Naoto Hirano

Naoto Hirano

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Naoto Hirano

Naoto Hirano

Publications by authors named "Naoto Hirano"

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Chaperones of the class I peptide-loading complex facilitate the constitutive presentation of endogenous antigens on HLA-DP.

J Autoimmun 2019 Aug 8;102:114-125. Epub 2019 May 8.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 2M9, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.04.023DOI Listing
August 2019

In vitro-generated MART-1-specific CD8 T cells display a broader T-cell receptor repertoire than ex vivo naïve and tumor-infiltrating lymphocytes.

Immunol Cell Biol 2019 04 15;97(4):427-434. Epub 2019 Feb 15.

Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/imcb.12231DOI Listing
April 2019

Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells.

J Autoimmun 2019 Feb 11;97:10-21. Epub 2018 Oct 11.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 2M9, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183028
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http://dx.doi.org/10.1016/j.jaut.2018.09.011DOI Listing
February 2019

Gene Modification and Immunological Analyses for the Development of Immunotherapy Utilizing T Cells Redirected with Antigen-Specific Receptors.

Methods Mol Biol 2019 ;2048:27-39

Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-9728-2_3DOI Listing
January 2019

Mechanisms of HLA-DP Antigen Processing and Presentation Revisited.

Trends Immunol 2018 12 8;39(12):960-964. Epub 2018 Nov 8.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 2M9, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.it.2018.10.008DOI Listing
December 2018

Two Weeks' Notice from Allogeneic Sources.

Clin Cancer Res 2018 11 25;24(21):5195-5197. Epub 2018 Jun 25.

Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1552DOI Listing
November 2018

DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models.

Nat Commun 2018 05 15;9(1):1915. Epub 2018 May 15.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1038/s41467-018-04262-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954061PMC
May 2018

A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects.

Nat Med 2018 03 5;24(3):352-359. Epub 2018 Feb 5.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nm.4478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839992PMC
March 2018

Mechanisms underlying the lack of endogenous processing and CLIP-mediated binding of the invariant chain by HLA-DP.

Sci Rep 2018 03 19;8(1):4804. Epub 2018 Mar 19.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1038/s41598-018-22931-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859192PMC
March 2018

A Subset of Human Autoreactive CD1c-Restricted T Cells Preferentially Expresses TRBV4-1 TCRs.

J Immunol 2018 01 13;200(2):500-511. Epub 2017 Dec 13.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada;

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http://dx.doi.org/10.4049/jimmunol.1700677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760327PMC
January 2018

Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors.

PLoS One 2016 23;11(5):e0156114. Epub 2016 May 23.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156114PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877060PMC
July 2017

HLA-DP constitutively presents endogenous peptides generated by the class I antigen processing pathway.

Nat Commun 2017 05 10;8:15244. Epub 2017 May 10.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5G 2M9.

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http://dx.doi.org/10.1038/ncomms15244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436232PMC
May 2017

Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs.

J Immunol 2017 02 21;198(3):1056-1065. Epub 2016 Dec 21.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada;

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http://dx.doi.org/10.4049/jimmunol.1601556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5262525PMC
February 2017

Petit-spot as definitive evidence for partial melting in the asthenosphere caused by CO.

Nat Commun 2017 02 2;8:14302. Epub 2017 Feb 2.

Center for Northeast Asian Studies, Tohoku University, Kawauchi 41, Aoba-ku, Sendai 980-8576, Japan.

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http://dx.doi.org/10.1038/ncomms14302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296659PMC
February 2017

Transient stimulation expands superior antitumor T cells for adoptive therapy.

JCI Insight 2017 01 26;2(2):e89580. Epub 2017 Jan 26.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1172/jci.insight.89580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256130PMC
January 2017

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain.

J Vis Exp 2016 10 25(116). Epub 2016 Oct 25.

Department of Immunology, University of Toronto; Princess Margaret Cancer Centre, University Health Network;

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http://dx.doi.org/10.3791/54697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519318PMC
October 2016

CDR3β sequence motifs regulate autoreactivity of human invariant NKT cell receptors.

J Autoimmun 2016 Apr 31;68:39-51. Epub 2015 Dec 31.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2M9, Canada; Department of Immunology, University of Toronto, Toronto, ON, M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2015.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792736PMC
April 2016

CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells.

Sci Rep 2016 Mar 31;6:23821. Epub 2016 Mar 31.

Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1038/srep23821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814874PMC
March 2016

Optimization of T-cell Reactivity by Exploiting TCR Chain Centricity for the Purpose of Safe and Effective Antitumor TCR Gene Therapy.

Cancer Immunol Res 2015 Sep 5;3(9):1070-81. Epub 2015 May 5.

Immune Therapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

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http://cancerimmunolres.aacrjournals.org/cgi/doi/10.1158/232
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http://dx.doi.org/10.1158/2326-6066.CIR-14-0222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561213PMC
September 2015

Adoptive T Cell Therapy Targeting CD1 and MR1.

Front Immunol 2015 20;6:247. Epub 2015 May 20.

Department of Immunology, University of Toronto , Toronto, ON , Canada ; Princess Margaret Cancer Centre, University Health Network , Toronto, ON , Canada.

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http://dx.doi.org/10.3389/fimmu.2015.00247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440381PMC
June 2015

Specific roles of each TCR hemichain in generating functional chain-centric TCR.

J Immunol 2015 Apr 20;194(7):3487-500. Epub 2015 Feb 20.

Immune Therapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada; Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada; Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada; Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; and

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http://dx.doi.org/10.4049/jimmunol.1401717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369446PMC
April 2015

Human cell-based artificial antigen-presenting cells for cancer immunotherapy.

Immunol Rev 2014 Jan;257(1):191-209

Immune Therapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada.

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http://doi.wiley.com/10.1111/imr.12129
Publisher Site
http://dx.doi.org/10.1111/imr.12129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869003PMC
January 2014

[The cutting edge of antitumor adoptive cell therapy].

Rinsho Ketsueki 2011 Oct;52(10):1713-20

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October 2011

Juvenile myelomonocytic leukemia: epidemiology, etiopathogenesis, diagnosis, and management considerations.

Paediatr Drugs 2010 ;12(1):11-21

Department of HSCT Data Management, Nagoya University, Japan.

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http://link.springer.com/10.2165/11316200-000000000-00000
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http://dx.doi.org/10.2165/11316200-000000000-00000DOI Listing
February 2010

Volcanism in response to plate flexure.

Science 2006 Sep 27;313(5792):1426-8. Epub 2006 Jul 27.

Department of Earth and Planetary Sciences, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8551, Japan.

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http://dx.doi.org/10.1126/science.1128235DOI Listing
September 2006

The chemical structure of the Hawaiian mantle plume.

Nature 2005 Aug;436(7052):837-40

Department of Earth and Planetary Sciences, Tokyo Institute of Technology 2-12-1 Ookayama, Meguro-ku, 152-8551, Japan.

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http://dx.doi.org/10.1038/nature03907DOI Listing
August 2005

Presence of anti-kinectin and anti-PMS1 antibodies in Japanese aplastic anaemia patients.

Br J Haematol 2005 Jan;128(2):221-3

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2004.05317.xDOI Listing
January 2005

Autoantibodies frequently detected in patients with aplastic anemia.

Blood 2003 Dec 28;102(13):4567-75. Epub 2003 Aug 28.

Dana-Farber Cancer Institute, Department of Medical Oncology, 44 Binney St, Boston MA 02115, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-11-34
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http://dx.doi.org/10.1182/blood-2002-11-3409DOI Listing
December 2003