Epub 2008 May 23.

EA 3508, Université Paris Diderot - Paris 7, Paris, France.

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http://dx.doi.org/10.1016/j.bbadis.2008.05.003DOI Listing
August 2008

Identification of the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 as a new target of cisplatin in breast cancer cells: molecular and cellular mechanisms of inhibition.

Mol Pharmacol 2008 Jun 29;73(6):1761-8. Epub 2008 Feb 29.

Laboratoire de Cytophysiologie et Toxicologie Cellulaire (EA 1553), Université Paris Diderot-Paris 7, 75005, Paris, France.

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http://dx.doi.org/10.1124/mol.108.045328DOI Listing
June 2008

Mice lacking cystathionine beta synthase have lung fibrosis and air space enlargement.

Exp Mol Pathol 2007 Oct 6;83(2):249-53. Epub 2007 May 6.

EA 3508, Université Paris Diderot, Paris 7, Case 7104, 2 Place Jussieu, 75251 Paris cedex 05, Paris, France.

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http://dx.doi.org/10.1016/j.yexmp.2007.04.005DOI Listing
October 2007

Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway.

Mol Genet Metab 2007 Aug 11;91(4):396-8. Epub 2007 Jun 11.

INSERM U724, Faculte de Médecine, Vandoeuvre-lès-Nancy, France.

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http://dx.doi.org/10.1016/j.ymgme.2007.05.002DOI Listing
August 2007

Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis.

Proc Natl Acad Sci U S A 2007 Apr 30;104(15):6229-34. Epub 2007 Mar 30.

Unité de Génétique des Déficits Sensoriels, Unité Mixte de Recherche S 587, Institut National de la Santé et de la Recherche Médicale, 75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1073/pnas.0605108104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851033PMC
April 2007

Effects of catechin on homocysteine metabolism in hyperhomocysteinemic mice.

Biochem Biophys Res Commun 2007 Mar 2;355(1):221-7. Epub 2007 Feb 2.

EA 3508, Université Paris 7-Denis Diderot, Case 7104, 2 Place Jussieu, 75251 Paris Cedex 05, France.

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http://dx.doi.org/10.1016/j.bbrc.2007.01.142DOI Listing
March 2007

Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice.

J Hepatol 2007 Jan 22;46(1):151-9. Epub 2006 Sep 22.

EA 3508, Université Paris 7 - Denis Diderot, Case 7104, 2 Place Jussieu, 75251 Paris cedex 05, France.

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http://dx.doi.org/10.1016/j.jhep.2006.07.028DOI Listing
January 2007

Thiol compounds metabolism in mice, rats and humans: comparative study and potential explanation of rodents protection against vascular diseases.

Clin Chim Acta 2006 Oct 7;372(1-2):140-6. Epub 2006 Apr 7.

Assistance Publique-Hôpitaux de Paris, Service de Biochimie, Hôpital Européen Georges Pompidou, Paris, France.

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http://dx.doi.org/10.1016/j.cca.2006.03.035DOI Listing
October 2006

Paraoxonase-1 expression is up-regulated in Down syndrome fetal liver.

Biochem Biophys Res Commun 2006 Aug 16;346(4):1303-6. Epub 2006 Jun 16.

EA 3508, Université Paris 7--Denis Diderot, Paris, France.

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http://dx.doi.org/10.1016/j.bbrc.2006.06.048DOI Listing
August 2006

Plasma homocysteine levels are not increased in murine models of Alzheimer's disease.

Neurosci Res 2005 Dec 6;53(4):447-9. Epub 2005 Oct 6.

Central Nervous System Department, Aventis, France.

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http://dx.doi.org/10.1016/j.neures.2005.09.001DOI Listing
December 2005

Cystathionine beta synthase deficiency affects mouse endochondral ossification.

Anat Rec A Discov Mol Cell Evol Biol 2005 Jan;282(1):1-7

EA 3508, University of Paris 7, Denis Diderot, 2 Place Jussieu, 75251 Paris Cedex 05, France.

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http://dx.doi.org/10.1002/ar.a.20145DOI Listing
January 2005

Hyperkeratosis in cystathionine beta synthase-deficient mice: an animal model of hyperhomocysteinemia.

Anat Rec A Discov Mol Cell Evol Biol 2004 Oct;280(2):1072-6

EA 3508, University of Paris 7, Denis Diderot, 75251 Paris 05, France.

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http://doi.wiley.com/10.1002/ar.a.20082
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http://dx.doi.org/10.1002/ar.a.20082DOI Listing
October 2004

Altered gene expression in liver from a murine model of hyperhomocysteinemia.

J Biol Chem 2003 Aug 10;278(34):31504-11. Epub 2003 Jun 10.

EA 3508, Université Paris 7, Denis Diderot, Case 7104, 2 Place Jussieu, 75251 Paris Cedex, France.

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http://dx.doi.org/10.1074/jbc.M213036200DOI Listing
August 2003