Naoto Oku

Naoto Oku

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Naoto Oku

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Applications of Liposomal Drug Delivery Systems to Develop Neuroprotective Agents for the Treatment of Ischemic Stroke.

Biol Pharm Bull 2019 ;42(3):319-326

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka.

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http://dx.doi.org/10.1248/bpb.b18-00683DOI Listing
July 2019

Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques.

J Control Release 2019 May 29;302:105-115. Epub 2019 Mar 29.

Department of Molecular Imaging, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan; Laboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.03.025DOI Listing
May 2019

Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule.

Biomacromolecules 2019 Apr 15;20(4):1644-1654. Epub 2019 Mar 15.

Department of Medical Biochemistry, Graduate School of Pharmaceutical Sciences , University of Shizuoka , 52-1 Yada, Suruga-ku , Shizuoka , Shizuoka 422-8526 , Japan.

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01820
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http://dx.doi.org/10.1021/acs.biomac.8b01820DOI Listing
April 2019

[The Role of the Pharmaceutical Society of Japan in Advancing of Clinical Pharmacy Research].

Authors:
Naoto Oku

Yakugaku Zasshi 2019 ;139(3):401-404

School of Pharmaceutical Sciences, University of Shizuoka.

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http://dx.doi.org/10.1248/yakushi.18-00186-2DOI Listing
March 2019

Rigorous control of vesicle-forming lipid pK by fluorine-conjugated bioisosteres for gene-silencing with siRNA.

J Control Release 2019 Feb 26;295:87-92. Epub 2018 Dec 26.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.12.044DOI Listing
February 2019

Design of a Novel PEGylated Liposomal Vector for Systemic Delivery of siRNA to Solid Tumors.

Biol Pharm Bull 2019 ;42(6):996-1003

Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences.

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http://dx.doi.org/10.1248/bpb.b19-00032DOI Listing
January 2019

Anticancer Efficacy of the Combination of Berberine and PEGylated Liposomal Doxorubicin in Meth A Sarcoma-Bearing Mice.

Biol Pharm Bull 2018 ;41(7):1103-1106

Natural Products and Integrative Medicine Research Section, Research Division, National Cancer Institute.

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http://dx.doi.org/10.1248/bpb.b17-00989DOI Listing
October 2018

Nobiletin Reduces Intracellular and Extracellular β-Amyloid in iPS Cell-Derived Alzheimer's Disease Model Neurons.

Biol Pharm Bull 2018 ;41(4):451-457

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka.

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http://dx.doi.org/10.1248/bpb.b17-00364DOI Listing
September 2018

Involvement of Tumor Lymphatic System in Translocation of Intratumorally Injected Liposomes.

Biol Pharm Bull 2018 ;41(4):652-656

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka.

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http://dx.doi.org/10.1248/bpb.b17-00730DOI Listing
September 2018

Systemic Administration of siRNA with Anti-HB-EGF Antibody-Modified Lipid Nanoparticles for the Treatment of Triple-Negative Breast Cancer.

Mol Pharm 2018 04 12;15(4):1495-1504. Epub 2018 Mar 12.

Department of Medical Biochemistry, School of Pharmaceutical Sciences , University of Shizuoka , 52-1 Yada, Suruga-ku , Shizuoka 422-8526 , Japan.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b01055DOI Listing
April 2018

Co-administration of liposomal fasudil and tissue plasminogen activator ameliorated ischemic brain damage in occlusion model rats prepared by photochemically induced thrombosis.

Biochem Biophys Res Commun 2018 01 21;495(1):873-877. Epub 2017 Nov 21.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.11.107DOI Listing
January 2018

Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins.

J Control Release 2017 Dec 20;268:335-342. Epub 2017 Oct 20.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.10.028DOI Listing
December 2017

A polymer nanoparticle with engineered affinity for a vascular endothelial growth factor (VEGF).

Nat Chem 2017 07 27;9(7):715-722. Epub 2017 Mar 27.

Department of Chemistry, University of California Irvine, Irvine, California 92697, USA.

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http://dx.doi.org/10.1038/nchem.2749DOI Listing
July 2017

Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke.

FASEB J 2017 05 12;31(5):1879-1890. Epub 2017 Jan 12.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan; and

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http://dx.doi.org/10.1096/fj.201601209RDOI Listing
May 2017

Process optimization by use of design of experiments: Application for liposomalization of FK506.

Eur J Pharm Sci 2017 May 7;102:196-202. Epub 2017 Mar 7.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.03.007DOI Listing
May 2017

Targeted delivery of anticancer drugs to tumor vessels by use of liposomes modified with a peptide identified by phage biopanning with human endothelial progenitor cells.

Int J Pharm 2017 May 27;524(1-2):364-372. Epub 2017 Mar 27.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2017.03.059DOI Listing
May 2017

Amelioration of Citrobacter rodentium proliferation in early stage of infection in mice by pretreatment with Lactobacillus brevis KB290 and verification using in vivo bioluminescence imaging.

FEMS Microbiol Lett 2017 03;364(6)

Laboratory of Microbiology, Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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https://academic.oup.com/femsle/article-lookup/doi/10.1093/f
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http://dx.doi.org/10.1093/femsle/fnw254DOI Listing
March 2017

Innovations in Liposomal DDS Technology and Its Application for the Treatment of Various Diseases.

Authors:
Naoto Oku

Biol Pharm Bull 2017 ;40(2):119-127

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka.

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http://dx.doi.org/10.1248/bpb.b16-00857DOI Listing
February 2017

Ameliorating Effects of Sphingomyelin-Based Liposomes on Sarcopenia in Senescence-Accelerated Mice.

Biol Pharm Bull 2016 ;39(5):786-93

Department of Medical Biochemistry, Graduate School of Pharmaceutical Sciences, University of Shizuoka.

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http://dx.doi.org/10.1248/bpb.b15-00915DOI Listing
January 2017

Specific delivery of an immunosuppressive drug to splenic B cells by antigen-modified liposomes and its antiallergic effect.

J Drug Target 2016 11 25;24(9):890-895. Epub 2016 May 25.

a Department of Medical Biochemistry , School of Pharmaceutical Sciences, University of Shizuoka , Yada , Suruga-Ku , Shizuoka , Japan.

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http://dx.doi.org/10.3109/1061186X.2016.1172588DOI Listing
November 2016

Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity.

Sci Rep 2016 07 21;6:30127. Epub 2016 Jul 21.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1038/srep30127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954989PMC
July 2016

Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil.

Int J Pharm 2016 Jun 20;506(1-2):129-37. Epub 2016 Apr 20.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2016.04.046DOI Listing
June 2016

One-step encapsulation of siRNA between lipid-layers of multi-layer polycation liposomes by lipoplex freeze-thawing.

J Control Release 2016 Apr 28;228:1-8. Epub 2016 Jan 28.

Department of Medical Biochemistry, Graduate Division of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.01.032DOI Listing
April 2016

Bauhinia purprea agglutinin-modified liposomes for human prostate cancer treatment.

Cancer Sci 2016 Jan 11;107(1):53-9. Epub 2015 Dec 11.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

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http://doi.wiley.com/10.1111/cas.12839
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http://dx.doi.org/10.1111/cas.12839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724813PMC
January 2016

Enhanced Efficacy of Doxorubicin by microRNA-499-Mediated Improvement of Tumor Blood Flow.

J Clin Med 2016 Jan 19;5(1). Epub 2016 Jan 19.

Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.3390/jcm5010010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730135PMC
January 2016

Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions.

Eur J Pharm Biopharm 2015 Nov 9;97(Pt A):1-7. Epub 2015 Oct 9.

Department of Medical Biochemistry, University of Shizuoka Graduate School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2015.09.020DOI Listing
November 2015

Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model.

Int J Pharm 2015 Aug 6;492(1-2):20-7. Epub 2015 Jul 6.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2015.07.004DOI Listing
August 2015

Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin.

Biol Pharm Bull 2014 26;37(9):1555-8. Epub 2014 Jun 26.

Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka.

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May 2015

Formulation design and evaluation of liposomal sepantronium bromide (YM155), a small-molecule survivin suppressant, based on pharmacokinetic modeling and simulation.

Pharm Res 2015 Jan 18;32(1):238-47. Epub 2014 Jul 18.

Pharmaceutical Research and Technology Labs., Technology, Astellas Pharma Inc.,, 180 Ozumi, Yaizu-shi,, Shizuoka, 425-0072, Japan,

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http://dx.doi.org/10.1007/s11095-014-1458-4DOI Listing
January 2015

Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of rapamycin.

Nanomedicine 2015 Jan 18;11(1):185-94. Epub 2014 Sep 18.

Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Shizuoka, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15499634140052
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http://dx.doi.org/10.1016/j.nano.2014.09.003DOI Listing
January 2015

Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin.

PLoS One 2014 3;9(2):e85520. Epub 2014 Feb 3.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Shizuoka, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085520PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911897PMC
December 2014

Suppression in mice of immunosurveillance against PEGylated liposomes by encapsulated doxorubicin.

J Control Release 2014 Oct 17;192:167-73. Epub 2014 Jul 17.

Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.07.010DOI Listing
October 2014

Systemic delivery of small RNA using lipid nanoparticles.

Biol Pharm Bull 2014 ;37(2):201-5

Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences.

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September 2014

Antitumor efficacy and biodistribution of liposomal sepantronium bromide (YM155), a novel small-molecule survivin suppressant.

Eur J Pharm Biopharm 2014 Sep 30;88(1):283-9. Epub 2014 Jun 30.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Japan.

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http://dx.doi.org/10.1016/j.ejpb.2014.06.015DOI Listing
September 2014

Antibody-modified lipid nanoparticles for selective delivery of siRNA to tumors expressing membrane-anchored form of HB-EGF.

Biochem Biophys Res Commun 2014 Jul 20;449(4):460-5. Epub 2014 May 20.

Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.05.043DOI Listing
July 2014

Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499.

J Control Release 2014 May 2;181:32-9. Epub 2014 Mar 2.

Department of Medical Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.02.019DOI Listing
May 2014

[In vivo imaging of liposomal small interfering RNA (siRNA) trafficking by positron emission tomography].

Yakugaku Zasshi 2012 ;132(12):1373-81

Department of Medical Biochemistry, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

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April 2014

Enhanced active targeting via cooperative binding of ligands on liposomes to target receptors.

PLoS One 2013 28;8(6):e67550. Epub 2013 Jun 28.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067550PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695877PMC
April 2014

Enhanced susceptibility to spontaneous seizures of noda epileptic rats by loss of synaptic zn(2+).

PLoS One 2013 12;8(8):e71372. Epub 2013 Aug 12.

Department of Bioorganic chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE-21, 52- 1 Yada, Suruga-ku, Shizuoka, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071372PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741169PMC
April 2014

Cell-penetrating peptide-conjugated lipid nanoparticles for siRNA delivery.

Biochem Biophys Res Commun 2014 Feb 31;444(4):599-604. Epub 2014 Jan 31.

Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2014.01.107DOI Listing
February 2014

Polycation liposomes as a vector for potential intracellular delivery of microRNA.

J Gene Med 2013 Oct;15(10):375-83

Department of Medical Biochemistry, University of Shizuoka Graduate School of Pharmaceutical Sciences, Shizuoka, Japan.

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http://dx.doi.org/10.1002/jgm.2744DOI Listing
October 2013

Liposomes and nanotechnology in drug development: focus on ocular targets.

Int J Nanomedicine 2013 14;8:495-503. Epub 2013 Feb 14.

Department of Ophthalmology, Juntendo University Urayasu Hospital, Chiba, Japan.

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http://dx.doi.org/10.2147/IJN.S30725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576887PMC
September 2013

Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy.

Biol Pharm Bull 2013 ;36(2):287-91

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52–1 Yada, Suruga-ku, Shizuoka 422–8526, Japan.

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August 2013

Suppression of immune response by antigen-modified liposomes encapsulating model agents: a novel strategy for the treatment of allergy.

J Control Release 2013 May 16;167(3):284-9. Epub 2013 Feb 16.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.jconrel.2013.02.002DOI Listing
May 2013

Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506.

FASEB J 2013 Apr 14;27(4):1362-70. Epub 2012 Dec 14.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

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http://dx.doi.org/10.1096/fj.12-221325DOI Listing
April 2013

Biomembrane damage caused by exposure to multi-walled carbon nanotubes.

J Toxicol Sci 2013 Feb;38(1):7-12

Department of Medical Biochemistry, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

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February 2013

Development of a miR-92a delivery system for anti-angiogenesis-based cancer therapy.

J Gene Med 2013 Jan;15(1):20-7

Department of Medical Biochemistry, University of Shizuoka Graduate School of Pharmaceutical Sciences, Shizuoka, Japan.

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http://dx.doi.org/10.1002/jgm.2690DOI Listing
January 2013

Nanoparticles accumulate in ischemic core and penumbra region even when cerebral perfusion is reduced.

Biochem Biophys Res Commun 2013 Jan 23;430(4):1201-5. Epub 2012 Dec 23.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2012.12.080DOI Listing
January 2013

Inhibitory effect of liposomal rhinacanthin-N isolated from Rhinacanthus nasutus on pulmonary metastasis in mice.

Biol Pharm Bull 2012 ;35(7):1197-200

Natural Products Research Section, Research Division, National Cancer Institute, Bangkok 10400, Thailand.

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December 2012

A single injection of liposomal asialo-erythropoietin improves motor function deficit caused by cerebral ischemia/reperfusion.

Int J Pharm 2012 Dec 16;439(1-2):269-74. Epub 2012 Sep 16.

Department of Medical Biochemistry and Global COE, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2012.09.026DOI Listing
December 2012

Ability of fibrinogen γ-derived dodecapeptides with different sequences to bind to rat platelets.

Int J Pharm 2012 Nov 15;438(1-2):296-301. Epub 2012 Sep 15.

Pharmaceutical Research Department of CMC Research Center, Mitsubishi Tanabe Pharma Corporation, 3-16-89, Kashima, Yodogawa-ku, Osaka 532-8505, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2012.09.016DOI Listing
November 2012

Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles.

Int J Pharm 2012 Aug 26;432(1-2):75-9. Epub 2012 Apr 26.

Department of Medical Biochemistry and Global COE Program, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S037851731200395
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http://dx.doi.org/10.1016/j.ijpharm.2012.04.049DOI Listing
August 2012

Transient increase in Zn2+ in hippocampal CA1 pyramidal neurons causes reversible memory deficit.

PLoS One 2011 7;6(12):e28615. Epub 2011 Dec 7.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE-21, Suruga-ku, Shizuoka, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028615PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233599PMC
July 2012

RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment.

J Control Release 2012 Jun 13;160(2):177-81. Epub 2011 Oct 13.

Department of Medical Biochemistry and Global COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.jconrel.2011.10.004DOI Listing
June 2012

Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer.

J Control Release 2012 Jun 14;160(2):274-80. Epub 2011 Oct 14.

Department of Medical Biochemistry and Global COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.jconrel.2011.10.010DOI Listing
June 2012

Amelioration of cerebral ischemia-reperfusion injury based on liposomal drug delivery system with asialo-erythropoietin.

J Control Release 2012 May 10;160(1):81-7. Epub 2012 Feb 10.

Department of Medical Biochemistry and Global COE, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Japan.

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http://dx.doi.org/10.1016/j.jconrel.2012.02.004DOI Listing
May 2012

Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice.

Brain Res Bull 2012 Apr 21;87(6):551-5. Epub 2012 Feb 21.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52-1 Yada, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.brainresbull.2012.02.003DOI Listing
April 2012

Involvement of N-methyl-D-aspartate receptor subunits in zinc-mediated modification of CA1 long-term potentiation in the developing hippocampus.

J Neurosci Res 2012 Mar 4;90(3):551-8. Epub 2011 Nov 4.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, Shizuoka, Japan.

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http://dx.doi.org/10.1002/jnr.22787DOI Listing
March 2012

Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress.

Neurochem Int 2012 Mar 27;60(4):394-9. Epub 2012 Jan 27.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.

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http://dx.doi.org/10.1016/j.neuint.2012.01.021DOI Listing
March 2012

[Education of graduate school of pharmaceutical sciences in new generation: introduction].

Yakugaku Zasshi 2011 ;131(6):931

Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Japan.

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January 2012

Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response.

Cell Mol Neurobiol 2012 Jan 8;32(1):41-8. Epub 2011 Jul 8.

Graduate School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.

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http://dx.doi.org/10.1007/s10571-011-9732-zDOI Listing
January 2012

Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency.

Behav Brain Res 2012 Jan 19;226(1):259-64. Epub 2011 Sep 19.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S01664328110069
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http://dx.doi.org/10.1016/j.bbr.2011.09.026DOI Listing
January 2012

Design and synthesis of high-avidity tetravalent glycoclusters as probes for Sambucus sieboldiana agglutinin and characterization of their binding properties.

Bioconjug Chem 2012 Jan 6;23(1):97-105. Epub 2012 Jan 6.

Department of Bioscience, Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga, Shizuoka, Japan.

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http://dx.doi.org/10.1021/bc200440eDOI Listing
January 2012

The rational design of a synthetic polymer nanoparticle that neutralizes a toxic peptide in vivo.

Proc Natl Acad Sci U S A 2012 Jan 22;109(1):33-8. Epub 2011 Dec 22.

Department of Chemical Engineering, Kyushu University, 744 Motooka, Fukuoka 819-0395, Japan.

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http://dx.doi.org/10.1073/pnas.1112828109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252894PMC
January 2012

Proapoptotic action of p53-Tom5 in p53-resistant A549 human non-small cell lung cancer cells through direct mitochondrial dysfunction.

Biol Pharm Bull 2011 ;34(4):551-4

Department of Medical Biochemistry, Global COE Program, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Yada, Suruga-ku, Japan.

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December 2011

Anti-angiogenic activity and intracellular distribution of epigallocatechin-3-gallate analogs.

Biol Pharm Bull 2011 ;34(3):396-400

Department of Medical Biochemistry, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan.

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November 2011

Inhibition of Akt (ser473) phosphorylation and rapamycin-resistant cell growth by knockdown of mammalian target of rapamycin with small interfering RNA in vascular endothelial growth factor receptor-1-targeting vector.

Biol Pharm Bull 2011 ;34(5):602-8

Department of Medical Biochemistry and Global COE Program, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan.

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September 2011

Argonaute2 is a potential target for siRNA-based cancer therapy for HT1080 human fibrosarcoma.

Drug Deliv Transl Res 2011 Aug;1(4):277-88

Department of Pharmacokinetics and Biopharmaceutics, Subdivision of Biopharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima, 770-8505, Japan.

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http://dx.doi.org/10.1007/s13346-011-0025-3DOI Listing
August 2011

Agitation during lipoplex formation improves the gene knockdown effect of siRNA.

Int J Pharm 2011 May 8;410(1-2):153-60. Epub 2011 Mar 8.

Department of Pharmacokinetics and Biopharmaceutics, Institute of Health Biosciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2011.03.001DOI Listing
May 2011

Decoration of fibrinogen γ-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets.

Int J Pharm 2011 Apr 18;407(1-2):151-7. Epub 2011 Jan 18.

Pharmaceutical Research Department of CMC Research Center, Mitsubishi Tanabe Pharma Corporation, 3-16-89, Kashima, Yodogawa-ku, Osaka 532-8505, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2011.01.014DOI Listing
April 2011

Evaluating tamsulosin hydrochloride-released microparticles prepared using single-step matrix coating.

Int J Pharm 2011 Apr 1;408(1-2):84-90. Epub 2011 Feb 1.

Pharmaceutical Research and Technology Labs, Astellas Pharma Inc., 180 Ozumi, Yaizu, Shizuoka 425-0072, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2011.01.053DOI Listing
April 2011

PET imaging of nobiletin based on a practical total synthesis.

Chem Commun (Camb) 2011 Mar 18;47(10):2868-70. Epub 2011 Jan 18.

School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1039/c0cc04936kDOI Listing
March 2011

Dicetyl phosphate-tetraethylenepentamine-based liposomes for systemic siRNA delivery.

Bioconjug Chem 2011 Mar 1;22(3):429-35. Epub 2011 Mar 1.

Department of Medical Biochemistry and Global COE, University of Shizuoka Graduate School of Pharmaceutical Sciences, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1021/bc1004697DOI Listing
March 2011

Suppression of choroidal neovascularization by intravitreal injection of liposomal SU5416.

Arch Ophthalmol 2011 Mar;129(3):317-21

Department of Ophthalmology, Juntendo University Urayasu Hospital, Chiba, Japan.

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http://dx.doi.org/10.1001/archophthalmol.2011.12DOI Listing
March 2011

Synthesis of long-chain [¹⁸F]Deoxyfluoropoly(ethylene glycol) methyl ethers and their noninvasive pharmacokinetic analysis by positron emission tomography.

Mol Pharm 2011 Feb 15;8(1):302-8. Epub 2010 Dec 15.

Department of Synthetic Organic Chemistry, Department of Medical Biochemistry, and Global COE Program, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1021/mp100271gDOI Listing
February 2011

Concise synthesis of catechin probes enabling analysis and imaging of EGCg.

Chem Commun (Camb) 2011 Feb 3;47(6):1794-6. Epub 2010 Dec 3.

School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1039/c0cc03676eDOI Listing
February 2011

PET imaging of brain cancer with positron emitter-labeled liposomes.

Int J Pharm 2011 Jan 8;403(1-2):170-7. Epub 2010 Oct 8.

Department of Medical Biochemistry, University of Shizuoka, Yada, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2010.10.001DOI Listing
January 2011

Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78.

Int J Cancer 2010 Dec;127(11):2685-98

Department of Medical Biochemistry, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.

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http://dx.doi.org/10.1002/ijc.25276DOI Listing
December 2010

Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin.

Neurochem Int 2010 Nov 30;57(5):608-14. Epub 2010 Jul 30.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.

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http://dx.doi.org/10.1016/j.neuint.2010.07.010DOI Listing
November 2010

Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice.

Brain Res Bull 2010 Nov 9;83(6):351-5. Epub 2010 Sep 9.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.brainresbull.2010.08.013DOI Listing
November 2010

Anti-obesity effect of phosphatidylinositol on diet-induced obesity in mice.

J Agric Food Chem 2010 Nov 8;58(21):11218-25. Epub 2010 Oct 8.

Department of Medical Biochemistry and Global Center of Excellence (COE) Program, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1021/jf102075jDOI Listing
November 2010

Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components.

Brain Res 2010 Oct 21;1354:188-95. Epub 2010 Jul 21.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE-21, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.brainres.2010.07.039DOI Listing
October 2010

Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice.

Biol Pharm Bull 2010 ;33(1):117-21

Department of Medical Biochemistry and Global COE Program, University of Shizuoka, Shizuoka, Japan.

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June 2010

T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.

Int J Pharm 2010 Jun 21;392(1-2):218-23. Epub 2010 Mar 21.

Department of Medical Biochemistry and Global COE Program, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2010.03.022DOI Listing
June 2010

Liposomal polyamine-dialkyl phosphate conjugates as effective gene carriers: chemical structure, morphology, and gene transfer activity.

Bioconjug Chem 2010 May;21(5):844-52

Department of Life and Materials Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan.

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http://dx.doi.org/10.1021/bc900376yDOI Listing
May 2010

Angiogenic vessel-targeting DDS by liposomalized oligopeptides.

Methods Mol Biol 2010 ;605:335-47

Department of Medical Biochemistry and Global COE, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

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http://dx.doi.org/10.1007/978-1-60327-360-2_23DOI Listing
April 2010

Zinc differentially acts on components of long-term potentiation at hippocampal CA1 synapses.

Brain Res 2010 Apr 6;1323:59-64. Epub 2010 Feb 6.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.brainres.2010.01.085DOI Listing
April 2010

Development of double-stranded siRNA labeling method using positron emitter and its in vivo trafficking analyzed by positron emission tomography.

Bioconjug Chem 2010 Apr;21(4):756-63

Department of Medical Biochemistry and Global COE Program, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka-city, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1021/bc9005267DOI Listing
April 2010

Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion.

Brain Res 2010 Mar 21;1321:164-8. Epub 2010 Jan 21.

Department of Medical Biochemistry and Global COE, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.brainres.2010.01.039DOI Listing
March 2010