Nanduri R Prabhakar

Nanduri R Prabhakar

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Publications by authors named "Nanduri R Prabhakar"

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Long-Term Facilitation of Catecholamine Secretion from Adrenal Chromaffin Cells of Neonatal Rats by Chronic Intermittent Hypoxia.

J Neurophysiol 2019 Sep 4. Epub 2019 Sep 4.

Institute for Integrative Physiology, The University of Chicago, United States.

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http://dx.doi.org/10.1152/jn.00435.2019DOI Listing
September 2019

Therapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model.

Adv Exp Med Biol 2018;1071:109-114

Institute for Integrative Physiology and Center for Systems Biology of Oxygen Sensing, Biological Sciences Division, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1007/978-3-319-91137-3_14DOI Listing
July 2019

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

PLoS One 2019 24;14(4):e0215905. Epub 2019 Apr 24.

Institute for Integrative Physiology, Center for Systems Biology of O2 Sensing, Biological Sciences Division, The University of Chicago, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215905PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481834PMC
April 2019

Recent advances in understanding the physiology of hypoxic sensing by the carotid body.

F1000Res 2018 6;7. Epub 2018 Dec 6.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, The University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.12688/f1000research.16247.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284772PMC
March 2019

Neural Activation of Molecular Circuitry in Intermittent Hypoxia.

Curr Opin Physiol 2019 Feb 29;7:9-14. Epub 2018 Nov 29.

Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Department of Medicine, University of Chicago, Chicago, IL. USA.

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http://dx.doi.org/10.1016/j.cophys.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753940PMC
February 2019

Measurement of Sensory Nerve Activity from the Carotid Body.

Methods Mol Biol 2018 ;1742:115-124

Biological Sciences Division, Department of Medicine, Institute for Integrative Physiology, Center for Systems Biology of Oxygen Sensing, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1007/978-1-4939-7665-2_11DOI Listing
January 2019

Immunohistochemistry of the Carotid Body.

Methods Mol Biol 2018 ;1742:155-166

Institute for Integrative Physiology, Center for Systems Biology of Oxygen Sensing, Biological Sciences Division, Department of Medicine, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1007/978-1-4939-7665-2_14DOI Listing
January 2019

HS mediates carotid body response to hypoxia but not anoxia.

Respir Physiol Neurobiol 2019 01 4;259:75-85. Epub 2018 Aug 4.

Institute for Integrative Physiology and Center for Systems Biology of O2Sensing, University of Chicago, Chicago, IL, 60637, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15699048183008
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http://dx.doi.org/10.1016/j.resp.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252114PMC
January 2019

DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity.

J Physiol 2018 08 4;596(15):3087-3100. Epub 2018 Jan 4.

Institute for Integrative Physiology and Centre for Systems Biology of O2 Sensing, Biological Science Division, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1113/JP274833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068255PMC
August 2018

The role of hypoxia-inducible factors in carotid body (patho) physiology.

J Physiol 2018 08 12;596(15):2977-2983. Epub 2018 Feb 12.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1113/JP275696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068252PMC
August 2018

Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia.

Cell Tissue Res 2018 05 22;372(2):427-431. Epub 2018 Feb 22.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, MC 5068, 5841 South Maryland Avenue, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1007/s00441-018-2807-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918151PMC
May 2018

Oxygen Sensing by the Carotid Body: Past and Present.

Adv Exp Med Biol 2017 ;977:3-8

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1007/978-3-319-55231-6_1DOI Listing
January 2018

Epigenetic changes by DNA methylation in chronic and intermittent hypoxia.

Am J Physiol Lung Cell Mol Physiol 2017 Dec 24;313(6):L1096-L1100. Epub 2017 Aug 24.

Institute For Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, The University of Chicago, Chicago, Illinois;

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http://dx.doi.org/10.1152/ajplung.00325.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814703PMC
December 2017

Systems biology of oxygen homeostasis.

Wiley Interdiscip Rev Syst Biol Med 2017 07 21;9(4). Epub 2017 Feb 21.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/wsbm.1382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606335PMC
July 2017

Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia.

J Physiol 2017 01 2;595(1):63-77. Epub 2016 Oct 2.

Institute For Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1113/JP272346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199741PMC
January 2017

Carotid body chemoreflex: a driver of autonomic abnormalities in sleep apnoea.

Exp Physiol 2016 08;101(8):975-85

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1113/EP085624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968581PMC
August 2016

H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea.

Sci Signal 2016 08 16;9(441):ra80. Epub 2016 Aug 16.

Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1126/scisignal.aaf3204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505181PMC
August 2016

Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex.

Front Neurosci 2016 4;10. Epub 2016 Feb 4.

Center for Integrative Brain Research, Seattle Children's Research InstituteSeattle, WA, USA; Departments of Neurological Surgery and Pediatrics, University of WashingtonSeattle, WA, USA.

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http://dx.doi.org/10.3389/fnins.2016.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740384PMC
February 2016

HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase.

PLoS One 2015 9;10(3):e0119762. Epub 2015 Mar 9.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119762PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353619PMC
January 2016

Regulation of carotid body oxygen sensing by hypoxia-inducible factors.

Pflugers Arch 2016 Jan 13;468(1):71-75. Epub 2015 Aug 13.

Institute for Cell Engineering; Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1007/s00424-015-1719-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548826PMC
January 2016

Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications.

Adv Exp Med Biol 2015 ;860:1-8

Biological Science Division, Institute for Integrative Physiology, 5841 S. Maryland Avenue, MC 5068, Room N-711, University of Chicago, Chicago, IL, 60637, USA,

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http://dx.doi.org/10.1007/978-3-319-18440-1_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870818PMC
January 2016

Carotid Body Chemoreflex Mediates Intermittent Hypoxia-Induced Oxidative Stress in the Adrenal Medulla.

Adv Exp Med Biol 2015 ;860:195-9

Institute for Integrative Physiology & Center for Systems Biology for O2 Sensing, The University of Chicago, Chicago, IL, 60637, USA,

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http://dx.doi.org/10.1007/978-3-319-18440-1_21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872510PMC
January 2016

CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia.

J Neurophysiol 2016 Jan 11;115(1):345-54. Epub 2015 Nov 11.

Institute for Integrative Physiology and Center for Systems Biology of Oxygen Sensing, University of Chicago, Chicago, Illinois

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http://dx.doi.org/10.1152/jn.00775.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760493PMC
January 2016

Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea.

J Appl Physiol (1985) 2015 Nov 7;119(10):1152-6. Epub 2015 May 7.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1152/japplphysiol.00162.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816415PMC
November 2015

Oxygen Sensing and Homeostasis.

Physiology (Bethesda) 2015 Sep;30(5):340-8

Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland; and McKusick-Nathans Institute of Genetic Medicine and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1152/physiol.00022.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556828PMC
September 2015

Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome.

J Mol Med (Berl) 2015 May 15;93(5):473-80. Epub 2015 Mar 15.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, Chicago, IL, 60615, USA.

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http://dx.doi.org/10.1007/s00109-015-1274-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409567PMC
May 2015

Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla.

Respir Physiol Neurobiol 2015 Apr 10;209:115-9. Epub 2015 Jan 10.

Institute for Integrative Physiology and Center for Systems Biology of O(2) Sensing, Biological Sciences Division, University of Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.resp.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373452PMC
April 2015

Peripheral chemoreception and arterial pressure responses to intermittent hypoxia.

Compr Physiol 2015 Apr;5(2):561-77

Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/cphy.c140039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423746PMC
April 2015

Protein kinase G-regulated production of H2S governs oxygen sensing.

Sci Signal 2015 Apr 21;8(373):ra37. Epub 2015 Apr 21.

Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1126/scisignal.2005846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418480PMC
April 2015

CaV3.2 T-type Ca²⁺ channels in H₂S-mediated hypoxic response of the carotid body.

Am J Physiol Cell Physiol 2015 Jan 5;308(2):C146-54. Epub 2014 Nov 5.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, The University of Chicago, Chicago, Illinois

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http://dx.doi.org/10.1152/ajpcell.00141.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297770PMC
January 2015

Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats.

J Physiol 2014 Sep 27;592(17):3841-58. Epub 2014 Jun 27.

Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, IL, 60637, USA

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http://dx.doi.org/10.1113/jphysiol.2014.273789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192707PMC
September 2014

Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia.

PLoS One 2013 4;8(10):e75838. Epub 2013 Oct 4.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075838PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790816PMC
July 2014

Is insulin the new intermittent hypoxia?

Med Hypotheses 2014 Jun 18;82(6):730-5. Epub 2014 Mar 18.

Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mehy.2014.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023546PMC
June 2014

TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.

Cell Rep 2014 Jun 15;7(5):1343-1352. Epub 2014 May 15.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247140034
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http://dx.doi.org/10.1016/j.celrep.2014.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516227PMC
June 2014

Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation.

Am J Physiol Cell Physiol 2014 Apr 29;306(8):C745-52. Epub 2014 Jan 29.

University of Chicago, Institute For Integrative Physiology and Center for Systems Biology of O2 Sensing, Chicago, Illinois; and.

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http://dx.doi.org/10.1152/ajpcell.00313.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989715PMC
April 2014

Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression.

Biochem J 2014 Mar;458(2):203-11

§Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, IL 60637, U.S.A.

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http://dx.doi.org/10.1042/BJ20131350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374488PMC
March 2014

Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body.

Physiology (Bethesda) 2014 Jan;29(1):49-57

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois; and.

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http://dx.doi.org/10.1152/physiol.00034.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929115PMC
January 2014

Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema.

Proc Natl Acad Sci U S A 2014 Jan 6;111(3):1174-9. Epub 2014 Jan 6.

Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, IL 60637.

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http://dx.doi.org/10.1073/pnas.1322172111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903201PMC
January 2014

Central and peripheral factors contributing to obstructive sleep apneas.

Respir Physiol Neurobiol 2013 Nov 11;189(2):344-53. Epub 2013 Jun 11.

Center for Integrative Brain Research, Seattle Children's Research Institute, Department of Neurological Surgery and Pediatrics, University of Washington School of Medicine, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.resp.2013.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901437PMC
November 2013

Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia.

Exp Physiol 2013 Nov 2;98(11):1620-30. Epub 2013 Aug 2.

N. R. Prabhakar: Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, MC 5068, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1113/expphysiol.2013.073700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808500PMC
November 2013

Impairment of pancreatic β-cell function by chronic intermittent hypoxia.

Exp Physiol 2013 Sep 24;98(9):1376-85. Epub 2013 May 24.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1113/expphysiol.2013.072454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756548PMC
September 2013

Sensing hypoxia: physiology, genetics and epigenetics.

J Physiol 2013 May 4;591(9):2245-57. Epub 2013 Mar 4.

Institute for Integrative Physiology, Center for Systems Biology of O(2) Sensing, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1113/jphysiol.2012.247759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650692PMC
May 2013

Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis.

Proc Natl Acad Sci U S A 2013 May 22;110(19):E1788-96. Epub 2013 Apr 22.

Biological Sciences Division, Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.1305961110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651442PMC
May 2013

The role of hypoxia-inducible factors in oxygen sensing by the carotid body.

Adv Exp Med Biol 2012 ;758:1-5

Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1007/978-94-007-4584-1_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715076PMC
April 2013

Hydrogen sulfide (H(2)S): a physiologic mediator of carotid body response to hypoxia.

Adv Exp Med Biol 2012 ;758:109-13

Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1007/978-94-007-4584-1_15DOI Listing
April 2013

Differential regulation of tyrosine hydroxylase by continuous and intermittent hypoxia.

Adv Exp Med Biol 2012 ;758:381-5

Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1007/978-94-007-4584-1_51DOI Listing
April 2013

Developmental programming of O(2) sensing by neonatal intermittent hypoxia via epigenetic mechanisms.

Respir Physiol Neurobiol 2013 Jan 27;185(1):105-9. Epub 2012 Jul 27.

Institute for Integrative Physiology and Center for Systems Biology of O(2) Sensing, Biological Science Division, University of Chicago, Chicago, USA.

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http://dx.doi.org/10.1016/j.resp.2012.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893877PMC
January 2013

Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body.

Respir Physiol Neurobiol 2012 Nov 2;184(2):165-9. Epub 2012 Jun 2.

Institute for Integrative Physiology and Center for Systems Biology of O(2) Sensing, Biological Sciences Division, University of Chicago, IL 60637, USA.

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http://ac.els-cdn.com/S156990481200136X/1-s2.0-S156990481200
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http://linkinghub.elsevier.com/retrieve/pii/S156990481200136
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http://dx.doi.org/10.1016/j.resp.2012.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449038PMC
November 2012

Endogenous H2S is required for hypoxic sensing by carotid body glomus cells.

Am J Physiol Cell Physiol 2012 Nov 27;303(9):C916-23. Epub 2012 Jun 27.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1152/ajpcell.00100.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492824PMC
November 2012

Sympatho-adrenal activation by chronic intermittent hypoxia.

J Appl Physiol (1985) 2012 Oct 21;113(8):1304-10. Epub 2012 Jun 21.

Institute for Integrative Physiology and The Center for Systems Biology of Oxygen Sensing, Biological Sciences Division, Dept. of Medicine, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.

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http://dx.doi.org/10.1152/japplphysiol.00444.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472486PMC
October 2012

NADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells.

Antioxid Redox Signal 2012 Aug 2;17(3):445-59. Epub 2012 Mar 2.

Department of Medicine, Institute for Integrative Physiology, University of Chicago, Chicago, IL 60637-1470, USA.

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http://dx.doi.org/10.1089/ars.2011.4176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365360PMC
August 2012

Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.

Physiol Rev 2012 Jul;92(3):967-1003

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1152/physrev.00030.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893888PMC
July 2012

Gaseous messengers in oxygen sensing.

J Mol Med (Berl) 2012 Mar 16;90(3):265-72. Epub 2012 Feb 16.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1007/s00109-012-0876-1DOI Listing
March 2012

Gas biology: small molecular medicine.

J Mol Med (Berl) 2012 Mar;90(3):213-5

Vascular Program, Institute for Cell Engineering, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s00109-012-0877-0DOI Listing
March 2012

Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis.

Proc Natl Acad Sci U S A 2012 Feb 9;109(7):2515-20. Epub 2012 Jan 9.

Institute For Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, Department of Medicine University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.1120600109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289330PMC
February 2012

Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia.

J Appl Physiol (1985) 2012 Jan 20;112(1):187-96. Epub 2011 Oct 20.

Institute for Integrative Physiology and Center for Systems Biology for O(2) Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1152/japplphysiol.00529.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774513PMC
January 2012

Peripheral chemoreceptors: function and plasticity of the carotid body.

Compr Physiol 2012 Jan;2(1):141-219

School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1002/cphy.c100069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919066PMC
January 2012

Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus.

J Neurophysiol 2011 Dec 17;106(6):3045-55. Epub 2011 Aug 17.

Center for Integrative Brain Research, Seattle Children's Research Institute, 1900 9th Ave., Seattle, WA, USA.

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http://dx.doi.org/10.1152/jn.00550.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234088PMC
December 2011

Institute for integrative physiology: resurrection of physiology at the University of Chicago.

Physiologist 2011 Dec;54(6):235-6

Institute for Integrative Physiology, University of Chicago, USA.

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December 2011

Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia.

J Cell Physiol 2011 Nov;226(11):2925-33

Institute for Integrative Physiology and The Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1002/jcp.22640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695992PMC
November 2011

Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase.

J Appl Physiol (1985) 2011 Oct 2;111(4):964-70. Epub 2011 Jun 2.

Institute for Integrative Physiology and Center for Systems Biology of O₂ Sensing, Biological Science Division, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1152/japplphysiol.00022.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191792PMC
October 2011

Sensory plasticity of the carotid body: role of reactive oxygen species and physiological significance.

Respir Physiol Neurobiol 2011 Sep 18;178(3):375-80. Epub 2011 May 18.

Institute for Integrative Physiology and Center for Systems Biology of O(2) Sensing, Biological Sciences Division, University of Chicago, 5841 S. Maryland Avenue, MC 5068, Room N-711, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.resp.2011.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170509PMC
September 2011

Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing.

Antioxid Redox Signal 2011 Apr 6;14(7):1179-90. Epub 2011 Feb 6.

The Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1089/ars.2010.3353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048839PMC
April 2011

NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats.

Antioxid Redox Signal 2011 Feb 19;14(4):533-42. Epub 2010 Oct 19.

Department of Medicine, Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1089/ars.2010.3213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038125PMC
February 2011

Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension.

Proc Natl Acad Sci U S A 2011 Feb 31;108(7):3065-70. Epub 2011 Jan 31.

Biological Sciences Division, Institute for Integrated Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.1100064108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041114PMC
February 2011

Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS.

Respir Physiol Neurobiol 2010 Dec 8;174(3):230-4. Epub 2010 Sep 8.

Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.resp.2010.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042769PMC
December 2010

Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling.

J Neurochem 2010 Dec 19;115(6):1568-78. Epub 2010 Nov 19.

Department of Medicine, Center for Systems Biology of Oxygen Sensing, University of Chicago, Chicago, Illinois 60637-1470, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.07063.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997678PMC
December 2010

Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia.

Respir Physiol Neurobiol 2010 Nov 8;174(1-2):156-61. Epub 2010 Sep 8.

Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.resp.2010.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042768PMC
November 2010

Redox Pioneer: Professor Gregg L. Semenza.

Antioxid Redox Signal 2010 Aug;13(4):559-64

Department of Medicine, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1089/ars.2010.3155DOI Listing
August 2010

Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells.

Am J Physiol Cell Physiol 2010 Aug;299(2):C381-8

Department of Medicine, The Center for Systems Biology of O(2) Sensing, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1152/ajpcell.00530.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928622PMC
August 2010

Hypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS.

Biochem Biophys Res Commun 2009 Oct 3;388(2):212-6. Epub 2009 Aug 3.

Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.07.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735591PMC
October 2009

Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2.

Ann N Y Acad Sci 2009 Oct;1177:162-8

Center for Systems Biology of O Sensing, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05034.xDOI Listing
October 2009

Contrasting effects of intermittent and continuous hypoxia on low O(2) evoked catecholamine secretion from neonatal rat chromaffin cells.

Adv Exp Med Biol 2009 ;648:345-9

The Center for Systems Biology, Departments of Medicine, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1007/978-90-481-2259-2_39DOI Listing
July 2009

Neonatal intermittent hypoxia leads to long-lasting facilitation of acute hypoxia-evoked catecholamine secretion from rat chromaffin cells.

J Neurophysiol 2009 Jun 1;101(6):2837-46. Epub 2009 Apr 1.

Department of Medicine, The Center for Systems Biology of O2Sensing, University of Chicago, MC 5068, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1152/jn.00036.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694101PMC
June 2009

Refinement of telemetry for measuring blood pressure in conscious rats.

J Am Assoc Lab Anim Sci 2009 May;48(3):268-71

Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, Illinois, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696829PMC
May 2009

Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia.

Am J Physiol Regul Integr Comp Physiol 2009 Mar 24;296(3):R735-42. Epub 2008 Dec 24.

Center for Systems Biology of O2 Sensing, Dept. of Medicine, The Univ. of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1152/ajpregu.90490.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665844PMC
March 2009

Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities.

Proc Natl Acad Sci U S A 2009 Jan 14;106(4):1199-204. Epub 2009 Jan 14.

Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.0811018106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626608PMC
January 2009

Post-translational modification of proteins during intermittent hypoxia.

Respir Physiol Neurobiol 2008 Dec;164(1-2):272-6

The Center for Systems Biology, Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.resp.2008.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642904PMC
December 2008

Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.

J Cell Physiol 2008 Dec;217(3):674-85

The Center for Systems Biology, Department of Medicine, University of Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1002/jcp.21537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696817PMC
December 2008

Transcriptional responses to intermittent hypoxia.

Respir Physiol Neurobiol 2008 Dec;164(1-2):277-81

The Center for Systems Biology, Department of Medicine, University of Chicago, MC 5068, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.resp.2008.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390913PMC
December 2008

Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein.

Biochem Biophys Res Commun 2008 Aug 18;373(2):309-14. Epub 2008 Jun 18.

Center for Systems Biology, Department of Medicine, University of Chicago, 5841S. Maryland Avenue, N603, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.bbrc.2008.06.028DOI Listing
August 2008

Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia.

J Appl Physiol (1985) 2008 May 10;104(5):1287-94. Epub 2008 Jan 10.

Center for Systems Biology, Department of Medicine, The University of Chicago, 5841 S. Maryland MC, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1152/japplphysiol.00644.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893879PMC
May 2008

Pronounced depression by propofol on carotid body response to CO2 and K+-induced carotid body activation.

Respir Physiol Neurobiol 2008 Feb 26;160(3):284-8. Epub 2007 Oct 26.

Department of Anesthesiology and Intensive Care Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S156990480700293
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http://dx.doi.org/10.1016/j.resp.2007.10.011DOI Listing
February 2008

Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C.

J Physiol 2007 Oct 16;584(Pt 1):313-9. Epub 2007 Aug 16.

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106-4970, USA.

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http://dx.doi.org/10.1113/jphysiol.2007.140624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277058PMC
October 2007

Cellular mechanisms associated with intermittent hypoxia.

Essays Biochem 2007 ;43:91-104

Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1042/BSE0430091DOI Listing
October 2007

ROS signaling in systemic and cellular responses to chronic intermittent hypoxia.

Antioxid Redox Signal 2007 Sep;9(9):1397-403

Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1089/ars.2007.1732DOI Listing
September 2007

HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia.

Antioxid Redox Signal 2007 Sep;9(9):1391-6

Vascular Biology Program, Institute for Cell Engineering, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1089/ars.2007.1691DOI Listing
September 2007

Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas.

Respir Physiol Neurobiol 2007 Jul 11;157(1):148-53. Epub 2007 Jan 11.

Department of Physiology & Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.resp.2006.12.009DOI Listing
July 2007

Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia.

Exp Physiol 2007 Jan 23;92(1):39-44. Epub 2006 Nov 23.

Department of Physiology & Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44109, USA.

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http://dx.doi.org/10.1113/expphysiol.2006.036434DOI Listing
January 2007

Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia.

J Physiol 2006 Dec 14;577(Pt 2):705-16. Epub 2006 Sep 14.

Department of Physiology & Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44109, USA.

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http://dx.doi.org/10.1113/jphysiol.2006.114033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890436PMC
December 2006