Natalie S Ryan

Natalie S Ryan

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Natalie S Ryan

Natalie S Ryan

Publications by authors named "Natalie S Ryan"

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Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gena Roschupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer's disease.

Alzheimers Res Ther 2019 Feb 20;11(1):19. Epub 2019 Feb 20.

Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, Queen Square, Box 16, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1186/s13195-019-0472-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383280PMC
February 2019

Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration.

Neurology 2017 Nov 25;89(21):2167-2175. Epub 2017 Oct 25.

From the Dementia Research Centre (P.S.J.W., T.P., N.S.R., A.N., Y.L., K.M., I.B.M., R.L.A., H.P., J.K., M.N.R., J.M.S., N.C.F.) and MRC Prion Unit (R.D., S.M.), Department of Neurodegenerative Diseases, UCL Institute of Neurology; Department of Medical Statistics (T.P.), London School of Hygiene & Tropical Medicine, UK; and Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology (K.B., H.Z.), the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000004667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696646PMC
November 2017

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Cell 2017 Jul;170(3):443-456.e14

KU Leuven-VIB Center for Brain & Disease Research, VIB, 3000 Leuven, Belgium; Department of Neurosciences, Leuven Institute for Neuroscience and Disease, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.004DOI Listing
July 2017

Brain imaging evidence of early involvement of subcortical regions in familial and sporadic Alzheimer's disease.

Brain Res 2017 01 12;1655:23-32. Epub 2016 Nov 12.

Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2016.11.011DOI Listing
January 2017

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Lancet Neurol 2016 Dec 21;15(13):1326-1335. Epub 2016 Oct 21.

Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(16)30193-4DOI Listing
December 2016

Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.

Neurology 2016 Nov 12;87(19):2050-2057. Epub 2016 Oct 12.

From the Dementia Research Centre (P.S.J.W., J.M.N., M.L., N.S.R., Y.L., K.M., M.M., M.N.R., J.M.S., N.C.F.), UCL Institute of Neurology; Transitional Imaging Group (M.M., S.O.), Centre for Medical Image Computing, University College London; and London School of Hygiene and Tropical Medicine (J.M.N.), UK.

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http://dx.doi.org/10.1212/WNL.0000000000003322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109950PMC
November 2016

Alzheimer's disease in the 100 years since Alzheimer's death.

Brain 2015 Dec 4;138(Pt 12):3816-21. Epub 2015 Nov 4.

Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1093/brain/awv316DOI Listing
December 2015

Spontaneous ARIA (amyloid-related imaging abnormalities) and cerebral amyloid angiopathy related inflammation in presenilin 1-associated familial Alzheimer's disease.

J Alzheimers Dis 2015 ;44(4):1069-74

Department of Clinical Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.3233/JAD-142325DOI Listing
November 2015

Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.

J Exp Med 2015 Nov 19;212(12):2003-13. Epub 2015 Oct 19.

VIB Center for the Biology of Disease, University of Leuven (KU Leuven), 3000 Leuven, Belgium Center for Human Genetics (CME) and Leuven Research Institute for Neuroscience and Disease (LIND), University of Leuven (KU Leuven), 3000 Leuven, Belgium

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http://dx.doi.org/10.1084/jem.20150892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647268PMC
November 2015

Diffusion imaging changes in grey matter in Alzheimer's disease: a potential marker of early neurodegeneration.

Alzheimers Res Ther 2015 1;7(1):47. Epub 2015 Jul 1.

Dementia Research Centre, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Box 16, Queen Square, London, WC1N 3BG UK.

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http://dx.doi.org/10.1186/s13195-015-0132-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487800PMC
July 2015

Imaging endpoints for clinical trials in Alzheimer's disease.

Alzheimers Res Ther 2014 20;6(9):87. Epub 2014 Dec 20.

Dementia Research Centre, Box 16, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG UK.

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http://dx.doi.org/10.1186/s13195-014-0087-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304258PMC
January 2015

Motor features in posterior cortical atrophy and their imaging correlates.

Neurobiol Aging 2014 Dec 6;35(12):2845-2857. Epub 2014 Jun 6.

Dementia Research Centre, Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236588PMC
December 2014

Reply: Implications of presymptomatic change in thalamus and caudate in Alzheimer's disease.

Brain 2013 Nov 3;136(Pt 11):e259. Epub 2013 Jul 3.

Dementia Research Centre, Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1093/brain/awt168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808685PMC
November 2013

The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study.

Neurology 2013 Oct 18;81(16):1425-33. Epub 2013 Sep 18.

From the Dementia Research Centre (D.M.C., Y.L., N.S.R., K.M.K., T.Y., I.B.M., M.N.R., S.O., N.C.F.) and Wellcome Trust Centre for Neuroimaging (G.R.R.), UCL Institute of Neurology, London, UK; Washington University School of Medicine (T.L.S.B., N.J.C., D.S.M., C.X., R.J.B., J.C.M.), St. Louis, MO; Mayo Clinic (C.R.J.), Rochester, MN; Imaging Genetics Center (P.M.T.), Laboratory of Neuroimaging, Department of Neurology & Psychiatry, UCLA School of Medicine, Los Angeles, CA; Indiana University School of Medicine (B.F.G., A.J.S.), Indianapolis; Mental Health Research Institute (C.L.M.), The University Of Melbourne, Victoria, Australia; Mary S. Easton Center for Alzheimer's Disease (J.M.R.), UCLA Department of Neurology, Los Angeles, CA; Butler Hospital (S.P.S.), Providence, RI; Neuroscience Research Australia (P.R.S.), Sydney; and the Center for Alzheimer Research and Treatment (R.A.S.), Brigham and Women's Hospital, Cambridge, MA.

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http://www.neurology.org/cgi/doi/10.1212/WNL.0b013e3182a841c
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http://dx.doi.org/10.1212/WNL.0b013e3182a841c6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806583PMC
October 2013

Imaging the onset and progression of Alzheimer's disease: implications for prevention trials.

J Alzheimers Dis 2013 ;33 Suppl 1:S305-12

Dementia Research Centre, University College London Institute of Neurology, London, UK.

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http://dx.doi.org/10.3233/JAD-2012-129010DOI Listing
June 2013

An unbiased longitudinal analysis framework for tracking white matter changes using diffusion tensor imaging with application to Alzheimer's disease.

Neuroimage 2013 May 28;72:153-63. Epub 2013 Jan 28.

Dementia Research Centre, UCL Institute of Neurology, London, UK; Centre for Medical Image Computing (CMIC), University College London, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2013.01.044DOI Listing
May 2013

Global gray matter changes in posterior cortical atrophy: a serial imaging study.

Alzheimers Dement 2012 Nov 23;8(6):502-12. Epub 2012 Feb 23.

Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1016/j.jalz.2011.09.225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359276PMC
November 2012

Defining and describing the pre-dementia stages of familial Alzheimer's disease.

Alzheimers Res Ther 2011 Sep 27;3(5):29. Epub 2011 Sep 27.

Dementia Research Centre, Department of Neurodegenerative Diseases, Box 16, National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1186/alzrt91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218806PMC
September 2011

Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers.

Brain 2011 Jan 16;134(Pt 1):293-300. Epub 2010 Nov 16.

Department of Neurodegeneration, UCL Institute of Neurology, University College London, Dementia Research Centre, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1093/brain/awq310DOI Listing
January 2011

Correlating familial Alzheimer's disease gene mutations with clinical phenotype.

Biomark Med 2010 Feb;4(1):99-112

Dementia Research Centre, Department of Neurodegenerative Diseases, University College London, Institute of Neurology, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937872PMC
http://dx.doi.org/10.2217/bmm.09.92DOI Listing
February 2010

Imaging biomarkers in Alzheimer's disease.

Ann N Y Acad Sci 2009 Oct;1180:20-7

University College London, Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05062.xDOI Listing
October 2009

Alzheimer disease: Visual rating of atrophy aids diagnostic accuracy.

Nat Rev Neurol 2009 May;5(5):243-4

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http://dx.doi.org/10.1038/nrneurol.2009.52DOI Listing
May 2009