Narayan G Avadhani

Narayan G Avadhani

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Narayan G Avadhani

Publications by authors named "Narayan G Avadhani"

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Cytochrome c oxidase dysfunction enhances phagocytic function and osteoclast formation in macrophages.

FASEB J 2019 Aug 7;33(8):9167-9181. Epub 2019 May 7.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1096/fj.201900010RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662975PMC
August 2019

Mitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models.

J Biol Chem 2019 Jun 20;294(26):10336-10348. Epub 2019 May 20.

From the Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,

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http://dx.doi.org/10.1074/jbc.RA119.008848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664168PMC
June 2019

Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens.

Adv Exp Med Biol 2018;1032:15-35

Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-3-319-98788-0_2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371814PMC
May 2019

Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection.

Biochim Biophys Acta Bioenerg 2017 Aug 16;1858(8):602-614. Epub 2017 Jan 16.

The Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, #189E, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487289PMC
August 2017

Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia.

Biochim Biophys Acta Bioenerg 2017 Jul 23;1858(7):519-528. Epub 2017 Apr 23.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6009, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2017.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507603PMC
July 2017

ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds.

Am J Cancer Res 2016 15;6(4):781-96. Epub 2016 Mar 15.

Gastroenterology Division, Department of Medicine, University of Pennsylvania Perelman School of MedicinePhiladelphia, PA, USA; University of Pennsylvania Abramson Cancer CenterPhiladelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859883PMC
May 2016

Mitochondrial respiratory defects promote the Warburg effect and cancer progression.

Mol Cell Oncol 2016 Mar 10;3(2):e1085120. Epub 2015 Dec 10.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA, USA.

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http://dx.doi.org/10.1080/23723556.2015.1085120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905388PMC
March 2016

Enhanced osteoclastogenesis by mitochondrial retrograde signaling through transcriptional activation of the cathepsin K gene.

Ann N Y Acad Sci 2016 Jan 18;1364:52-61. Epub 2015 Mar 18.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/nyas.12709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575226PMC
January 2016

Defects in cytochrome c oxidase expression induce a metabolic shift to glycolysis and carcinogenesis.

Genom Data 2015 Dec 14;6:99-107. Epub 2015 Aug 14.

The Department of Biomedical Sciences, School of Veterinary Medicines, University of Pennsylvania, PA, United States.

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http://dx.doi.org/10.1016/j.gdata.2015.07.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664720PMC
December 2015

Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity.

Redox Biol 2014 23;2:273-83. Epub 2013 Jul 23.

The Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.redox.2013.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909819PMC
June 2015

Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.

J Biol Chem 2014 Oct 26;289(43):29614-30. Epub 2014 Aug 26.

From the Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and

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http://dx.doi.org/10.1074/jbc.M114.583062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207977PMC
October 2014

Oxidative stress induced mitochondrial protein kinase A mediates cytochrome c oxidase dysfunction.

PLoS One 2013 10;8(10):e77129. Epub 2013 Oct 10.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077129PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795003PMC
June 2014

Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction.

J Biol Chem 2014 Apr 4;289(14):9936-51. Epub 2014 Feb 4.

From the Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1074/jbc.M113.525659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975038PMC
April 2014

Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics.

Mitochondrion 2013 Nov 1;13(6):577-91. Epub 2013 Sep 1.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2013.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832239PMC
November 2013

Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes.

Proc Natl Acad Sci U S A 2013 Jul 17;110(27):11115-20. Epub 2013 Jun 17.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19147, USA.

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http://dx.doi.org/10.1073/pnas.1220919110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704019PMC
July 2013

Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models.

J Biol Chem 2013 May 7;288(18):12627-44. Epub 2013 Mar 7.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M113.452367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642310PMC
May 2013

Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.

J Biol Chem 2013 Feb 20;288(6):4436-51. Epub 2012 Dec 20.

Department of Animal Biology and Marie Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6046, USA.

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http://dx.doi.org/10.1074/jbc.M112.402123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567693PMC
February 2013

Mitochondrial dysfunction in myocardium obtained from clinically normal dogs, clinically normal anesthetized dogs, and dogs with dilated cardiomyopathy.

Am J Vet Res 2012 Nov;73(11):1759-64

Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.2460/ajvr.73.11.1759DOI Listing
November 2012

Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo.

Carcinogenesis 2012 Sep 27;33(9):1762-8. Epub 2012 May 27.

Department of Animal Biology and Marie Lowe Center for Comparative Oncology, University of Pennsylvania, Philadelphia, PA 19104,USA.

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http://dx.doi.org/10.1093/carcin/bgs190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514893PMC
September 2012

Cytochrome c oxidase dysfunction in oxidative stress.

Free Radic Biol Med 2012 Sep 25;53(6):1252-63. Epub 2012 Jul 25.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436951PMC
September 2012

Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes.

J Biol Chem 2012 May 6;287(19):15284-97. Epub 2012 Mar 6.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M111.314062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346148PMC
May 2012

The effects of smoke carcinogens on bone.

Curr Osteoporos Rep 2011 Dec;9(4):202-9

University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://link.springer.com/content/pdf/10.1007/s11914-011-0068
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http://link.springer.com/10.1007/s11914-011-0068-x
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http://dx.doi.org/10.1007/s11914-011-0068-xDOI Listing
December 2011

Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals.

FEBS J 2011 Nov 24;278(22):4218-29. Epub 2011 Oct 24.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2011.08356.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204614PMC
November 2011

Targeting of the same proteins to multiple subcellular destinations: mechanisms and physiological implications.

FEBS J 2011 Nov 24;278(22):4217. Epub 2011 Oct 24.

Department of Animal Biology and the Mari Low Center for Comparative Oncology, the School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2011.08355.xDOI Listing
November 2011

Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets.

Biochim Biophys Acta 2010 Jun-Jul;1797(6-7):1055-65. Epub 2010 Feb 11.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.bbabio.2010.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891149PMC
January 2011

Cell signaling.

Ann N Y Acad Sci 2010 Nov;1211:3-8

Department of Animal Biology, University of Pennsylvania Veterinary School, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05811.xDOI Listing
November 2010

Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicity.

Expert Opin Drug Metab Toxicol 2010 Oct;6(10):1231-51

University of Pennsylvania, School of Veterinary Medicine, Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1517/17425255.2010.503955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940958PMC
October 2010

Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2.

Mol Biol Cell 2010 Oct 18;21(20):3578-89. Epub 2010 Aug 18.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1091/mbc.E10-03-0192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954122PMC
October 2010

Leucine-rich pentatricopeptide-repeat containing protein regulates mitochondrial transcription.

Biochemistry 2010 Sep;49(35):7467-73

Department of Pediatrics, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1021/bi1008479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932791PMC
September 2010

Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress.

J Biol Chem 2010 Aug 7;285(32):24609-19. Epub 2010 Jun 7.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.121822
Publisher Site
http://dx.doi.org/10.1074/jbc.M110.121822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915697PMC
August 2010

Role of mitochondrial reactive oxygen species in osteoclast differentiation.

Ann N Y Acad Sci 2010 Mar;1192:245-52

Department of Animal Biology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05377.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856121PMC
March 2010

Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting.

Mol Genet Metab 2010 Jan;99(1):90-7

Dept. of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ymgme.2009.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794965PMC
January 2010

Heterogeneous nuclear ribonucleoprotein A2 is a common transcriptional coactivator in the nuclear transcription response to mitochondrial respiratory stress.

Mol Biol Cell 2009 Sep 29;20(18):4107-19. Epub 2009 Jul 29.

Department of Animal Biology and Marie Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1091/mbc.e09-04-0296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743628PMC
September 2009

Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism.

FEBS J 2009 Jul 11;276(13):3440-53. Epub 2009 May 11.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2009.07067.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789264PMC
July 2009

Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.

J Biol Chem 2009 Jun 28;284(25):17352-63. Epub 2009 Apr 28.

Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M109.007492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719370PMC
June 2009

Bimodal protein targeting through activation of cryptic mitochondrial targeting signals by an inducible cytosolic endoprotease.

Mol Cell 2008 Oct;32(1):32-42

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743273PMC
October 2008

An unusual TOM20/TOM22 bypass mechanism for the mitochondrial targeting of cytochrome P450 proteins containing N-terminal chimeric signals.

J Biol Chem 2008 Jul 14;283(28):19769-80. Epub 2008 May 14.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M801464200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443649PMC
July 2008

A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling.

J Biol Chem 2008 May 13;283(18):12586-94. Epub 2008 Feb 13.

Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M710481200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2335355PMC
May 2008

Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain.

J Biol Chem 2008 Apr 1;283(14):9089-100. Epub 2008 Feb 1.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1074/jbc.M710012200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2431021PMC
April 2008

Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers.

Free Radic Biol Med 2008 Mar 4;44(5):835-46. Epub 2007 Dec 4.

Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692199PMC
March 2008

Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling.

Proc Natl Acad Sci U S A 2008 Jan 2;105(1):186-91. Epub 2008 Jan 2.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0706183104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224183PMC
January 2008

Hypoxia-mediated mitochondrial stress in RAW264.7 cells induces osteoclast-like TRAP-positive cells.

Ann N Y Acad Sci 2007 Nov;1117:51-61

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1196/annals.1402.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446731PMC
November 2007

Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae--role of protein kinase A in the mitochondrial targeting of CYP2E1.

FEBS J 2007 Sep 14;274(17):4615-30. Epub 2007 Aug 14.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2007.05990.xDOI Listing
September 2007

beta1-Adrenoreceptor activation contributes to ischemia-reperfusion damage as well as playing a role in ischemic preconditioning.

Am J Physiol Heart Circ Physiol 2007 May 19;292(5):H2459-66. Epub 2007 Jan 19.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia PA 19104-6046, USA.

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http://dx.doi.org/10.1152/ajpheart.00459.2006DOI Listing
May 2007

Activation of a novel calcineurin-mediated insulin-like growth factor-1 receptor pathway, altered metabolism, and tumor cell invasion in cells subjected to mitochondrial respiratory stress.

J Biol Chem 2007 May 13;282(19):14536-46. Epub 2007 Mar 13.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1074/jbc.M611693200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800738PMC
May 2007

Site specific phosphorylation of cytochrome c oxidase subunits I, IVi1 and Vb in rabbit hearts subjected to ischemia/reperfusion.

FEBS Lett 2007 Apr 28;581(7):1302-10. Epub 2007 Feb 28.

Laboratory of Biochemistry, The Department of Animal Biology, School of Veterinary Medicine, 3800 Spruce Street, University of Pennsylvania, Philadelphia, PA 19104, United States.

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http://dx.doi.org/10.1016/j.febslet.2007.02.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995084PMC
April 2007

Role of protein kinase C-mediated protein phosphorylation in mitochondrial translocation of mouse CYP1A1, which contains a non-canonical targeting signal.

J Biol Chem 2006 Oct 9;281(41):30834-47. Epub 2006 Aug 9.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M510725200DOI Listing
October 2006

Modulation of mitochondrial metabolic function by phorbol 12-myristate 13-acetate through increased mitochondrial translocation of protein kinase Calpha in C2C12 myocytes.

Biochem Pharmacol 2006 Sep 8;72(7):881-92. Epub 2006 Aug 8.

Laboratories of Biochemistry, Department of Animal Biology and The Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.bcp.2006.06.032DOI Listing
September 2006

Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury.

J Biol Chem 2006 Jan 22;281(4):2061-70. Epub 2005 Nov 22.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1074/jbc.M507741200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271455PMC
January 2006

Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis.

Gene 2005 Jul;354:132-9

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.gene.2005.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800739PMC
July 2005

Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness.

Sleep 2005 Jan;28(1):21-7

Center for Sleep and Respiratory Neurobiology, School of Medicine, Hospital of the Univesity of Pennsylvania, Philadelphia, PA 19104-4283, USA.

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http://dx.doi.org/10.1093/sleep/28.1.21DOI Listing
January 2005

Mitochondrial signaling: the retrograde response.

Mol Cell 2004 Apr;14(1):1-15

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/s1097-2765(04)00179-0DOI Listing
April 2004

Competitive and noncompetitive inhibition of myocardial cytochrome C oxidase in sepsis.

Shock 2004 Feb;21(2):110-4

Department of Anesthesia, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-4283, USA.

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http://dx.doi.org/10.1097/01.shk.0000108400.56565.abDOI Listing
February 2004

Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress.

Diabetes 2004 Jan;53(1):185-94

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.2337/diabetes.53.1.185DOI Listing
January 2004

Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70.

J Biol Chem 2003 May 19;278(21):18960-70. Epub 2003 Mar 19.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M301807200DOI Listing
May 2003

Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta.

J Cell Biol 2003 May 5;161(3):507-19. Epub 2003 May 5.

Dept. of Animal Biology, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1083/jcb.200211104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172940PMC
May 2003

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells.

J Cell Biol 2003 Apr;161(1):41-54

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1083/jcb.200207030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172865PMC
April 2003

Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia.

Eur J Biochem 2003 Mar;270(5):871-9

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1046/j.1432-1033.2003.03447.xDOI Listing
March 2003

Transcription termination at the mouse mitochondrial H-strand promoter distal site requires an A/T rich sequence motif and sequence specific DNA binding proteins.

Eur J Biochem 2003 Mar;270(6):1128-40

Laboratories of Biochemistry, Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1046/j.1432-1033.2003.03461.xDOI Listing
March 2003

Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells.

Oncogene 2002 Nov;21(51):7839-49

Department of Animal Biology and Mari Lowe Center for Comparative Oncology School of Veterinary Medicine, University of Pennsylvania 3800 Spruce Street, Philadelphia, PA 19104-6047, USA.

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http://dx.doi.org/10.1038/sj.onc.1205983DOI Listing
November 2002

Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation.

J Biol Chem 2002 Oct 20;277(43):40583-93. Epub 2002 Aug 20.

Department of Animal Biology, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1074/jbc.M203292200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800117PMC
October 2002

Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress.

Biochem J 2002 Aug;366(Pt 1):45-55

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6047, U.S.A.

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http://biochemj.org/lookup/doi/10.1042/bj20020533
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http://dx.doi.org/10.1042/BJ20020533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222767PMC
August 2002