Natasha Karp

Natasha Karp

UNVERIFIED PROFILE

Are you Natasha Karp?   Register this Author

Register author
Natasha Karp

Natasha Karp

Publications by authors named "Natasha Karp"

Are you Natasha Karp?   Register this Author

66Publications

1835Reads

25Profile Views

Sex bias in preclinical research and an exploration of how to change the status quo.

Br J Pharmacol 2019 Nov 12;176(21):4107-4118. Epub 2018 Dec 12.

Council for Science and Animal Welfare, AstraZeneca, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.14539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877896PMC
November 2019

onlineFDR: an R package to control the false discovery rate for growing data repositories.

Bioinformatics 2019 Oct;35(20):4196-4199

Quantitative Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/bioinformatics/advance-article/doi/
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btz191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792083PMC
October 2019

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Commun Biol 2019 7;2:97. Epub 2019 Mar 7.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s42003-019-0349-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405960PMC
March 2019

Pharmacological validation of individual animal locomotion, temperature and behavioural analysis in group-housed rats using a novel automated home cage analysis system: A comparison with the modified Irwin test.

J Pharmacol Toxicol Methods 2018 Nov - Dec;94(Pt 1):1-13. Epub 2018 Apr 1.

Safety and ADME Translational Sciences, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Babraham Research Campus, Cambridge CB22 3AT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vascn.2018.03.008DOI Listing
December 2018

Optimizing the design of population-based patient-derived tumor xenograft studies to better predict clinical response.

Dis Model Mech 2018 10 31;11(11). Epub 2018 Oct 31.

Quantitative Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge CB4 0WG, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.036160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262806PMC
October 2018

Reproducible preclinical research-Is embracing variability the answer?

Authors:
Natasha A Karp

PLoS Biol 2018 03 5;16(3):e2005413. Epub 2018 Mar 5.

Quantitative Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.2005413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837077PMC
March 2018

A high-throughput in vivo screening method in the mouse for identifying regulators of metastatic colonization.

Nat Protoc 2017 Dec 2;12(12):2465-2477. Epub 2017 Nov 2.

Experimental Cancer Genetics Group, Wellcome Trust Sanger Institute, Hinxton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2017.118DOI Listing
December 2017

The Experimental Design Assistant.

Nat Methods 2017 11 28;14(11):1024-1025. Epub 2017 Sep 28.

Certus Technology Associates Ltd, Exeter, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.4462DOI Listing
November 2017

Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.

Sci Data 2017 09 12;4:170129. Epub 2017 Sep 12.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sdata.2017.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827107PMC
September 2017

Improving the Identification of Phenotypic Abnormalities and Sexual Dimorphism in Mice When Studying Rare Event Categorical Characteristics.

Genetics 2017 02 7;205(2):491-501. Epub 2016 Dec 7.

Department of Statistics and Operations Research, School of Mathematical Sciences, Tel Aviv University, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1534/genetics.116.195388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289831PMC
February 2017

Reporting phenotypes in mouse models when considering body size as a potential confounder.

J Biomed Semantics 2016 9;7. Epub 2016 Feb 9.

Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13326-016-0050-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748495PMC
October 2016

Evaluating and Optimizing Fish Health and Welfare During Experimental Procedures.

Zebrafish 2016 07 25;13 Suppl 1:S127-31. Epub 2016 Feb 25.

1 Research Support Facility, Wellcome Trust Sanger Institute , Cambridge, United Kingdom .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/zeb.2015.1165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931752PMC
July 2016

Standardized Welfare Terms for the Zebrafish Community.

Zebrafish 2016 07 20;13 Suppl 1:S164-8. Epub 2016 Apr 20.

1 Research Support Facility, Wellcome Trust Sanger Institute , Cambridge, United Kingdom .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/zeb.2016.1248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931771PMC
July 2016

PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data.

PLoS One 2015 6;10(7):e0131274. Epub 2015 Jul 6.

Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131274PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493137PMC
April 2016

A common control group - optimising the experiment design to maximise sensitivity.

PLoS One 2014 11;9(12):e114872. Epub 2014 Dec 11.

Mouse Informatics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114872PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263717PMC
December 2015

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Authors:
Martin Hrabě de Angelis George Nicholson Mohammed Selloum Jacqui White Hugh Morgan Ramiro Ramirez-Solis Tania Sorg Sara Wells Helmut Fuchs Martin Fray David J Adams Niels C Adams Thure Adler Antonio Aguilar-Pimentel Dalila Ali-Hadji Gregory Amann Philippe André Sarah Atkins Aurelie Auburtin Abdel Ayadi Julien Becker Lore Becker Elodie Bedu Raffi Bekeredjian Marie-Christine Birling Andrew Blake Joanna Bottomley Mike Bowl Véronique Brault Dirk H Busch James N Bussell Julia Calzada-Wack Heather Cater Marie-France Champy Philippe Charles Claire Chevalier Francesco Chiani Gemma F Codner Roy Combe Roger Cox Emilie Dalloneau André Dierich Armida Di Fenza Brendan Doe Arnaud Duchon Oliver Eickelberg Chris T Esapa Lahcen El Fertak Tanja Feigel Irina Emelyanova Jeanne Estabel Jack Favor Ann Flenniken Alessia Gambadoro Lilian Garrett Hilary Gates Anna-Karin Gerdin George Gkoutos Simon Greenaway Lisa Glasl Patrice Goetz Isabelle Goncalves Da Cruz Alexander Götz Jochen Graw Alain Guimond Wolfgang Hans Geoff Hicks Sabine M Hölter Heinz Höfler John M Hancock Robert Hoehndorf Tertius Hough Richard Houghton Anja Hurt Boris Ivandic Hughes Jacobs Sylvie Jacquot Nora Jones Natasha A Karp Hugo A Katus Sharon Kitchen Tanja Klein-Rodewald Martin Klingenspor Thomas Klopstock Valerie Lalanne Sophie Leblanc Christoph Lengger Elise le Marchand Tonia Ludwig Aline Lux Colin McKerlie Holger Maier Jean-Louis Mandel Susan Marschall Manuel Mark David G Melvin Hamid Meziane Kateryna Micklich Christophe Mittelhauser Laurent Monassier David Moulaert Stéphanie Muller Beatrix Naton Frauke Neff Patrick M Nolan Lauryl Mj Nutter Markus Ollert Guillaume Pavlovic Natalia S Pellegata Emilie Peter Benoit Petit-Demoulière Amanda Pickard Christine Podrini Paul Potter Laurent Pouilly Oliver Puk David Richardson Stephane Rousseau Leticia Quintanilla-Fend Mohamed M Quwailid Ildiko Racz Birgit Rathkolb Fabrice Riet Janet Rossant Michel Roux Jan Rozman Ed Ryder Jennifer Salisbury Luis Santos Karl-Heinz Schäble Evelyn Schiller Anja Schrewe Holger Schulz Ralf Steinkamp Michelle Simon Michelle Stewart Claudia Stöger Tobias Stöger Minxuan Sun David Sunter Lydia Teboul Isabelle Tilly Glauco P Tocchini-Valentini Monica Tost Irina Treise Laurent Vasseur Emilie Velot Daniela Vogt-Weisenhorn Christelle Wagner Alison Walling Bruno Weber Olivia Wendling Henrik Westerberg Monja Willershäuser Eckhard Wolf Anne Wolter Joe Wood Wolfgang Wurst Ali Önder Yildirim Ramona Zeh Andreas Zimmer Annemarie Zimprich Chris Holmes Karen P Steel Yann Herault Valérie Gailus-Durner Ann-Marie Mallon Steve Dm Brown

Nat Genet 2015 Sep 27;47(9):969-978. Epub 2015 Jul 27.

MRC Harwell, Medical Research Council, Harwell, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564951PMC
September 2015

A high-throughput in vivo micronucleus assay for genome instability screening in mice.

Nat Protoc 2015 Jan 31;10(1):205-15. Epub 2014 Dec 31.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Genome Campus, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2015.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806852PMC
January 2015

Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia.

Exp Hematol 2014 Dec 12;42(12):1053-8.e1. Epub 2014 Aug 12.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2014.07.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271779PMC
December 2014

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.

Nucleic Acids Res 2014 Jan 4;42(Database issue):D802-9. Epub 2013 Nov 4.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK and Mouse Informatics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964955PMC
January 2014

Robust and sensitive analysis of mouse knockout phenotypes.

PLoS One 2012 26;7(12):e52410. Epub 2012 Dec 26.

Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052410PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530558PMC
July 2013

The fallacy of ratio correction to address confounding factors.

Lab Anim 2012 Jul;46(3):245-52

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1258/la.2012.012003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152922PMC
July 2012

Optimising experimental design for high-throughput phenotyping in mice: a case study.

Mamm Genome 2010 Oct 27;21(9-10):467-76. Epub 2010 Aug 27.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00335-010-9279-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974211PMC
October 2010

Addressing accuracy and precision issues in iTRAQ quantitation.

Mol Cell Proteomics 2010 Sep 10;9(9):1885-97. Epub 2010 Apr 10.

European Bioinformatics Institute, European Molecular Biology Laboratory Outstation, Hinxton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.M900628-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938101PMC
September 2010

Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock.

Curr Biol 2009 Dec 12;19(23):2031-6. Epub 2009 Nov 12.

Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2009.10.024DOI Listing
December 2009

Gel-based proteomics approach to the study of metabolic changes in pear tissue during storage.

J Agric Food Chem 2009 Aug;57(15):6997-7004

BIOSYST-MeBioS Division, Katholieke Universiteit Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jf901432hDOI Listing
August 2009

Investigating sample pooling strategies for DIGE experiments to address biological variability.

Proteomics 2009 Jan;9(2):388-97

Department of Biochemistry, Cambridge University, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200800485DOI Listing
January 2009

Comparison of DIGE and post-stained gel electrophoresis with both traditional and SameSpots analysis for quantitative proteomics.

Proteomics 2008 Mar;8(5):948-60

Department of Biochemistry, Cambridge University, Cambridge, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200700812DOI Listing
March 2008

Design and analysis issues in quantitative proteomics studies.

Proteomics 2007 Sep;7 Suppl 1:42-50

Department of Biochemistry, Cambridge University, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200700683DOI Listing
September 2007

Experimental and statistical considerations to avoid false conclusions in proteomics studies using differential in-gel electrophoresis.

Mol Cell Proteomics 2007 Aug 17;6(8):1354-64. Epub 2007 May 17.

Department of Biochemistry, University of Cambridge, Building O, Downing Site, Cambridge CB2 1QW, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.M600274-MCP200DOI Listing
August 2007

Glucocorticoid signaling synchronizes the liver circadian transcriptome.

Hepatology 2007 Jun;45(6):1478-88

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, Cabridgeshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.21571DOI Listing
June 2007

Identification of clock genes using difference gel electrophoresis.

Methods Mol Biol 2007 ;362:265-87

Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-257-1_18DOI Listing
May 2007

Circadian orchestration of the hepatic proteome.

Curr Biol 2006 Jun;16(11):1107-15

Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2006.04.026DOI Listing
June 2006

Impact of replicate types on proteomic expression analysis.

J Proteome Res 2005 Sep-Oct;4(5):1867-71

Biochemistry Department, University of Cambridge, Cambridge, England, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr050084gDOI Listing
January 2006

Maximising sensitivity for detecting changes in protein expression: experimental design using minimal CyDyes.

Proteomics 2005 Aug;5(12):3105-15

Department of Biochemistry, Cambridge University, Downing Site, Cambridge CB2 1QW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200500083DOI Listing
August 2005

Analysis of calibration methodologies for solvent effects in drug discovery studies using evanescent wave biosensors.

Biosens Bioelectron 2005 Jul;21(1):128-34

Affinity Sensors, Saxon Way, Bar Hill, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bios.2004.08.027DOI Listing
July 2005

Application of partial least squares discriminant analysis to two-dimensional difference gel studies in expression proteomics.

Proteomics 2005 Jan;5(1):81-90

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200400881DOI Listing
January 2005

DNA microarray normalization methods can remove bias from differential protein expression analysis of 2D difference gel electrophoresis results.

Bioinformatics 2004 Sep 25;20(13):2026-34. Epub 2004 Mar 25.

Department of Genetics/Inference Group (Cavendish Laboratory), University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/bth193DOI Listing
September 2004