Publications by authors named "Natalie J Serkova"

98Publications

Complement factor H-deficient mice develop spontaneous hepatic tumors.

J Clin Invest 2020 Aug;130(8):4039-4054

Department of Medicine, Nephrology and Hypertension, University of Colorado School of Medicine, Aurora, Colorado, USA.

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http://dx.doi.org/10.1172/JCI135105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410061PMC
August 2020

Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma.

Cell Rep 2020 04;31(1):107485

Morgan Adams Foundation Pediatric Brain Tumor Research Program, Aurora, CO, USA; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA; Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO, USA; Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.03.049DOI Listing
April 2020

Electromagnetic wave propagation in a fast pulse line ion accelerator.

Med Phys 2019 Dec 4;46(12):5714-5721. Epub 2019 Nov 4.

Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1002/mp.13875DOI Listing
December 2019

Feraheme (Ferumoxytol) Is Recognized by Proinflammatory and Anti-inflammatory Macrophages via Scavenger Receptor Type AI/II.

Mol Pharm 2019 10 26;16(10):4274-4281. Epub 2019 Sep 26.

Colorado Center for Nanomedicine and Nanosafety , University of Colorado Anschutz Medical Campus , Aurora , Colorado 80045 , United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513579PMC
October 2019

Bitter melon juice-intake modulates glucose metabolism and lactate efflux in tumors in its efficacy against pancreatic cancer.

Carcinogenesis 2019 Jun 13. Epub 2019 Jun 13.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA.

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https://academic.oup.com/carcin/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/carcin/bgz114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384253PMC
June 2019

Quantitative NMR-Based Metabolomics on Tissue Biomarkers and Its Translation into In Vivo Magnetic Resonance Spectroscopy.

Methods Mol Biol 2019 ;1978:369-387

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA.

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http://dx.doi.org/10.1007/978-1-4939-9236-2_23DOI Listing
November 2019

Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver.

Am J Physiol Regul Integr Comp Physiol 2019 05 13;316(5):R427-R440. Epub 2019 Feb 13.

Perinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine , Aurora, Colorado.

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http://dx.doi.org/10.1152/ajpregu.00359.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589601PMC
May 2019

Design considerations for a pulse line ion accelerator (PLIA)-based PET isotope generator.

Med Phys 2018 Jun 15. Epub 2018 Jun 15.

Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1002/mp.13050DOI Listing
June 2018

Unique Heterogeneous Topological Pattern of the Metabolic Landscape in Rabbit Fetal Lungs following Tracheal Occlusion.

Fetal Diagn Ther 2019 18;45(3):145-154. Epub 2018 Apr 18.

Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.

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http://dx.doi.org/10.1159/000487752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314905PMC
July 2019

Nanoparticle-Based Magnetic Resonance Imaging on Tumor-Associated Macrophages and Inflammation.

Front Immunol 2017 22;8:590. Epub 2017 May 22.

Department of Anesthesiology, Anschutz Medical Center, Aurora, CO, USA.

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http://dx.doi.org/10.3389/fimmu.2017.00590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439008PMC
May 2017

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Proc Natl Acad Sci U S A 2016 10 10;113(43):E6669-E6678. Epub 2016 Oct 10.

Department of Biochemistry and Molecular Genetics, University of Colorado, Aurora, CO 80045; School of Medicine, University of Colorado, Aurora, CO 80045; Integrated Department of Immunology, University of Colorado, Aurora, CO 80045; Cancer Biology Program, University of Colorado, Aurora, CO 80045; Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado, Aurora, CO 80045

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http://dx.doi.org/10.1073/pnas.1603876113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086999PMC
October 2016

Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.

Circulation 2016 10 25;134(15):1105-1121. Epub 2016 Aug 25.

From Cardiovascular Pulmonary Research Laboratories, Department of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO (M.L., S.R., H.Z., A.F., B.A.M., M.F., S.K., M.A.F., K.R.S.); Department of Biochemistry and Molecular Genetics and Biological Mass Spectrometry Shared Resource (A.D., K.C.H.), Department of Anesthesiology (N.J.S.), Advanced Light Microscopy Core Facility (R.M.), Department of Dermatology (H.L., H.L., Q.Z.), and Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition (K.C.E.K.), University of Colorado, Denver; Department of Mitochondrial Physiology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic (L.P.-H., P.J.); Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany (D.I., S.P.); Center for Genetic Improvement of Livestock, Department of Animal Bioscience, University of Guelph, Guelph, ON, Canada (A.C.); Department of Animal Science, University of California-Davis, Davis (J.F.M.); and Department of Animal Science, Colorado State University, Fort Collins (M.G.T.).

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http://circ.ahajournals.org/content/134/15/1105.full.pdf?dow
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069179PMC
http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023171DOI Listing
October 2016

Metabolic Imaging to Assess Treatment Response to Cytotoxic and Cytostatic Agents.

Front Oncol 2016 15;6:152. Epub 2016 Jul 15.

Developmental Therapeutics Program, University of Colorado Comprehensive Cancer Center, Aurora, CO, USA; Division of Medical Oncology, Anschutz Medical Center, University of Colorado Denver, Aurora, CO, USA.

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http://dx.doi.org/10.3389/fonc.2016.00152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946377PMC
July 2016

Non-invasive imaging to monitor lupus nephritis and neuropsychiatric systemic lupus erythematosus.

F1000Res 2015 16;4:153. Epub 2015 Jun 16.

Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536614PMC
http://dx.doi.org/10.12688/f1000research.6587.2DOI Listing
November 2015

Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.

Am J Physiol Lung Cell Mol Physiol 2015 Sep 26;309(5):L435-40. Epub 2015 Jun 26.

Department of Medicine, University of Colorado Denver, Aurora, Colorado;

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http://dx.doi.org/10.1152/ajplung.00169.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556932PMC
September 2015

Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[(18)F]Fluoro-D-Glucose Uptake in Prostate Cancer Mouse Xenografts.

Mol Imaging Biol 2015 Aug;17(4):529-38

Division of Medical Oncology, Genitourinary Cancer Program, University of Colorado School of Medicine, MS 8117 12801 E. 17th Ave, Room L18-8101D, Aurora, CO, 80045, USA,

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http://dx.doi.org/10.1007/s11307-014-0814-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493937PMC
August 2015

Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.

Clin Cancer Res 2015 Mar 29;21(6):1360-72. Epub 2014 Dec 29.

Integrated Department of Immunology, University of Colorado Anschutz Medical Campus, Aurora, Colorado. School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Cancer Biology Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Department of Medicine, Section of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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http://clincancerres.aacrjournals.org/content/early/2014/12/
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http://clincancerres.aacrjournals.org/content/21/6/1360.full
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-2146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359967PMC
March 2015

High-relaxivity superparamagnetic iron oxide nanoworms with decreased immune recognition and long-circulating properties.

ACS Nano 2014 Dec 26;8(12):12437-49. Epub 2014 Nov 26.

The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver , Anschutz Medical Campus, 12850 E. Montview Boulevard, Aurora, Colorado 80045, United States.

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http://dx.doi.org/10.1021/nn505126bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692719PMC
December 2014

Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo.

Mol Carcinog 2015 Nov 22;54(11):1417-29. Epub 2014 Sep 22.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado.

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http://dx.doi.org/10.1002/mc.22220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369479PMC
November 2015

1H-NMR metabolomic biomarkers of poor outcome after hemorrhagic shock are absent in hibernators.

PLoS One 2014 11;9(9):e107493. Epub 2014 Sep 11.

Department of Chemistry and Biochemistry, University of Alaska Fairbanks, Fairbanks, AK, United States of America; Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107493PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161479PMC
October 2015

Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium.

J Lipid Res 2014 06 25;55(6):1052-65. Epub 2014 Apr 25.

Program in Molecular Biology, University of Colorado Anschutz Medical Campus, Aurora, CO Departments of Pathology University of Colorado Anschutz Medical Campus, Aurora, CO.

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http://dx.doi.org/10.1194/jlr.M044487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031937PMC
June 2014

Nanosized contrast agents to noninvasively detect kidney inflammation by magnetic resonance imaging.

Adv Chronic Kidney Dis 2013 Nov;20(6):488-99

Department of Medicine, University of Colorado-Denver School of Medicine, Aurora, CO; and Department of Anesthesiology, University of Colorado-Denver School of Medicine, Aurora, CO. Electronic address:

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http://dx.doi.org/10.1053/j.ackd.2013.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828648PMC
November 2013

Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia.

PLoS One 2013 18;8(9):e74809. Epub 2013 Sep 18.

Division of Medical Oncology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America ; University of Colorado Cancer Center, Aurora, Colorado, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074809PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776760PMC
June 2014

Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation.

Cancer Prev Res (Phila) 2013 Jul 2;6(7):625-33. Epub 2013 May 2.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-13-0053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701740PMC
July 2013

Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries.

Autophagy 2013 May 27;9(5):697-713. Epub 2013 Feb 27.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.4161/auto.23960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669180PMC
May 2013

Inositol hexaphosphate inhibits tumor growth, vascularity, and metabolism in TRAMP mice: a multiparametric magnetic resonance study.

Cancer Prev Res (Phila) 2013 Jan 4;6(1):40-50. Epub 2012 Dec 4.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-12-0387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662486PMC
January 2013

Immunophyllin ligands show differential effects on alcohol self-administration in C57BL mice.

J Pharmacol Exp Ther 2012 Jun 28;341(3):611-6. Epub 2012 Feb 28.

Psychiatry and Research Services, Department of Veterans Affairs Medical Center, Denver, Colorado, USA.

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http://dx.doi.org/10.1124/jpet.111.188169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362882PMC
June 2012

Quantitative analysis in magnetic resonance spectroscopy: from metabolic profiling to in vivo biomarkers.

Bioanalysis 2012 Feb;4(3):321-41

Department of Anesthesiology, Cancer Center Animal Imaging Core, Anschutz Medical Center, University of Colorado Denver, Aurora, Aurora, CO 80045, USA.

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http://www.future-science.com/doi/10.4155/bio.11.320
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http://dx.doi.org/10.4155/bio.11.320DOI Listing
February 2012

Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models.

Clin Cancer Res 2012 Feb 15;18(4):1051-62. Epub 2011 Dec 15.

Division of Medical Oncology, Department of Anesthesiology and Radiology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876277PMC
February 2012

Detection of glomerular complement C3 fragments by magnetic resonance imaging in murine lupus nephritis.

Kidney Int 2012 Jan 28;81(2):152-9. Epub 2011 Sep 28.

Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, USA.

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http://dx.doi.org/10.1038/ki.2011.332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375901PMC
January 2012

The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses.

Am J Respir Crit Care Med 2011 Sep 16;184(6):647-55. Epub 2011 Jun 16.

Department of Anesthesiology, School of Medicine, University of Colorado Denver, Aurora, Colorado, USA.

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http://dx.doi.org/10.1164/rccm.201103-0474CIDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208597PMC
September 2011

Translational imaging endpoints to predict treatment response to novel targeted anticancer agents.

Drug Resist Updat 2011 Aug-Oct;14(4-5):224-35. Epub 2011 Jun 2.

Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Center, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1016/j.drup.2011.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159818PMC
February 2012

Synthesis of gadolinium nanoscale metal-organic framework with hydrotropes: manipulation of particle size and magnetic resonance imaging capability.

ACS Appl Mater Interfaces 2011 May 12;3(5):1502-10. Epub 2011 Apr 12.

Department of Chemistry and Geochemistry, Colorado School of Mines, Golden, Colorado 80401, USA.

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http://pubs.acs.org/doi/10.1021/am200075q
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http://dx.doi.org/10.1021/am200075qDOI Listing
May 2011

Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies.

Clin Cancer Res 2011 Feb 10;17(4):753-61. Epub 2010 Dec 10.

Department of Pharmaceutical Sciences, University of Colorado Cancer Center, University of Colorado Denver, Aurora, Colorado, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066181PMC
February 2011

Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism.

Neurotoxicology 2011 Jan 12;32(1):50-7. Epub 2010 Nov 12.

Max Planck Institute for Biological Cybernetics, High-Field Magnetic Resonance Center, Tübingen, Germany.

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http://dx.doi.org/10.1016/j.neuro.2010.10.006DOI Listing
January 2011

Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model.

Nephrol Dial Transplant 2011 Jun 10;26(6):1813-20. Epub 2010 Nov 10.

Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1093/ndt/gfq646DOI Listing
June 2011

Metabolic consequences of sepsis-induced acute lung injury revealed by plasma ¹H-nuclear magnetic resonance quantitative metabolomics and computational analysis.

Am J Physiol Lung Cell Mol Physiol 2011 Jan 1;300(1):L4-L11. Epub 2010 Oct 1.

Dept. of Clinical, Social, and Administrative Sciences, Univ. of Michigan, Ann Arbor, 48109-1065, USA.

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http://dx.doi.org/10.1152/ajplung.00231.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023293PMC
January 2011

1H-NMR-based metabolic signatures of clinical outcomes in trauma patients--beyond lactate and base deficit.

J Trauma 2010 Jul;69(1):31-40

Department of Surgery, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1097/TA.0b013e3181e043feDOI Listing
July 2010

Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats.

J Gastroenterol 2010 Nov 15;45(11):1103-10. Epub 2010 Jun 15.

Department of Surgery, Division of Transplantation, University of California, San Francisco, CA 94143-0648, USA.

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http://dx.doi.org/10.1007/s00535-010-0262-0DOI Listing
November 2010

Distinct patterns of kidney and liver cyst growth in pkd2(WS25/-) mice.

Nephrol Dial Transplant 2010 Nov 13;25(11):3496-504. Epub 2010 Apr 13.

Department of Medicine, University of Colorado Denver, Aurora, CO, USA.

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https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/
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http://dx.doi.org/10.1093/ndt/gfq195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980992PMC
November 2010

Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in mice.

Radiology 2010 May 23;255(2):517-26. Epub 2010 Mar 23.

Department of Anesthesiology, University of Colorado-Denver School of Medicine, 1775 N Aurora Ct, M20-3103, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1148/radiol.09091134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858816PMC
May 2010

Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer.

Biomark Med 2009 Jun;3(3):289-306

Cancer Center Metabolomics NMR Core, University of Colorado, CO, USA.

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https://www.futuremedicine.com/doi/10.2217/bmm.09.15
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http://dx.doi.org/10.2217/BMM.09.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756767PMC
June 2009

Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolism.

Chem Res Toxicol 2010 Mar;23(3):608-19

Clinical Research & Development, Department of Anesthesiology, and University of Colorado Cancer Center, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1021/tx900351qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841482PMC
March 2010

Imaging biochemistry noninvasively: magnetic resonance spectroscopy in liver disease.

JPEN J Parenter Enteral Nutr 2009 Nov-Dec;33(6):726-8

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http://dx.doi.org/10.1177/0148607109344727DOI Listing
March 2010

Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning.

Am J Physiol Regul Integr Comp Physiol 2010 Jan 28;298(1):R166-72. Epub 2009 Oct 28.

Department of Anesthesiology, University of Colorado Denver Health Sciences Center, Aurora, Colorado, USA.

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http://dx.doi.org/10.1152/ajpregu.00383.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806207PMC
January 2010

Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells.

Br J Pharmacol 2009 Sep 6;158(2):588-600. Epub 2009 Aug 6.

Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80045, USA.

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http://dx.doi.org/10.1111/j.1476-5381.2009.00345.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757699PMC
September 2009

Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture.

Biomed Chromatogr 2009 Dec;23(12):1251-8

Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045-7503, USA.

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http://dx.doi.org/10.1002/bmc.1247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044679PMC
December 2009

Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells.

Clin Cancer Res 2009 May 28;15(10):3442-50. Epub 2009 Apr 28.

Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-3291DOI Listing
May 2009

Magnetic resonance spectroscopy of living tissues.

Methods Mol Biol 2009 ;520:315-27

Department of Anesthesiology and Radiology, University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA.

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http://infoscience.epfl.ch/record/177505/files/ross97.pdf
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http://link.springer.com/10.1007/978-1-60327-811-9_22
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http://dx.doi.org/10.1007/978-1-60327-811-9_22DOI Listing
May 2009

Metabolomics of cancer.

Methods Mol Biol 2009 ;520:273-95

Department of Anesthesiology and Radiology, University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA.

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http://link.springer.com/10.1007/978-1-60327-811-9_20
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http://dx.doi.org/10.1007/978-1-60327-811-9_20DOI Listing
May 2009

Toxicity of MRI and CT contrast agents.

Expert Opin Drug Metab Toxicol 2009 Apr;5(4):403-16

University of Colorado, Anschutz Medical Center, Cancer Center Animal MRI/PET/CT Core, Department of Anesthesiology and Radiology, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1517/17425250902873796DOI Listing
April 2009

Silibinin feeding alters the metabolic profile in TRAMP prostatic tumors: 1H-NMRS-based metabolomics study.

Cancer Res 2009 May 14;69(9):3731-5. Epub 2009 Apr 14.

Department of Pharmaceutical Sciences, University of Colorado Cancer Center, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679526PMC
May 2009

Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m.

Free Radic Biol Med 2009 Jun 19;46(11):1551-7. Epub 2009 Mar 19.

Department of Anesthesiology, University of Colorado at Denver School of Medicine, Aurora, CO 80045, USA.

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June 2009

Use of the 1-mm micro-probe for metabolic analysis on small volume biological samples.

J Cell Mol Med 2009 Aug;13(8B):1933-41

Biomedical MRI/MRS Cancer Center Core, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://doi.wiley.com/10.1111/j.1582-4934.2008.00464.x
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http://dx.doi.org/10.1111/j.1582-4934.2008.00464.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940789PMC
August 2009

Oncologic imaging end-points for the assessment of therapy response.

Recent Pat Anticancer Drug Discov 2009 Jan;4(1):36-53

Department of Anesthesiology, University of Colorado Cancer Center, Aurora, CO 80045, USA.

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http://dx.doi.org/10.2174/157489209787002434DOI Listing
January 2009

Clinical applications of metabolomics in oncology: a review.

Clin Cancer Res 2009 Jan;15(2):431-40

Department of Medical Oncology, University of Colorado Health Sciences Center, Denver, Colorado, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676437PMC
January 2009

Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3.

Breast Cancer Res 2008 13;10(4):R70. Epub 2008 Aug 13.

Department of Pathology, University of Colorado Denver, Research Complex I, South Tower, Mail Stop 8104, 12801 East 17thAvenue, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1186/bcr2132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575543PMC
April 2009

Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury.

Am J Physiol Lung Cell Mol Physiol 2008 Jul 25;295(1):L152-61. Epub 2008 Apr 25.

Department of Anesthesiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA.

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http://dx.doi.org/10.1152/ajplung.00515.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494785PMC
July 2008

The metabolites citrate, myo-inositol, and spermine are potential age-independent markers of prostate cancer in human expressed prostatic secretions.

Prostate 2008 May;68(6):620-8

Department of Anesthesiology and Radiology, Biomedical MRI/MRS, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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http://dx.doi.org/10.1002/pros.20727DOI Listing
May 2008

Metabolic markers of hypoxia: systems biology application in biomedicine.

Toxicol Mech Methods 2008 ;18(1):81-95

Associate Professor, Cancer Center MRI/MRS Core, Department of Anesthesiology and Radiology, University of Colorado Health Sciences Center, Denver, CO.

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http://dx.doi.org/10.1080/15376510701795769DOI Listing
October 2012

NMR-based metabolomics: translational application and treatment of cancer.

Curr Opin Mol Ther 2007 Dec;9(6):572-85

University of Colorado Health Sciences Center, Department of Anesthesiology and Radiology, Denver, CO 80262, USA.

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December 2007

N-(3-hydroxyhexanoyl)-l-homoserine lactone is the biologically relevant quormone that regulates the phz operon of Pseudomonas chlororaphis strain 30-84.

Appl Environ Microbiol 2007 Nov 5;73(22):7443-55. Epub 2007 Oct 5.

Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1128/AEM.01354-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168216PMC
November 2007

Biochemical mechanisms of nephrotoxicity: application for metabolomics.

Expert Opin Drug Metab Toxicol 2007 Aug;3(4):527-44

University of California San Francisco, Division of Transplantation, Department of Anesthesia and Perioperative Care, San Francisco, California, USA.

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http://dx.doi.org/10.1517/17425225.3.4.527DOI Listing
August 2007

Quantitative analysis of liver metabolites in three stages of the circannual hibernation cycle in 13-lined ground squirrels by NMR.

Physiol Genomics 2007 Sep 29;31(1):15-24. Epub 2007 May 29.

Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado 80238, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00028.2007DOI Listing
September 2007

Early detection of graft failure using the blood metabolic profile of a liver recipient.

Transplantation 2007 Feb;83(4):517-21

Department of Anesthesiology and Radiology, Biomedical MRI/MRS Cancer Center Core, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://dx.doi.org/10.1097/01.tp.0000251649.01148.f8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709529PMC
February 2007

Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine.

Physiol Genomics 2007 Feb 14;28(3):323-36. Epub 2006 Nov 14.

Department of Physiology and Biophysics, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00020.2006DOI Listing
February 2007

Ischemia-reperfusion injury is more severe in older versus young rat livers.

J Surg Res 2007 Jan 24;137(1):96-102. Epub 2006 Oct 24.

Department of Surgery, Gachon Medical School, Gil Medical Center, Incheon, Korea.

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http://dx.doi.org/10.1016/j.jss.2006.08.013DOI Listing
January 2007

Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism.

Pharmacogenomics 2006 Oct;7(7):1109-23

The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, 212 Traylor Building Baltimore, MD 21205, USA.

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October 2006

Pattern recognition and biomarker validation using quantitative 1H-NMR-based metabolomics.

Expert Rev Mol Diagn 2006 Sep;6(5):717-31

University of Colorado Health Sciences Center, Biomedical MRI/MRS Cancer Center Core, Department of Anesthesiology, Denver, CO 80262, USA.

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http://dx.doi.org/10.1586/14737159.6.5.717DOI Listing
September 2006

Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion.

Surgery 2006 Sep 28;140(3):404-12. Epub 2006 Jul 28.

Anesthesia and Perioperative Care, Division of Liver Transplantation, University of California San Francisco, San Francisco, CA 94143-0648, USA.

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http://dx.doi.org/10.1016/j.surg.2006.01.021DOI Listing
September 2006

Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression.

JPEN J Parenter Enteral Nutr 2006 Sep-Oct;30(5):373-8; discussion 379

Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, 80262, USA.

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http://dx.doi.org/10.1177/0148607106030005373DOI Listing
December 2006

Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats.

Liver Int 2006 Aug;26(6):734-41

Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143-0648, USA.

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http://dx.doi.org/10.1111/j.1478-3231.2006.01292.xDOI Listing
August 2006

Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood.

Ther Drug Monit 2005 Dec;27(6):733-7

Department of Anesthesiology, Clinical Research and Development, MRI/MRS Cancer Center Core, University of Colorado Health Sciences Center, Denver 80262, USA.

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http://dx.doi.org/10.1097/01.ftd.0000179846.30342.65DOI Listing
December 2005

Metabolic profiling of livers and blood from obese Zucker rats.

J Hepatol 2006 May 2;44(5):956-62. Epub 2005 Aug 2.

Biomedical MRI/NMR, Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA.

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http://dx.doi.org/10.1016/j.jhep.2005.07.009DOI Listing
May 2006

Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells.

Clin Cancer Res 2004 Oct;10(19):6661-8

Department of Biology/Chemistry, University of Bremen, Bremen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0039DOI Listing
October 2004

Biochemical mechanisms of cyclosporine neurotoxicity.

Mol Interv 2004 Apr;4(2):97-107

Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://dx.doi.org/10.1124/mi.4.2.7DOI Listing
April 2004