Publications

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface.
Proc Natl Acad Sci U S A 2017 Jul 17. Epub 2017 Jul 17.
Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;

Identification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatis.
PLoS One 2016 14;11(10):e0164253. Epub 2016 Oct 14.
School of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.

Essential role for autophagy during invariant NKT cell development.
Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5678-87. Epub 2014 Dec 15.
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom;

Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.
Proc Natl Acad Sci U S A 2014 Sep 2;111(37):13433-8. Epub 2014 Sep 2.
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;

A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.
Immunity 2014 Jan 9;40(1):105-16. Epub 2014 Jan 9.
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.
Proc Natl Acad Sci U S A 2013 Dec 18;110(49):E4753-61. Epub 2013 Nov 18.
Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom.


SAP expression in invariant NKT cells is required for cognate help to support B-cell responses.
Blood 2012 Jul 21;120(1):122-9. Epub 2012 May 21.
Division of Immunology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Saposins utilize two strategies for lipid transfer and CD1 antigen presentation.
Proc Natl Acad Sci U S A 2012 Mar 13;109(12):4357-64. Epub 2012 Feb 13.
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.


Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents.
PLoS One 2010 Dec 17;5(12):e14374. Epub 2010 Dec 17.
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.


Recognition of lyso-phospholipids by human natural killer T lymphocytes.
PLoS Biol 2009 Oct 27;7(10):e1000228. Epub 2009 Oct 27.
Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.


Natural killer T-cell autoreactivity leads to a specialized activation state.
Blood 2008 Nov 8;112(10):4128-38. Epub 2008 Sep 8.
Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, USA.


Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.
Proc Natl Acad Sci U S A 2007 Dec 11;104(51):20490-5. Epub 2007 Dec 11.
Tumor Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.

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