Nathalie Grandvaux

Nathalie Grandvaux

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Nathalie Grandvaux

Nathalie Grandvaux

Publications by authors named "Nathalie Grandvaux"

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Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes.

Front Immunol 2018 15;9:256. Epub 2018 Feb 15.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

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http://dx.doi.org/10.3389/fimmu.2018.00256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818456PMC
March 2019

Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome.

Trends Pharmacol Sci 2019 02 31;40(2):116-127. Epub 2018 Dec 31.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2018.12.003DOI Listing
February 2019

CSV2018: The 2nd Symposium of the Canadian Society for Virology.

Viruses 2019 01 18;11(1). Epub 2019 Jan 18.

Department of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, Canada.

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http://dx.doi.org/10.3390/v11010079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356965PMC
January 2019

Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function.

Proc Natl Acad Sci U S A 2018 01 9;115(4):E601-E609. Epub 2018 Jan 9.

European Molecular Biology Laboratory, 38042 Grenoble, France;

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http://dx.doi.org/10.1073/pnas.1718426115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789952PMC
January 2018

Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight.

Viruses 2018 01 30;10(2). Epub 2018 Jan 30.

CRCHUM-Centre Hospitalier de l'Université de Montréal, 900 rue Saint Denis, Montréal, QC H2X 0A9, Canada.

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http://dx.doi.org/10.3390/v10020056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850363PMC
January 2018

Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.

BMC Cancer 2017 05 22;17(1):356. Epub 2017 May 22.

CRCHUM - Centre de recherche du Centre Hospitalier de l'Université de Montréal, 900 rue Saint-Denis, Montréal, Qc H2X 0A9, Canada.

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http://dx.doi.org/10.1186/s12885-017-3321-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441089PMC
May 2017

1st Workshop of the Canadian Society for Virology.

Viruses 2017 03 20;9(3). Epub 2017 Mar 20.

Département de Biochimie et Médecine Moléculaire, Université de Montréal, QC H3C 3J7, Canada.

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http://www.mdpi.com/1999-4915/9/3/54
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http://dx.doi.org/10.3390/v9030054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371809PMC
March 2017

Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology.

Viruses 2016 05 12;8(5). Epub 2016 May 12.

CRCHUM-Centre Hospitalier de l'Université de Montréal, Montréal, QC H2X 0A9, Canada.

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http://dx.doi.org/10.3390/v8050124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885079PMC
May 2016

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3.

J Vis Exp 2016 Jan 24(107):e53723. Epub 2016 Jan 24.

CRCHUM - Research center, Centre Hospitalier de l'Université de Montréal, Université de Montréal; Department of Biochemistry and Molecular Medicine, Université de Montréal; Faculty of Medicine, Université de Montréal;

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http://dx.doi.org/10.3791/53723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781702PMC
January 2016

Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines.

Redox Biol 2015 Dec 23;6:9-18. Epub 2015 Jun 23.

CRCHUM - Centre Hospitalier de l'Université de Montréal, 900 Rue Saint Denis, Montréal, QC, Canada H2X 0A9; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada H3C 3J7. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2015.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511630PMC
December 2015

Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.

PLoS One 2014 9;9(6):e99211. Epub 2014 Jun 9.

Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal and Institut du Cancer de Montréal, Montréal, Québec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099211PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050125PMC
July 2015

Lung epithelial NOX/DUOX and respiratory virus infections.

Clin Sci (Lond) 2015 Mar;128(6):337-47

*CRCHUM-Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada, H2X 0A9.

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http://dx.doi.org/10.1042/CS20140321DOI Listing
March 2015

Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective.

Trends Microbiol 2013 Nov 9;21(11):568-74. Epub 2013 Oct 9.

Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada; Child & Family Research Institute, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.1016/j.tim.2013.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848032PMC
November 2013

STAT2 and IRF9: Beyond ISGF3.

JAKSTAT 2013 Oct 18;2(4):e27521. Epub 2013 Dec 18.

CRCHUM-Centre de Recherche du Centre Hospitalier de l'Université de Montréal; Montréal, QC Canada ; Department of Biochemistry; Faculty of Medicine; Université de Montréal; Montréal, QC Canada.

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http://dx.doi.org/10.4161/jkst.27521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906322PMC
October 2013

2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV.

J Leukoc Biol 2013 Feb 12;93(2):267-76. Epub 2012 Dec 12.

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Département de Médecine, Québec City, Canada.

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http://dx.doi.org/10.1189/jlb.0412200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995105PMC
February 2013

Individual interferon regulatory factor-3 thiol residues are not critical for its activation following virus infection.

J Interferon Cytokine Res 2012 Sep 20;32(9):393-400. Epub 2012 Jul 20.

CRCHUM-Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1089/jir.2012.0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438828PMC
September 2012

Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients.

J Hepatol 2012 Jan 9;56(1):70-7. Epub 2011 Aug 9.

Institut de Recherche en Immunologie et en Cancérologie (IRIC), Université de Montréal, Québec, Canada H3T 1J4.

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http://dx.doi.org/10.1016/j.jhep.2011.07.017DOI Listing
January 2012

Regulation of normal and cystic fibrosis airway epithelial repair processes by TNF-α after injury.

Am J Physiol Lung Cell Mol Physiol 2011 Dec 9;301(6):L945-55. Epub 2011 Sep 9.

Centre de recherche, Centre hospitalier de l’Université de Montréal, Hôtel-Dieu, Montréal, Québec, Canada.

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http://dx.doi.org/10.1152/ajplung.00149.2011DOI Listing
December 2011

The ribonucleotide reductase R1 subunits of herpes simplex virus 1 and 2 protect cells against poly(I · C)-induced apoptosis.

J Virol 2011 Sep 22;85(17):8689-701. Epub 2011 Jun 22.

Centre de Recherche, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.00362-11
Publisher Site
http://dx.doi.org/10.1128/JVI.00362-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165841PMC
September 2011

[The IKKε kinase in breast cancer: from oncogenesis to treatment resistance].

Med Sci (Paris) 2011 Jun-Jul;27(6-7):619-25. Epub 2011 Jul 1.

Chaire de recherche du Canada en signalisation et infections virales, centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Hôpital Saint-Luc, 264, boulevard René Lévesque Est, PEA 311 Montréal (Québec), H2X 1P1, Canada.

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http://dx.doi.org/10.1051/medsci/2011276014DOI Listing
September 2011

Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta.

J Virol 2010 Jul 21;84(14):7267-77. Epub 2010 Apr 21.

Centre de recherche du CHUM-Hôpital St Luc, 264 René Levesque-Est, PEA 311, Montréal, Quebec H2X 1P1, Canada.

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http://dx.doi.org/10.1128/JVI.00142-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898247PMC
July 2010

Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease.

J Hepatol 2010 Feb 27;52(2):167-75. Epub 2009 Nov 27.

Laboratoire d'immunologie virale, Centre de Recherche du CHUM (CRCHUM), Hôpital Saint-Luc, 264 René Levesque-Est, PEA 312, Québec, Canada.

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http://dx.doi.org/10.1016/j.jhep.2009.11.011DOI Listing
February 2010

Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells.

J Immunol 2008 May;180(10):6911-22

Centre Hospitalier de l'Université de Montréal Research Center- St-Luc Hospital and Institut National de la Santé et de la Recherche Médicale Unité 743, Montreal, Quebec, Canada.

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http://dx.doi.org/10.4049/jimmunol.180.10.6911DOI Listing
May 2008

Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients.

Blood 2007 Nov 23;110(10):3722-8. Epub 2007 Aug 23.

Laboratoire de Virologie-Immunologie and Jeune Equipe (JE) 2503, Centre Hospitalier Universitaire de Fort-de-France, Fort-de-France, Martinique, France.

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http://dx.doi.org/10.1182/blood-2007-04-085076DOI Listing
November 2007

Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression.

J Virol 2007 Oct 25;81(20):10950-60. Epub 2007 Jul 25.

Rheumatology and Immunology Research Center, Room T1-49, 2705 Laurier Blvd., Quebec, Quebec G1V 4G2, Canada.

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http://dx.doi.org/10.1128/JVI.00183-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045525PMC
October 2007

Synergistic activation of interferon-beta gene transcription by the viral FLICE inhibitory protein of Kaposi's sarcoma-associated herpesvirus and type I IFN activators.

Eur J Immunol 2007 Oct;37(10):2772-8

Laboratory of Virology, Rheumatology and Immunology Research Center, CHUL Research Center and Faculty of Medicine, Laval University, Quebec, Canada.

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http://dx.doi.org/10.1002/eji.200737181DOI Listing
October 2007

Innate host defense: Nox and Duox on phox's tail.

Biochimie 2007 Sep 21;89(9):1113-22. Epub 2007 Apr 21.

Department of Biochemistry, Faculty of Medicine and Unite INSERM U743, Centre de recherche du CHUM-Hôpital St Luc, University of Montreal, 264 Rene Levesque-est, PEA 311, Montreal, Quebec, Canada H2X 1P1.

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http://dx.doi.org/10.1016/j.biochi.2007.04.008DOI Listing
September 2007

Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein.

J Virol 2007 Jun 21;81(11):5737-48. Epub 2007 Mar 21.

Rheumatology and Immunology Research Center, Room T1-49, 2705 Laurier Blvd., Quebec, Quebec, Canada G1V 4G2.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.02443-06
Publisher Site
http://dx.doi.org/10.1128/JVI.02443-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900312PMC
June 2007

Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.

J Immunol 2006 Aug;177(4):2527-35

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 chemin de la Cote Sainte Catherine, Montréal, Québec, Canada.

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http://dx.doi.org/10.4049/jimmunol.177.4.2527DOI Listing
August 2006

Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes.

J Mol Biol 2006 Feb 28;355(5):898-910. Epub 2005 Nov 28.

Molecular Oncology Group Lady Davis Institute for Medical Research, Montréal, QC, Canada, H3T 1E2.

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http://dx.doi.org/10.1016/j.jmb.2005.11.026DOI Listing
February 2006

Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.

J Virol 2005 Jul;79(14):9180-91

McGill AIDS Center, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, 3755 Cote Ste. Catherine, Montreal, Quebec, Canada H3T1E2.

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http://dx.doi.org/10.1128/JVI.79.14.9180-9191.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168763PMC
July 2005

Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response.

FEBS J 2005 Jun;272(12):3120-31

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Canada.

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http://dx.doi.org/10.1111/j.1742-4658.2005.04726.xDOI Listing
June 2005

Cryptic O2- -generating NADPH oxidase in dendritic cells.

J Cell Sci 2004 May;117(Pt 11):2215-26

Laboratoire de Biochimie et Biophysique des Systèmes Intégrés (UMR 5092 CNRS-CEA-UJF), Département Réponse et Dynamique Cellulaires, CEA-Grenoble, Grenoble Cedex, France.

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http://dx.doi.org/10.1242/jcs.01085DOI Listing
May 2004

Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis.

Ann N Y Acad Sci 2003 Dec;1010:237-48

Lady Davis Institute for Medical Research, Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Canada H3T 1E2.

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http://dx.doi.org/10.1196/annals.1299.042DOI Listing
December 2003

Triggering the interferon antiviral response through an IKK-related pathway.

Science 2003 May 17;300(5622):1148-51. Epub 2003 Apr 17.

Lady Davis Institute for Medical Research-Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1126/science.1081315DOI Listing
May 2003

Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

J Biol Chem 2003 Mar 10;278(11):9441-7. Epub 2003 Jan 10.

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and the Departments of Microbiology & Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1074/jbc.M209851200DOI Listing
March 2003

Repression of IRF-4 target genes in human T cell leukemia virus-1 infection.

Oncogene 2002 Oct;21(44):6751-65

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology and Immunology, McGill University, Montreal, Canada H3T 1E2.

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http://dx.doi.org/10.1038/sj.onc.1205843DOI Listing
October 2002

Multiple signaling pathways leading to the activation of interferon regulatory factor 3.

Biochem Pharmacol 2002 Sep;64(5-6):985-92

Terry Fox Molecular Oncology Group, Lady Davis Institute-Jewish General Hospital, McGill University, 3755 Cote Ste., Catherine Montreal, Que., Canada.

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http://dx.doi.org/10.1016/s0006-2952(02)01165-6DOI Listing
September 2002

Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells.

J Immunol 2002 Sep;169(6):3120-30

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada.

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http://dx.doi.org/10.4049/jimmunol.169.6.3120DOI Listing
September 2002

The interferon antiviral response: from viral invasion to evasion.

Curr Opin Infect Dis 2002 Jun;15(3):259-67

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, Quebec, Canada.

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http://pdfs.journals.lww.com/co-infectiousdiseases/2002/0600
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http://dx.doi.org/10.1097/00001432-200206000-00008DOI Listing
June 2002

Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation.

J Virol 2002 Apr;76(8):3659-69

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136070PMC
http://dx.doi.org/10.1128/jvi.76.8.3659-3669.2002DOI Listing
April 2002

IRF-4 activities in HTLV-I-induced T cell leukemogenesis.

J Interferon Cytokine Res 2002 Jan;22(1):135-43

Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology & Immunology, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1089/107999002753452746DOI Listing
January 2002