Natasha J Caplen

Natasha J Caplen

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Natasha J Caplen

Natasha J Caplen

Publications by authors named "Natasha J Caplen"

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Fusion transcripts: Unexploited vulnerabilities in cancer?

Wiley Interdiscip Rev RNA 2020 Jan 13;11(1):e1562. Epub 2019 Aug 13.

Functional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, Maryland.

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http://dx.doi.org/10.1002/wrna.1562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916338PMC
January 2020

HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction.

RNA 2019 12 11;25(12):1731-1750. Epub 2019 Sep 11.

Functional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1261/rna.072454.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859848PMC
December 2019

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival.

Proc Natl Acad Sci U S A 2019 03 1;116(10):4508-4517. Epub 2019 Feb 1.

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1817494116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410784PMC
March 2019

EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis.

Mol Carcinog 2018 10 19;57(10):1342-1357. Epub 2018 Jun 19.

Functional Genetics Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, Maryland.

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http://dx.doi.org/10.1002/mc.22849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175245PMC
October 2018

Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.

Clin Exp Metastasis 2014 Oct 3;31(7):771-86. Epub 2014 Aug 3.

Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Building 37/Room 1126, 37 Convent Drive, Bethesda, MD, 20892, USA,

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http://dx.doi.org/10.1007/s10585-014-9667-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948753PMC
October 2014

Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation.

Eur J Cancer 2013 Sep 18;49(14):3020-8. Epub 2013 Jun 18.

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ejca.2013.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755049PMC
September 2013

The 8q24 gene desert: an oasis of non-coding transcriptional activity.

Front Genet 2012 30;3:69. Epub 2012 Apr 30.

Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MD, USA.

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http://dx.doi.org/10.3389/fgene.2012.00069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339310PMC
October 2012

p53-Dependent induction of PVT1 and miR-1204.

J Biol Chem 2012 Jan 22;287(4):2509-19. Epub 2011 Nov 22.

Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

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http://dx.doi.org/10.1074/jbc.M111.322875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268411PMC
January 2012

Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA.

Breast Cancer Res Treat 2011 Nov 4;130(2):663-79. Epub 2011 Aug 4.

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bldg. 37, Rm. 6128, NCI, NIH, Bethesda, MD 20892, USA.

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http://link.springer.com/content/pdf/10.1007/s10549-011-1690
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http://link.springer.com/10.1007/s10549-011-1690-0
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http://dx.doi.org/10.1007/s10549-011-1690-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381742PMC
November 2011

Genomic instability and mouse microRNAs.

Toxicol Mech Methods 2011 May;21(4):325-33

Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3109/15376516.2011.562759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401939PMC
May 2011

Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome.

Breast Cancer Res Treat 2010 Jul 10;122(2):347-57. Epub 2009 Oct 10.

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892-4256, USA.

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http://dx.doi.org/10.1007/s10549-009-0571-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462346PMC
July 2010

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response.

J Biol Chem 2009 Jul 5;284(27):18085-95. Epub 2009 May 5.

Laboratory of Molecular Pharmacology, Genetics Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.003020
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http://dx.doi.org/10.1074/jbc.M109.003020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709352PMC
July 2009

SpliceCenter: a suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies.

BMC Bioinformatics 2008 Jul 18;9:313. Epub 2008 Jul 18.

Genomics & Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1186/1471-2105-9-313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491637PMC
July 2008

The identification of microRNAs in a genomically unstable region of human chromosome 8q24.

Mol Cancer Res 2008 Feb;6(2):212-21

Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0105DOI Listing
February 2008

Pvt1-encoded microRNAs in oncogenesis.

Retrovirology 2008 Jan 14;5. Epub 2008 Jan 14.

Department of Microbiology and Immunology, University of California, San Francisco, CA 94143-0414, USA.

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http://dx.doi.org/10.1186/1742-4690-5-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2257975PMC
January 2008

Applications of RNA interference in mammalian systems.

Annu Rev Genomics Hum Genet 2007 ;8:81-108

Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1146/annurev.genom.8.080706.092424DOI Listing
December 2007

Multiplexing siRNAs to compress RNAi-based screen size in human cells.

Nucleic Acids Res 2007 28;35(8):e57. Epub 2007 Mar 28.

Gene Silencing Section, Office of Science and Technology Partnership, OD, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/nar/gkm141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885663PMC
June 2007

MicroRNAs and genomic instability.

Semin Cancer Biol 2007 Feb 26;17(1):65-73. Epub 2006 Oct 26.

Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.semcancer.2006.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839944PMC
February 2007

Mismatched siRNAs downregulate mRNAs as a function of target site location.

FEBS Lett 2006 Jun 5;580(15):3694-8. Epub 2006 Jun 5.

Gene Silencing Section, Office of Science and Technology Partnerships, Office of the Director, CCR, NCI, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.febslet.2006.05.056DOI Listing
June 2006

Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirions.

Hum Gene Ther 2005 Sep;16(9):1110-5

Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA.

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http://dx.doi.org/10.1089/hum.2005.16.1110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618762PMC
September 2005

Defining and assaying RNAi in mammalian cells.

Mol Cell 2005 Jan;17(1):1-10

Gene Silencing Section, Office of Science and Technology Partnerships, Office of the Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, 3128B, 37 Convent Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.molcel.2004.12.017DOI Listing
January 2005

RNAi quashes polyQ.

Authors:
Natasha J Caplen

Nat Med 2004 Aug;10(8):775-6

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http://dx.doi.org/10.1038/nm0804-775DOI Listing
August 2004

RNAi quashes polyQ.

Authors:
Natasha J Caplen

Nat Med 2004 Aug;10(8):775-6

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http://dx.doi.org/10.1038/nm0804-775DOI Listing
August 2004

Short interfering RNA (siRNA)-mediated RNA interference (RNAi) in human cells.

Ann N Y Acad Sci 2003 Dec;1002:56-62

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1196/annals.1281.007DOI Listing
December 2003

RNAi microarray analysis in cultured mammalian cells.

Genome Res 2003 Oct;13(10):2341-7

Cancer Drug Development Laboratory, Translational Genomics Research Institute (TGen), Gaithersburg, Maryland 20878, USA.

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http://dx.doi.org/10.1101/gr.1478703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC403721PMC
October 2003

RNAi as a gene therapy approach.

Authors:
Natasha J Caplen

Expert Opin Biol Ther 2003 Jul;3(4):575-86

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, 10C103, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1517/14712598.3.4.575DOI Listing
July 2003

Inhibition of viral gene expression and replication in mosquito cells by dsRNA-triggered RNA interference.

Mol Ther 2002 Aug;6(2):243-51

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA.

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http://dx.doi.org/10.1006/mthe.2002.0652DOI Listing
August 2002

A new approach to the inhibition of gene expression.

Authors:
Natasha J Caplen

Trends Biotechnol 2002 Feb;20(2):49-51

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http://dx.doi.org/10.1016/s0167-7799(01)01900-xDOI Listing
February 2002

Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference.

Hum Mol Genet 2002 Jan;11(2):175-84

Medical Genetics Branch, National Human Genome Research Institute and Neurogenetics Branch, National Institute of Neurological Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/hmg/11.2.175DOI Listing
January 2002