Nanhai Chen

Nanhai Chen

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Nanhai Chen

Publications by authors named "Nanhai Chen"

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A Novel Chimeric Poxvirus Encoding hNIS Is Tumor-Tropic, Imageable, and Synergistic with Radioiodine to Sustain Colon Cancer Regression.

Mol Ther Oncolytics 2019 Jun 11;13:82-92. Epub 2019 Apr 11.

Department of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.omto.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495072PMC
June 2019

Oncolytic Viruses and Immune Checkpoint Inhibition: The Best of Both Worlds.

Mol Ther Oncolytics 2019 Jun 25;13:93-106. Epub 2019 Apr 25.

Department of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.omto.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503136PMC
June 2019

A chimeric poxvirus with J2R (thymidine kinase) deletion shows safety and anti-tumor activity in lung cancer models.

Cancer Gene Ther 2019 Jun 17. Epub 2019 Jun 17.

Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.

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http://dx.doi.org/10.1038/s41417-019-0114-xDOI Listing
June 2019

A Novel Oncolytic Chimeric Orthopoxvirus Encoding Luciferase Enables Real-Time View of Colorectal Cancer Cell Infection.

Mol Ther Oncolytics 2018 Jun 22;9:13-21. Epub 2018 Mar 22.

Department of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.omto.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026443PMC
June 2018

Oncolytic viruses and immunity.

Curr Opin Immunol 2018 04 16;51:83-90. Epub 2018 Mar 16.

Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA; Center for Gene Therapy, Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2018.03.008DOI Listing
April 2018

Oncolytic Virotherapy versus Cancer Stem Cells: A Review of Approaches and Mechanisms.

Cancers (Basel) 2018 Apr 19;10(4). Epub 2018 Apr 19.

Department of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.3390/cancers10040124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923379PMC
April 2018

Novel oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose.

J Transl Med 2018 04 26;16(1):110. Epub 2018 Apr 26.

Department of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, 1500 Duarte Rd., Duarte, CA, 91010, USA.

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http://dx.doi.org/10.1186/s12967-018-1483-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918769PMC
April 2018

Novel chimeric parapoxvirus CF189 as an oncolytic immunotherapy in triple-negative breast cancer.

Surgery 2018 02 22;163(2):336-342. Epub 2017 Nov 22.

Department of Surgery, City of Hope National Medical Center, Duarte, CA; Center for Gene Therapy, Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2017.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780196PMC
February 2018

From Benchtop to Bedside: A Review of Oncolytic Virotherapy.

Biomedicines 2016 Aug 2;4(3). Epub 2016 Aug 2.

Department of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.3390/biomedicines4030018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344257PMC
August 2016

Expression of anti-VEGF antibody together with anti-EGFR or anti-FAP enhances tumor regression as a result of vaccinia virotherapy.

Mol Ther Oncolytics 2015 18;2:15003. Epub 2015 Mar 18.

Department of Biochemistry, Rudolph Virchow Center for Experimental Biomedicine, Institute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany; Genelux Corporation, San Diego Science Center, San Diego, California, USA; Department of Radiation Medicine and Applied Sciences, Rebecca & John Moores Comprehensive Cancer Center, University of California, San Diego, California, USA.

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http://dx.doi.org/10.1038/mto.2015.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782963PMC
April 2016

Recombinant vaccinia virus GLV-1h68 is a promising oncolytic vector in the treatment of cholangiocarcinoma.

Cancer Gene Ther 2015 Dec 20;22(12):591-6. Epub 2015 Nov 20.

Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.

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http://www.nature.com/articles/cgt201560
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http://dx.doi.org/10.1038/cgt.2015.60DOI Listing
December 2015

Evaluation of a new recombinant oncolytic vaccinia virus strain GLV-5b451 for feline mammary carcinoma therapy.

PLoS One 2014 5;9(8):e104337. Epub 2014 Aug 5.

Department of Biochemistry, University of Wuerzburg, Wuerzburg, Germany; Genelux Corporation, San Diego Science Center, San Diego, California, United States of America; Division of Medicine Clinic III, Hematology, Oncology and Palliative Medicine University of Rostock, Rostock, Germany; Department of Radiation Medicine and Applied Sciences, Rebecca & John Moores Comprehensive Cancer Center, University of California San Diego, La Jolla, California, United States of America; Rudolf Virchow Center for Experimental Biomedicine, University of Wuerzburg, Wuerzburg, Germany; Institute for Molecular Infection Biology, University of Wuerzburg, Wuerzburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104337PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122492PMC
November 2015

Isolated limb perfusion with melphalan, tumour necrosis factor-alpha and oncolytic vaccinia virus improves tumour targeting and prolongs survival in a rat model of advanced extremity sarcoma.

Int J Cancer 2015 Feb 22;136(4):965-76. Epub 2014 Jul 22.

Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom; Department of Academic Surgery, Sarcoma/Melanoma Unit, Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1002/ijc.29059DOI Listing
February 2015

Characterization of metastasis formation and virotherapy in the human C33A cervical cancer model.

PLoS One 2014 2;9(6):e98533. Epub 2014 Jun 2.

Institute of Biochemistry, University of Wuerzburg, Wuerzburg, Germany; Genelux Corporation, San Diego Science Center, San Diego, California, United States of America; Department of Radiation Medicine and Applied Sciences, Rebecca & John Moores Comprehensive Cancer Center, University of California, San Diego, California, United States of America; Genelux GmbH, Bernried, Germany; Rudolph Virchow Center for Experimental Biomedicine and Institute for Molecular Infection Biology, University of Wuerzburg, Wuerzburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098533PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041767PMC
January 2015

Combination of fractionated irradiation with anti-VEGF expressing vaccinia virus therapy enhances tumor control by simultaneous radiosensitization of tumor associated endothelium.

Int J Cancer 2013 Dec 5;133(12):2989-99. Epub 2013 Aug 5.

Department of Biochemistry, Rudolph Virchow Center for Experimental Biomedicine and Institute for Molecular Infection Biology, University of Würzburg, D-97074, Würzburg, Germany; Genelux Corporation, San Diego Science Center, San Diego, CA.

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http://dx.doi.org/10.1002/ijc.28296DOI Listing
December 2013

Vaccinia virus-mediated expression of human erythropoietin in tumors enhances virotherapy and alleviates cancer-related anemia in mice.

Mol Ther 2013 Nov 14;21(11):2054-62. Epub 2013 Jun 14.

Department of Biochemistry, Rudolph Virchow Center for Experimental Biomedicine, and Institute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1038/mt.2013.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831032PMC
November 2013

Oncolytic vaccinia virus therapy of salivary gland carcinoma.

JAMA Otolaryngol Head Neck Surg 2013 Feb;139(2):173-82

Departments of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1001/jamaoto.2013.1360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413455PMC
February 2013

Vaccinia virus GLV-1h153 is effective in treating and preventing metastatic triple-negative breast cancer.

Ann Surg 2012 Sep;256(3):437-45

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1097/SLA.0b013e3182654572DOI Listing
September 2012

Oncolytic viruses.

Adv Virol 2012 6;2012:320206. Epub 2012 Jun 6.

Genelux Corporation, San Diego Science Center, San Diego, CA 92019, USA.

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http://dx.doi.org/10.1155/2012/320206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384932PMC
August 2012

A novel genetically modified oncolytic vaccinia virus in experimental models is effective against a wide range of human cancers.

Ann Surg Oncol 2012 Jul 19;19 Suppl 3:S665-74. Epub 2012 Jan 19.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1245/s10434-011-2198-xDOI Listing
July 2012

Effective oncolytic vaccinia therapy for human sarcomas.

J Surg Res 2012 Jun 14;175(2):e53-60. Epub 2011 Dec 14.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1016/j.jss.2011.11.1030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350611PMC
June 2012

Preferential replication of systemically delivered oncolytic vaccinia virus in focally irradiated glioma xenografts.

Clin Cancer Res 2012 May 29;18(9):2579-90. Epub 2012 Feb 29.

Department of Radiation Medicine and Applied Sciences and Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2394DOI Listing
May 2012

Novel therapy for anaplastic thyroid carcinoma cells using an oncolytic vaccinia virus carrying the human sodium iodide symporter.

Surgery 2011 Dec;150(6):1040-7

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.surg.2011.09.010DOI Listing
December 2011

Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68.

BMC Cancer 2011 Oct 19;11:451. Epub 2011 Oct 19.

Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center and trans-NIH Center of Human Immunology, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/1471-2407-11-451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213037PMC
October 2011

Poxvirus interleukin-4 expression overcomes inherent resistance and vaccine-induced immunity: pathogenesis, prophylaxis, and antiviral therapy.

Virology 2011 Jan 10;409(2):328-37. Epub 2010 Nov 10.

Genelux Corporation, San Diego Science Center, 3030 Bunker Hill Street, Suite 310, San Diego, CA 92109, USA.

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http://dx.doi.org/10.1016/j.virol.2010.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008208PMC
January 2011

Ectromelia virus inhibitor of complement enzymes protects intracellular mature virus and infected cells from mouse complement.

J Virol 2010 Sep 7;84(18):9128-39. Epub 2010 Jul 7.

Department of Medicine/Division of Rheumatology, Washington University School of Medicine, Campus Box 8045, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1128/JVI.02677-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937632PMC
September 2010

The highly attenuated oncolytic recombinant vaccinia virus GLV-1h68: comparative genomic features and the contribution of F14.5L inactivation.

Mol Genet Genomics 2009 Oct 22;282(4):417-35. Epub 2009 Aug 22.

Genelux Corporation, San Diego Science Center, 3030 Bunker Hill St., Ste. 310, San Diego, CA 92109, USA.

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http://link.springer.com/10.1007/s00438-009-0475-1
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http://dx.doi.org/10.1007/s00438-009-0475-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746888PMC
October 2009

Anti-VEGF single-chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances antitumor therapy.

Proc Natl Acad Sci U S A 2009 Aug 15;106(31):12915-20. Epub 2009 Jul 15.

Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA.

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http://dx.doi.org/10.1073/pnas.0900660106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722284PMC
August 2009

Oncolytic vaccinia therapy of squamous cell carcinoma.

Mol Cancer 2009 Jul 6;8:45. Epub 2009 Jul 6.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1476-4598-8-45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714037PMC
July 2009

Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo.

J Clin Endocrinol Metab 2008 Nov 12;93(11):4403-7. Epub 2008 Aug 12.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1210/jc.2008-0316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728375PMC
November 2008

Primary naive and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication.

J Gen Virol 2008 Mar;89(Pt 3):751-759

Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, 1402 South Grand Blvd, St Louis, MO 63104, USA.

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http://dx.doi.org/10.1099/vir.0.83205-0DOI Listing
March 2008

Genomic differences of Vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3.

Vaccine 2007 Dec 8;25(52):8807-32. Epub 2007 Nov 8.

Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, United States.

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http://dx.doi.org/10.1016/j.vaccine.2007.10.040DOI Listing
December 2007

Treatment of anaplastic thyroid carcinoma in vitro with a mutant vaccinia virus.

Surgery 2007 Dec 5;142(6):976-83; discussion 976-83. Epub 2007 Nov 5.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1016/j.surg.2007.09.017DOI Listing
December 2007

Poxvirus-encoded gamma interferon binding protein dampens the host immune response to infection.

J Virol 2007 Apr 17;81(7):3346-53. Epub 2007 Jan 17.

The John Curtin School of Medical Research, Australian National University, Acton, ACT 0200, Australia.

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http://dx.doi.org/10.1128/JVI.01927-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866021PMC
April 2007

The unique C termini of orthopoxvirus gamma interferon binding proteins are essential for ligand binding.

J Virol 2006 Nov 23;80(21):10675-82. Epub 2006 Aug 23.

Saint Louis University, Department of Molecular Microbiology and Immunology, 1402 South Grand Blvd., St. Louis, MO 63104, USA.

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http://dx.doi.org/10.1128/JVI.01015-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1641743PMC
November 2006

Virulence differences between monkeypox virus isolates from West Africa and the Congo basin.

Virology 2005 Sep;340(1):46-63

Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, M432, St. Louis, MO 63104, USA.

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http://dx.doi.org/10.1016/j.virol.2005.05.030DOI Listing
September 2005

Biosynthesis of the IFN-gamma binding protein of ectromelia virus, the causative agent of mousepox.

Virology 2005 Mar;334(1):41-50

Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, 1402 South Grand Boulevard, St. Louis, MO 63104, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S004268220500037
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http://dx.doi.org/10.1016/j.virol.2005.01.015DOI Listing
March 2005

The genomic sequence of ectromelia virus, the causative agent of mousepox.

Virology 2003 Dec;317(1):165-86

Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, 1402 South Grand Boulevard, St. Louis, MO 63104, USA.

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http://dx.doi.org/10.1016/s0042-6822(03)00520-8DOI Listing
December 2003

Viral binding proteins as antibody surrogates in immunoassays of cytokines.

Biotechniques 2002 Jan;32(1):160, 162-4, 166-71

St. Louis University Health Sciences Center, MO 63104, USA.

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http://dx.doi.org/10.2144/02321dd02DOI Listing
January 2002