Natarajan V Bhanu

Natarajan V Bhanu

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Natarajan V Bhanu

Natarajan V Bhanu

Publications by authors named "Natarajan V Bhanu"

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Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance.

Mol Cell 2020 Jan 26;77(1):51-66.e8. Epub 2019 Nov 26.

Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.10.018DOI Listing
January 2020

Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand.

ACS Chem Neurosci 2019 Nov 5;10(11):4716-4728. Epub 2019 Nov 5.

Department of Anesthesiology & Critical Care , University of Pennsylvania Perelman School of Medicine , 3620 Hamilton Walk , Philadelphia , Pennsylvania 19104 , United States.

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http://dx.doi.org/10.1021/acschemneuro.9b00484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889220PMC
November 2019

A mass spectrometry-based assay using metabolic labeling to rapidly monitor chromatin accessibility of modified histone proteins.

Sci Rep 2019 Sep 20;9(1):13613. Epub 2019 Sep 20.

Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41598-019-49894-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754405PMC
September 2019

Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis.

J Biol Chem 2019 05 14;294(20):8296-8308. Epub 2019 Mar 14.

From the Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1074/jbc.RA118.004977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527175PMC
May 2019

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription.

Cell Rep 2019 04;27(2):400-415.e5

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664437PMC
April 2019

Phosphorylation of TIP60 Suppresses 53BP1 Localization at DNA Damage Sites.

Mol Cell Biol 2019 01 11;39(1). Epub 2018 Dec 11.

Department of Cancer Biology, Basser Center for BRCA, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://mcb.asm.org/lookup/doi/10.1128/MCB.00209-18
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http://dx.doi.org/10.1128/MCB.00209-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290371PMC
January 2019

Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors.

FASEB J 2018 08 5;32(8):4172-4189. Epub 2018 Mar 5.

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1096/fj.201701347RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044061PMC
August 2018

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription.

Nature 2017 07 22;547(7664):463-467. Epub 2017 Jun 22.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nature23267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576860PMC
July 2017

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

Mol Cell 2017 May 5;66(4):568-576.e4. Epub 2017 May 5.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662137PMC
May 2017

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.

Cell Rep 2017 05;19(8):1669-1684

Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531293PMC
May 2017

Complete Workflow for Analysis of Histone Post-translational Modifications Using Bottom-up Mass Spectrometry: From Histone Extraction to Data Analysis.

J Vis Exp 2016 05 17(111). Epub 2016 May 17.

Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania;

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http://dx.doi.org/10.3791/54112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927705PMC
May 2016

Folate deficiency affects histone methylation.

Med Hypotheses 2016 Mar 9;88:63-7. Epub 2016 Jan 9.

Department of Biochemistry, Vanderbilt University School of Medicine, 21st Avenue South, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mehy.2015.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769866PMC
March 2016

Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation.

Proteomics 2016 Feb 28;16(3):448-58. Epub 2016 Jan 28.

Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/pmic.201500231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819991PMC
February 2016

Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cells.

BMC Genomics 2016 Feb 4;17:95. Epub 2016 Feb 4.

Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s12864-016-2414-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740988PMC
February 2016

Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH) Analysis for Characterization and Quantification of Histone Post-translational Modifications.

Mol Cell Proteomics 2015 Sep 30;14(9):2420-8. Epub 2015 Jan 30.

From the ‡Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104;

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http://dx.doi.org/10.1074/mcp.O114.046102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563725PMC
September 2015

EpiProfile Quantifies Histone Peptides With Modifications by Extracting Retention Time and Intensity in High-resolution Mass Spectra.

Mol Cell Proteomics 2015 Jun 24;14(6):1696-707. Epub 2015 Mar 24.

From the ‡Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104;

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http://dx.doi.org/10.1074/mcp.M114.046011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458730PMC
June 2015

Multi-faceted quantitative proteomics analysis of histone H2B isoforms and their modifications.

Epigenetics Chromatin 2015 22;8:15. Epub 2015 Apr 22.

Department of Biochemistry and Biophysics, Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Room 9-124, 3400 Civic Center Blvd., Bldg. 421, Philadelphia, PA 19104 USA.

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http://dx.doi.org/10.1186/s13072-015-0006-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411797PMC
April 2015

Initial characterization of histone H3 serine 10 O-acetylation.

Epigenetics 2013 Oct 15;8(10):1101-13. Epub 2013 Aug 15.

Epigenetics Program; Department of Biochemistry and Biophysics; Perelman School of Medicine; University of Pennsylvania; Philadelphia, PA USA.

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http://dx.doi.org/10.4161/epi.26025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891691PMC
October 2013

Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives.

Biochim Biophys Acta 2008 Sep 30;1782(9):504-10. Epub 2008 Jun 30.

Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Laboratory Medicine Department, Hematology Service, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.bbadis.2008.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613185PMC
September 2008

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.

Nat Med 2007 Sep 26;13(9):1096-101. Epub 2007 Aug 26.

Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nm1629DOI Listing
September 2007

Cl-IB-MECA inhibits human erythropoiesis.

Br J Haematol 2007 May;137(3):233-6

Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06540.xDOI Listing
May 2007

Fetal hemoglobin silencing in humans.

Blood 2006 Sep 30;108(6):2081-6. Epub 2006 May 30.

Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bldg 10, Rm 9B17, Bethesda, MD 20892, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-04-01
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http://dx.doi.org/10.1182/blood-2006-04-015859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895549PMC
September 2006

A newly discovered human alpha-globin gene.

Blood 2005 Aug 26;106(4):1466-72. Epub 2005 Apr 26.

Molecular Medicine Branch, National Institute of Diabetes, Digestive and Kidney Disease, National Institutes of Health, Bldg 10/Rm 9B17, 10 Center Dr, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2005-03-0948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895206PMC
August 2005

A sustained and pancellular reversal of gamma-globin gene silencing in adult human erythroid precursor cells.

Blood 2005 Jan 14;105(1):387-93. Epub 2004 Sep 14.

Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2004-04-1599DOI Listing
January 2005

A signaling mechanism for growth-related expression of fetal hemoglobin.

Blood 2004 Mar 30;103(5):1929-33. Epub 2003 Oct 30.

Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2003-05-1624DOI Listing
March 2004