Dr. Naseh Pahlavani, PhD - Department of Nutrition, Faculty of Medicine - Clinical Nutrition Specialist

Dr. Naseh Pahlavani

PhD

Department of Nutrition, Faculty of Medicine

Clinical Nutrition Specialist

Mashhad, Razavi Khorasan | Iran (Islamic Republic of)

Main Specialties: Allergy & Immunology, Biochemical Genetics, Critical Care Medicine, Endocrinology Diabetes & Metabolism, Internal Medicine

ORCID logohttps://orcid.org/0000-0001-7960-7267


Top Author

Dr. Naseh Pahlavani, PhD - Department of Nutrition, Faculty of Medicine - Clinical Nutrition Specialist

Dr. Naseh Pahlavani

PhD

Introduction

PhD in Clinical Nutrition at Faculty of Medicine in Mashhad University of Medical Sciences

Primary Affiliation: Department of Nutrition, Faculty of Medicine - Mashhad, Razavi Khorasan , Iran (Islamic Republic of)

Specialties:

Research Interests:


View Dr. Naseh Pahlavani’s Resume / CV

Education

Aug 2016
Mashhad University of Medical Sciences
PhD
Clinical Nutrition

Experience

Mar 2020
Award Grant
Author
India
Sep 2019
Clinical trial in ICU
Administrator
Iran

Publications

11Publications

73Reads

34Profile Views

The relation between CYP2C9 gene polymorphism and warfarin dosing in an Iranian population

J Cardiovasc Disease Res

ABSTRACT

Background: Warfarin is a common anticoagulant agent which is widely used in many countries. However, Warfarin is one of

those drugs which requires close monitoring and dosing while inappropriate could lead to hemorrhagic epoxides. Achieving

a desirable international normalized ratio (INR) range depends on various demographic factors and genetic factors are now

becoming an emerging area of interest in cardiovascular research. CYP2C9 is a gene encoding a member of cytochrome P450

enzyme which metabolizes many drugs. Genetic variation in this gene has been linked to abruption in Warfarin drug response. In

present study the effect of genetic polymorphisms in CYP2C9 gene and its response to Warfarin is investigated.

Methods: Total of 95 patients who had cardiovascular diseases and were using Warfarin for at least 3 months were enrolled in this

cross sectional study. Their DNA was extracted and the genetic polymorphisms in CYP2C9 gene (RS1799853 as CYP2C*2 and

RS1057910 as CYP2C9*3) were evaluated by using polymerase chain reaction and sequencing. Kruskal-Wallis test were used for

comparing the Warfarin values between the genotype groups. The SPSS software 22v was used for data analysis.

Results: Among the study population the prevalence of genotypes were as follow: CC/AA: 61.1, CT/AA: 17.9, CT/AC: 1.1, CC/AC:

3.6, TT/AA: 2.3, CC/CC: 0%. The CC/AA and CC/AC variants were related to Warfarin dose (P<0.05). These patients require lesser

doses of Warfarin in order to achieve the desired INR range.

Conclusion: Determination of genetic polymorphisms of effective genes in Warfarin response such as CYP2C9 gene is important

in initiating the Warfarin therapy and reducing possible complication of Warfarin. Considering genetic polymorphisms in every

population alongside with other effective factors on warfarin dosing should be considered in initiation of anticoagulant therapy.

Keywords: Anticoagulants; Genotype; Polymorphism, Genetic; Warfarin

https://www.jcdronline.org/?mno=93799

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March 2020
1 Read

Effect of Egg Consumption on Blood Pressure: a Systematic Review and Meta-analysis of Randomized Clinical Trials.

Curr Hypertens Rep 2020 Feb 29;22(3):24. Epub 2020 Feb 29.

Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

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http://dx.doi.org/10.1007/s11906-020-1029-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189334PMC
February 2020
3.435 Impact Factor

Nuts effects in chronic disease and relationship between walnuts and satiety: Review on the available evidence

Obesity Medicine

According to epidemiological studies overweight and obesity are increasing rapidly and an inverse relationship between nuts intake and body weight has been seen, however the results of studies have not yet confirmed these effects. The aim of the present study was to conduct a literature review in systematic format on the available evidence to assess the relationship between nuts consumption with obesity and satiety factors with emphasis on walnut consumption with review of clinical trial studies. The literatures search to find related studies were performed through four scientific databases, including Web of Knowledge, PubMed, SCOPUS, and Google Scholar. One of the possible mechanisms for the effect of nuts intake on weight control is promoting satiety. Clinical trial reports have shown that probable nuts intake is associated with weight loss and may help with weight control by reducing appetite and decreasing fat absorption. Walnut contains 18% protein and 58% fat (linoleic acid (50.58–66.60%), oleic acid (14.88–28.71%) and linolenic acid (9.16–16.42%). It seems that appetite-suppressing effect of walnut is related to its PUFA and fiber content. Despite beneficial effects of walnut consumption on health, it appears that further long-term studies should be conducted to evaluate the satiating properties of walnut.

View Article
January 2020
2 Reads

Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies.

Clin Nutr ESPEN 2019 10 5;33:125-131. Epub 2019 Jul 5.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054577193034
Publisher Site
http://dx.doi.org/10.1016/j.clnesp.2019.06.007DOI Listing
October 2019
2 Reads

Possible molecular mechanisms of glucose-lowering activities of Momordica charantia (karela) in diabetes.

J Cell Biochem 2019 Feb 20. Epub 2019 Feb 20.

Department of Modern Sciences and Technology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

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http://dx.doi.org/10.1002/jcb.28483DOI Listing
February 2019
41 Reads
3.263 Impact Factor

The effect of honey consumption compared with sucrose on lipid profile in young healthy subjects (randomized clinical trial).

Clin Nutr ESPEN 2018 08 19;26:8-12. Epub 2018 May 19.

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.clnesp.2018.04.016DOI Listing
August 2018
6 Reads

Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran.

Iran J Neurol 2015 Apr;14(2):74-80

Food Security Research Center AND Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449397PMC
April 2015
9 Reads

L-arginine supplementation and risk factors of cardiovascular diseases in healthy men: a double-blind randomized clinical trial.

F1000Res 2014 12;3:306. Epub 2014 Dec 12.

Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.12688/f1000research.5877.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510020PMC
December 2014
13 Reads

Top co-authors

Soudabeh Fallah
Soudabeh Fallah

Iran University of Medical Sciences

2
Naheed Aryaeian
Naheed Aryaeian

Tehran University of Medical Sciences

2
Fatemeh Ebrahimi
Fatemeh Ebrahimi

University of Birjand

2
Nariman Moradi
Nariman Moradi

Tehran University of Medical Sciences

2
Agha Fatemeh Hosseini
Agha Fatemeh Hosseini

Tehran University of Medical Sciences

2
Omid Sadeghi
Omid Sadeghi

Food Security Research Center

2
Hamid Rasad
Hamid Rasad

School of Nutrition and Food Science

2
Majid Ghayour-Mobarhan
Majid Ghayour-Mobarhan

Mashhad University of Medical Sciences

2
Abdolreza Norouzy
Abdolreza Norouzy

University of Medical Sciences

2
Jamshid Gholizadeh Navashenaq
Jamshid Gholizadeh Navashenaq

Immunology Research Center

2