Publications by authors named "Naser Hatami"

9 Publications

  • Page 1 of 1

Gender Differences in COVID-19 Deceased Cases in Jahrom City, South of Iran.

Bull Emerg Trauma 2021 Apr;9(2):80-85

Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.

Objective: To evaluate the clinical and epidemiological features of deceased patients and comparing the discrepancies between male and female patients based on high prevalence of coronavirus disease 2019 (COVID-19), its irreversible effects and the rising ‎mortality rate in Jahrom city.

Methods: This is a descriptive-analytical retrospective study that was conducted from the beginning of March 2020 to the end of November 2020. The study population were included all patients with COVID-19 who admitted to Peymaniyeh Hospital in Jahrom and died of COVID-19. Clinical and demographic data were collected from medical records and analyzed by SPSS software.

Results: In this study, 61 patients (57.54%) were men and 45 patients (42.36%) were women. The mean age was 68.7±18.33 in men and 68.82±14.24 in women. The mean hospitalization length was 9.69±7.75 days in men and 9.69±7.75 days in women patients. There was no statistically significant difference between men and women patients (>0.05). The results showed that 17 (27.87%) men and 28 (45.9%) of women patients had hypertension and the prevalence of this disease was significantly higher in women than men (=0.01). In this study, 7 (11.48%) men and 13 (21.31%) women had hyperlipidemia. The frequency of hyperlipidemia in women cases was significantly higher than in men patients (=0.024). Men cases' diastolic blood pressure (mean=77.53) was significantly higher than women's diastolic blood pressure at the same time with a mean of 71.42 (<0.05).

Conclusion: The findings of the study represented the mortality rate in men which is higher than women patients. The prevalence of underlying diseases such as hypertension and hyperlipidemia were higher in women than men. Despite higher mortality among women, symptoms such as fever and dyspnea were less common in women than men.
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http://dx.doi.org/10.30476/BEAT.2021.89206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195831PMC
April 2021

COVID-19 as a worldwide selective event and bitter taste receptor polymorphisms: An ecological correlational study.

Int J Biol Macromol 2021 Apr 11;177:204-210. Epub 2021 Feb 11.

Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran. Electronic address:

Background: Given the observed olfactory and gustatory dysfunctions in patients with COVID-19 and recent findings on taste receptors possible important activities in the immune system, we elected to estimate the correlation between COVID-19 mortality and polymorphism of a particular type of bitter taste receptor gene called TAS2R38, in a worldwide epidemiological point of view.

Methods: Pooled rate of each of the rs713598, rs1726866, rs10246939, and PAV/AVI polymorphisms of the TAS2R38 gene was obtained in different countries using a systematic review methodology and its relationship with the mortality of COVID-19. Data were analyzed by the comprehensive meta-analysis software and SPSS.

Results: There was only a significant reverse Pearson correlation in death counts and PAV/AVI ratio, p = 0.047, r = -0.503. Also, a significant reverse correlation of PAV/AVI ratio and death rate was seen, r = -0.572 p = 0.021. rs10246939 ratio had a significant positive correlation with death rate, r = 0.851 p = 0.031. Further analysis was not significant. Our results showed that the higher presence of PAV allele than AVI, and a higher rate of G allele than A in rs10246939 polymorphism in a country, could be associated with lower COVID-19 mortality. While assessing all three polymorphisms showed a huge diversity worldwide.

Conclusion: Due to extraoral activities of bitter taste receptor genes, especially in mucosal immunity, this gene seems to be a good candidate for future studies on COVID-19 pathophysiology. Also, the high worldwide diversity of TAS2R38 genes polymorphism and its possible assassination with mortality raises concerns about the efficiency of vaccine projects in different ethnicities.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.02.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043766PMC
April 2021

The epidemiology and medical care costs of in Jahrom, southern Iran from 2007 to 2017.

Infect Ecol Epidemiol 2020 Sep 24;10(1):1821503. Epub 2020 Sep 24.

Department of Medical Parasitology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

 Echinococcus granulosus is a rare parasitic infection causing Cystic Echinococcosis, which can be dangerous due to involving the body. This parasitic infection is a significant health problem in Iran. However, little is known about this disease, specifically in Jahrom city; thus, we aimed to investigate the epidemiology and the economic impact of the illness. In this descriptive cross-sectional study, the files of 137 patients who were under the care, and treatment of the final diagnosis of Cystic Echinococcosis were evaluated by reviewing the information such as age, gender, occupation, place of residence was collected, and analyzed. Human cystic echinococcosis cases were more common in females, 57.2% (12 patients) and 42.8% (9 patients) were male. In terms of age, most patients (23.8%) were in the age range from 21 to 30 years. The chief complaint at diagnosis, in all cases, was abdominal pain. Besides, 71.42% of the cases had the liver involvement alone, 9.52% had the lung involvement alone, 9.52% had a co-infection of liver and lung, and 4.74% had the kidney involvement alone. The results of the present study are beneficial in determining the disease status and the epidemiology of hydatid cyst in this area.
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http://dx.doi.org/10.1080/20008686.2020.1821503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534386PMC
September 2020

Worldwide ACE (I/D) polymorphism may affect COVID-19 recovery rate: an ecological meta-regression.

Endocrine 2020 06 15;68(3):479-484. Epub 2020 Jun 15.

Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.

With the emergence of the Novel Coronavirus (2019-nCoV), researchers worldwide have started detecting the probable pathogenesis of the disease. The renin-angiotensin system (RAS) and angiotensin-converting enzymes have received a good deal of attention as possible pathways involved in 2019-nCoV pathogenesis. As the experiments seeking to find potential medications acting on these pathways are being conducted in the early phases, having an ecological worldview on the relationship between the prevalence of COVID-19 disease and the genetic differences in the genes involved in the RAS system could be valuable for the field. In this regard, we conducted a meta-analysis study of the prevalence of ACE (I/D) genotype in countries most affected by the COVID-19. In the meta-analysis, 48,758 healthy subjects from 30 different countries were evaluated in 116 studies, using the Comprehensive Meta-analysis software. The I/D allele frequency ratio was pooled by a random-effect model. The COVID-19 prevalence data of death and recovery rates were evaluated as the latitudes for the meta-regression analysis. Our results demonstrated that with the increase of the I/D allele frequency ratio, the recovery rate significantly increased (point estimate: 0.48, CI 95%: 0.05-0.91, p = 0.027). However, there was no significant difference in the case of death rate (point estimate: 1.74, CI 95%: 4.5-1.04, p = 0.22). This ecological perspective coupled with many limitations does not provide a direct clinical relevance between the COVID-19 and RAS system, but it shows potential pathophysiological associations. Our results raise concerns about ethnic and genetic differences that could affect the effectiveness of the currently investigated RAS-associated medications in different regions.
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http://dx.doi.org/10.1007/s12020-020-02381-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294766PMC
June 2020

Diagnostic Accuracy of Physical Examination and History Taking in Traumatic Rib Fracture; A Single Center Experience.

Bull Emerg Trauma 2020 Apr;8(2):111-114

Department of Emergency Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

Objective: To evaluate the diagnostic accuracy of history taking and physical examination in the patients with traumatic rib fractures.

Methods: In a cross-sectional study, all patients with multiple traumas who referred to the emergency department were evaluated for the mechanism of injury, chief complaints, vital signs and oxygen saturation. History taking and physical examination were performed according to Barbara Bates reference. Fracture was diagnosed based on chest x-ray results and CT scan, if needed. The results were analyzed by receiver operating characteristic (ROC) curves and area under the curve (AUC) analysis.

Results: Isolated rib fractures of thoracic bones were found in 8 out of 99 subjects with mean age of 33.4±19.43 years. In the sensitivity analysis of history taking and physical exam tests, the highest sensitivity was chest tenderness and deformity with 100% sensitivity for each one and the lowest was for the dyspnea with 28.10%; however, the highest sensitivity was for dyspnea with 62.50% sensitivity; and pulmonary hearing aid and chest deformity were not specific (0%). For heart rate, AUC analysis was significant. Heart rate above 80/min was associated with 87.5% sensitivity and 62.5% specificity for rib fractures.

Conclusion: Proper and physical examination and history taking can help to detect rib fractures with high sensitivity and specificity denoting to the importance of the issue; while, radiographic or surgical approval is required to diagnose rib fractures.
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http://dx.doi.org/10.30476/BEAT.2020.46451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211385PMC
April 2020

The first case of COVID-19 infection in a 75-day-old infant in Jahrom City, south of Iran.

J Formos Med Assoc 2020 05 13;119(5):995-997. Epub 2020 Apr 13.

Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.

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http://dx.doi.org/10.1016/j.jfma.2020.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194963PMC
May 2020

Vitamin D deficiency in non-autoimmune hypothyroidism: a case-control study.

BMC Endocr Disord 2020 Mar 20;20(1):41. Epub 2020 Mar 20.

Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Although in many studies, the relationship between autoimmune hypothyroidism (Hashimoto) and Vitamin D deficiency was shown, no research has been performed on the role of vitamin D in non-autoimmune hypothyroidism.

Methods: This was a case-control study in Endocrinology clinic of Jahrom (south of Iran). The patients with Hashimoto (n = 633) and non-Hashimoto hypothyroidism (n = 305), along with a control group (n = 200) were evaluated. 25(OH) D level, T3 and T4 levels were studied and Anti TPO and Anti TG tests were performed. The results of vitamin D level were analyzed and interpreted using SPSS in terms of the cause of hypothyroidism (immune and non-immune).

Results: The results of the study showed a significantly lower level of vitamin D in both immune and non-immune Hashimoto's thyroiditis (HT) in comparison to healthy controls (P < 0.05). We observed a significant inverse correlation between the vitamin D and TGAb level (p = 0.001, r = - 0.261) and a direct correlation of vitamin D with TSH level (p = 0.008, r = 0.108) in Hashimoto thyroiditis patients.

Conclusion: Finally, the results indicated that non-autoimmune hypothyroidism, as well as HT, is associated with vitamin D deficiency. The role of vitamin D deficiency in Hashimoto thyroiditis was thought to be in the association of higher autoantibody (TGAb) level; while, there should be further studies determining vitamin D deficiency's role in non-immune hypothyroidism.
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http://dx.doi.org/10.1186/s12902-020-0522-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082994PMC
March 2020

A Declining Trend of Leishmaniasis Based on Previous Data in Larstan, South of Iran 2007-2017.

Ann Glob Health 2019 03 5;85(1). Epub 2019 Mar 5.

Department of Medical, Shahid behshti University of Medical Sciences, Tehran, IR.

Introduction: Cutaneous Leishmaniasis is a unicellular of the Leishmania type, and 0.7 to 1.2 million people are annually infected by Cutaneous Leishmaniasis. Larestan is one of the southern cities of Fars Province. Every year, some issues of Cutaneous Leishmaniasis are reported from Larestan. This study aims to analyze the prevalence of Cutaneous Leishmaniasis in Larestan from 2007 to 2017.

Methodology: The present study is a cross-sectional descriptive-analytical study which is carried out in Larestan. The study population consists of those people who are infected by Cutaneous Leishmaniasis during 2007 to 2017 and are referred to health care centers. The methodology and data collection are done based on the recorded information.

Results: Among 4,965 Cutaneous Leishmaniasis infected patients who referred to health care centers of Larestan, 2407 patients (48.47%) are males and 2558 patients (51.53%) are females. In the ten-year time period of the study, 1,315 (26.6%) were infected to Cutaneous Leishmaniasis in 2010. The maximum infected group consisted of 1,303 patients ranging from 0-5 years old, and the minimum infected group consisted of 90 patients ranging from 55-60 years old.

Discussion: This study showed that female subjects were more polluted in Larestan city. There is also a significant relationship between age and cutaneous leishmaniasis. Finally, it was found that the disease in the city of Larestan has been decreasing.
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http://dx.doi.org/10.5334/aogh.1539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997518PMC
March 2019