Publications by authors named "Nashwa Tawfek"

2 Publications

  • Page 1 of 1

Synthesis and anti-H5N1 virus activity of triazole- and oxadiazole-pyrimidine hybrids and their nucleoside analogs.

Nucleosides Nucleotides Nucleic Acids 2020 10;39(5):649-670. Epub 2019 Oct 10.

Environmental Research Division, National Research Center, Dokki, Cairo, Egypt.

New 1,2,3-triazole glycosides and 1,2,4-thioglycosides incorporating a substituted pyrimidinedione ring system were synthesized via click dipolar cycloaddition and heterocyclization of hydrazine-1-carbodithioate derivatives, respectively. The sugar hydrazine derivatives linked aminodimethyluracil were also prepared. In addition, the oxadiazoline substituted with acyclic sugar moieties linked to the pyrimidinedione as acyclic nucleoside analogs were synthesized. The antiviral activity of the synthesized compounds against avian influenza H5N1 virus was investigated and compounds , and showed good activities against the virus strains.
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http://dx.doi.org/10.1080/15257770.2019.1674331DOI Listing
December 2020

Antimicrobial activity of new 2,4-disubstituted thiazolidinone derivatives.

Z Naturforsch C J Biosci 2009 Nov-Dec;64(11-12):785-9

Photochemistry Department, National Research Center, El Dokki, Cairo, Egypt.

A number of new disubstituted 2,5-thiazolidinone derivatives were synthesized and tested for their antimicrobial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes). They displayed different degrees of antimicrobial activities or inhibitory actions.
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http://dx.doi.org/10.1515/znc-2009-11-1205DOI Listing
April 2010