Natasha Leighl

Natasha Leighl

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Natasha Leighl

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Immune checkpoint-inhibitors and chemoradiation in stage III unresectable non-small cell lung cancer.

Lung Cancer 2019 Aug 29;134:259-267. Epub 2019 May 29.

Cross Cancer Institute and University of Alberta, 11560 University Ave, Edmonton, AB, T6G 1Z2, Canada.

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http://dx.doi.org/10.1016/j.lungcan.2019.05.027DOI Listing
August 2019

Systemic Therapy Use and Outcomes After Relapse from Preoperative Radiation and Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma.

Oncologist 2019 Jul 26;24(7):e510-e517. Epub 2018 Nov 26.

Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1634/theoncologist.2018-0501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656469PMC
July 2019

Financial Burden Among Patients With Lung Cancer in a Publically Funded Health Care System.

Clin Lung Cancer 2019 Jul 22;20(4):231-236. Epub 2018 Dec 22.

Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cllc.2018.12.010DOI Listing
July 2019

Adherence to human epidermal growth factor receptor-2 testing and adjuvant trastuzumab treatment guidelines in Ontario.

J Oncol Pharm Pract 2019 Jun 2:1078155219850299. Epub 2019 Jun 2.

4 Canadian Centre for Applied Research in Cancer Control (ARCC), Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1177/1078155219850299DOI Listing
June 2019

Advantages of the net benefit regression framework for trial-based economic evaluations of cancer treatments: an example from the Canadian Cancer Trials Group CO.17 trial.

BMC Cancer 2019 Jun 7;19(1):552. Epub 2019 Jun 7.

Division of Health Policy and Management, Department of Public Health Sciences and Associate Director, Center for Healthcare Policy and Research, 2103 Stockton Blvd, Sacramento, CA, 95817, USA.

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http://dx.doi.org/10.1186/s12885-019-5779-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555934PMC
June 2019

Effect of Coexisting KRAS and TP53 Mutations in Patients Treated With Chemotherapy for Non-small-cell Lung Cancer.

Clin Lung Cancer 2019 May 19;20(3):e338-e345. Epub 2018 Dec 19.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network and Department of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.cllc.2018.12.009DOI Listing
May 2019

Amplifying Outcomes: Checkpoint Inhibitor Combinations in First-Line Non-Small Cell Lung Cancer.

Oncologist 2019 May 28. Epub 2019 May 28.

Cross Cancer Institute and Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2019-0027DOI Listing
May 2019

Emerging therapies for non-small cell lung cancer.

J Hematol Oncol 2019 Apr 25;12(1):45. Epub 2019 Apr 25.

Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, People's Republic of China.

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https://jhoonline.biomedcentral.com/articles/10.1186/s13045-
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http://dx.doi.org/10.1186/s13045-019-0731-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482588PMC
April 2019

Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.

Oncotarget 2019 Mar 5;10(19):1760-1774. Epub 2019 Mar 5.

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.18632/oncotarget.26678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442994PMC
March 2019

Improving lung cancer diagnosis: the evolving role of patients and care providers.

J Thorac Dis 2019 Mar;11(Suppl 3):S422-S424

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.21037/jtd.2018.11.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424746PMC
March 2019

The role of cytology in molecular testing and personalized medicine in lung cancer: A clinical perspective.

Cancer Cytopathol 2019 Feb 4;127(2):72-78. Epub 2018 Dec 4.

Division of Medical Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/cncy.22085
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http://dx.doi.org/10.1002/cncy.22085DOI Listing
February 2019

The Role of Angiogenesis Inhibitors in the Era of Immune Checkpoint Inhibitors and Targeted Therapy in Metastatic Non-Small Cell Lung Cancer.

Curr Treat Options Oncol 2019 Feb 18;20(3):21. Epub 2019 Feb 18.

Princess Margaret Cancer Centre, Division of Medical Oncology, University of Toronto, 7-913 700 University Avenue, Toronto, ON, M5G 1Z5, Canada.

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http://dx.doi.org/10.1007/s11864-019-0617-6DOI Listing
February 2019

The Value of Biomarkers in Optimizing the Use of Immuno-oncologic Therapy.

Curr Drug Targets 2019 ;20(1):81-86

Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.2174/1389450119666180911093143DOI Listing
January 2019

Economic analysis of osimertinib in previously untreated EGFR-mutant advanced non-small cell lung cancer in Canada.

Lung Cancer 2018 11 30;125:1-7. Epub 2018 Aug 30.

Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.lungcan.2018.08.024DOI Listing
November 2018

Rationale and Protocol for a Canadian Multicenter Phase II Randomized Trial Assessing Selective Metabolically Adaptive Radiation Dose Escalation in Locally Advanced Non-small-cell Lung Cancer (NCT02788461).

Clin Lung Cancer 2018 09 16;19(5):e699-e703. Epub 2018 May 16.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2018.05.002DOI Listing
September 2018

The prognostic effect of single and multiple cancer-related somatic mutations in resected non-small-cell lung cancer.

Lung Cancer 2018 09 19;123:22-29. Epub 2018 Jun 19.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183043
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http://dx.doi.org/10.1016/j.lungcan.2018.06.023DOI Listing
September 2018

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Authors:
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert Chu Chen M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D Tobin Louise V Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I Amos

Nat Commun 2018 08 13;9(1):3221. Epub 2018 Aug 13.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.

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http://dx.doi.org/10.1038/s41467-018-05074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967PMC
August 2018

CNS Response to Osimertinib Versus Standard Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.

J Clin Oncol 2018 Aug 28:JCO2018783118. Epub 2018 Aug 28.

Thanyanan Reungwetwattana, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Kazuhiko Nakagawa, Kindai University School of Medicine, Osaka; Naoyuki Nogami, National Hospital Organization Shikoku Cancer Center, Matsuyama; Isamu Okamoto, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Byoung Chul Cho, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Eun Kyung Cho, Gachon University Gil Medical Center, Incheon; Ki Hyeong Lee, Chungbuk National University Hospital, Cheong-ju, Republic of Korea; Manuel Cobo, Institute of Biomedical Research in Málaga, Málaga University Hospital Regional, Málaga, Spain; Alessandro Bertolini, Hospital of Sondrio, Sondrio, Italy; Sabine Bohnet, Universitätsklinik Schleswig-Holstein, Lübeck, Germany; Caicun Zhou, Pulmonary Hospital of Tongji University, Shanghai, People's Republic of China; Natasha Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Rachel Hodge, Astrid McKeown, Andrew P. Brown, and Yuri Rukazenkov, AstraZeneca, Cambridge, United Kingdom; Suresh S. Ramalingam, Winship Cancer Institute, Emory University, Atlanta, GA; and Johan Vansteenkiste, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1200/JCO.2018.78.3118DOI Listing
August 2018

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.

J Clin Oncol 2018 06 14;36(17):1714-1768. Epub 2018 Feb 14.

Julie R. Brahmer, Johns Hopkins Kimmel Cancer Center; Jennifer S. Mammen, Johns Hopkins University, Baltimore, MD; Christina Lacchetti, American Society of Clinical Oncology, Alexandria; Alexander Spira, Virginia Cancer Specialists and US Oncology Research, Fairfax, VA; Bryan J. Schneider, University of Michigan Health System, Ann Arbor, MI; Michael B. Atkins, Georgetown Lombardi Comprehensive Cancer Center; Cristina A. Reichner, Georgetown University; Laura D. Porter, Colon Cancer Alliance; Washington, DC; Kelly J. Brassil, Aung Naing, Loretta J. Nastoupil, Maria E. Suarez-Almazor, and Yinghong Wang, MD Anderson Cancer Center, Houston, TX; Jeffrey M. Caterino, The Ohio State University Wexner Medical Center, Columbus, OH; Ian Chau, The Royal Marsden Hospital and Institute of Cancer Research, London and Surrey, United Kingdom; Marc S. Ernstoff and Igor Puzanov, Roswell Park Cancer Institute, Buffalo; Bianca D. Santomasso and Jedd D. Wolchok, Memorial Sloan Kettering Cancer Center; Jeffrey S. Weber, New York University Langone Medical Center, New York, NY; Pamela Ginex, Oncology Nursing Society, Pittsburgh, PA; Jennifer M. Gardner, Seattle Cancer Care Alliance and University of Washington, Seattle, WA; Sigrun Hallmeyer, Oncology Specialists SC, Park Ridge, IL; Jennifer Holter Chakrabarty, University of Oklahoma, Stephenson Cancer Center, Oklahoma City, OK; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; David F. McDermott, Beth Israel Deaconess Medical Center; Carole Seigel, Massachusetts General Hospital Cancer Center, Boston, MA; John A. Thompson, Seattle Cancer Care Alliance, University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle, WA; and Tanyanika Phillips, CHRISTUS St Frances Cabrini Cancer Center, Alexandria, LA.

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http://dx.doi.org/10.1200/JCO.2017.77.6385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481621PMC
June 2018

Systemic Therapy of Lung Cancer CNS Metastases Using Molecularly Targeted Agents and Immune Checkpoint Inhibitors.

CNS Drugs 2018 06;32(6):527-542

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, 7W-389, 700 University Avenue, Toronto, ON, M5G 1Z5, Canada.

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http://link.springer.com/10.1007/s40263-018-0526-4
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http://dx.doi.org/10.1007/s40263-018-0526-4DOI Listing
June 2018

Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population.

Carcinogenesis 2018 03;39(3):336-346

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.1093/carcin/bgx113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248554PMC
March 2018

Molecular Testing Guideline for the Selection of Patients With Lung Cancer for Treatment With Targeted Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Clinical Practice Guideline Update.

J Clin Oncol 2018 03 5;36(9):911-919. Epub 2018 Feb 5.

Gregory P. Kalemkerian and Madelyn Lew, University of Michigan, Ann Arbor; James Pantelas, Greater Detroit Area; Michael Simoff, Henry Ford Hospital, Detroit, MI; Navneet Narula, Weill Cornell Medical College; Jessica Donington, New York University School of Medicine: Anjali Saqi, Columbia University Medical Center, New York, NY; Erin B. Kennedy, American Society of Clinical Oncology, Alexandria, VA; William A. Biermann, Chestnut Hill Hospital and Mercy Suburban Hospital, East Norriton; Baskaran Sundaram, Thomas Jefferson Medical School, Philadelphia, PA; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, ON, Canada; Suresh S. Ramalingam, Winship Cancer Institute of Emory University, Atlanta, GA; Martin Reck, Lung Clinic Grosshansdorf, Grosshansdorf, Germany; and Navneet Singh, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://ascopubs.org/doi/10.1200/JCO.2017.76.7293
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http://dx.doi.org/10.1200/JCO.2017.76.7293DOI Listing
March 2018

Personalized medicine for non-small cell lung cancer: where are we now and where can we go?

Expert Rev Respir Med 2018 02 5;12(2):81-82. Epub 2017 Dec 5.

a Division of Medical Oncology and Hematology , Princess Margaret Cancer Centre/University Health Network , Toronto , Canada.

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http://dx.doi.org/10.1080/17476348.2018.1411805DOI Listing
February 2018

Radical Treatment of Stage II Non-small-cell Lung Cancer With Nonsurgical Approaches: A Multi-institution Report of Outcomes.

Clin Lung Cancer 2018 01 21;19(1):e11-e18. Epub 2017 Jun 21.

Division of Medical Oncology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2017.06.007DOI Listing
January 2018

Chemotherapy and radiation treatment decision-making experiences of older adults with cancer: A qualitative study.

J Geriatr Oncol 2018 01 19;9(1):47-52. Epub 2017 Aug 19.

Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jgo.2017.07.013DOI Listing
January 2018

Economic Considerations in the Use of Novel Targeted Therapies for Lung Cancer: Review of Current Literature.

Pharmacoeconomics 2017 Dec;35(12):1195-1209

Princess Margaret Cancer Center, University Health Network, c/o 700 University Avenue, Room 7-913, Toronto, ON, M5G 1Z5, Canada.

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http://dx.doi.org/10.1007/s40273-017-0563-8DOI Listing
December 2017

Case for Stopping Targeted Therapy When Lung Cancer Progresses on Treatment in Hospice-Eligible Patients.

J Oncol Pract 2017 12 5;13(12):780-783. Epub 2017 Oct 5.

Johns Hopkins, Baltimore, MD; Indiana University, Bloomington, IN; UT Southwestern Medical School, Dallas, TX; Virginia Commonwealth University Massey Cancer Center, Richmond; Inova Schar Cancer Institute, Falls Church; ASCO, Alexandria, VA; Einstein Medical Center, Philadelphia, PA; Juravinski Cancer Centre, Hamilton; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Lombardi Cancer Center, Washington, DC; Lahey Hospital & Medical Center, Burlington, MA; William Beaumont Hospital, Royal Oak; University of Michigan, Ann Arbor, MI; Memorial Sloan Kettering Cancer Center, New York, NY; Circle of Hope for Cancer Research, St Cloud, FL; and Helen F. Graham Cancer Center, Newark, DE.

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http://dx.doi.org/10.1200/JOP.2017.027367DOI Listing
December 2017

Nintedanib Plus Pemetrexed/Cisplatin in Patients With Malignant Pleural Mesothelioma: Phase II Results From the Randomized, Placebo-Controlled LUME-Meso Trial.

J Clin Oncol 2017 Nov 11;35(31):3591-3600. Epub 2017 Sep 11.

Federica Grosso, Azienda Ospedaliera SS Antonio e Biagio General Hospital, Alessandria; Silvia Novello and Giorgio Scagliotti, L'università di Torino, Azienda Sanitaria Ospedale San Luigi Gonzaga, Turin, Italy; Anna K. Nowak, University of Western Australia, Crawley, and Sir Charles Gairdner Hospital, Nedlands, Western Australia; Thomas John, Olivia Newton-John Cancer Research Institute, Austin Hospital, Heidelberg, Victoria, Australia; Sanjay Popat, The Royal Marsden Hospital National Health Service (NHS) Foundation Trust, London; Nicola Steele, The Beatson West of Scotland Cancer Centre, Glasgow; Paul Taylor, University Hospitals of South Manchester NHS Trust, Wythenshawe, Manchester, United Kingdom; Laurent Greillier, Assitance Publique Hôpitaux de Marseille, Aix Marseille University, Marseille; David Planchard, Institut Gustave Roussy, Villejuif; Nassim Morsli, Boehringer Ingelheim France S.A.S., Paris, France; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Martin Reck, Lung Clinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf; Ute von Wangenheim, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; Jens Benn Sørensen, Rigshospitalet - Finsencentret, Copenhagen, Denmark; Mark A. Socinski, Florida Hospital Cancer Institute, Orlando, FL; Arsène Bienvenu Loembé, Boehringer Ingelheim B.V., Alkmaar, the Netherlands; and José Barrueco, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT.

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http://dx.doi.org/10.1200/JCO.2017.72.9012DOI Listing
November 2017

Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.

J Clin Oncol 2017 Oct 14;35(30):3484-3515. Epub 2017 Aug 14.

Nasser Hanna, Indiana University Simon Cancer Center, Indianapolis, IN; David Johnson, University of Texas Southwestern Medical Center, Dallas, TX; Sarah Temin, American Society of Clinical Oncology, Alexandria; Sherman Baker Jr, Virginia Commonwealth University Health System Massey Cancer Center, Richmond; Joan H. Schiller, Inova Schar Cancer Institute, Fairfax, VA; Julie Brahmer and Thomas J. Smith, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD; Peter M. Ellis, Juravinski Cancer Centre, Hamilton; Natasha B. Leighl, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Giuseppe Giaccone, Georgetown University, Washington, DC; Paul J. Hesketh, Lahey Hospital and Medical Center, Burlington, MA; Ishmael Jaiyesimi, William Beaumont Hospital, Royal Oak; Bryan J. Schneider, University of Michigan Health System, Ann Arbor, MI; Gregory J. Riely, Memorial Sloan-Kettering Cancer Center, New York, NY; Joan Tashbar, Circle of Hope for Cancer Research, Orlando, FL; William A. Biermann, Einstein Medical Center Montgomery, East Norriton, PA; and Gregory Masters, Helen F. Graham Cancer Center and Research Institute, Newark, DE.

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http://dx.doi.org/10.1200/JCO.2017.74.6065DOI Listing
October 2017

Brigatinib in Patients With Crizotinib-Refractory Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer: A Randomized, Multicenter Phase II Trial.

J Clin Oncol 2017 Aug 5;35(22):2490-2498. Epub 2017 May 5.

Dong-Wan Kim, Seoul National University Hospital; Myung-Ju Ahn, Samsung Medical Center; Sang-We Kim, Asan Medical Center, Seoul, South Korea; Marcello Tiseo, University Hospital of Parma, Parma, Italy; Karen L. Reckamp, City of Hope, Duarte, CA; Karin Holmskov Hansen, Odense University Hospital, Odense, Denmark; Rudolf M. Huber, University Hospital of Munich, German Centre for Lung Research, Munich, Germany; Howard L. West, Swedish Cancer Institute, Seattle, WA; Harry J.M. Groen, University of Groningen, University Medical Center Groningen, Groningen; Egbert F. Smit, VU University Medical Center, Amsterdam, the Netherlands; Maximilian J. Hochmair, Otto Wagner Hospital, Vienna, Austria; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Scott N. Gettinger, Yale Cancer Center, New Haven, CT; Corey J. Langer, University of Pennsylvania Abramson Cancer Center, Philadelphia, PA; Luis G. Paz-Ares Rodríguez, Hospital Universitario 12 de Octubre, Madrid, Spain; Edward S. Kim, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC; William Reichmann, Frank G. Haluska, and David Kerstein, ARIAD Pharmaceuticals, Cambridge, MA; and D. Ross Camidge, University of Colorado Cancer Center, Aurora, CO.

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http://dx.doi.org/10.1200/JCO.2016.71.5904DOI Listing
August 2017

Do the American Society of Clinical Oncology Value Framework and the European Society of Medical Oncology Magnitude of Clinical Benefit Scale Measure the Same Construct of Clinical Benefit?

J Clin Oncol 2017 Aug 2;35(24):2764-2771. Epub 2017 Jun 2.

Sierra Cheng, Erica J. McDonald, Matthew C. Cheung, Vanessa S. Arciero, Mahin Qureshi, Di Jiang, Natasha Leighl, and Kelvin K.W. Chan, University of Toronto; Mona Sabharwal, Alexandra Chambers, Dolly Han, and Kelley-Anne Sabarre, Canadian Agency for Drugs and Technologies in Health; Kelvin K.W. Chan, Canadian Centre for Applied Research in Cancer Control, Toronto, Ontario; and Doreen Ezeife, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1200/JCO.2016.71.6894DOI Listing
August 2017

Uncommon EGFR mutations in advanced non-small cell lung cancer.

Lung Cancer 2017 07 27;109:137-144. Epub 2017 Apr 27.

Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.lungcan.2017.04.016DOI Listing
July 2017

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Authors:
James D McKay Rayjean J Hung Younghun Han Xuchen Zong Robert Carreras-Torres David C Christiani Neil E Caporaso Mattias Johansson Xiangjun Xiao Yafang Li Jinyoung Byun Alison Dunning Karen A Pooley David C Qian Xuemei Ji Geoffrey Liu Maria N Timofeeva Stig E Bojesen Xifeng Wu Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier Alberto Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher A Haiman Lynne R Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Henricus F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer A Doherty Matt P Barnett Chu Chen Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske H-Erich Wichmann Judith Manz Thomas R Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances A Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard S Houlston John McLaughlin Victoria L Stevens Philippe Joubert Maxime Lamontagne David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song Linda Kachuri María Soler Artigas Martin D Tobin Louise V Wain Thorunn Rafnar Thorgeir E Thorgeirsson Gunnar W Reginsson Kari Stefansson Dana B Hancock Laura J Bierut Margaret R Spitz Nathan C Gaddis Sharon M Lutz Fangyi Gu Eric O Johnson Ahsan Kamal Claudio Pikielny Dakai Zhu Sara Lindströem Xia Jiang Rachel F Tyndale Georgia Chenevix-Trench Jonathan Beesley Yohan Bossé Stephen Chanock Paul Brennan Maria Teresa Landi Christopher I Amos

Nat Genet 2017 Jul 12;49(7):1126-1132. Epub 2017 Jun 12.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1038/ng.3892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510465PMC
July 2017

Review of the use of pretest probability for molecular testing in non-small cell lung cancer and overview of new mutations that may affect clinical practice.

Ther Adv Med Oncol 2017 Jun 26;9(6):405-414. Epub 2017 Apr 26.

Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1758834017704329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455881PMC
June 2017

Evolution of Symptom Burden of Advanced Lung Cancer Over a Decade.

Clin Lung Cancer 2017 05 5;18(3):274-280.e6. Epub 2017 Jan 5.

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2016.12.010DOI Listing
May 2017

Indications for Adjuvant Mediastinal Radiotherapy in Surgically Resected Small Cell Lung Cancer.

Ann Thorac Surg 2017 May 3;103(5):1647-1653. Epub 2017 Mar 3.

Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.athoracsur.2016.11.039DOI Listing
May 2017

Third-Generation Tyrosine Kinase Inhibitors Targeting Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer.

Front Oncol 2017 31;7:113. Epub 2017 May 31.

Department of Medical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fonc.2017.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449484PMC
May 2017

Impact of tumour thickness on survival after radical radiation and surgery in malignant pleural mesothelioma.

Eur Respir J 2017 03 15;49(3). Epub 2017 Mar 15.

Dept of Radiation Oncology, Princess Margaret Cancer Centre and Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01428
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http://dx.doi.org/10.1183/13993003.01428-2016DOI Listing
March 2017

Update on the Treatment of Metastatic Squamous Non-Small Cell Lung Cancer in New Era of Personalized Medicine.

Front Oncol 2017 27;7:50. Epub 2017 Mar 27.

Division of Medical Oncology, Princess Margaret Cancer Centre , Toronto, ON , Canada.

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http://dx.doi.org/10.3389/fonc.2017.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366319PMC
March 2017

Curing Early-Stage Lung Cancer: Is There an Easy Way Out?

J Oncol Pract 2017 02 20;13(2):63-65. Epub 2016 Dec 20.

Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JOP.2016.018309DOI Listing
February 2017

A phase II trial of dovitinib in previously-treated advanced pleural mesothelioma: The Ontario Clinical Oncology Group.

Lung Cancer 2017 02 15;104:65-69. Epub 2016 Dec 15.

Ontario Clinical Oncology Group, McMaster University, 711 Concession St, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2016.12.004DOI Listing
February 2017

Monitoring and Management of Immune-Related Adverse Events Associated With Programmed Cell Death Protein-1 Axis Inhibitors in Lung Cancer.

Oncologist 2017 01 17;22(1):70-80. Epub 2016 Aug 17.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1634/theoncologist.2016-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313273PMC
January 2017

Targeting the KRAS Pathway in Non-Small Cell Lung Cancer.

Oncologist 2016 12 2;21(12):1450-1460. Epub 2016 Nov 2.

Division of Medical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1634/theoncologist.2015-0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153335PMC
December 2016

Are immune checkpoint blockade monoclonal antibodies active against CNS metastases from NSCLC?-current evidence and future perspectives.

Transl Lung Cancer Res 2016 Dec;5(6):628-636

Department of Medical Oncology and Hematology, Princess Margaret Cancer Center, Toronto, Ontario, Canada.

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http://dx.doi.org/10.21037/tlcr.2016.09.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233870PMC
December 2016

Early Palliative Care and Its Role in Oncology: A Qualitative Study.

Oncologist 2016 Nov 22;21(11):1387-1395. Epub 2016 Jul 22.

Division of Medical Oncology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1634/theoncologist.2016-0176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189624PMC
November 2016

Perceptions of palliative care among patients with advanced cancer and their caregivers.

CMAJ 2016 Jul 18;188(10):E217-E227. Epub 2016 Apr 18.

Division of Medical Oncology (Zimmermann, Krzyzanowska, Leighl, Tannock, Hannon), Department of Medicine, Department of Psychiatry (Zimmermann, Rodin), University of Toronto; Department of Supportive Care (Zimmermann, Swami, Rydall, Rodin, Hannon), Department of Medical Oncology (Krzyzanowska, Tannock), The Campbell Family Cancer Research Institute (Zimmermann, Rodin, Tannock), Princess Margaret Cancer Centre, University Health Network, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.151171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938707PMC
July 2016

The influence of gene expression profiling on decisional conflict in decision making for early-stage breast cancer chemotherapy.

Eur J Cancer 2016 07 4;61:85-93. Epub 2016 May 4.

Department of Community Health Sciences, University of Calgary, McMaster University, Room 3C56, Health Research Innovation Centre, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.03.077DOI Listing
July 2016

Pointed Progress in Second-Line Advanced Non-Small-Cell Lung Cancer: The Rapidly Evolving Field of Checkpoint Inhibition.

J Clin Oncol 2016 05 16;34(14):1676-88. Epub 2016 Feb 16.

Barbara Melosky, British Columbia Cancer Agency, Vancouver Centre, Vancouver, British Columbia; Quincy Chu, Cross Cancer Institute and University of Alberta, Edmonton, Alberta; Rosalyn Juergens, McMaster University, Juravinski Cancer Centre, Hamilton; Natasha Leighl, Princess Margaret Hospital and University of Toronto; Deanna McLeod, Kaleidoscope Strategic, Toronto, Ontario; and Vera Hirsh, Montreal General Hospital, Royal Victoria Hospital, and McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1200/JCO.2015.63.8049DOI Listing
May 2016

Approach to the non-operative management of patients with stage II non-small cell lung cancer (NSCLC): A survey of Canadian medical and radiation oncologists.

Lung Cancer 2016 Apr 3;94:74-80. Epub 2016 Feb 3.

Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Division of Medical Oncology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01695002163022
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http://dx.doi.org/10.1016/j.lungcan.2016.02.002DOI Listing
April 2016

The impact of brain metastasis on quality of life, resource utilization and survival in patients with non-small-cell lung cancer.

Cancer Treat Rev 2016 Apr 15;45:139-62. Epub 2016 Mar 15.

Princess Margaret Hospital/University Health Network, 610 University Avenue, Toronto M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2016.03.009DOI Listing
April 2016

Pan Canadian Rash Trial: A Randomized Phase III Trial Evaluating the Impact of a Prophylactic Skin Treatment Regimen on Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Induced Skin Toxicities in Patients With Metastatic Lung Cancer.

J Clin Oncol 2016 Mar 16;34(8):810-5. Epub 2015 Nov 16.

Barbara Melosky, Vincent Ho, Cheryl Ho, Nevin Murray, Sophie Sun, and Janessa J. Laskin, British Columbia Cancer Agency (BCCA) Vancouver Centre, Vancouver; Helen Anderson, BCCA Vancouver Island Centre, Victoria; Wendy Lam, Burnaby Regional Hospital, Burnaby; Christopher W. Lee, BCCA Fraser Valley Cancer Centre, Surrey; Robert Winston, BCCA Abbotsford Centre, Abbotsford, British Columbia; Ronald L. Burkes, Mount Sinai Hospital; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario; Quincy Chu, Cross Cancer Institute, Edmonton; and Desiree Hao, Tom Baker Care Centre, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1200/JCO.2015.62.3918DOI Listing
March 2016

Accelerated hemithoracic radiation followed by extrapleural pneumonectomy for malignant pleural mesothelioma.

J Thorac Cardiovasc Surg 2016 Feb 19;151(2):468-73. Epub 2015 Oct 19.

Department of Radiation Oncology, Princess Margaret Cancer Centre and Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jtcvs.2015.09.129DOI Listing
February 2016

Pembrolizumab for the treatment of thoracic malignancies: current landscape and future directions.

Future Oncol 2016 Jan 3;12(1):9-23. Epub 2015 Dec 3.

Department of Medical Oncology, Princess Margaret Cancer Center/University Health Network, 5-105 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

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https://www.futuremedicine.com/doi/10.2217/fon.15.294
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http://dx.doi.org/10.2217/fon.15.294DOI Listing
January 2016

Clinical role of a new prognostic score using platelet-to-lymphocyte ratio in patients with malignant pleural mesothelioma undergoing extrapleural pneumonectomy.

J Thorac Dis 2015 Nov;7(11):1898-906

1 Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada ; 2 Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan ; 3 Department of Thoracic Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan ; 4 Division of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan ; 5 Department of Radiation Oncology, 6 Department of Medical Oncology, 7 Department of Pathology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.3978/j.issn.2072-1439.2015.11.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669297PMC
November 2015

Recommendations for the Use of WBC Growth Factors: American Society of Clinical Oncology Clinical Practice Guideline Update.

J Clin Oncol 2015 Oct 13;33(28):3199-212. Epub 2015 Jul 13.

Thomas J. Smith, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Kari Bohlke, American Society of Clinical Oncology, Alexandria; Scott J. Cross, Virginia Oncology Associates, Norfolk; James L. Khatcheressian, Virginia Cancer Institute, Richmond, VA; Gary H. Lyman, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA; Kenneth R. Carson, Washington University, St Louis, MO; Jeffrey Crawford, Duke Medicine, Durham, NC; John M. Goldberg, University of Miami Miller School of Medicine, Miami, FL; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Cheryl L. Perkins, patient representative, Dallas, TX; George Somlo, City of Hope National Medical Center, Duarte, CA; James L. Wade, Cancer Care Specialists of Central Illinois, Decatur, IL; Antoinette J. Wozniak, Karmanos Cancer Institute, Detroit, MI; and James O. Armitage, University of Nebraska Medical Center, Omaha, NE.

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http://dx.doi.org/10.1200/JCO.2015.62.3488DOI Listing
October 2015

Central Nervous System Pseudoprogression in a Patient Treated with PD-1 Checkpoint Inhibitor.

J Thorac Oncol 2015 Oct;10(10):e100-1

*Department of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada; and †Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JTO.0000000000000587DOI Listing
October 2015

Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.

J Clin Oncol 2015 Aug 29;33(22):2472-80. Epub 2015 Jun 29.

Erin L. Stewart, Celine Mascaux, Nhu-An Pham, Shingo Sakashita, Jenna Sykes, Lucia Kim, Naoki Yanagawa, Ghassan Allo, Kota Ishizawa, Dennis Wang, Chang-Qi Zhu, Ming Li, Christine Ng, Ni Liu, Melania Pintilie, Petra Martin, Tom John, Igor Jurisica, Natasha B. Leighl, Benjamin G. Neel, Thomas K. Waddell, Frances A. Shepherd, Geoffrey Liu, Ming-Sound Tsao, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Lucia Kim, Inha University College of Medicine, Incheon, South Korea; and Tom John, Austin Hospital, Heidelberg, Australia.

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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.60.1492
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August 2015