Natasha B Leighl

Natasha B Leighl

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Natasha B Leighl

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Improving the Management of Brain Metastases in Oncogene-Addicted Non-Small-Cell Lung Cancer.

J Oncol Pract 2019 Nov;15(11):571-572

Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1200/JOP.19.00575DOI Listing
November 2019

Hyperprogressive disease with immunotherapy: new directions.

J Thorac Dis 2019 Sep;11(Suppl 15):S1877-S1880

Princess Margaret Cancer Center, University Health Network, Toronto ON, Canada.

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http://dx.doi.org/10.21037/jtd.2019.08.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783768PMC
September 2019

Defining the role of adjuvant therapy for early-stage large cell neuroendocrine carcinoma.

J Thorac Cardiovasc Surg 2019 Sep 30. Epub 2019 Sep 30.

Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jtcvs.2019.09.077DOI Listing
September 2019

Systemic Therapy Use and Outcomes After Relapse from Preoperative Radiation and Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma.

Oncologist 2019 Jul 26;24(7):e510-e517. Epub 2018 Nov 26.

Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1634/theoncologist.2018-0501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656469PMC
July 2019

Financial Burden Among Patients With Lung Cancer in a Publically Funded Health Care System.

Clin Lung Cancer 2019 07 22;20(4):231-236. Epub 2018 Dec 22.

Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cllc.2018.12.010DOI Listing
July 2019

Adherence to human epidermal growth factor receptor-2 testing and adjuvant trastuzumab treatment guidelines in Ontario.

J Oncol Pharm Pract 2019 Jun 2:1078155219850299. Epub 2019 Jun 2.

4 Canadian Centre for Applied Research in Cancer Control (ARCC), Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1177/1078155219850299DOI Listing
June 2019

Advantages of the net benefit regression framework for trial-based economic evaluations of cancer treatments: an example from the Canadian Cancer Trials Group CO.17 trial.

BMC Cancer 2019 Jun 7;19(1):552. Epub 2019 Jun 7.

Division of Health Policy and Management, Department of Public Health Sciences and Associate Director, Center for Healthcare Policy and Research, 2103 Stockton Blvd, Sacramento, CA, 95817, USA.

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http://dx.doi.org/10.1186/s12885-019-5779-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555934PMC
June 2019

Effect of Coexisting KRAS and TP53 Mutations in Patients Treated With Chemotherapy for Non-small-cell Lung Cancer.

Clin Lung Cancer 2019 05 19;20(3):e338-e345. Epub 2018 Dec 19.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network and Department of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.cllc.2018.12.009DOI Listing
May 2019

Emerging therapies for non-small cell lung cancer.

J Hematol Oncol 2019 04 25;12(1):45. Epub 2019 Apr 25.

Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, People's Republic of China.

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https://jhoonline.biomedcentral.com/articles/10.1186/s13045-
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http://dx.doi.org/10.1186/s13045-019-0731-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482588PMC
April 2019

Improving lung cancer diagnosis: the evolving role of patients and care providers.

J Thorac Dis 2019 Mar;11(Suppl 3):S422-S424

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.21037/jtd.2018.11.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424746PMC
March 2019

The Role of Angiogenesis Inhibitors in the Era of Immune Checkpoint Inhibitors and Targeted Therapy in Metastatic Non-Small Cell Lung Cancer.

Curr Treat Options Oncol 2019 Feb 18;20(3):21. Epub 2019 Feb 18.

Princess Margaret Cancer Centre, Division of Medical Oncology, University of Toronto, 7-913 700 University Avenue, Toronto, ON, M5G 1Z5, Canada.

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http://dx.doi.org/10.1007/s11864-019-0617-6DOI Listing
February 2019

Economic analysis of osimertinib in previously untreated EGFR-mutant advanced non-small cell lung cancer in Canada.

Lung Cancer 2018 11 30;125:1-7. Epub 2018 Aug 30.

Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.lungcan.2018.08.024DOI Listing
November 2018

The prognostic effect of single and multiple cancer-related somatic mutations in resected non-small-cell lung cancer.

Lung Cancer 2018 09 19;123:22-29. Epub 2018 Jun 19.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183043
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http://dx.doi.org/10.1016/j.lungcan.2018.06.023DOI Listing
September 2018

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.

J Clin Oncol 2018 06 14;36(17):1714-1768. Epub 2018 Feb 14.

Julie R. Brahmer, Johns Hopkins Kimmel Cancer Center; Jennifer S. Mammen, Johns Hopkins University, Baltimore, MD; Christina Lacchetti, American Society of Clinical Oncology, Alexandria; Alexander Spira, Virginia Cancer Specialists and US Oncology Research, Fairfax, VA; Bryan J. Schneider, University of Michigan Health System, Ann Arbor, MI; Michael B. Atkins, Georgetown Lombardi Comprehensive Cancer Center; Cristina A. Reichner, Georgetown University; Laura D. Porter, Colon Cancer Alliance; Washington, DC; Kelly J. Brassil, Aung Naing, Loretta J. Nastoupil, Maria E. Suarez-Almazor, and Yinghong Wang, MD Anderson Cancer Center, Houston, TX; Jeffrey M. Caterino, The Ohio State University Wexner Medical Center, Columbus, OH; Ian Chau, The Royal Marsden Hospital and Institute of Cancer Research, London and Surrey, United Kingdom; Marc S. Ernstoff and Igor Puzanov, Roswell Park Cancer Institute, Buffalo; Bianca D. Santomasso and Jedd D. Wolchok, Memorial Sloan Kettering Cancer Center; Jeffrey S. Weber, New York University Langone Medical Center, New York, NY; Pamela Ginex, Oncology Nursing Society, Pittsburgh, PA; Jennifer M. Gardner, Seattle Cancer Care Alliance and University of Washington, Seattle, WA; Sigrun Hallmeyer, Oncology Specialists SC, Park Ridge, IL; Jennifer Holter Chakrabarty, University of Oklahoma, Stephenson Cancer Center, Oklahoma City, OK; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; David F. McDermott, Beth Israel Deaconess Medical Center; Carole Seigel, Massachusetts General Hospital Cancer Center, Boston, MA; John A. Thompson, Seattle Cancer Care Alliance, University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle, WA; and Tanyanika Phillips, CHRISTUS St Frances Cabrini Cancer Center, Alexandria, LA.

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http://dx.doi.org/10.1200/JCO.2017.77.6385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481621PMC
June 2018

Systemic Therapy of Lung Cancer CNS Metastases Using Molecularly Targeted Agents and Immune Checkpoint Inhibitors.

CNS Drugs 2018 06;32(6):527-542

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, 7W-389, 700 University Avenue, Toronto, ON, M5G 1Z5, Canada.

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http://link.springer.com/10.1007/s40263-018-0526-4
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http://dx.doi.org/10.1007/s40263-018-0526-4DOI Listing
June 2018

Molecular Testing Guideline for the Selection of Patients With Lung Cancer for Treatment With Targeted Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Clinical Practice Guideline Update.

J Clin Oncol 2018 03 5;36(9):911-919. Epub 2018 Feb 5.

Gregory P. Kalemkerian and Madelyn Lew, University of Michigan, Ann Arbor; James Pantelas, Greater Detroit Area; Michael Simoff, Henry Ford Hospital, Detroit, MI; Navneet Narula, Weill Cornell Medical College; Jessica Donington, New York University School of Medicine: Anjali Saqi, Columbia University Medical Center, New York, NY; Erin B. Kennedy, American Society of Clinical Oncology, Alexandria, VA; William A. Biermann, Chestnut Hill Hospital and Mercy Suburban Hospital, East Norriton; Baskaran Sundaram, Thomas Jefferson Medical School, Philadelphia, PA; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, ON, Canada; Suresh S. Ramalingam, Winship Cancer Institute of Emory University, Atlanta, GA; Martin Reck, Lung Clinic Grosshansdorf, Grosshansdorf, Germany; and Navneet Singh, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://ascopubs.org/doi/10.1200/JCO.2017.76.7293
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http://dx.doi.org/10.1200/JCO.2017.76.7293DOI Listing
March 2018

Personalized medicine for non-small cell lung cancer: where are we now and where can we go?

Expert Rev Respir Med 2018 02 5;12(2):81-82. Epub 2017 Dec 5.

a Division of Medical Oncology and Hematology , Princess Margaret Cancer Centre/University Health Network , Toronto , Canada.

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http://dx.doi.org/10.1080/17476348.2018.1411805DOI Listing
February 2018

Radical Treatment of Stage II Non-small-cell Lung Cancer With Nonsurgical Approaches: A Multi-institution Report of Outcomes.

Clin Lung Cancer 2018 01 21;19(1):e11-e18. Epub 2017 Jun 21.

Division of Medical Oncology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2017.06.007DOI Listing
January 2018

Economic Considerations in the Use of Novel Targeted Therapies for Lung Cancer: Review of Current Literature.

Pharmacoeconomics 2017 Dec;35(12):1195-1209

Princess Margaret Cancer Center, University Health Network, c/o 700 University Avenue, Room 7-913, Toronto, ON, M5G 1Z5, Canada.

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http://dx.doi.org/10.1007/s40273-017-0563-8DOI Listing
December 2017

Case for Stopping Targeted Therapy When Lung Cancer Progresses on Treatment in Hospice-Eligible Patients.

J Oncol Pract 2017 12 5;13(12):780-783. Epub 2017 Oct 5.

Johns Hopkins, Baltimore, MD; Indiana University, Bloomington, IN; UT Southwestern Medical School, Dallas, TX; Virginia Commonwealth University Massey Cancer Center, Richmond; Inova Schar Cancer Institute, Falls Church; ASCO, Alexandria, VA; Einstein Medical Center, Philadelphia, PA; Juravinski Cancer Centre, Hamilton; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Lombardi Cancer Center, Washington, DC; Lahey Hospital & Medical Center, Burlington, MA; William Beaumont Hospital, Royal Oak; University of Michigan, Ann Arbor, MI; Memorial Sloan Kettering Cancer Center, New York, NY; Circle of Hope for Cancer Research, St Cloud, FL; and Helen F. Graham Cancer Center, Newark, DE.

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http://dx.doi.org/10.1200/JOP.2017.027367DOI Listing
December 2017

Nintedanib Plus Pemetrexed/Cisplatin in Patients With Malignant Pleural Mesothelioma: Phase II Results From the Randomized, Placebo-Controlled LUME-Meso Trial.

J Clin Oncol 2017 Nov 11;35(31):3591-3600. Epub 2017 Sep 11.

Federica Grosso, Azienda Ospedaliera SS Antonio e Biagio General Hospital, Alessandria; Silvia Novello and Giorgio Scagliotti, L'università di Torino, Azienda Sanitaria Ospedale San Luigi Gonzaga, Turin, Italy; Anna K. Nowak, University of Western Australia, Crawley, and Sir Charles Gairdner Hospital, Nedlands, Western Australia; Thomas John, Olivia Newton-John Cancer Research Institute, Austin Hospital, Heidelberg, Victoria, Australia; Sanjay Popat, The Royal Marsden Hospital National Health Service (NHS) Foundation Trust, London; Nicola Steele, The Beatson West of Scotland Cancer Centre, Glasgow; Paul Taylor, University Hospitals of South Manchester NHS Trust, Wythenshawe, Manchester, United Kingdom; Laurent Greillier, Assitance Publique Hôpitaux de Marseille, Aix Marseille University, Marseille; David Planchard, Institut Gustave Roussy, Villejuif; Nassim Morsli, Boehringer Ingelheim France S.A.S., Paris, France; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Martin Reck, Lung Clinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf; Ute von Wangenheim, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; Jens Benn Sørensen, Rigshospitalet - Finsencentret, Copenhagen, Denmark; Mark A. Socinski, Florida Hospital Cancer Institute, Orlando, FL; Arsène Bienvenu Loembé, Boehringer Ingelheim B.V., Alkmaar, the Netherlands; and José Barrueco, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT.

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http://dx.doi.org/10.1200/JCO.2017.72.9012DOI Listing
November 2017

Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.

J Clin Oncol 2017 Oct 14;35(30):3484-3515. Epub 2017 Aug 14.

Nasser Hanna, Indiana University Simon Cancer Center, Indianapolis, IN; David Johnson, University of Texas Southwestern Medical Center, Dallas, TX; Sarah Temin, American Society of Clinical Oncology, Alexandria; Sherman Baker Jr, Virginia Commonwealth University Health System Massey Cancer Center, Richmond; Joan H. Schiller, Inova Schar Cancer Institute, Fairfax, VA; Julie Brahmer and Thomas J. Smith, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD; Peter M. Ellis, Juravinski Cancer Centre, Hamilton; Natasha B. Leighl, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Giuseppe Giaccone, Georgetown University, Washington, DC; Paul J. Hesketh, Lahey Hospital and Medical Center, Burlington, MA; Ishmael Jaiyesimi, William Beaumont Hospital, Royal Oak; Bryan J. Schneider, University of Michigan Health System, Ann Arbor, MI; Gregory J. Riely, Memorial Sloan-Kettering Cancer Center, New York, NY; Joan Tashbar, Circle of Hope for Cancer Research, Orlando, FL; William A. Biermann, Einstein Medical Center Montgomery, East Norriton, PA; and Gregory Masters, Helen F. Graham Cancer Center and Research Institute, Newark, DE.

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http://dx.doi.org/10.1200/JCO.2017.74.6065DOI Listing
October 2017

Brigatinib in Patients With Crizotinib-Refractory Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer: A Randomized, Multicenter Phase II Trial.

J Clin Oncol 2017 Aug 5;35(22):2490-2498. Epub 2017 May 5.

Dong-Wan Kim, Seoul National University Hospital; Myung-Ju Ahn, Samsung Medical Center; Sang-We Kim, Asan Medical Center, Seoul, South Korea; Marcello Tiseo, University Hospital of Parma, Parma, Italy; Karen L. Reckamp, City of Hope, Duarte, CA; Karin Holmskov Hansen, Odense University Hospital, Odense, Denmark; Rudolf M. Huber, University Hospital of Munich, German Centre for Lung Research, Munich, Germany; Howard L. West, Swedish Cancer Institute, Seattle, WA; Harry J.M. Groen, University of Groningen, University Medical Center Groningen, Groningen; Egbert F. Smit, VU University Medical Center, Amsterdam, the Netherlands; Maximilian J. Hochmair, Otto Wagner Hospital, Vienna, Austria; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Scott N. Gettinger, Yale Cancer Center, New Haven, CT; Corey J. Langer, University of Pennsylvania Abramson Cancer Center, Philadelphia, PA; Luis G. Paz-Ares Rodríguez, Hospital Universitario 12 de Octubre, Madrid, Spain; Edward S. Kim, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC; William Reichmann, Frank G. Haluska, and David Kerstein, ARIAD Pharmaceuticals, Cambridge, MA; and D. Ross Camidge, University of Colorado Cancer Center, Aurora, CO.

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http://dx.doi.org/10.1200/JCO.2016.71.5904DOI Listing
August 2017

Uncommon EGFR mutations in advanced non-small cell lung cancer.

Lung Cancer 2017 07 27;109:137-144. Epub 2017 Apr 27.

Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.lungcan.2017.04.016DOI Listing
July 2017

Review of the use of pretest probability for molecular testing in non-small cell lung cancer and overview of new mutations that may affect clinical practice.

Ther Adv Med Oncol 2017 Jun 26;9(6):405-414. Epub 2017 Apr 26.

Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1758834017704329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455881PMC
June 2017

Evolution of Symptom Burden of Advanced Lung Cancer Over a Decade.

Clin Lung Cancer 2017 05 5;18(3):274-280.e6. Epub 2017 Jan 5.

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2016.12.010DOI Listing
May 2017

Indications for Adjuvant Mediastinal Radiotherapy in Surgically Resected Small Cell Lung Cancer.

Ann Thorac Surg 2017 May 3;103(5):1647-1653. Epub 2017 Mar 3.

Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.athoracsur.2016.11.039DOI Listing
May 2017

Third-Generation Tyrosine Kinase Inhibitors Targeting Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer.

Front Oncol 2017 31;7:113. Epub 2017 May 31.

Department of Medical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fonc.2017.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449484PMC
May 2017

Impact of tumour thickness on survival after radical radiation and surgery in malignant pleural mesothelioma.

Eur Respir J 2017 03 15;49(3). Epub 2017 Mar 15.

Dept of Radiation Oncology, Princess Margaret Cancer Centre and Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01428
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http://dx.doi.org/10.1183/13993003.01428-2016DOI Listing
March 2017

Update on the Treatment of Metastatic Squamous Non-Small Cell Lung Cancer in New Era of Personalized Medicine.

Front Oncol 2017 27;7:50. Epub 2017 Mar 27.

Division of Medical Oncology, Princess Margaret Cancer Centre , Toronto, ON , Canada.

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http://dx.doi.org/10.3389/fonc.2017.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366319PMC
March 2017

Curing Early-Stage Lung Cancer: Is There an Easy Way Out?

J Oncol Pract 2017 02 20;13(2):63-65. Epub 2016 Dec 20.

Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JOP.2016.018309DOI Listing
February 2017

A phase II trial of dovitinib in previously-treated advanced pleural mesothelioma: The Ontario Clinical Oncology Group.

Lung Cancer 2017 02 15;104:65-69. Epub 2016 Dec 15.

Ontario Clinical Oncology Group, McMaster University, 711 Concession St, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2016.12.004DOI Listing
February 2017

Monitoring and Management of Immune-Related Adverse Events Associated With Programmed Cell Death Protein-1 Axis Inhibitors in Lung Cancer.

Oncologist 2017 01 17;22(1):70-80. Epub 2016 Aug 17.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1634/theoncologist.2016-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313273PMC
January 2017

Targeting the KRAS Pathway in Non-Small Cell Lung Cancer.

Oncologist 2016 12 2;21(12):1450-1460. Epub 2016 Nov 2.

Division of Medical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1634/theoncologist.2015-0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153335PMC
December 2016

Are immune checkpoint blockade monoclonal antibodies active against CNS metastases from NSCLC?-current evidence and future perspectives.

Transl Lung Cancer Res 2016 Dec;5(6):628-636

Department of Medical Oncology and Hematology, Princess Margaret Cancer Center, Toronto, Ontario, Canada.

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http://dx.doi.org/10.21037/tlcr.2016.09.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233870PMC
December 2016

Approach to the non-operative management of patients with stage II non-small cell lung cancer (NSCLC): A survey of Canadian medical and radiation oncologists.

Lung Cancer 2016 Apr 3;94:74-80. Epub 2016 Feb 3.

Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Division of Medical Oncology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01695002163022
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http://dx.doi.org/10.1016/j.lungcan.2016.02.002DOI Listing
April 2016

Pan Canadian Rash Trial: A Randomized Phase III Trial Evaluating the Impact of a Prophylactic Skin Treatment Regimen on Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Induced Skin Toxicities in Patients With Metastatic Lung Cancer.

J Clin Oncol 2016 Mar 16;34(8):810-5. Epub 2015 Nov 16.

Barbara Melosky, Vincent Ho, Cheryl Ho, Nevin Murray, Sophie Sun, and Janessa J. Laskin, British Columbia Cancer Agency (BCCA) Vancouver Centre, Vancouver; Helen Anderson, BCCA Vancouver Island Centre, Victoria; Wendy Lam, Burnaby Regional Hospital, Burnaby; Christopher W. Lee, BCCA Fraser Valley Cancer Centre, Surrey; Robert Winston, BCCA Abbotsford Centre, Abbotsford, British Columbia; Ronald L. Burkes, Mount Sinai Hospital; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario; Quincy Chu, Cross Cancer Institute, Edmonton; and Desiree Hao, Tom Baker Care Centre, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1200/JCO.2015.62.3918DOI Listing
March 2016

Expectations in the care of lung cancer.

Am Soc Clin Oncol Educ Book 2015 :e420-4

From the Yale Cancer Center, New Haven, CT; Princess Margaret Cancer Center, Toronto, Canada; McKesson Specialty Health, The Woodlands, TX.

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http://dx.doi.org/10.14694/EdBook_AM.2015.35.e420DOI Listing
February 2016

Accelerated hemithoracic radiation followed by extrapleural pneumonectomy for malignant pleural mesothelioma.

J Thorac Cardiovasc Surg 2016 Feb 19;151(2):468-73. Epub 2015 Oct 19.

Department of Radiation Oncology, Princess Margaret Cancer Centre and Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jtcvs.2015.09.129DOI Listing
February 2016

Recommendations for the Use of WBC Growth Factors: American Society of Clinical Oncology Clinical Practice Guideline Update.

J Clin Oncol 2015 Oct 13;33(28):3199-212. Epub 2015 Jul 13.

Thomas J. Smith, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Kari Bohlke, American Society of Clinical Oncology, Alexandria; Scott J. Cross, Virginia Oncology Associates, Norfolk; James L. Khatcheressian, Virginia Cancer Institute, Richmond, VA; Gary H. Lyman, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA; Kenneth R. Carson, Washington University, St Louis, MO; Jeffrey Crawford, Duke Medicine, Durham, NC; John M. Goldberg, University of Miami Miller School of Medicine, Miami, FL; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Cheryl L. Perkins, patient representative, Dallas, TX; George Somlo, City of Hope National Medical Center, Duarte, CA; James L. Wade, Cancer Care Specialists of Central Illinois, Decatur, IL; Antoinette J. Wozniak, Karmanos Cancer Institute, Detroit, MI; and James O. Armitage, University of Nebraska Medical Center, Omaha, NE.

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http://dx.doi.org/10.1200/JCO.2015.62.3488DOI Listing
October 2015

Central Nervous System Pseudoprogression in a Patient Treated with PD-1 Checkpoint Inhibitor.

J Thorac Oncol 2015 Oct;10(10):e100-1

*Department of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada; and †Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JTO.0000000000000587DOI Listing
October 2015

Real-world chemotherapy treatment patterns in metastatic non-small cell lung cancer: Are patients undertreated?

Cancer 2015 Aug 17;121(15):2562-9. Epub 2015 Apr 17.

Division of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

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http://doi.wiley.com/10.1002/cncr.29386
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http://dx.doi.org/10.1002/cncr.29386DOI Listing
August 2015

Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.

J Clin Oncol 2015 Aug 29;33(22):2472-80. Epub 2015 Jun 29.

Erin L. Stewart, Celine Mascaux, Nhu-An Pham, Shingo Sakashita, Jenna Sykes, Lucia Kim, Naoki Yanagawa, Ghassan Allo, Kota Ishizawa, Dennis Wang, Chang-Qi Zhu, Ming Li, Christine Ng, Ni Liu, Melania Pintilie, Petra Martin, Tom John, Igor Jurisica, Natasha B. Leighl, Benjamin G. Neel, Thomas K. Waddell, Frances A. Shepherd, Geoffrey Liu, Ming-Sound Tsao, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Lucia Kim, Inha University College of Medicine, Incheon, South Korea; and Tom John, Austin Hospital, Heidelberg, Australia.

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http://jco.ascopubs.org/content/33/22/2472.full.pdf
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http://200.40.135.66:90/toc/0873/2015/0873-20150801-22-09.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.60.1492
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http://dx.doi.org/10.1200/JCO.2014.60.1492DOI Listing
August 2015

Correlation of dosimetric and clinical factors with the development of esophagitis and radiation pneumonitis in patients with limited-stage small-cell lung carcinoma.

Clin Lung Cancer 2015 May 2;16(3):216-20. Epub 2014 Dec 2.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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May 2015

Sunitinib: the next advance in small-cell lung cancer?

Authors:
Natasha B Leighl

J Clin Oncol 2015 May 13;33(15):1637-9. Epub 2015 Apr 13.

Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1200/JCO.2014.60.1815DOI Listing
May 2015

The value of personalizing medicine: medical oncologists' views on gene expression profiling in breast cancer treatment.

Oncologist 2015 Apr 6;20(4):351-6. Epub 2015 Mar 6.

Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada; Insititute of Health Policy, Management and Evaluation, Department of Medicine, and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Independent Qualitative Researcher; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Princess Margaret Cancer Centre, Toronto, Ontario, Canada; DeGroote School of Business, McMaster University, Hamilton, Ontario, Canada; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1634/theoncologist.2014-0268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391763PMC
April 2015

Symptomatic toxicities experienced during anticancer treatment: agreement between patient and physician reporting in three randomized trials.

J Clin Oncol 2015 Mar 26;33(8):910-5. Epub 2015 Jan 26.

Massimo Di Maio, Maria Carmela Piccirillo, Gennaro Daniele, Francesco Nuzzo, Andrea de Matteis, Jane Bryce, Alessandro Morabito, Gaetano Rocco, and Francesco Perrone, Istituto Nazionale Tumori-Fondazione "G. Pascale" Istituto di Ricovero e Cura a Carattere Scientifico; Ciro Gallo, Fortunato Ciardiello, and Simona Signoriello, Second University; Sabino De Placido, Federico II University, Napoli; Cesare Gridelli, S.G. Moscati Hospital, Avellino; Vittorio Gebbia, Istituto La Maddalena, Palermo; Anna Ceribelli, Regina Elena National Cancer Institute, Roma; Adolfo G. Favaretto, Istituto Oncologico Veneto, Padova, Italy; Natasha B. Leighl and Ronald Feld, Princess Margaret Hospital/University Health Network, Toronto; and Charles Butts, Cross Cancer Institute, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1200/JCO.2014.57.9334DOI Listing
March 2015

Reply to G. Spitzer and M.A. Socinski.

J Clin Oncol 2015 Feb 12;33(5):525-6. Epub 2015 Jan 12.

Princess Margaret Cancer Centre/University Health Network, Toronto, Canada

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http://dx.doi.org/10.1200/JCO.2014.58.5307DOI Listing
February 2015

Reply to C.G. Azzoli et al and C. Chouaid et al.

J Clin Oncol 2014 Nov 8;32(31):3578-9. Epub 2014 Sep 8.

Cancer Care Ontario, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2014.57.2552DOI Listing
November 2014

Molecular testing for selection of patients with lung cancer for epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors: American Society of Clinical Oncology endorsement of the College of American Pathologists/International Association for the study of lung cancer/association for molecular pathology guideline.

J Clin Oncol 2014 Nov 13;32(32):3673-9. Epub 2014 Oct 13.

Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Natasha Rekhtman and James Huang, Memorial Sloan Kettering Cancer Center, New York, NY; William A. Biermann, Einstein Medical Center Montgomery, East Norriton, PA; Mari Mino-Kenudson, Massachusetts General Hospital and Harvard Medical School, Boston, MA; Suresh S. Ramalingam, Winship Cancer Institute, Emory University, Atlanta, GA; Howard West, Swedish Cancer Institute, Seattle, WA; Sara Whitlock, Free to Breathe, Madison, WI; and Mark R. Somerfield, American Society of Clinical Oncology, Alexandria, VA.

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http://www.jco.ascopubs.org/content/early/2014/10/10/JCO.201
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.57.3055
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http://dx.doi.org/10.1200/JCO.2014.57.3055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321089PMC
November 2014

Resource utilization and costs during the initial years of lung cancer screening with computed tomography in Canada.

J Thorac Oncol 2014 Oct;9(10):1449-58

*The Canadian Centre for Applied Research in Cancer Control, and the British Columbia Cancer Agency, Vancouver, British Columbia, Canada; †The British Columbia Cancer Agency, Vancouver, British Columbia, Canada; ‡Brock University, St. Catherines, Ontario, Canada; §Cancer Care Ontario and the Juravinski Cancer Centre, Hamilton, Ontario, Canada; ‖University Health Network and Princess Margaret Cancer Centre, Toronto, Ontario, Canada; ¶The Canadian Centre for Applied Research in Cancer Control, the British Columbia Cancer Agency and School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada; #The University of British Columbia School of Population and Public Health, Vancouver, British Columbia, Canada; **Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada; ††The British Columbia Cancer Agency and The Canadian Centre for Applied Research in Cancer Control and the University of British Columbia, Vancouver, British Columbia, Canada; ‡‡Beatrice Hunter Cancer Research Institute and Dalhousie University, Halifax, Nova Scotia, Canada; §§The Vancouver General Hospital, Vancouver, British Columbia, Canada; ‖‖Fionna Stanley Hospital and Sir Charles Gairdner Hospital, Perth, Western Australia; ¶¶Université Laval, Québec, Canada; ##Vancouver General Hospital, The University of British Columbia, Vancouver, British Columbia, Canada; ***The Juravinski Cancer Centre and McMaster University, Hamilton, Ontario, Canada; †††Princess Margaret Cancer Centre, Toronto, Ontario, Canada; ‡‡‡University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canada; §§§Foothills Medical Centre, Calgary, Alberta, Canada; ‖‖‖Memorial University, St. Johns, Newfoundland, Canada; ¶¶¶The Ottawa Hospital, Ottawa, Ontario, Canada; ###Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; ****The Vancouver General Hospital and The University of British Columbia, Vancouver, British

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http://dx.doi.org/10.1097/JTO.0000000000000283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165479PMC
October 2014

Developing a service model that integrates palliative care throughout cancer care: the time is now.

J Clin Oncol 2014 Oct 8;32(29):3330-6. Epub 2014 Sep 8.

Ann H. Partridge and Davinia S.E. Seah, Dana-Farber Cancer Institute, Boston, MA; Tari King, Memorial Sloan-Kettering Cancer Center, New York, NY; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Ralph Hauke, Nebraska Cancer Specialists, Omaha, NE; Dana S. Wollins, American Society of Clinical Oncology, Alexandra, VA; and Jamie Hayden Von Roenn, Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1200/JCO.2013.54.8149DOI Listing
October 2014

Economic Impact of Tissue Testing and Treatments of Metastatic NSCLC in the Era of Personalized Medicine.

Front Oncol 2014 22;4:258. Epub 2014 Sep 22.

Department of Medicine, Division of Hematology and Oncology, Princess Margaret Cancer Centre, University of Toronto , Toronto, ON , Canada.

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http://journal.frontiersin.org/article/10.3389/fonc.2014.002
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http://dx.doi.org/10.3389/fonc.2014.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170132PMC
October 2014

Long-term outcome after resection of non-small cell lung cancer invading the thoracic inlet.

Ann Thorac Surg 2014 Sep 25;98(3):962-7. Epub 2014 Jul 25.

Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2014.05.015DOI Listing
September 2014

Biomarkers That Currently Affect Clinical Practice in Lung Cancer: EGFR, ALK, MET, ROS-1, and KRAS.

Front Oncol 2014 11;4:204. Epub 2014 Aug 11.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto , Toronto, ON , Canada.

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http://dx.doi.org/10.3389/fonc.2014.00204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127527PMC
August 2014

Sample features associated with success rates in population-based EGFR mutation testing.

J Thorac Oncol 2014 Jul;9(7):947-56

*Department of Pathology, University Health Network, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; †Department of Pathology, Royal Columbian Hospital, New Westminster, British Columbia, Canada; ‡Department of Biostatistics, University Health Network, and Princess Margaret Cancer Centre, Toronto, Ontario, Canada; and §Division of Hematology and Medical Oncology, Princess Margaret Cancer Centre, and Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S15560864153032
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http://dx.doi.org/10.1097/JTO.0000000000000196DOI Listing
July 2014

Second-line therapy in non-small-cell lung cancer: the DELTA between different genotypes widens.

J Clin Oncol 2014 Jun 19;32(18):1874-81. Epub 2014 May 19.

Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1200/JCO.2013.54.4270DOI Listing
June 2014

Shifting patterns in the interpretation of phase III clinical trial outcomes in advanced non-small-cell lung cancer: the bar is dropping.

J Clin Oncol 2014 May 3;32(14):1407-11. Epub 2014 Mar 3.

All authors: Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://ascopubs.org/doi/10.1200/JCO.2013.52.7804
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http://dx.doi.org/10.1200/JCO.2013.52.7804DOI Listing
May 2014

Cost effectiveness of EML4-ALK fusion testing and first-line crizotinib treatment for patients with advanced ALK-positive non-small-cell lung cancer.

J Clin Oncol 2014 Apr 24;32(10):1012-9. Epub 2014 Feb 24.

Sandjar Djalalov, Jaclyn Beca, and Jeffrey S. Hoch, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital and Cancer Care Ontario; Sandjar Djalalov, Jaclyn Beca, Jeffrey S. Hoch, Murray Krahn, and Natasha B. Leighl, Canadian Centre for Applied Research in Cancer Control; Murray Krahn, Toronto Health Economics and Technology Assessment Collaborative; Ming-Sound Tsao and Natasha B. Leighl, Ontario Cancer Institute and Princess Margaret Cancer Centre, Toronto; and Jean-Claude Cutz, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2013.53.1186DOI Listing
April 2014

End-of-life home care utilization and costs in patients with advanced colorectal cancer.

J Community Support Oncol 2014 Mar;12(3):92-8

Health Outcomes and PharmacoEconomic (HOPE) Research Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Email:

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http://dx.doi.org/10.12788/jcso.0025DOI Listing
March 2014

Second-hand smoke as a predictor of smoking cessation among lung cancer survivors.

J Clin Oncol 2014 Feb 13;32(6):564-70. Epub 2014 Jan 13.

Lawson Eng, Jie Su, Xin Qiu, Prakruthi R. Palepu, Henrique Hon, Ehab Fadhel, Luke Harland, Anthony La Delfa, Steven Habbous, Aidin Kashigar, Sinead Cuffe, Frances A. Shepherd, Natasha B. Leighl, Andrew F. Pierre, David P. Goldstein, Wei Xu, and Geoffrey Liu, Princess Margaret Hospital/Ontario Cancer Institute/University Health Network, University of Toronto; Peter Selby, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1200/JCO.2013.50.9695DOI Listing
February 2014

Utilization and costs of home care for patients with colorectal cancer: a population-based study.

CMAJ Open 2014 Jan 4;2(1):E11-7. Epub 2014 Feb 4.

Institute for Clinical Evaluative Sciences, Toronto, Ont. ; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ont.

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http://dx.doi.org/10.9778/cmajo.20130026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986021PMC
January 2014

Long-term outcome after en bloc resection of non-small-cell lung cancer invading the pulmonary sulcus and spine.

J Thorac Oncol 2013 Dec;8(12):1538-44

Divisions of *Thoracic Surgery, †Orthopedic Surgery, ‡Medical Oncology, §Radiation Oncology, and ‖Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/01.JTO.0000437419.31348.a4DOI Listing
December 2013